L Beutin

Summary

Country: Germany

Publications

  1. pmc Spread of a distinct Stx2-encoding phage prototype among Escherichia coli O104:H4 strains from outbreaks in Germany, Norway, and Georgia
    Lothar Beutin
    Federal Institute for Risk Assessment, Department of Biological Safety, Berlin, Germany
    J Virol 86:10444-55. 2012
  2. doi request reprint Outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 infection in Germany causes a paradigm shift with regard to human pathogenicity of STEC strains
    Lothar Beutin
    National Reference Laboratory for Escherichia coli, Unit 41, Microbial Toxins, Germany
    J Food Prot 75:408-18. 2012
  3. pmc Virulence gene profiling of enterohemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli strains: a basis for molecular risk assessment of typical and atypical EPEC strains
    Marie Bugarel
    National Reference Laboratory for Escherichia coli NRL E, coli, Federal Institute for Risk Assessment BfR, Berlin, Germany
    BMC Microbiol 11:142. 2011
  4. pmc Characterization of attaching and effacing Escherichia coli (AEEC) isolated from pigs and sheep
    Erik Fröhlicher
    Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Winterthurerstrasse 272, 8057 Zurich, Switzerland
    BMC Microbiol 8:144. 2008
  5. pmc Common origin of plasmid encoded alpha-hemolysin genes in Escherichia coli
    Ylanna Burgos
    Federal Institute for Risk Assessment, Berlin, Germany
    BMC Microbiol 10:193. 2010
  6. doi request reprint Evaluation of the 'GeneDisc' real-time PCR system for detection of enterohaemorrhagic Escherichia coli (EHEC) O26, O103, O111, O145 and O157 strains according to their virulence markers and their O- and H-antigen-associated genes
    L Beutin
    Centre for Infectiology and Pathogen Characterization, Federal Institute for Risk Assessment, Berlin, Germany
    J Appl Microbiol 106:1122-32. 2009
  7. pmc Epidemiological relatedness and clonal types of natural populations of Escherichia coli strains producing Shiga toxins in separate populations of cattle and sheep
    L Beutin
    Department of Microbiology, Robert Koch Institute, D 13353, Berlin, Germany
    Appl Environ Microbiol 63:2175-80. 1997
  8. ncbi request reprint Absence of DNA sequence homology with genes of the Escherichia coli hemB locus in Shiga-toxin producing E. coli (STEC) O157 strains
    P Stümpfle
    Robert Koch Institut, Division of Emerging Bacterial Pathogens, Berlin, Germany
    FEMS Microbiol Lett 174:97-103. 1999
  9. pmc Human infections with Shiga toxin-producing Escherichia coli other than serogroup O157 in Germany
    L Beutin
    Robert Koch Institut, Abt Mikrobiologie, Berlin, Germany
    Emerg Infect Dis 4:635-9. 1998
  10. doi request reprint [Tasks and duties of veterinary reference laboratories for food borne zoonoses]
    Lüppo Ellerbroek
    Bundesinstitut für Risikobewertung, Berlin, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 52:208-13. 2009

Collaborators

Detail Information

Publications14

  1. pmc Spread of a distinct Stx2-encoding phage prototype among Escherichia coli O104:H4 strains from outbreaks in Germany, Norway, and Georgia
    Lothar Beutin
    Federal Institute for Risk Assessment, Department of Biological Safety, Berlin, Germany
    J Virol 86:10444-55. 2012
    ..Major proteins of the virion particles were analyzed by mass spectrometry. Stx2 production in STEC O104:H4 strains was inducible by mitomycin C and was compared to Stx2 production of E. coli K-12 lysogens...
  2. doi request reprint Outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 infection in Germany causes a paradigm shift with regard to human pathogenicity of STEC strains
    Lothar Beutin
    National Reference Laboratory for Escherichia coli, Unit 41, Microbial Toxins, Germany
    J Food Prot 75:408-18. 2012
    ..The survival of EAHEC in seeds and the frequency of human carriers of EAHEC should be investigated for a better understanding of EAHEC transmission routes...
  3. pmc Virulence gene profiling of enterohemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli strains: a basis for molecular risk assessment of typical and atypical EPEC strains
    Marie Bugarel
    National Reference Laboratory for Escherichia coli NRL E, coli, Federal Institute for Risk Assessment BfR, Berlin, Germany
    BMC Microbiol 11:142. 2011
    ..coli (EPEC). The objective of this study was to analyze the relationship between EHEC and EPEC for virulence genes encoded by genomic O-islands and by the EHEC-plasmids...
  4. pmc Characterization of attaching and effacing Escherichia coli (AEEC) isolated from pigs and sheep
    Erik Fröhlicher
    Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Winterthurerstrasse 272, 8057 Zurich, Switzerland
    BMC Microbiol 8:144. 2008
    ..This study reports data on the occurrence of eae positive E. coli carried by healthy pigs and sheep at the point of slaughter, and on serotypes, intimin variants, and further virulence factors of isolated AEEC strains...
  5. pmc Common origin of plasmid encoded alpha-hemolysin genes in Escherichia coli
    Ylanna Burgos
    Federal Institute for Risk Assessment, Berlin, Germany
    BMC Microbiol 10:193. 2010
    ..coli (UPEC), the alpha-hly genes are located on chromosomal pathogenicity islands. Previous work suggested that plasmid and chromosomally encoded alpha-hly may have evolved independently. This was explored in our study...
  6. doi request reprint Evaluation of the 'GeneDisc' real-time PCR system for detection of enterohaemorrhagic Escherichia coli (EHEC) O26, O103, O111, O145 and O157 strains according to their virulence markers and their O- and H-antigen-associated genes
    L Beutin
    Centre for Infectiology and Pathogen Characterization, Federal Institute for Risk Assessment, Berlin, Germany
    J Appl Microbiol 106:1122-32. 2009
    ..To evaluate the GeneDisc multiplex real-time PCR assay for detection of enterohaemorrhagic Escherichia coli (EHEC) O26, O103, O111, O145 and O157 strains...
  7. pmc Epidemiological relatedness and clonal types of natural populations of Escherichia coli strains producing Shiga toxins in separate populations of cattle and sheep
    L Beutin
    Department of Microbiology, Robert Koch Institute, D 13353, Berlin, Germany
    Appl Environ Microbiol 63:2175-80. 1997
    ..Our results indicate that stx-encoding bacteriophages might be the origin of the genetic heterogeneity in STEC from animals...
  8. ncbi request reprint Absence of DNA sequence homology with genes of the Escherichia coli hemB locus in Shiga-toxin producing E. coli (STEC) O157 strains
    P Stümpfle
    Robert Koch Institut, Division of Emerging Bacterial Pathogens, Berlin, Germany
    FEMS Microbiol Lett 174:97-103. 1999
    ..coli K-12 carrying pEO67. We suggest that the cloned gene is involved in iron uptake of E. coli and that the alteration in this part of the hemB locus is clonally inherited in genetically closely related STEC O157 and O55 strains...
  9. pmc Human infections with Shiga toxin-producing Escherichia coli other than serogroup O157 in Germany
    L Beutin
    Robert Koch Institut, Abt Mikrobiologie, Berlin, Germany
    Emerg Infect Dis 4:635-9. 1998
    ..EaeA-negative STEC were found in 35 (39.3%) of the patients and were more associated with clinically uncomplicated cases and adult patients. For pediatric patients, a serotype-independent diagnosis of STEC is recommended...
  10. doi request reprint [Tasks and duties of veterinary reference laboratories for food borne zoonoses]
    Lüppo Ellerbroek
    Bundesinstitut für Risikobewertung, Berlin, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 52:208-13. 2009
    ..coli, for the performance of analysis and tests on zoonoses (Salmonella), and from the group of parasitological zoonotic agents, the national reference laboratory for Trichinella...
  11. ncbi request reprint Comparative evaluation of the Ridascreen Verotoxin enzyme immunoassay for detection of Shiga-toxin producing strains of Escherichia coli (STEC) from food and other sources
    L Beutin
    National Reference Laboratory for Escherichia coli, Federal Institute for Risk Assessment BfR, Berlin, Germany
    J Appl Microbiol 102:630-9. 2007
    ....
  12. ncbi request reprint Escherichia coli as a pathogen in dogs and cats
    L Beutin
    Robert Koch Institut, Division of Emerging Bacterial Pathogens, Berlin, Germany
    Vet Res 30:285-98. 1999
    ..coli between dogs and humans was reported. Further research is needed, however, to determine the role of dogs and cats as transmission vectors of pathogenic E. coli strains to other animals and humans...
  13. ncbi request reprint Occurrence of Shiga toxin-producing Escherichia coli in fecal samples from children with diarrhea and from healthy zebu cattle in Uganda
    D H Kaddu-Mulindw
    Mikrobiologisches Labor, Berlin, Germany
    Int J Food Microbiol 66:95-101. 2001
    ..Our report demonstrates that STEC are not frequent in urban children in Uganda, but domestic cattle were identified as an important natural reservoir for these organisms in this country...
  14. ncbi request reprint Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen
    L Beutin
    National Reference Laboratory for Escherichia coli NRL E coli, Federal Institute for Risk Assessment BfR, Diedersdorfer Weg 1, D 12277 Berlin, Germany
    J Vet Med B Infect Dis Vet Public Health 53:299-305. 2006
    ..Development of new vaccines and probiotics may serve as future tools to control the spread of STEC in animals and humans...