C Beste

Summary

Country: Germany

Publications

  1. doi request reprint Alterations in voluntary movement execution in Huntington's disease are related to the dominant motor system: evidence from event-related potentials
    Christian Beste
    Leibniz Research Centre for Working Environment and Human Factors, WHO Collaborating Centre for Occupational Health, Dortmund, Germany
    Exp Neurol 216:148-57. 2009
  2. doi request reprint Stress improves task processing efficiency in dual-tasks
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Behav Brain Res 252:260-5. 2013
  3. pmc A novel cognitive-neurophysiological state biomarker in premanifest Huntington's disease validated on longitudinal data
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Sci Rep 3:1797. 2013
  4. doi request reprint Learning without training
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Universitatsstrasse 150, D 44780 Bochum, Germany
    Curr Biol 23:R489-99. 2013
  5. ncbi request reprint Faster perceptual learning through excitotoxic neurodegeneration
    Christian Beste
    Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Curr Biol 22:1914-7. 2012
  6. doi request reprint Differential effects of ADORA2A gene variations in pre-attentive visual sensory memory subprocesses
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Eur Neuropsychopharmacol 22:555-61. 2012
  7. doi request reprint Mechanisms mediating parallel action monitoring in fronto-striatal circuits
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Neuroimage 62:137-46. 2012
  8. ncbi request reprint Dissociable influences of NR2B-receptor related neural transmission on functions of distinct associative basal ganglia circuits
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Bochum, Germany
    Neuroimage 52:309-15. 2010
  9. doi request reprint The biopsychology-nonlinear analysis toolbox: a free, open-source Matlab-toolbox for the non-linear analysis of time series data
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Neuroinformatics 8:197-200. 2010
  10. doi request reprint Associations between the tumor necrosis factor alpha gene (-308G→A) and event-related potential indices of attention and mental rotation
    C Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Germany
    Neuroscience 170:742-8. 2010

Detail Information

Publications36

  1. doi request reprint Alterations in voluntary movement execution in Huntington's disease are related to the dominant motor system: evidence from event-related potentials
    Christian Beste
    Leibniz Research Centre for Working Environment and Human Factors, WHO Collaborating Centre for Occupational Health, Dortmund, Germany
    Exp Neurol 216:148-57. 2009
    ..Despite neurophysiological alterations originating in the dominant left hemisphere in HDs, they also affect the right hemisphere, probably due to a dysfunction in interhemispheric inhibition in HD...
  2. doi request reprint Stress improves task processing efficiency in dual-tasks
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Behav Brain Res 252:260-5. 2013
    ..Increases in processing efficiency in dual-tasks were predictable by means of individual salivary cortisol levels. ..
  3. pmc A novel cognitive-neurophysiological state biomarker in premanifest Huntington's disease validated on longitudinal data
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Sci Rep 3:1797. 2013
    ..The study provides a biomarker, which could change practice of progression diagnostics in a major basal ganglia disease and which may help to evaluate potential neuroprotective treatments in future clinical trials...
  4. doi request reprint Learning without training
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Universitatsstrasse 150, D 44780 Bochum, Germany
    Curr Biol 23:R489-99. 2013
    ..Although the underlying mechanisms are far from being understood, training-independent sensory learning opens novel possibilities for applications aimed at augmenting human cognition...
  5. ncbi request reprint Faster perceptual learning through excitotoxic neurodegeneration
    Christian Beste
    Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Curr Biol 22:1914-7. 2012
    ....
  6. doi request reprint Differential effects of ADORA2A gene variations in pre-attentive visual sensory memory subprocesses
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Eur Neuropsychopharmacol 22:555-61. 2012
    ..Hence, we assume that this modulation may be due to differential effects of increased adenosine A(2A) receptor signaling on glutamatergic transmission and striatal medium spiny neuron (MSN) interaction...
  7. doi request reprint Mechanisms mediating parallel action monitoring in fronto-striatal circuits
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Neuroimage 62:137-46. 2012
    ....
  8. ncbi request reprint Dissociable influences of NR2B-receptor related neural transmission on functions of distinct associative basal ganglia circuits
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Bochum, Germany
    Neuroimage 52:309-15. 2010
    ..We provide a model on this that may be a target for future research...
  9. doi request reprint The biopsychology-nonlinear analysis toolbox: a free, open-source Matlab-toolbox for the non-linear analysis of time series data
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Neuroinformatics 8:197-200. 2010
    ..The Biopsychology--Nonlinear Analysis Toolbox and documentation are available freely and open-source from http://biopsynltoolbox.sourceforge.net...
  10. doi request reprint Associations between the tumor necrosis factor alpha gene (-308G→A) and event-related potential indices of attention and mental rotation
    C Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Germany
    Neuroscience 170:742-8. 2010
    ....
  11. doi request reprint The role of the BDNF Val66Met polymorphism for the synchronization of error-specific neural networks
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    J Neurosci 30:10727-33. 2010
    ..The results suggest that alterations in neural synchronization processes modulated by the genetic variants of BDNF Val66Met may be the mechanism by which cognitive functions are affected...
  12. doi request reprint Variations in the TNF-α gene (TNF-α -308G→A) affect attention and action selection mechanisms in a dissociated fashion
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Bochum, Germany
    J Neurophysiol 104:2523-31. 2010
    ..The results refine the picture of the effects of the TNF-α -308G→A SNP on cognitive functions and emphasize the known divergent effects of TNF-α on brain functions...
  13. doi request reprint The functional BDNF Val66Met polymorphism affects functions of pre-attentive visual sensory memory processes
    Christian Beste
    Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr University Bochum, Universitatsstrasse 150, D 44780 Bochum, Germany
    Neuropharmacology 60:467-71. 2011
    ..Thus, these results show that the BDNF Val66Met polymorphism has an effect on pre-attentive visual sensory memory processes...
  14. doi request reprint Double dissociated effects of the functional TNF-α -308G/A polymorphism on processes of cognitive control
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Germany
    Neuropsychologia 49:196-202. 2011
    ..In the GG genotype group, the pattern of results was vice versa. The results refine the view of the effects of TNF-α on cognitive functions...
  15. doi request reprint Improvement and impairment of visually guided behavior through LTP- and LTD-like exposure-based visual learning
    Christian Beste
    Abteilung Biopsychologie, Institut für Kognitive Neurowissenschaft, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Curr Biol 21:876-82. 2011
    ....
  16. doi request reprint The functional 5-HT1A receptor polymorphism affects response inhibition processes in a context-dependent manner
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Universitatsstrasse 150, D 44780 Bochum, Germany
    Neuropsychologia 49:2664-72. 2011
    ....
  17. doi request reprint On the role of fronto-striatal neural synchronization processes for response inhibition--evidence from ERP phase-synchronization analyses in pre-manifest Huntington's disease gene mutation carriers
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr University Bochum, Bochum, Germany
    Neuropsychologia 49:3484-93. 2011
    ..This suggests that phase-locking parameters may prove useful in future studies evaluating a possible function as a biomarker in Huntington's disease...
  18. doi request reprint Paradoxical association of the brain-derived-neurotrophic-factor val66met genotype with response inhibition
    C Beste
    Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr Universitat Bochum, Germany
    Neuroscience 166:178-84. 2010
    ..This is the first study showing that met alleles of the BDNF val66met polymorphism confer an advantage for a specific cognitive function. We propose a neuronal model how this advantage gets manifest on a neuronal level...
  19. doi request reprint The relevance of the functional 5-HT1A receptor polymorphism for attention and working memory processes during mental rotation of characters
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Universitatsstrasse 150, D 44780 Bochum, Germany
    Neuropsychologia 48:1248-54. 2010
    ..It is hypothesized that decreased attentional processes, dependent on different 5-HT1A C(-1019)G genotypes, may cause parietal networks to increase saccadic activity in order to perform mental rotation...
  20. doi request reprint Differential modulations of response control processes by 5-HT1A gene variation
    Christian Beste
    Institute for Cognitive Neuroscience, Department of Biopsychology, Ruhr Universitat Bochum, Germany
    Neuroimage 50:764-71. 2010
    ..The examined functions are precisely regulated on a neuronal level, since neurophysiological and behavioural effects are driven in an allele-dose fashion. Because of this, the results are of importance for future clinical applications...
  21. doi request reprint Individual differences in ERPs during mental rotation of characters: lateralization, and performance level
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany Leibniz Research Centre, Dortmund, Germany
    Brain Cogn 72:238-43. 2010
    ....
  22. doi request reprint Response inhibition subprocesses and dopaminergic pathways: basal ganglia disease effects
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University of Bochum, Bochum, Germany
    Neuropsychologia 48:366-73. 2010
    ..In contrast, inhibition monitoring is most likely modulated by the mesocortico-limbic dopamine system. These processes are equally affected in healthy aging and both basal ganglia diseases (i.e. PD, HD)...
  23. ncbi request reprint Error processing in normal aging and in basal ganglia disorders
    C Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University of Bochum, Germany
    Neuroscience 159:143-9. 2009
    ..Although many aging, Parkinson's disease and Huntington's disease studies on error processing functions have already been published, this study ties together several related observations across all of these groups in one experiment...
  24. doi request reprint Functional 5-HT1a receptor polymorphism selectively modulates error-specific subprocesses of performance monitoring
    Christian Beste
    Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr Universitat Bochum, Germany
    Hum Brain Mapp 31:621-30. 2010
    ....
  25. ncbi request reprint Effects of stimulus-response compatibility on inhibitory processes in Parkinson's disease
    Christian Beste
    IfADo, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Eur J Neurosci 29:855-60. 2009
    ..The results suggest that inhibitory deficits in PD are only evident in complex (incompatible) stimulus-response mappings. These effects are probably due to an overstrain of striatal processes...
  26. doi request reprint Stimulus-response compatibility in Huntington's disease: a cognitive-neurophysiological analysis
    Christian Beste
    Leibniz Research Centre for Working Environment and Human Factors, WHO Collaborating Centre for Occupational Health and Human Factors, Ardeystrasse 67, Dortmund, Germany
    J Neurophysiol 99:1213-23. 2008
    ..Overall, the results suggest alterations in attentional control, conflict processing, and controlled response selection in HD but not in automatic response selection...
  27. doi request reprint Increased cognitive functioning in symptomatic Huntington's disease as revealed by behavioral and event-related potential indices of auditory sensory memory and attention
    Christian Beste
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    J Neurosci 28:11695-702. 2008
    ..In contrast, selectively enhanced cognitive functioning can emerge together with otherwise impaired cognitive functioning...
  28. doi request reprint Response inhibition in Huntington's disease-a study using ERPs and sLORETA
    Christian Beste
    Department of Neurology, Huntington Centre NRW, St Josef Hospital, Ruhr University Bochum, Germany
    Neuropsychologia 46:1290-7. 2008
    ..The differentially affected Nogo-components suggest that they rely on different neuronal circuits, even within the ACC. For HD this suggests that this structure is not entirely dysfunctional...
  29. pmc Error processing in Huntington's disease
    Christian Beste
    Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    PLoS ONE 1:e86. 2006
    ..Since dopaminergic alterations are related to the CAG-repeat, a Ne reduction may furthermore also be related to the genetic disease load...
  30. ncbi request reprint Levels of error processing in Huntington's disease: a combined study using event-related potentials and voxel-based morphometry
    Christian Beste
    Leibniz Research Centre for Working Environment and Human Factors, WHO Collaborating Centre for Occupational Health and Human Factors, Dortmund, Germany
    Hum Brain Mapp 29:121-30. 2008
    ..In conclusion a deterioration in error processing in HD compared to pHD is mainly reflected by the Ne. The deterioration might rely on two factors: a neurofunctional and a neuroanatomical...
  31. ncbi request reprint Functional compensation or pathology in cortico-subcortical interactions in preclinical Huntington's disease?
    Christian Beste
    Department of Neurology, Huntington Centre NRW, St Josef Hospital, Ruhr University Bochum, Germany
    Neuropsychologia 45:2922-30. 2007
    ..It is proposed that compensation is a transient effect of the whole pathogenetic dynamics of HD, with these two processes not foreclosing each other...
  32. doi request reprint Lateralized neural mechanisms underlying the modulation of response inhibition processes
    Sebastian Ocklenburg
    Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr University of Bochum, Bochum, Germany
    Neuroimage 55:1771-8. 2011
    ..Instead, hemispheric dominances in information processing can induce differences in demands on cognitive processes operating via bilateral networks that ultimately drive behavioural asymmetries...
  33. ncbi request reprint Developmental changes in visual line bisection in women throughout adulthood
    Christian Beste
    Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr University Bochum, D 44780 Bochum, Germany
    Dev Neuropsychol 30:753-67. 2006
    ..The results suggest that developmental changes in hemispheric asymmetry of spatial attention are more pronounced in women and support the view that neuromorphological changes during adulthood differ between sexes...
  34. pmc Response monitoring in de novo patients with Parkinson's disease
    Rita Willemssen
    Leibniz Research Centre for Working Environment and Human Factors, WHO Collaborating Research Centre Dortmund, Dortmund, Germany
    PLoS ONE 4:e4898. 2009
    ..One of these is error processing, which depends upon phasic decreases of medial prefrontal dopaminergic activity. Until now, there is no study evaluating these processes in newly diagnosed, untreated patients with PD ("de novo PD")...
  35. doi request reprint fMRI reveals altered auditory processing in manifest and premanifest Huntington's disease
    Carsten Saft
    Department of Neurology, Huntington Center NRW, St Josef Hospital, Ruhr University Bochum, Germany
    Neuropsychologia 46:1279-89. 2008
    ..They also stress the involvement of the basal ganglia-thalamic circuits in the processing of sensory auditory stimuli...
  36. pmc Time processing in Huntington's disease: a group-control study
    Christian Beste
    Department of Neurology, Huntington Centre NRW, St Josef Hospital, Ruhr University, Bochum, Germany
    PLoS ONE 2:e1263. 2007
    ..It may be hypothesized that timing functions may be deteriorated to a different extent in motor and non-motor timing, because in motor timing the underlying brain structures may be more demanding than in non-motor timing...