R Beschorner

Summary

Country: Germany

Publications

  1. ncbi CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injury
    Rudi Beschorner
    Institute of Brain Research, University of Tubingen, Medical School, Calwerstr 3, 72076, Germany
    Acta Neuropathol 103:541-9. 2002
  2. ncbi Extradural ependymal tumor with myxopapillary and ependymoblastic differentiation in a case of Schinzel-Giedion syndrome
    Rudi Beschorner
    Institute of Brain Research, Eberhard Karls University, Medical School, Tuebingen, Germany
    Acta Neuropathol 113:339-46. 2007
  3. ncbi Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium
    Rudi Beschorner
    Institute for Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 117:667-75. 2009
  4. ncbi Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Histopathology 50:897-910. 2007
  5. ncbi Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1
    Rudi Beschorner
    Institute of Brain Research Neuropathology, Eberhard Karls University, Tuebingen, Germany
    Hum Pathol 37:854-60. 2006
  6. ncbi Atypical teratoid-rhabdoid tumor spreading along the trigeminal nerve
    R Beschorner
    Institute of Brain Research, Tubingen, Germany
    Pediatr Neurosurg 42:258-63. 2006
  7. ncbi Mature cerebellar teratoma in adulthood
    Rudi Beschorner
    Institute for Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Neuropathology 29:176-80. 2009
  8. ncbi Expression of EAAT1 reflects a possible neuroprotective function of reactive astrocytes and activated microglia following human traumatic brain injury
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tuebingen, Germany
    Histol Histopathol 22:515-26. 2007
  9. ncbi Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans
    R Beschorner
    Institute of Brain Research, University of Tubingen, Germany
    Acta Neuropathol 100:377-84. 2000
  10. ncbi Differential regulation of the monocytic calcium-binding peptides macrophage-inhibiting factor related protein-8 (MRP8/S100A8) and allograft inflammatory factor-1 (AIF-1) following human traumatic brain injury
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 100:627-34. 2000

Detail Information

Publications53

  1. ncbi CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injury
    Rudi Beschorner
    Institute of Brain Research, University of Tubingen, Medical School, Calwerstr 3, 72076, Germany
    Acta Neuropathol 103:541-9. 2002
    ..In contrast to activated parenchymal microglia/macrophages, resting parenchymal microglial cells lacked CD14. Thus, early CD14 expression constitutes an essential part of the acute inflammatory CNS response following trauma...
  2. ncbi Extradural ependymal tumor with myxopapillary and ependymoblastic differentiation in a case of Schinzel-Giedion syndrome
    Rudi Beschorner
    Institute of Brain Research, Eberhard Karls University, Medical School, Tuebingen, Germany
    Acta Neuropathol 113:339-46. 2007
    ..The present case is the first report on an ependymal tumor with a mixture of myxopapillary, anaplastic and ependymoblastic features and the first report on an ependymal tumor arising on the genetic background of SGS...
  3. ncbi Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium
    Rudi Beschorner
    Institute for Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 117:667-75. 2009
    ..In conclusion, in contrast to neoplastic CP samples, expression of EAAT-1 is exceptionally rare in non-neoplastic CP. Thus, EAAT-1 is superior to GFAP as a helpful diagnostic tool in CP samples...
  4. ncbi Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Histopathology 50:897-910. 2007
    ..Thus, excitatory amino acid transporters (EAATs) might be a promising therapeutic target. The aim of this study was to investigate glial expression of EAATs following ischaemia...
  5. ncbi Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1
    Rudi Beschorner
    Institute of Brain Research Neuropathology, Eberhard Karls University, Tuebingen, Germany
    Hum Pathol 37:854-60. 2006
    ..Our findings indicate that EAAT1 immunohistochemistry may be useful in differentiating CPT from metastatic carcinomas...
  6. ncbi Atypical teratoid-rhabdoid tumor spreading along the trigeminal nerve
    R Beschorner
    Institute of Brain Research, Tubingen, Germany
    Pediatr Neurosurg 42:258-63. 2006
    ..The origin of the trigeminal tumor as a late metastasis of the former ATRT or as a less likely irradiation-induced secondary ATRT and the operative approach are discussed...
  7. ncbi Mature cerebellar teratoma in adulthood
    Rudi Beschorner
    Institute for Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Neuropathology 29:176-80. 2009
    ..Late clinical manifestation of the tumor in this case is probably due to an acute late-onset hemorrhage within the tumor...
  8. ncbi Expression of EAAT1 reflects a possible neuroprotective function of reactive astrocytes and activated microglia following human traumatic brain injury
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tuebingen, Germany
    Histol Histopathol 22:515-26. 2007
    ....
  9. ncbi Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans
    R Beschorner
    Institute of Brain Research, University of Tubingen, Germany
    Acta Neuropathol 100:377-84. 2000
    ..Further, HO-1 was weakly expressed in astrocytes in the perifocal penumbra. In contrast to experimental data derived from rat focal ischemia, these results indicate a prolonged HO-1 expression in humans after brain injury...
  10. ncbi Differential regulation of the monocytic calcium-binding peptides macrophage-inhibiting factor related protein-8 (MRP8/S100A8) and allograft inflammatory factor-1 (AIF-1) following human traumatic brain injury
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 100:627-34. 2000
    ..We conclude that the delayed expression of MRP8 and the lack of AIF-1 up-regulation in microglia after TBI is in contrast to ischemic brain lesions and might reflect different activation cascades of microglia...
  11. ncbi Infiltrating CD14+ monocytes and expression of CD14 by activated parenchymal microglia/macrophages contribute to the pool of CD14+ cells in ischemic brain lesions
    Rudi Beschorner
    Institute of Brain Research, University of Tubingen Medical School, Calwer Str 3, Germany
    J Neuroimmunol 126:107-15. 2002
    ..5 days and remained elevated until late stages. Early CD14 expression suggests an essential part of CD14 in the acute inflammatory response following stroke...
  12. ncbi Lesion-associated accumulation of uPAR/CD87- expressing infiltrating granulocytes, activated microglial cells/macrophages and upregulation by endothelial cells following TBI and FCI in humans
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tuebingen, Germany
    Neuropathol Appl Neurobiol 26:522-7. 2000
    ..In conclusion, the study defines the localization, kinetic course and cellular source of uPAR as a potential pharmacological target following human TBI and FCI...
  13. ncbi Diagnostic value of WT1 in neuroepithelial tumours
    J Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 35:69-81. 2009
    ....
  14. ncbi De novo expression of the hemoglobin scavenger receptor CD163 by activated microglia is not associated with hemorrhages in human brain lesions
    K Holfelder
    Institute for Pathology and Neuropathology, Department for Neuropathology, Eberhard Karls University, Tuebingen, Germany
    Histol Histopathol 26:1007-17. 2011
    ..Thus, the antiinflammatory function of CD163 probably predominates, both in hemorrhagic and non-hemorrhagic brain lesions and points to possible immunomodulatory treatment strategies targeting CD163...
  15. ncbi Differential cellular accumulation of connective tissue growth factor defines a subset of reactive astrocytes, invading fibroblasts, and endothelial cells following central nervous system injury in rats and humans
    J M Schwab
    Institute of Brain Research, University of Tuebingen Medical School, Germany
    J Neurotrauma 18:377-88. 2001
    ..Furthermore, peri-lesional upregulation of endothelial CTGF expression points to a role in blood-brain barrier function and angiogenesis. In addition, CTGF appears to be a sensitive marker of early astrocyte activation...
  16. ncbi Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors
    R Beschorner
    Institute for Brain Research, Eberhard Karls University, Tuebingen, Germany
    Histol Histopathol 24:1507-14. 2009
    ..To date, no data exist on expression of CDX2 in normal and neoplastic choroid plexus epithelium. Aim: To investigate CDX2 expression in normal and neoplastic choroid plexus...
  17. ncbi T2 and DWI in pilocytic and pilomyxoid astrocytoma with pathologic correlation
    M Horger
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tubingen, Germany
    Can J Neurol Sci 39:491-8. 2012
    ..To quantify and compare T2 signal and apparent diffusion coefficient (ADC) in pilocytic and pilomyxoid astrocytoma (PA and PMA) and correlate results with myxoid content...
  18. ncbi Erythropoietin receptor expression in normal and neoplastic choroid plexus
    R Beschorner
    Institute for Brain Research, Tubingen, Germany
    Clin Neuropathol 30:33-40. 2011
    ..Lower levels of EpoR have been associated with shorter survival in high grade gliomas and higher risk of tumor recurrence in meningiomas...
  19. ncbi Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions
    E Postler
    nstitute for Brain Research, University of Tubingen, Calwer Strosse 3, D 72076, Tubingen, Germany
    J Neuroimmunol 104:85-91. 2000
    ..We conclude that AIF-1 is a sensitive marker of human microglial activation not only in inflammation but also in non-inflammatory lesions of the CNS...
  20. ncbi Common and uncommon imaging findings in progressive multifocal leukoencephalopathy (PML) with differential diagnostic considerations
    M Horger
    Department of Radiology, Diagnostic and Interventional Radiology, Eberhard Karls University, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    Clin Neurol Neurosurg 114:1123-30. 2012
    ....
  21. ncbi Primary anaplastic ganglioglioma with a small-cell glioblastoma component
    J Schittenhelm
    Institute of Brain Research, Eberhard Karls University Tubingen, Germany
    Clin Neuropathol 27:91-5. 2008
    ..To our knowledge, this is the first reported case of a primary anaplastic ganglioglioma with a small-cell glioblastoma component...
  22. ncbi Sellar neuroblastoma mimicking a pituitary tumour: case report and review of the literature
    K Schmalisch
    Department of Neurosurgery, University of Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    Clin Neurol Neurosurg 111:774-8. 2009
    ..No pituitary hormone receptors were expressed. The MIB-1 labelling index was positive in 5% of the cell nucleoli. In the further course, the patient underwent radiotherapy of the neuroaxis. A brief review of the literature is presented...
  23. ncbi Outcome of transanal endorectal pull-through in patients with Hirschsprung's disease
    F Obermayr
    Department of Pediatric Surgery, University of Tuebingen, Tuebingen, Germany
    Eur J Pediatr Surg 19:220-3. 2009
    ..In this study, the postoperative course and functional outcome after TERPT in 25 patients with HD is evaluated...
  24. ncbi Rosai-Dorfman disease involving the cranial base, paranasal sinuses and spinal cord
    J Kaminsky
    Department of Neurosurgery, University Hospital of Tubingen, Germany
    Clin Neuropathol 24:194-200. 2005
    ..The individual management of Rosai-Dorfman disease may be challenging due to diffuse involvement of neurovascular structures at the skull base...
  25. ncbi [Rare differential diagnosis of diabetes insipidus]
    K Müssig
    Medizinische Klinik IV, Universitätsklinik Tübingen, Institut für Hirnforschung, Universität Tübingen Otfried Müller Str 10 72076 Tübingen
    Dtsch Med Wochenschr 133:2159-60. 2008
  26. ncbi Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Mod Pathol 22:1600-11. 2009
    ..Thus, annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof...
  27. ncbi Water diffusivity: comparison of primary CNS lymphoma and astrocytic tumor infiltrating the corpus callosum
    Marius Horger
    Department of Diagnostic Radiology, Eberhard Karls University, 72076 Tubingen, Germany
    AJR Am J Roentgenol 193:1384-7. 2009
    ..The purpose of this study was to determine whether lymphoma and astrocytic tumor infiltrating the corpus callosum can be reliably differentiated with measurement of water diffusivity...
  28. ncbi Postoperative intracranial seeding of craniopharyngiomas--report of three cases and review of the literature
    Kathrin Schmalisch
    Department of Neurosurgery, University of Tuebingen, 72076 Tuebingen, Germany
    Acta Neurochir (Wien) 152:313-9; discussion 319. 2010
    ..Seeding of craniopharyngioma has been rarely reported. We present three cases that ectopically recurred with seeding along the surgical route and CSF spaces...
  29. ncbi WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes
    Jens Schittenhelm
    Institute of Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Brain Pathol 18:344-53. 2008
    ..68, respectively. Therefore, WT1 expression in astrocytes indicates a neoplastic origin and might represent an important diagnostic tool to differentiate reactive from neoplastic astrocytes by immunohistochemistry...
  30. ncbi Primary non-Hodgkin lymphoma of the cranial nerves mimicking neurofibromatosis Type 2. Case illustration
    Andrei Koerbel
    Department of Neurosurgery and Institute of Brain Research, , Germany
    J Neurosurg 102:1166. 2005
  31. ncbi Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, D 72076 Tuebingen, Germany
    Hum Pathol 36:854-7. 2005
    ..To our knowledge, this is the first case of a disseminating anaplastic brainstem oligodendroglioma associated with this specific allelic loss occurring in childhood...
  32. ncbi Coincidence of semilobar holoprosencephaly and Chiari II malformation: correlation of prenatal diagnostics and neuropathologic findings
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    J Child Neurol 21:426-9. 2006
    ....
  33. ncbi Multiple thromboembolic events in fetofetal transfusion syndrome in triplets contributing to the understanding of pathogenesis of hydranencephaly in combination with polymicrogyria
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Hum Pathol 37:1503-7. 2006
    ..Polymicrogyria can be considered as postmigratory laminar necrosis. Our findings contribute to the pathogenetic understanding of combined hydranencephaly and polymicrogyria...
  34. ncbi Albumin in immunohistochemistry: Foe and friend
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Medical School, D 72076 Tuebingen, Germany
    Appl Immunohistochem Mol Morphol 14:441-4. 2006
    ..Furthermore, these results imply that in case of a good specific staining pattern, the use of albumin in immunohistochemical solutions merely exerts significant negative background staining effects...
  35. ncbi Gliosarcoma with chondroid and osseous differentiation
    Jens Schittenhelm
    Institute of Brain Research, University Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:90-4. 2007
    ....
  36. ncbi Successful treatment of aspergillus granuloma involving the cavernous sinus and the middle fossa by using surgery and voriconazole. Case illustration
    Dirk Freudenstein
    Department of Neurosurgery, , Germany
    J Neurosurg 106:511. 2007
  37. ncbi Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: proposal of an unusual pathogenetic event and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, 72076 Tuebingen, Germany
    Neurosurg Rev 31:157-63. 2008
    ..Our review of the literature provides further insights regarding the clinical behavior and different histological types of the lesions as well as the inflammatory changes that can occur in Rathke's cleft cysts...
  38. ncbi Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:383-9. 2007
    ..Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed...
  39. ncbi Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury
    Jan M Schwab
    Institute of Brain Research, University of Tubingen, Medical School, Germany
    J Neurosurg 96:892-9. 2002
    ..The authors report the differential localization of COX-1 in human traumatic brain injury (TBI)...
  40. ncbi Expression and functional activity of osteoprotegerin in human malignant gliomas
    U Naumann
    Laboratory of Molecular Neuro Oncology, Department of Neurology, University of Tubingen Medical School, Auf der Morgenstelle 15, 72076, Tubingen, Germany
    Acta Neuropathol 107:17-22. 2004
    ..Altogether, however, these data suggest that OPG expression may not be a major pathway of glioma cell resistance to future Apo2L/TRAIL-based therapeutic approaches...
  41. ncbi Spinal pilocytic astrocytoma: MR imaging findings at first presentation and following surgery
    M Horger
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tubingen, Germany
    Eur J Radiol 79:389-99. 2011
    ....
  42. ncbi No evidence for WT1 involvement in a beta-catenin-independent activation of the Wnt signaling pathway in pituitary adenomas
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Calwerstr 3, 72076, Tubingen, Germany
    Endocr Pathol 20:158-62. 2009
    ..There is no evidence that WT1 does regulate the Wnt-4/beta-catenin-independent pathway which is activated in the Pit-1-expressing subset of pituitary adenomas...
  43. ncbi Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms
    Jens Schittenhelm
    Institute for Brain Research, Eberhard Karls University, 72076 Tuebingen, Germany
    Folia Neuropathol 48:75-80. 2010
    ..While many neoplasms have been studied, to date, no data is available on CDX2 expression in craniopharyngiomas. Furthermore, only very few data are available on CDX2 expression in normal pituitary gland tissue and/or pituitary adenomas...
  44. ncbi Pituicytoma in a patient with Cushing's disease: case report and review of the literature
    K Schmalisch
    Department of Neurosurgery, University of Tuebingen, 72076, Tuebingen, Germany
    Pituitary 15:10-6. 2012
    ..Coincidence of pituicytoma and pituitary-dependent Cushing's disease has not previously been reported...
  45. ncbi Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain
    Jan M Schwab
    Institute of Brain Research, School of Medicine, and Experimental Tissue Engineering, Institute of Anatomy, Eberhard Karls University of Tuebingen, Tuebingen, Germany
    Arch Neurol 62:1561-8. 2005
    ..However, the role of RGM in adult central nervous system lesions remains to be clarified...
  46. ncbi Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathology 27:463-7. 2007
    ....
  47. ncbi Lesional expression of RhoA and RhoB following traumatic brain injury in humans
    Christine Brabeck
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    J Neurotrauma 21:697-706. 2004
    ..As the observed upregulation of RhoA and RhoB was still detectable months after TBI, we speculate that even delayed treatment with Rho inhibitors might be a therapeutic option...
  48. ncbi A 27-year-old woman with cranial nerve dysfunction
    Andrei Koerbel
    Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
    Brain Pathol 17:327-8. 2007
  49. ncbi Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis
    Rudi Beschorner
    Brain Pathol 13:231; author reply 231-2. 2003
  50. ncbi Retroclival ecchordosis physaliphora: MR imaging and review of the literature
    Florian Mehnert
    Department of Neuroradiology, University of Tuebingen, Hoppe-Seyler-Str 3, D-72076 Tuebingen, Germany
    AJNR Am J Neuroradiol 25:1851-5. 2004
    ..On the basis of these five cases and a review of literature, contrast enhancement and the presence of clinical symptoms seem to be highly reliable parameters in the differential diagnosis of intradural chordoma and EP...
  51. ncbi Prognostic implications of atypical histologic features in choroid plexus papilloma
    Astrid Jeibmann
    Institute of Neuropathology, , , Germany
    J Neuropathol Exp Neurol 65:1069-73. 2006
    ..Close follow up of patients harboring atypical choroid plexus papillomas may be warranted...
  52. ncbi 47-year-old woman with a clival mass
    Rudi Beschorner
    Brain Pathol 18:100-2, 141. 2008
  53. ncbi A 63-year-old man with dementia, ataxia and VI nerve palsy
    Michel Mittelbronn
    Brain Pathol 17:466-7, 474. 2007