Wolfgang Bernhard

Summary

Country: Germany

Publications

  1. doi request reprint Choline supply of preterm infants: assessment of dietary intake and pathophysiological considerations
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, 72076, Tubingen, Germany
    Eur J Nutr 52:1269-78. 2013
  2. ncbi request reprint Developmental changes in rat surfactant lipidomics in the context of species variability
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
    Pediatr Pulmonol 42:794-804. 2007
  3. ncbi request reprint Increased palmitoyl-myristoyl-phosphatidylcholine in neonatal rat surfactant is lung specific and correlates with oral myristic acid supply
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, FRG
    J Appl Physiol (1985) 111:449-57. 2011
  4. ncbi request reprint From birds to humans: new concepts on airways relative to alveolar surfactant
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, Germany
    Am J Respir Cell Mol Biol 30:6-11. 2004
  5. ncbi request reprint Mass spectrometric analysis of surfactant metabolism in human volunteers using deuteriated choline
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, Germany
    Am J Respir Crit Care Med 170:54-8. 2004
  6. doi request reprint Effects of recombinant human keratinocyte growth factor on surfactant, plasma, and liver phospholipid homeostasis in hyperoxic neonatal rats
    Marco Raith
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, Tubingen, Germany
    J Appl Physiol (1985) 112:1317-28. 2012
  7. doi request reprint Myristate is selectively incorporated into surfactant and decreases dipalmitoylphosphatidylcholine without functional impairment
    Christopher J Pynn
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
    Am J Physiol Regul Integr Comp Physiol 299:R1306-16. 2010
  8. pmc Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo
    Christopher J Pynn
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
    J Lipid Res 52:399-407. 2011
  9. ncbi request reprint rhKGF stimulates lung surfactant production in neonatal rats in vivo
    Jens Gesche
    Faculty of Medicine, Department of Neonatology, Eberhard Karls University, Tubingen, Germany
    Pediatr Pulmonol 46:882-95. 2011
  10. doi request reprint Early feeding of fortified breast milk and in-hospital-growth in very premature infants: a retrospective cohort analysis
    Christoph Maas
    Department of Neonatology, University Children s Hospital Tubingen, Calwerstr, 7, Tuebingen 72076, Germany
    BMC Pediatr 13:178. 2013

Collaborators

Detail Information

Publications20

  1. doi request reprint Choline supply of preterm infants: assessment of dietary intake and pathophysiological considerations
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, 72076, Tubingen, Germany
    Eur J Nutr 52:1269-78. 2013
    ..While accepted as essential for fetal and neonatal development, its role in preterm infant nutrition has not yet gained much attention...
  2. ncbi request reprint Developmental changes in rat surfactant lipidomics in the context of species variability
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
    Pediatr Pulmonol 42:794-804. 2007
    ..In adult mammals, however, only concentrations of palmitoyl-palmitoleoyl-PC correlate with RR...
  3. ncbi request reprint Increased palmitoyl-myristoyl-phosphatidylcholine in neonatal rat surfactant is lung specific and correlates with oral myristic acid supply
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, FRG
    J Appl Physiol (1985) 111:449-57. 2011
    ..This was accompanied by reduced reactive oxygen species production. We propose that nutritional supply with C14:0 and its lung-specific enrichment may contribute to decreased reactive oxygen species production during alveolarization...
  4. ncbi request reprint From birds to humans: new concepts on airways relative to alveolar surfactant
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, Germany
    Am J Respir Cell Mol Biol 30:6-11. 2004
    ..We suggest that the molecular composition of surfactant is adapted to differences in the architecture of pulmonary surfaces and to the dynamics of surface area changes during respiration...
  5. ncbi request reprint Mass spectrometric analysis of surfactant metabolism in human volunteers using deuteriated choline
    Wolfgang Bernhard
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, Germany
    Am J Respir Crit Care Med 170:54-8. 2004
    ..0 +/- 1.2%), and equilibrium was achieved after only 48 hours. We conclude that infusion of deuteriated choline and electrospray ionization tandem mass spectrometry is useful to investigate surfactant metabolism in humans in vivo...
  6. doi request reprint Effects of recombinant human keratinocyte growth factor on surfactant, plasma, and liver phospholipid homeostasis in hyperoxic neonatal rats
    Marco Raith
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, Tubingen, Germany
    J Appl Physiol (1985) 112:1317-28. 2012
    ..We suggest that rhKGF has potential as a therapeutic agent in neonates by improving pulmonary and systemic PC homeostasis...
  7. doi request reprint Myristate is selectively incorporated into surfactant and decreases dipalmitoylphosphatidylcholine without functional impairment
    Christopher J Pynn
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
    Am J Physiol Regul Integr Comp Physiol 299:R1306-16. 2010
    ..Surfactant that is high in PC16:0/14:0 but low in PC16:0/16:0 is compatible with normal respiration and surfactant function in vitro...
  8. pmc Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo
    Christopher J Pynn
    Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
    J Lipid Res 52:399-407. 2011
    ....
  9. ncbi request reprint rhKGF stimulates lung surfactant production in neonatal rats in vivo
    Jens Gesche
    Faculty of Medicine, Department of Neonatology, Eberhard Karls University, Tubingen, Germany
    Pediatr Pulmonol 46:882-95. 2011
    ....
  10. doi request reprint Early feeding of fortified breast milk and in-hospital-growth in very premature infants: a retrospective cohort analysis
    Christoph Maas
    Department of Neonatology, University Children s Hospital Tubingen, Calwerstr, 7, Tuebingen 72076, Germany
    BMC Pediatr 13:178. 2013
    ..We aimed to investigate the impact of the cumulative intake of fortified human milk on early postnatal growth in a cohort of very low birth weight infants after early transition to full enteral feeds...
  11. ncbi request reprint Differential effect of surfactant and its saturated phosphatidylcholines on human blood macrophages
    Christian Gille
    University Children s Hospital, Department of Neonatology, Calwerstr 7, 72076 Tuebingen, Germany
    J Lipid Res 48:307-17. 2007
    ..These data identify individual surfactant PC species as modifiers of macrophage differentiation and suggest differential effects on innate and adaptive immune functions...
  12. ncbi request reprint Distribution of intracellular and secreted surfactant during postnatal rat lung development
    Andreas Schmiedl
    Department of Anatomy, Hannover Medical School, Hannover, Germany
    Pediatr Pulmonol 42:548-62. 2007
    ..4) The volume fractions of Lb correlated well with the pool sizes of phospholipids in lavaged lungs. Our study emphasizes differential patterns of developmental changes of the surfactant system relative to postnatal alveolarization...
  13. ncbi request reprint Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells
    Anthony D Postle
    Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton, UK
    J Lipid Res 47:1322-31. 2006
    ..These results suggest that hormonally differentiated human fetal type II cells do not select the molecular composition of surfactant phospholipid on the basis of saturation but, more likely, on the basis of acyl chain length...
  14. ncbi request reprint Surfactant from diving aquatic mammals
    Roger G Spragg
    Department of Medicine, University of California San Diego School of Medicine and San Diego Veterans Affairs HealthCare System, San Diego, CA 92161, USA
    J Appl Physiol (1985) 96:1626-32. 2004
    ..Further study of the composition and function of pinniped surfactants may contribute to the design of optimized therapeutic surfactants...
  15. ncbi request reprint Phosphatidylcholine metabolism of rat trachea in relation to lung parenchyma and surfactant
    Gunnar A Rau
    Department of Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany
    J Appl Physiol (1985) 95:1145-52. 2003
    ..We conclude that the surfactant fraction in the airways does not originate from the airways but is produced in the alveolar space and transported upward...
  16. ncbi request reprint Molecular and functional changes of pulmonary surfactant in response to hyperoxia
    Heike Dombrowsky
    Division of Pulmonary Pharmacology, Research Center Borstel, Borstel, Germany
    Pediatr Pulmonol 41:1025-39. 2006
    ....
  17. ncbi request reprint Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals
    Carol J Lang
    Environmental Biology, School of Earth and Environmental Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia
    Am J Physiol Regul Integr Comp Physiol 289:R1426-39. 2005
    ..We conclude that there is no single PL molsp composition that functions optimally in all mammals; rather, surfactant from each animal is unique and tailored to the biology of that animal...
  18. ncbi request reprint Surfactant in newborn compared with adolescent pigs: adaptation to neonatal respiration
    Gunnar A Rau
    Department of Pediatric Pulmonology, Hannover Medical School, Hannover, Germany
    Am J Respir Cell Mol Biol 30:694-701. 2004
    ....
  19. ncbi request reprint Molecular species compositions of lung and pancreas phospholipids in the cftr(tm1HGU/tm1HGU) cystic fibrosis mouse
    Heike Dombrowsky
    Department of Child Health, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, SO16 6YD, United Kingdom
    Pediatr Res 53:447-54. 2003
    ....
  20. ncbi request reprint Altered phospholipid composition and aggregate structure of lung surfactant is associated with impaired lung function in young children with respiratory infections
    Ann Mander
    Child Health, Infection Inflammation and Repair Division, School of Medicine, Southampton General Hospital, Southampton, UK
    Am J Respir Cell Mol Biol 27:714-21. 2002
    ..This accumulation of surface-inactive, large aggregate forms of surfactant, possibly due to mixing with membrane material from inflammatory cells, may contribute to severity of lung disease in children with respiratory infections...