Research Topics
| Wolfgang BernhardSummaryCountry: Germany Publications
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Detail Information
Publications
Choline supply of preterm infants: assessment of dietary intake and pathophysiological considerationsWolfgang Bernhard
Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, 72076, Tubingen, Germany
Eur J Nutr 52:1269-78. 2013..While accepted as essential for fetal and neonatal development, its role in preterm infant nutrition has not yet gained much attention...
Developmental changes in rat surfactant lipidomics in the context of species variabilityWolfgang Bernhard
Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
Pediatr Pulmonol 42:794-804. 2007..In adult mammals, however, only concentrations of palmitoyl-palmitoleoyl-PC correlate with RR...- Increased palmitoyl-myristoyl-phosphatidylcholine in neonatal rat surfactant is lung specific and correlates with oral myristic acid supplyWolfgang Bernhard
Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, FRG
J Appl Physiol 111:449-57. 2011..This was accompanied by reduced reactive oxygen species production. We propose that nutritional supply with C14:0 and its lung-specific enrichment may contribute to decreased reactive oxygen species production during alveolarization... - From birds to humans: new concepts on airways relative to alveolar surfactantWolfgang Bernhard
Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, Germany
Am J Respir Cell Mol Biol 30:6-11. 2004..We suggest that the molecular composition of surfactant is adapted to differences in the architecture of pulmonary surfaces and to the dynamics of surface area changes during respiration... - Mass spectrometric analysis of surfactant metabolism in human volunteers using deuteriated cholineWolfgang Bernhard
Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, D 72076 Tubingen, Germany
Am J Respir Crit Care Med 170:54-8. 2004..0 +/- 1.2%), and equilibrium was achieved after only 48 hours. We conclude that infusion of deuteriated choline and electrospray ionization tandem mass spectrometry is useful to investigate surfactant metabolism in humans in vivo... - Effects of recombinant human keratinocyte growth factor on surfactant, plasma, and liver phospholipid homeostasis in hyperoxic neonatal ratsMarco Raith
Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Calwer Strasse 7, Tubingen, Germany
J Appl Physiol 112:1317-28. 2012..We suggest that rhKGF has potential as a therapeutic agent in neonates by improving pulmonary and systemic PC homeostasis... 
Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivoChristopher J Pynn
Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
J Lipid Res 52:399-407. 2011....- Myristate is selectively incorporated into surfactant and decreases dipalmitoylphosphatidylcholine without functional impairmentChristopher J Pynn
Department of Neonatology, Faculty of Medicine, Eberhard Karls University, Tubingen, Germany
Am J Physiol Regul Integr Comp Physiol 299:R1306-16. 2010..Surfactant that is high in PC16:0/14:0 but low in PC16:0/16:0 is compatible with normal respiration and surfactant function in vitro... - rhKGF stimulates lung surfactant production in neonatal rats in vivoJens Gesche
Faculty of Medicine, Department of Neonatology, Eberhard Karls University, Tubingen, Germany
Pediatr Pulmonol 46:882-95. 2011.... - Differential effect of surfactant and its saturated phosphatidylcholines on human blood macrophagesChristian Gille
University Children s Hospital, Department of Neonatology, Calwerstr 7, 72076 Tuebingen, Germany
J Lipid Res 48:307-17. 2007..These data identify individual surfactant PC species as modifiers of macrophage differentiation and suggest differential effects on innate and adaptive immune functions... - Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cellsAnthony D Postle
Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton, UK
J Lipid Res 47:1322-31. 2006..These results suggest that hormonally differentiated human fetal type II cells do not select the molecular composition of surfactant phospholipid on the basis of saturation but, more likely, on the basis of acyl chain length... - Surfactant from diving aquatic mammalsRoger G Spragg
Department of Medicine, University of California San Diego School of Medicine and San Diego Veterans Affairs HealthCare System, San Diego, CA 92161, USA
J Appl Physiol 96:1626-32. 2004..Further study of the composition and function of pinniped surfactants may contribute to the design of optimized therapeutic surfactants... - Distribution of intracellular and secreted surfactant during postnatal rat lung developmentAndreas Schmiedl
Department of Anatomy, Hannover Medical School, Hannover, Germany
Pediatr Pulmonol 42:548-62. 2007..4) The volume fractions of Lb correlated well with the pool sizes of phospholipids in lavaged lungs. Our study emphasizes differential patterns of developmental changes of the surfactant system relative to postnatal alveolarization... - Phosphatidylcholine metabolism of rat trachea in relation to lung parenchyma and surfactantGunnar A Rau
Department of Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany
J Appl Physiol 95:1145-52. 2003..We conclude that the surfactant fraction in the airways does not originate from the airways but is produced in the alveolar space and transported upward... - Molecular and functional changes of pulmonary surfactant in response to hyperoxiaHeike Dombrowsky
Division of Pulmonary Pharmacology, Research Center Borstel, Borstel, Germany
Pediatr Pulmonol 41:1025-39. 2006.... - Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammalsCarol J Lang
Environmental Biology, School of Earth and Environmental Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia
Am J Physiol Regul Integr Comp Physiol 289:R1426-39. 2005..We conclude that there is no single PL molsp composition that functions optimally in all mammals; rather, surfactant from each animal is unique and tailored to the biology of that animal... - Surfactant in newborn compared with adolescent pigs: adaptation to neonatal respirationGunnar A Rau
Department of Pediatric Pulmonology, Hannover Medical School, Hannover, Germany
Am J Respir Cell Mol Biol 30:694-701. 2004.... - Molecular species compositions of lung and pancreas phospholipids in the cftr(tm1HGU/tm1HGU) cystic fibrosis mouseHeike Dombrowsky
Department of Child Health, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, SO16 6YD, United Kingdom
Pediatr Res 53:447-54. 2003.... - Altered phospholipid composition and aggregate structure of lung surfactant is associated with impaired lung function in young children with respiratory infectionsAnn Mander
Child Health, Infection Inflammation and Repair Division, School of Medicine, Southampton General Hospital, Southampton, UK
Am J Respir Cell Mol Biol 27:714-21. 2002..This accumulation of surface-inactive, large aggregate forms of surfactant, possibly due to mixing with membrane material from inflammatory cells, may contribute to severity of lung disease in children with respiratory infections...