H Schmitz

Summary

Affiliation: Bernhard Nocht Institute for Tropical Medicine
Country: Germany

Publications

  1. pmc Detection of Serotype-Specific Antibodies to the Four Dengue Viruses Using an Immune Complex Binding (ICB) ELISA
    Petra Emmerich
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS Negl Trop Dis 7:e2580. 2013
  2. doi request reprint Specific detection of antibodies to different flaviviruses using a new immune complex ELISA
    Herbert Schmitz
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Med Microbiol Immunol 200:233-9. 2011
  3. ncbi request reprint [Relevance of coronaviruses. The SARS example]
    H Schmitz
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:647-52. 2004
  4. pmc Detection of Lassa virus antinucleoprotein immunoglobulin G (IgG) and IgM antibodies by a simple recombinant immunoblot assay for field use
    J ter Meulen
    Medical Microbiology Section, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    J Clin Microbiol 36:3143-8. 1998
  5. pmc Antibodies of symptomatic human immunodeficiency virus type 1-infected individuals are directed to the V3 domain of noninfectious and not of infectious virions present in autologous serum
    M Schreiber
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Virol 68:3908-16. 1994
  6. ncbi request reprint Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum
    S Gunther
    Bernhard Nocht Institut fur Tropenmedizin, D 20359 Hamburg, Germany
    J Infect Dis 184:345-9. 2001
  7. pmc Characterization of human CD4(+) T-cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein
    J ter Meulen
    Departments of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Virol 74:2186-92. 2000
  8. ncbi request reprint Loss of N-linked glycans in the V3-loop region of gp120 is correlated to an enhanced infectivity of HIV-1
    S Polzer
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 75, 20359 Hamburg, Germany
    Glycobiology 11:11-9. 2001
  9. ncbi request reprint Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virus
    P Borowski
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Eur J Biochem 266:715-23. 1999
  10. ncbi request reprint Enhanced replication contributes to enrichment of hepatitis B virus with a deletion in the core gene
    S Gunther
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg, 20359, Federal Republic of Germany
    Virology 273:286-99. 2000

Collaborators

Detail Information

Publications17

  1. pmc Detection of Serotype-Specific Antibodies to the Four Dengue Viruses Using an Immune Complex Binding (ICB) ELISA
    Petra Emmerich
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS Negl Trop Dis 7:e2580. 2013
    ..An alternative to the complicated neutralization assays would be helpful to study the serotype-specific immune response in people in DENV hyperendemic areas but also in subjects upon DENV vaccination...
  2. doi request reprint Specific detection of antibodies to different flaviviruses using a new immune complex ELISA
    Herbert Schmitz
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Med Microbiol Immunol 200:233-9. 2011
    ..Due to low background reactions, sera could be tested at a dilution of 1:10. Moreover, using CD32 instead of RF coating, anti-flavivirus antibodies could be detected in various animal species...
  3. ncbi request reprint [Relevance of coronaviruses. The SARS example]
    H Schmitz
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:647-52. 2004
    ..Moreover, details of research on the pathogenesis, diagnostics, and therapy are given. The recent infections in December 2003 clearly document that SARS will be a major topic also in 2004...
  4. pmc Detection of Lassa virus antinucleoprotein immunoglobulin G (IgG) and IgM antibodies by a simple recombinant immunoblot assay for field use
    J ter Meulen
    Medical Microbiology Section, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    J Clin Microbiol 36:3143-8. 1998
    ..6 and 93.0%, respectively. Because of its high negative predictive value, a single IgM immunoblot result will be valuable for excluding acute Lassa fever for cases of FUO in areas where Lassa fever is endemic...
  5. pmc Antibodies of symptomatic human immunodeficiency virus type 1-infected individuals are directed to the V3 domain of noninfectious and not of infectious virions present in autologous serum
    M Schreiber
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Virol 68:3908-16. 1994
    ..These findings suggest that our in vitro isolation system selects for virions which are not recognized by V3-specific antibodies and are infectious both in vitro and in vivo...
  6. ncbi request reprint Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum
    S Gunther
    Bernhard Nocht Institut fur Tropenmedizin, D 20359 Hamburg, Germany
    J Infect Dis 184:345-9. 2001
    ..Lassa virus infection should be considered in West African patients or in travelers returning from this area who present only with fever and neurologic signs...
  7. pmc Characterization of human CD4(+) T-cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein
    J ter Meulen
    Departments of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Virol 74:2186-92. 2000
    ..Our findings may have important implications for the strategy of designing recombinant vaccines against this mainly T-cell-controlled human arenavirus infection...
  8. ncbi request reprint Loss of N-linked glycans in the V3-loop region of gp120 is correlated to an enhanced infectivity of HIV-1
    S Polzer
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 75, 20359 Hamburg, Germany
    Glycobiology 11:11-9. 2001
    ..Thus, loss of the oligosaccharides g15 and g17 in the V3 region of gp120 markedly influences CXCR4-specific infection...
  9. ncbi request reprint Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virus
    P Borowski
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Eur J Biochem 266:715-23. 1999
    ..Kinetic experiments with the NTPase/helicase indicate that both compounds inhibit the NTPase activity of the holoenzyme by interacting with its ATP-binding domain...
  10. ncbi request reprint Enhanced replication contributes to enrichment of hepatitis B virus with a deletion in the core gene
    S Gunther
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg, 20359, Federal Republic of Germany
    Virology 273:286-99. 2000
    ..If the variants constitute a small part of the ccc DNA, they can be fully trans-complemented by wild-type virus which may increase the overall virus production...
  11. ncbi request reprint Isolation and partial characterization of dengue virus type 2 and 4 strains from dengue fever and dengue haemorrhagic fever patients from Mindanao, Republic of the Philippines
    J ter Meulen
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Trop Med Int Health 5:325-9. 2000
    ..Isolation of dengue virus from dengue fever and dengue haemorrhagic fever cases from Mindanao, Republic of the Philippines...
  12. ncbi request reprint Reverse ELISA for the detection of anti West Nile virus IgG antibodies in humans
    D Ludolfs
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20356, Hamburg, Germany
    Eur J Clin Microbiol Infect Dis 26:467-73. 2007
    ..8% respectively. These results indicate that the reverse ELISA using a specific portion of the envelope antigen of West Nile virus is especially suitable for studies on the prevalence of West Nile infections in affected countries...
  13. pmc Antibody-dependent complement-mediated cytotoxicity in sera from patients with HIV-1 infection is controlled by CD55 and CD59
    J Schmitz
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Clin Invest 96:1520-6. 1995
    ..The finding of anti-HIV-1-specific cytotoxic antibodies in sera from HIV-1-infected patients should be considered in the pathogenesis of the HIV-1-infection...
  14. pmc Purification and characterization of West Nile virus nucleoside triphosphatase (NTPase)/helicase: evidence for dissociation of the NTPase and helicase activities of the enzyme
    P Borowski
    Abteilung fur Virologie, Bernhard Nocht Institut fur Tropenmedizin, D 20359 Hamburg, Germany
    J Virol 75:3220-9. 2001
    ..On the other hand the helicase activity could be modulated without changing the ATPase activity. Our observations show that the number of ATP hydrolysis events per unwinding cycle is not a constant value...
  15. ncbi request reprint First outbreak of callitrichid hepatitis in Germany: genetic characterization of the causative lymphocytic choriomeningitis virus strains
    M Asper
    , Hamburg, Germany
    Virology 284:203-13. 2001
    ..These data show that CH is widespread and can be caused by distantly related LCMV strains...
  16. ncbi request reprint Antibodies to Lassa virus Z protein and nucleoprotein co-occur in human sera from Lassa fever endemic regions
    S Gunther
    Bernhard Nocht Institut fur Tropenmedizin, Hamburg, Germany
    Med Microbiol Immunol 189:225-9. 2001
    ..001). These data provide evidence for appearance of antibodies to Z protein and NP following Lassa virus infection. A recombinant blot for detection of both antibody specificities seems to be specific but less sensitive than IIF...
  17. pmc The V3-directed immune response in natural human immunodeficiency virus type 1 infection is predominantly directed against a variable, discontinuous epitope presented by the gp120 V3 domain
    M Schreiber
    Medical Microbiology Section, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Virol 71:9198-205. 1997
    ..These antibodies are directed against discontinuous V3 epitopes, not against conserved linear V3 targets. The implications of these findings for viral escape and blockade of infection with V3-based vaccines are discussed...