P Fischer

Summary

Affiliation: Bernhard Nocht Institute for Tropical Medicine
Country: Germany

Publications

  1. ncbi request reprint Detection of filaria-specific IgG4 antibodies and filarial DNA, for the screening of blood spots for Brugia timori
    P Fischer
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Ann Trop Med Parasitol 99:53-60. 2005
  2. ncbi request reprint Lymphatic filariasis and Brugia timori: prospects for elimination
    Peter Fischer
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Trends Parasitol 20:351-5. 2004
  3. ncbi request reprint Long-lasting reduction of Brugia timori microfilariae following a single dose of diethylcarbamazine combined with albendazole
    Peter Fischer
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Trans R Soc Trop Med Hyg 97:446-8. 2003
  4. ncbi request reprint Occurrence and diagnosis of Mansonella streptocerca in Uganda
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology and Entomology, Hamburg, Germany
    Acta Trop 63:43-55. 1997
  5. ncbi request reprint Treatment of human Mansonella streptocerca infection with ivermectin
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology, Hamburg, Germany
    Trop Med Int Health 2:191-9. 1997
  6. ncbi request reprint Identification of a stress-responsive Onchocerca volvulus glutathione S-transferase (Ov-GST-3) by RT-PCR differential display
    E Liebau
    Department of Biochemical Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Mol Biochem Parasitol 109:101-10. 2000
  7. ncbi request reprint PCR-based detection and identification of the filarial parasite Brugia timori from Alor Island, Indonesia
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Ann Trop Med Parasitol 96:809-21. 2002
  8. ncbi request reprint Prevalence of Mansonella perstans in western Uganda and its detection using the QBC-fluorescence method
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Appl Parasitol 37:32-7. 1996
  9. ncbi request reprint Gene structure of the extracellular glutathione S-transferase from Onchocerca volvulus and its overexpression and promoter analysis in transgenic Caenorhabditis elegans
    S Krause
    Department of Biochemical Parasitology, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany
    Mol Biochem Parasitol 117:145-54. 2001
  10. pmc Structural analysis and antibody response to the extracellular glutathione S-transferases from Onchocerca volvulus
    A Sommer
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Infect Immun 69:7718-28. 2001

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Detection of filaria-specific IgG4 antibodies and filarial DNA, for the screening of blood spots for Brugia timori
    P Fischer
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Ann Trop Med Parasitol 99:53-60. 2005
    ....
  2. ncbi request reprint Lymphatic filariasis and Brugia timori: prospects for elimination
    Peter Fischer
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Trends Parasitol 20:351-5. 2004
    ..Therefore, elimination of B. timori appears to be achievable...
  3. ncbi request reprint Long-lasting reduction of Brugia timori microfilariae following a single dose of diethylcarbamazine combined with albendazole
    Peter Fischer
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Trans R Soc Trop Med Hyg 97:446-8. 2003
    ..timori mf for at least 1 year. Therefore, DEC+ ALB can be recommended as an effective strategy to control B. timori infection in the framework of the Global Programme to Eliminate Lymphatic Filariasis...
  4. ncbi request reprint Occurrence and diagnosis of Mansonella streptocerca in Uganda
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology and Entomology, Hamburg, Germany
    Acta Trop 63:43-55. 1997
    ..An itching acute or more often chronic papular dermatitis, predominantly on the upper parts of the body, was the typical skin lesion observed in 24% of 177 M. streptocerca mf carriers...
  5. ncbi request reprint Treatment of human Mansonella streptocerca infection with ivermectin
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology, Hamburg, Germany
    Trop Med Int Health 2:191-9. 1997
    ..streptocerca. Common adverse effects were increased pruritus and acute papular dermatitis in 45% of 86 mf carriers on day 6 after treatment. No serious adverse side-effects were noticed in about 700 treated persons...
  6. ncbi request reprint Identification of a stress-responsive Onchocerca volvulus glutathione S-transferase (Ov-GST-3) by RT-PCR differential display
    E Liebau
    Department of Biochemical Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Mol Biochem Parasitol 109:101-10. 2000
    ..The present study clearly demonstrates that Ov-GST-3 is a critical enzyme in the defense against oxidative stress...
  7. ncbi request reprint PCR-based detection and identification of the filarial parasite Brugia timori from Alor Island, Indonesia
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Ann Trop Med Parasitol 96:809-21. 2002
    ..malayi by other molecular markers. PCR-based techniques targeting the HhaI repeat can therefore be employed for monitoring B. timori in the framework of the Global Programme to Eliminate Lymphatic Filariasis...
  8. ncbi request reprint Prevalence of Mansonella perstans in western Uganda and its detection using the QBC-fluorescence method
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Appl Parasitol 37:32-7. 1996
    ..perstans were detected...
  9. ncbi request reprint Gene structure of the extracellular glutathione S-transferase from Onchocerca volvulus and its overexpression and promoter analysis in transgenic Caenorhabditis elegans
    S Krause
    Department of Biochemical Parasitology, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany
    Mol Biochem Parasitol 117:145-54. 2001
    ..This further demonstrates the potential of C. elegans as a host for expression of candidate vaccine antigens from O. volvulus and affirms the role of C. elegans as a model for parasitic nematodes...
  10. pmc Structural analysis and antibody response to the extracellular glutathione S-transferases from Onchocerca volvulus
    A Sommer
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Infect Immun 69:7718-28. 2001
    ..Analyses of the antibody responses to the unusual N-terminal extension show an enhanced recognition of this portion by patients as opposed to recognition of the recombinant protein without extension...
  11. ncbi request reprint Molecular phylogeny of the filaria genus Onchocerca with special emphasis on Afrotropical human and bovine parasites
    A Krueger
    Department of Molecular Parasitology, and Federal Forces Department for Tropical Medicine at the Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, D 20359 Hamburg, Germany
    Acta Trop 101:1-14. 2007
    ..The results provide better insight into the evolution and zoogeography of Onchocerca. They also have epidemiological and taxonomic implications by providing a framework for more accurate molecular diagnosis of filarial larvae in vectors...
  12. ncbi request reprint Long-term suppression of Mansonella streptocerca microfilariae after treatment with ivermectin
    P Fischer
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    J Infect Dis 180:1403-5. 1999
    ..Because these filarial parasites are often coendemic with M. streptocerca, the treated population may receive the additional benefit of suppression of M. streptocerca microfilariae...
  13. ncbi request reprint An internal control for the detection of Onchocerca volvulus DNA by PCR-ELISA and rapid detection of specific PCR products by DNA Detection Test Strips
    S Pischke
    Department of Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Trop Med Int Health 7:526-31. 2002
    ..Thus, the DNA Detection Test Strips are a rapid and low-tech tool for identification of PCR products in laboratories of countries endemic for onchocerciasis...
  14. ncbi request reprint Polymerase chain reaction-based detection of lymphatic filariasis
    Peter Fischer
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Med Microbiol Immunol 192:3-7. 2003
    ..These techniques can be most cost-effective when employed for pool screening, which is important in the later stages of control programs when infection rates of humans and vectors are low, and large numbers of samples must be examined...
  15. ncbi request reprint Onchocerca volvulus: expression and immunolocalization of a nematode cathepsin D-like lysosomal aspartic protease
    Abbas Jolodar
    Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse, 74, 20359 Hamburg, Germany
    Exp Parasitol 107:145-56. 2004
    ..The aspartic protease of O. volvulus appears to function in intestinal digestion and tissue degradation of the filaria...
  16. pmc Detection of Brugia parasite DNA in human blood by real-time PCR
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8051, St Louis, MO 63110, USA
    J Clin Microbiol 44:3887-93. 2006
    ..timori endemicity on Alor Island, Indonesia, where microfilaria-positive individuals had low densities after mass treatment. Thus, the Eclipse MGB real-time PCR assay is a sensitive means of detecting Brugia parasite DNA in human blood...
  17. ncbi request reprint Using knowledge, attitudes and practice (KAP) surveys on lymphatic filariasis to prepare a health promotion campaign for mass drug administration in Alor District, Indonesia
    Alison Krentel
    Deutsche Gesellschaft für Technische Zusammenarbeit GTZ SISKES Project, Kupang, Indonesia
    Trop Med Int Health 11:1731-40. 2006
    ..As a result, compliance was sufficient in the first round to successfully begin the elimination process...
  18. pmc Persistence of Brugia malayi DNA in vector and non-vector mosquitoes: implications for xenomonitoring and transmission monitoring of lymphatic filariasis
    Peter Fischer
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 76:502-7. 2007
    ....
  19. ncbi request reprint Treatment of Brugia timori and Wuchereria bancrofti infections in Indonesia using DEC or a combination of DEC and albendazole: adverse reactions and short-term effects on microfilariae
    Taniawati Supali
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    Trop Med Int Health 7:894-901. 2002
    ..timori infection. In Indonesia, where the prevalence of intestinal helminths is high, the use of a combination of DEC and Alb to control lymphatic filariasis may also have impact on the control of intestinal helminths...
  20. ncbi request reprint High prevalence of Brugia timori infection in the highland of Alor Island, Indonesia
    Taniawati Supali
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    Am J Trop Med Hyg 66:560-5. 2002
    ..No hydrocele or genital lymphedema were observed. This study showed that B. timori infection is not restricted to the lowland and indicated that it might have a wider distribution in the lesser Sunda archipelago than previously assumed...
  21. ncbi request reprint Estimation of the prevalence of lymphatic filariasis by a pool screen PCR assay using blood spots collected on filter paper
    Taniawati Supali
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Salemba 6, Jakarta 10430, Indonesia
    Trans R Soc Trop Med Hyg 100:753-9. 2006
    ..697) gave a better prediction compared with pool-5 PCR (R=0.483). This study suggests that pool screen PCR may be a useful tool for monitoring the Global Program to Eliminate Lymphatic Filariasis...
  22. ncbi request reprint Association study of the 5-HTTLPR polymorphism and depression in 75-Year-Old nondemented subjects from the Vienna Transdanube Aging (VITA) study
    Edna Grunblatt
    Ludwig Boltzmann Society, Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
    J Clin Psychiatry 67:1373-8. 2006
    ..We studied the association of this polymorphism in old age and depression in the Vienna Transdanube Aging (VITA) study, excluding subjects with dementia...
  23. ncbi request reprint Mathematical models and lymphatic filariasis control: monitoring and evaluating interventions
    Edwin Michael
    Department of Infectious Disease Epidemiology, Imperial College School of Medicine, Norfolk Place, London, W2 1PG, UK
    Trends Parasitol 22:529-35. 2006
    ..We focus on the use of such an approach for the control and/or elimination of the vector-borne parasitic disease, lymphatic filariasis...
  24. ncbi request reprint Estrogen receptor beta gene (ESRbeta) 3'-UTR variants in Alzheimer disease
    Christian Luckhaus
    Alzheimer Dis Assoc Disord 20:322-3. 2006
  25. ncbi request reprint Frequency and risk factors for meningioma in clinically healthy 75-year-old patients: results of the Transdanube Ageing Study (VITA)
    Wolfgang Krampla
    Department of Radiology, Danube Hospital, Vienna, Austria
    Cancer 100:1208-12. 2004
    ..The goals of the current study were to determine the frequency of asymptomatic patients with meningioma in advanced age and to identify risk factors for meningiomas in this population...
  26. ncbi request reprint Subjective memory complaints and objective memory impairment in the Vienna-Transdanube aging community
    Susanne Jungwirth
    Ludwig Boltzmann Institute for Aging Research, Vienna, Austria
    J Am Geriatr Soc 52:263-8. 2004
    ..To help answer the question of whether subjective memory complaints are a useful feature in classification systems addressing early stages of Alzheimer's disease...
  27. ncbi request reprint Test strip detection of Wuchereria bancrofti amplified DNA in wild-caught Culex pipiens and estimation of infection rate by a PoolScreen algorithm
    Hanan Helmy
    Research and Training Center on Vectors of Diseases, Ain Shams University, Cairo, Egypt
    Trop Med Int Health 9:158-63. 2004
    ..1% [95% confidence interval 5.85, 10.47]. Because it is faster and safer, the PCR test strip is a practical tool, especially when combined with the PoolScreen algorithm method, for xenomonitoring the success of elimination programmes...
  28. ncbi request reprint Brugia malayi and Wuchereria bancrofti: gene comparison and recombinant expression of pi-class related glutathione S-transferases
    Sushma Rathaur
    Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India
    Exp Parasitol 103:177-81. 2003
    ..The nucleotide sequences for Brugia malayi and Wuchereria bancrofti GST have been submitted to EMBL, GenBank, and DDBJ Nucleotide Sequence Databases under Accession Nos. Y12788 and AY195867...
  29. ncbi request reprint Tunga penetrans: molecular identification of Wolbachia endobacteria and their recognition by antibodies against proteins of endobacteria from filarial parasites
    Peter Fischer
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Exp Parasitol 102:201-11. 2002
    ..These results show that as in filariasis, humans with tungiasis are exposed to Wolbachia. Furthermore, antisera raised against proteins of Wolbachia from arthropods or from filarial parasites can be immunologically cross-reactive...
  30. ncbi request reprint An aspartate aminotransferase of Wolbachia endobacteria from Onchocerca volvulus is recognized by IgG1 antibodies from residents of endemic areas
    Peter Fischer
    Molecular Parasitology Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Parasitol Res 90:38-47. 2003
    ..These results also show that an intracellular protein of Wolbachia endobacteria (WolAspAT) acts as antigen in human filariasis...
  31. ncbi request reprint Isolation and characterization of the regulatory subunit of cAMP-dependent protein kinase from the filarial parasite Onchocerca volvulus
    Peter Fischer
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Mol Biochem Parasitol 128:33-42. 2003
    ..The predominant expression in the nervous system and sensory organs as well as the unique structural features identify this signaling molecule of O. volvulus as a new and interesting target for drug or vaccine development...
  32. ncbi request reprint Resolution of treatment-related arthralgias and serologic findings with a switch of TNF antagonist therapies in a patient with psoriatic arthritis
    Peter Fischer
    Sturdy Memorial Hospital, Attleboro, MA
    J Clin Rheumatol 13:294-5. 2007