J P Cramer

Summary

Affiliation: Bernhard Nocht Institute for Tropical Medicine
Country: Germany

Publications

  1. pmc Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children
    Jakob P Cramer
    Berlin Institute of Tropical Medicine, Berlin, Germany
    Malar J 3:11. 2004
  2. ncbi request reprint Disease-associated QT-shortage versus quinine associated QT-prolongation: age dependent ECG-effects in Ghanaian children with severe malaria
    Louise Roggelin
    Section Tropical Medicine, Department of Internal Medicine, University Center Hamburg Eppendorf, Hamburg, Germany
    Malar J 13:219. 2014
  3. pmc Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study
    Sabine Stauga
    Section Tropical Medicine, I, Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Malar J 12:246. 2013
  4. pmc Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia
    Thierry Rolling
    Department of Internal Medicine I, Section for Tropical Medicine and Infectious Diseases, University Medical Centre Hamburg Eppendorf UKE, Martinistrasse 52, 20246 Hamburg, Germany
    Malar J 11:169. 2012
  5. pmc Artesunate versus quinine in the treatment of severe imported malaria: comparative analysis of adverse events focussing on delayed haemolysis
    Thierry Rolling
    Department of Internal Medicine, Section Tropical Medicine University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Malar J 12:241. 2013
  6. doi request reprint Meningococcal disease in travelers: update on vaccine options
    Jakob P Cramer
    Section Infectious Diseases Tropical Medicine, I Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Infect Dis 25:507-17. 2012
  7. pmc Reduced cardiac output in imported Plasmodium falciparum malaria
    Johanna Herr
    University Medical Center Hamburg Eppendorf, Section Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Malar J 10:160. 2011
  8. pmc Treatment of imported severe malaria with artesunate instead of quinine--more evidence needed?
    Jakob P Cramer
    Bernhard Nocht Clinic for Tropical Medicine, I, Department of Tropical Medicine, University Medical Center Hamburg Eppendorf, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Malar J 10:256. 2011
  9. doi request reprint [Old dogmas and new perspectives in antibiotic-associated diarrhea]
    Jakob P Cramer
    I Medizinische Klinik und Poliklinik, Sektion Tropenmedizin und Infektiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg
    Med Klin (Munich) 103:325-38; quiz 339-40. 2008
  10. ncbi request reprint Pulmonary infection with rapidly growing mycobacteria in a singer with achalasia: a case report
    J P Cramer
    University Medical Center Hamburg Eppendorf, I Department of Internal Medicine, Section for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    J Infect 54:e219-21. 2007

Collaborators

Detail Information

Publications22

  1. pmc Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children
    Jakob P Cramer
    Berlin Institute of Tropical Medicine, Berlin, Germany
    Malar J 3:11. 2004
    ..Possible associations of the dimorphism with severe malaria have been analysed in a case-control study in northern Ghana...
  2. ncbi request reprint Disease-associated QT-shortage versus quinine associated QT-prolongation: age dependent ECG-effects in Ghanaian children with severe malaria
    Louise Roggelin
    Section Tropical Medicine, Department of Internal Medicine, University Center Hamburg Eppendorf, Hamburg, Germany
    Malar J 13:219. 2014
    ..Some earlier studies point to a direct impact of Plasmodium falciparum infection on the electric conduction system of the heart. The aim of this study was to analyse infection- and drug-induced effects on the electric conduction system...
  3. pmc Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study
    Sabine Stauga
    Section Tropical Medicine, I, Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Malar J 12:246. 2013
    ..The aim of this study was to determine the diagnostic and prognostic value of several biomarkers related to inflammation; endothelial and cardiac dysfunction; coagulation, and haemolysis in imported P. falciparum malaria...
  4. pmc Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia
    Thierry Rolling
    Department of Internal Medicine I, Section for Tropical Medicine and Infectious Diseases, University Medical Centre Hamburg Eppendorf UKE, Martinistrasse 52, 20246 Hamburg, Germany
    Malar J 11:169. 2012
    ..Further investigations are needed to assess frequency and pathophysiological background of this complication...
  5. pmc Artesunate versus quinine in the treatment of severe imported malaria: comparative analysis of adverse events focussing on delayed haemolysis
    Thierry Rolling
    Department of Internal Medicine, Section Tropical Medicine University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Malar J 12:241. 2013
    ..So far, delayed haemolysis has not been described after the use of parenteral quinine...
  6. doi request reprint Meningococcal disease in travelers: update on vaccine options
    Jakob P Cramer
    Section Infectious Diseases Tropical Medicine, I Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Infect Dis 25:507-17. 2012
    ..The purpose of this review is to provide up-to-date information on the current status of risk of meningococcal disease in travelers and vaccine recommendations...
  7. pmc Reduced cardiac output in imported Plasmodium falciparum malaria
    Johanna Herr
    University Medical Center Hamburg Eppendorf, Section Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Malar J 10:160. 2011
    ..In the present study, cardiac function and cardiac proteins have been assessed and correlated with parasitological and immunologic parameters in patients with imported Plasmodium falciparum malaria...
  8. pmc Treatment of imported severe malaria with artesunate instead of quinine--more evidence needed?
    Jakob P Cramer
    Bernhard Nocht Clinic for Tropical Medicine, I, Department of Tropical Medicine, University Medical Center Hamburg Eppendorf, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Malar J 10:256. 2011
    ..Here, the implications of existing evidence for the treatment of imported severe malaria are discussed...
  9. doi request reprint [Old dogmas and new perspectives in antibiotic-associated diarrhea]
    Jakob P Cramer
    I Medizinische Klinik und Poliklinik, Sektion Tropenmedizin und Infektiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg
    Med Klin (Munich) 103:325-38; quiz 339-40. 2008
    ..This review provides an update on latest findings and recommendations with respect to pathogenesis, diagnostics as well as therapeutic and prevention strategies...
  10. ncbi request reprint Pulmonary infection with rapidly growing mycobacteria in a singer with achalasia: a case report
    J P Cramer
    University Medical Center Hamburg Eppendorf, I Department of Internal Medicine, Section for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    J Infect 54:e219-21. 2007
    ..Several cases of pulmonary infections with these mycobacteria in patients with achalasia have been reported, suggesting a causative association. This is the first report of a case with isolation of M. abscessus in this context...
  11. ncbi request reprint Malaria, anemia, and malnutrition in african children--defining intervention priorities
    Stephan Ehrhardt
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Infect Dis 194:108-14. 2006
    ..Malaria, anemia, and malnutrition contribute substantially to childhood morbidity in sub-Saharan Africa, but their respective roles and interactions in conferring disease are complex. We aimed to investigate these interactions...
  12. ncbi request reprint Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue
    Dominic Wichmann
    Bernhard Nocht Institute for Tropical Medicine, Clinical Research Unit, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Apoptosis 12:1037-41. 2007
    ..However, in vivo injection of GPI induced limited apoptosis in mouse liver and spleen tissue. Apoptosis may be due to a direct GPI apoptotic effect or to an indirect effect via the induction of TNFalpha and nitric oxide production...
  13. ncbi request reprint High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria
    Stephan Ehrhardt
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Microbes Infect 7:1204-10. 2005
    ..These deleterious metabolic conditions contribute to myocardial affection which was evident but not predictive per se of fatal outcome...
  14. doi request reprint MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection
    Jakob P Cramer
    University Medical Center Hamburg Eppendorf, I Department of Medicine, Section Tropical Medicine, Martinistrasse 52, 20246 Hamburg, Germany
    Microbes Infect 10:1259-65. 2008
    ..We conclude that mainly IL-18/MyD88-dependent signalling but not TLR2/4/9-signalling is important for early parasite control in our model...
  15. ncbi request reprint Hemoglobin C and resistance to severe malaria in Ghanaian children
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Medical Faculty Charité, Humboldt University, Berlin, Germany
    J Infect Dis 190:1006-9. 2004
    ..These data support the notion that natural selection of HbC occurs because of the relative resistance it confers against severe malaria but argue against the notion that HbC offers resistance to infection...
  16. ncbi request reprint Manifestation and outcome of severe malaria in children in northern Ghana
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Am J Trop Med Hyg 71:167-72. 2004
    ..The current WHO criteria serve well in identifying life-threatening disease, but also include rather mild cases that may complicate the allocation of immediate care in settings with limited resources...
  17. ncbi request reprint A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Trop Med Int Health 10:512-20. 2005
    ....
  18. ncbi request reprint Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children
    Ulrich Bienzle
    Institute of Tropical Medicine, Charite University Medicine Berlin, Berlin, Germany
    Trop Med Int Health 10:668-71. 2005
    ..6; P = 0.04). These results indicate that Hp polymorhisms may have a rather limited influence on the development of severe malaria...
  19. ncbi request reprint Age-dependent effect of plasma nitric oxide on parasite density in Ghanaian children with severe malaria
    Jakob P Cramer
    Institute of Tropical Medicine Berlin, Charite University Medicine Berlin, Germany
    Trop Med Int Health 10:672-80. 2005
    ..This finding may have importance for the understanding of associations between iNOS variants and severe malaria in regions of differing disease manifestation...
  20. pmc Intermittent preventive treatment in infants as a means of malaria control: a randomized, double-blind, placebo-controlled trial in northern Ghana
    Frank P Mockenhaupt
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    Antimicrob Agents Chemother 51:3273-81. 2007
    ..Although this simple intervention offers one of the few available malaria-preventive measures for regions where malaria is endemic, the observed rebound of severe malaria advises caution and requires further investigation...
  21. pmc Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria
    Frank P Mockenhaupt
    Institute of Tropical Medicine Berlin, Charite Universitatsmedizin Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Proc Natl Acad Sci U S A 103:177-82. 2006
    ..5- and 2.6-fold increased risks of severe malaria, respectively. These findings suggest TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms to be associated with disease manifestation...
  22. ncbi request reprint iNOS promoter variants and severe malaria in Ghanaian children
    Jakob P Cramer
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Trop Med Int Health 9:1074-80. 2004
    ..These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children...