Research Topics
Species | D BergSummaryCountry: Germany Publications
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Detail Information
Publications
Iron accumulation in the substantia nigra in rats visualized by ultrasoundD Berg
Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
Ultrasound Med Biol 25:901-4. 1999..Therefore, we conclude that iron not bound to these proteins may lead to an increase of echogenicity of the SN...- Cognitive response control in writer's crampD Berg
Department of Neurology, , , Germany
Eur J Neurol 8:587-94. 2001..These results indicate an altered response control in patients with WC in widespread cortical brain areas and therefore support the hypothesis that the pathogenesis of WC is not restricted to a pure sensory-motor dysfunction... - Role of iron in neurodegenerative disordersDaniela Berg
Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain, , , Germany
Top Magn Reson Imaging 17:5-17. 2006.... 
Baroreflex sensitivity and power spectral analysis in different extrapyramidal syndromesC Friedrich
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
J Neural Transm 115:1527-36. 2008..This may have fundamental impact on the cardiovascular prognosis of patients with extrapyramidal disease...- Morphine in tardive and idiopathic dystonia (short communication)D Berg
Department of Neurology, University of Wurzburg, Federal Republic of Germany
J Neural Transm 108:1035-41. 2001..The effect was only transient in tardive dystonia while pain relief mediated by morphine overlasted the effect on involuntary movements... - Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injuryDaniela Berg
Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
Arch Neurol 59:999-1005. 2002..The same echo feature of the SN can be identified in 9% of healthy adults... - Brain iron pathways and their relevance to Parkinson's diseaseD Berg
Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Germany
J Neurochem 79:225-36. 2001..Because many neurodegenerative diseases show increased accumulation of iron at the site of neurodegeneration, it is believed that maintenance of cellular iron homeostasis is crucial for the viability of neurons... - Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findingsD Berg
Department of Neurology, University of Wurzburg
J Neurol 248:684-9. 2001..We conclude that SN hyperechogenicity is a typical finding in PD. The cause of hyperechogenicity is so far unknown. Investigation of the underlying reason might disclose a pathogenic factor in PD... - Echogenicity of substantia nigra determined by transcranial ultrasound correlates with severity of parkinsonian symptoms induced by neuroleptic therapyD Berg
Department of Neurology, , , Germany
Biol Psychiatry 50:463-7. 2001..01). CONCLUSIONS: Increased echogenicity of the substantia nigra is associated with impaired function of the nigrostriatal system that can be disclosed by neuroleptic drugs... - The cold hand sign in multiple system atrophy: skin perfusion revisitedK Pietzarka
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
J Neural Transm 117:475-9. 2010..By measuring skin temperature and blood flow, the presence of CHS can be diagnosed in MSA patients. Further studies are necessary to understand regulation of skin perfusion in patients with extrapyramidal disease... - Valsalva manoeuvre in patients with different Parkinsonian disordersC Schmidt
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, Dresden 01307, Germany
J Neural Transm 116:875-80. 2009..Metronomic breathing and tilt-table test seem more capable as parasympathetic resp. and sympathetic function tests to identify cardiovascular abnormalities in PS patients... - Evidence for disturbances of copper metabolism in dystonia: from the image towards a new conceptG Becker
Department of Neurology, Saarland University Homburg, University of Wurzburg, Germany
Neurology 57:2290-4. 2001.... - Reduction of Menkes mRNA and copper in leukocytes of patients with primary adult-onset dystoniaN Kruse
Department of Neurology, , , Germany
Ann Neurol 49:405-8. 2001..05). Changes were less distinct in patients with blepharospasm. Therefore, disturbances of copper metabolism in focal dystonia may not be restricted to the basal ganglia... - Relationship of substantia nigra echogenicity and motor function in elderly subjectsD Berg
Department of Neurology, , Germany
Neurology 56:13-7. 2001.... 
Differentiation of Parkinson's disease and atypical parkinsonian syndromes by transcranial ultrasoundS Behnke
Department of Neurology, University of the Saarland, Gebäude 9066421 Homburg Saar, Germany
J Neurol Neurosurg Psychiatry 76:423-5. 2005..The underlying causes for the differential echo pattern of the substantia nigra remain unknown...- Hyperechogenicity of the substantia nigra in healthy controls is related to MRI changes and to neuronal loss as determined by F-Dopa PETS Behnke
Department of Neurology, University Hospital of the Saarland, Homburg Saar, Germany
Neuroimage 47:1237-43. 2009.... - Bilateral cerebral emboli monitoring during extracorporeal circulationW Mullges
Department of Neurology, Julius Maximilians University Hospital, Wurzburg, Germany
Ultrasound Med Biol 25:755-8. 1999..The total embolic load to the brain during extracorporeal circulation cannot be precisely predicted from unilateral transcranial insonation alone... - Differences in substantia nigra echogenicity of nosological subtypes within the schizophrenic spectrum. A preliminary transcranial ultrasound studyB E Jabs
Department of Psychiatry, Julius Maximilians University, Wurzburg, Germany
Neuropsychobiology 44:183-6. 2001..Here, transcranial sonography (TCS) was used to test for differences in the susceptibility to NIP related to the echogenicity of the substantia nigra (SN) in different schizophrenic subforms... - Early natural course of transient encephalopathy after coronary artery bypass graftingW Mullges
Department of Neurology, Julius Maximilians University Hospital, Wurzburg, Germany
Crit Care Med 28:1808-11. 2000..A decline of neuropsychological performance is an unwanted side effect of coronary artery bypass grafting (CABG) with extracorporeal circulation. There is little data on the neuropsychological changes during the first 2 wks after CABG... - Basal limbic system alteration in major depression: a hypothesis supported by transcranial sonography and MRI findingsG Becker
Neurologische Universitätsklinik Würzburg, Germany
Int J Neuropsychopharmacol 4:21-31. 2001..The similarity of findings in MD and depression in PD might reflect a relationship between MD and neurodegenerative disorders... - Psychopathological symptoms of depression in Parkinson's disease compared to major depressionU Merschdorf
Department of Psychiatry, University of Wurzburg, Germany
Psychopathology 36:221-5. 2003..In conclusion, this investigation gives support to the assumption of a common neurobiological origin of depression in Parkinson's disease and major depression... - Cerebral microembolus generation in different extracorporeal circulation systemsW Mullges
Department of Neurology, Julius Maximilians University Hospital, Wurzburg, Germany
Cerebrovasc Dis 9:265-9. 1999..Total counts did not differ significantly between the three groups. Intraoperative events in individual patients may lead to massive embolus generation overcoming positive properties of a distinct ECC system... - Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern GermanyC B Lücking
Department of Neurology, Ludwig Maximilians University, Marchioninistr 15, 81377 Munchen, Germany
Neurobiol Aging 31:167-8. 2010.... - Genetic analysis of immunomodulating factors in sporadic Parkinson's diseaseR Kruger
Department of Molecular Human Genetics, University of Wurzburg, Federal Republic of Germany
J Neural Transm 107:553-62. 2000..0097, p(c) = 0.048, chi2 = 6.69) with a relative risk reduced to 0.52. Our results suggest an involvement of immunomodulating factors in the pathogenesis of sporadic PD as revealed by a molecular genetic approach... - Disturbance of iron metabolism in Parkinson's disease -- ultrasonography as a biomarkerDaniela Berg
Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
Neurotox Res 9:1-13. 2006..Future studies aim at substantiating the hypothesis that healthy subjects with SN hyperechogenicity indeed represent a population at risk for nigrostriatal degeneration, which would have a significant impact on therapeutical options... - Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigraBettina Felletschin
Institute for Human Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
Neurosci Lett 352:53-6. 2003.... - Transcranial brain parenchyma sonography in movement disorders: state of the artUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Ultrasound Med Biol 33:15-25. 2007..As TCS is a quick and noninvasive method, using the same duplex-ultrasound machines as for investigation of intracranial vessels, applicable even in agitated patients, this method has a great potential to be more widely used... - Transcranial ultrasound in different monogenetic subtypes of Parkinson's diseaseKatherine J Schweitzer
Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
J Neurol 254:613-6. 2007..As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD... - Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: implications for idiopathic and monogenetic formsDaniela Berg
Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
Neurochem Res 32:1646-54. 2007..Moreover, early detection of subjects at risk is essential for the application of therapeutic strategies at a stage at which neuroprotection is still possible... - Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brainJulia Fuchs
University of Tubingen, Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Hoppe Seyler Str 3, 72076 Tubingen, Germany
FASEB J 22:1327-34. 2008..In conclusion, we provide evidence that alpha-synuclein levels are influenced by genetic variability in the promoter and 3' region of the SNCA gene in vivo... - Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECTMarcus M Unger
Department of Neurology, Philipps Universitat Marburg, Germany
Mov Disord 23:596-9. 2008..Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD... - Multiregional brain iron deficiency in restless legs syndromeJana Godau
Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen, Germany
Mov Disord 23:1184-7. 2008..61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. (c) 2008 Movement Disorder Society... - Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutationJügen Prestel
Hertie Institute for Clinical Brain Research, Dept for Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
J Neurol 255:643-8. 2008..MR spectroscopy revealed raised myoinositol levels in the basal ganglia of both patients, reflecting possible astroglial proliferation... - Biomarkers for the early detection of Parkinson's and Alzheimer's diseaseDaniela Berg
Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
Neurodegener Dis 5:133-6. 2008.... - Substantia nigra hyperechogenicity assessed by transcranial sonography is related to neuropsychological impairment in the elderly populationInga Liepelt
Center of Neurology, Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
J Neural Transm 115:993-9. 2008..02). Binary logistic regression analysis revealed that, besides UPDRS-III (P<0.001) and positive family history for PD (P<0.01), LogII (P<0.05) seems to be independently associated with SN+... - The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded studyAlexandra Gaenslen
Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
Lancet Neurol 7:417-24. 2008..We aimed to determine the diagnostic value of TCS in the early stages of parkinsonian syndromes, when the clinical symptoms often do not enable a definite diagnosis to be made... - Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP modelWalter Maetzler
Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Otfried Mueller Strasse 27, 72076 Tuebingen, Germany
Neurobiol Dis 25:473-82. 2007..Loss of tyrosine-hydroxylase-positive cells in the SN and of dopaminergic fibers in the striatum was reduced 3 weeks after MPTP intoxication in OPN-null mice. These data suggest that OPN is involved in PD-associated neurodegeneration... - Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's diseasePetra Ruprecht-Dörfler
Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
Neuroimage 18:416-22. 2003..This sign is associated with clinical findings and objective measurements, indicating some degree of impaired nigrostriatal function... - Therapeutic strategies for Parkinson's disease based on data derived from genetic researchOlaf Riess
Department of Medical Genetics, University of Tubingen, Calwer Strasse 7, 72076 Tubingen, Germany
J Neurol 250:I3-10. 2003.... - Specification of 14-3-3 proteins in Lewy bodiesDaniela Berg
Ann Neurol 54:135. 2003 - Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)Robert Hering
Department of Medical Genetics, University of Tubingen, Tubingen, Germany
Hum Mutat 24:321-9. 2004.... - Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's diseaseDaniela Berg
Institute for Medical Genetics, University of Tubingen, Tubingen, Germany
Mov Disord 20:383-5. 2005..In conjunction with earlier findings in children and adolescents, this evidence indicates that, from late adolescence onward, this ultrasound finding is a trait marker for nigrostriatal vulnerability... - Postnatal decrease in substantia nigra echogenicity. Implications for the pathogenesis of Parkinson's diseaseAlexander Iova
Saint-Petersburg Medical Academy of Postgraduate Education, Department of Child Neurology and Neurosurgery, St. Petersburg, Russia
J Neurol 251:1451-4. 2004..As SN echogenicity is related to the tissue iron content in adults our findings suggest a failure in SN iron metabolism in some children with increased echogenicity during development which can be disclosed by TCS... - In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damageLuigi Zecca
Institute of Biomedical Technologies-CNR, Segrate (Milano, Italy
Mov Disord 20:1278-85. 2005.... - Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's diseaseKatherine J Schweitzer
Hertie Institute of Clinical Brain Research, , , and Department of Neurology, University Hospital, Cologne, Germany
Mov Disord 21:94-8. 2006..It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD... - Functional relevance of ceruloplasmin mutations in Parkinson's diseaseHelmine Hochstrasser
Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
FASEB J 19:1851-3. 2005..Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD... - Iron metabolism in Parkinsonian syndromesDaniela Berg
Hertie Institute of Clinical Brain Research and Department of Medical Genetics, University of Tubingen, Germany
Mov Disord 21:1299-310. 2006.... - Predictive value of transcranial sonography in the diagnosis of Parkinson's diseaseJürgen Prestel
Hertie Institute for Clinical Brain Research, Tubingen, Germany
Mov Disord 21:1763-5. 2006..7% and a negative predictive value of 82.9% in the diagnosis of PD solely by interpreting the results of TCS, indicating that TCS is a valuable additional tool in the diagnosis of PD... - Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigraNilgün Akbas
Institute of Medical Genetics, University of Tuebingen, Tuebingen, Germany
Neurosci Lett 407:16-9. 2006..Future studies are necessary to reveal a possible functional relevance of these mutations for PD. Our results indicate that mutations in the HFE gene are not a common cause for PD with increased iron levels of the SN... - Substantia nigra hyperechogenicity correlates with subtle motor dysfunction in tap dancersPetra Ruprecht Dörfler
Department of Neurology, University of Wurzburg, Wurzburg, Germany
Parkinsonism Relat Disord 13:362-4. 2007.... - Substantia nigra hypoechogenicity: definition and findings in restless legs syndromeJana Godau
Hertie Institute of Clinical Brain Research, Division of Neurodegeneration, University of Tubingen, Germany
Mov Disord 22:187-92. 2007..Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications... - Evidence for shoulder girdle dystonia in selected patients with cervical disc prolapseGeorg Becker
Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Germany
Mov Disord 17:710-6. 2002..This suggests a link between both disorders. A peripheral trauma to the nerve roots may precipitate dystonic movements in susceptible patients and chronic dystonic muscle contraction would account for the persistent nuchal pain...