D Berg

Summary

Country: Germany

Publications

  1. ncbi request reprint Iron accumulation in the substantia nigra in rats visualized by ultrasound
    D Berg
    Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Ultrasound Med Biol 25:901-4. 1999
  2. ncbi request reprint Cognitive response control in writer's cramp
    D Berg
    Department of Neurology, , , Germany
    Eur J Neurol 8:587-94. 2001
  3. ncbi request reprint Role of iron in neurodegenerative disorders
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain, University of Tubingen, Tubingen, Germany
    Top Magn Reson Imaging 17:5-17. 2006
  4. doi request reprint Baroreflex sensitivity and power spectral analysis in different extrapyramidal syndromes
    C Friedrich
    Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
    J Neural Transm 115:1527-36. 2008
  5. ncbi request reprint Morphine in tardive and idiopathic dystonia (short communication)
    D Berg
    Department of Neurology, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 108:1035-41. 2001
  6. ncbi request reprint Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury
    Daniela Berg
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Arch Neurol 59:999-1005. 2002
  7. ncbi request reprint Brain iron pathways and their relevance to Parkinson's disease
    D Berg
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Germany
    J Neurochem 79:225-36. 2001
  8. ncbi request reprint Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings
    D Berg
    Department of Neurology, University of Wurzburg
    J Neurol 248:684-9. 2001
  9. ncbi request reprint Echogenicity of substantia nigra determined by transcranial ultrasound correlates with severity of parkinsonian symptoms induced by neuroleptic therapy
    D Berg
    Department of Neurology, , , Germany
    Biol Psychiatry 50:463-7. 2001
  10. doi request reprint The cold hand sign in multiple system atrophy: skin perfusion revisited
    K Pietzarka
    Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Neural Transm 117:475-9. 2010

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Iron accumulation in the substantia nigra in rats visualized by ultrasound
    D Berg
    Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Ultrasound Med Biol 25:901-4. 1999
    ..Therefore, we conclude that iron not bound to these proteins may lead to an increase of echogenicity of the SN...
  2. ncbi request reprint Cognitive response control in writer's cramp
    D Berg
    Department of Neurology, , , Germany
    Eur J Neurol 8:587-94. 2001
    ..These results indicate an altered response control in patients with WC in widespread cortical brain areas and therefore support the hypothesis that the pathogenesis of WC is not restricted to a pure sensory-motor dysfunction...
  3. ncbi request reprint Role of iron in neurodegenerative disorders
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain, University of Tubingen, Tubingen, Germany
    Top Magn Reson Imaging 17:5-17. 2006
    ....
  4. doi request reprint Baroreflex sensitivity and power spectral analysis in different extrapyramidal syndromes
    C Friedrich
    Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
    J Neural Transm 115:1527-36. 2008
    ..This may have fundamental impact on the cardiovascular prognosis of patients with extrapyramidal disease...
  5. ncbi request reprint Morphine in tardive and idiopathic dystonia (short communication)
    D Berg
    Department of Neurology, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 108:1035-41. 2001
    ..The effect was only transient in tardive dystonia while pain relief mediated by morphine overlasted the effect on involuntary movements...
  6. ncbi request reprint Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury
    Daniela Berg
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Arch Neurol 59:999-1005. 2002
    ..The same echo feature of the SN can be identified in 9% of healthy adults...
  7. ncbi request reprint Brain iron pathways and their relevance to Parkinson's disease
    D Berg
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Germany
    J Neurochem 79:225-36. 2001
    ..Because many neurodegenerative diseases show increased accumulation of iron at the site of neurodegeneration, it is believed that maintenance of cellular iron homeostasis is crucial for the viability of neurons...
  8. ncbi request reprint Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings
    D Berg
    Department of Neurology, University of Wurzburg
    J Neurol 248:684-9. 2001
    ..We conclude that SN hyperechogenicity is a typical finding in PD. The cause of hyperechogenicity is so far unknown. Investigation of the underlying reason might disclose a pathogenic factor in PD...
  9. ncbi request reprint Echogenicity of substantia nigra determined by transcranial ultrasound correlates with severity of parkinsonian symptoms induced by neuroleptic therapy
    D Berg
    Department of Neurology, , , Germany
    Biol Psychiatry 50:463-7. 2001
    ..01). CONCLUSIONS: Increased echogenicity of the substantia nigra is associated with impaired function of the nigrostriatal system that can be disclosed by neuroleptic drugs...
  10. doi request reprint The cold hand sign in multiple system atrophy: skin perfusion revisited
    K Pietzarka
    Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Neural Transm 117:475-9. 2010
    ..By measuring skin temperature and blood flow, the presence of CHS can be diagnosed in MSA patients. Further studies are necessary to understand regulation of skin perfusion in patients with extrapyramidal disease...
  11. doi request reprint Valsalva manoeuvre in patients with different Parkinsonian disorders
    C Schmidt
    Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, Dresden 01307, Germany
    J Neural Transm 116:875-80. 2009
    ..Metronomic breathing and tilt-table test seem more capable as parasympathetic resp. and sympathetic function tests to identify cardiovascular abnormalities in PS patients...
  12. ncbi request reprint Evidence for disturbances of copper metabolism in dystonia: from the image towards a new concept
    G Becker
    Department of Neurology, Saarland University Homburg, University of Wurzburg, Germany
    Neurology 57:2290-4. 2001
    ....
  13. ncbi request reprint Reduction of Menkes mRNA and copper in leukocytes of patients with primary adult-onset dystonia
    N Kruse
    Department of Neurology, , , Germany
    Ann Neurol 49:405-8. 2001
    ..05). Changes were less distinct in patients with blepharospasm. Therefore, disturbances of copper metabolism in focal dystonia may not be restricted to the basal ganglia...
  14. ncbi request reprint Relationship of substantia nigra echogenicity and motor function in elderly subjects
    D Berg
    Department of Neurology, , Germany
    Neurology 56:13-7. 2001
    ....
  15. pmc Differentiation of Parkinson's disease and atypical parkinsonian syndromes by transcranial ultrasound
    S Behnke
    Department of Neurology, University of the Saarland, Gebäude 9066421 Homburg Saar, Germany
    J Neurol Neurosurg Psychiatry 76:423-5. 2005
    ..The underlying causes for the differential echo pattern of the substantia nigra remain unknown...
  16. doi request reprint Hyperechogenicity of the substantia nigra in healthy controls is related to MRI changes and to neuronal loss as determined by F-Dopa PET
    S Behnke
    Department of Neurology, University Hospital of the Saarland, Homburg Saar, Germany
    Neuroimage 47:1237-43. 2009
    ....
  17. ncbi request reprint Bilateral cerebral emboli monitoring during extracorporeal circulation
    W Mullges
    Department of Neurology, Julius Maximilians University Hospital, Wurzburg, Germany
    Ultrasound Med Biol 25:755-8. 1999
    ..The total embolic load to the brain during extracorporeal circulation cannot be precisely predicted from unilateral transcranial insonation alone...
  18. ncbi request reprint Differences in substantia nigra echogenicity of nosological subtypes within the schizophrenic spectrum. A preliminary transcranial ultrasound study
    B E Jabs
    Department of Psychiatry, Julius Maximilians University, Wurzburg, Germany
    Neuropsychobiology 44:183-6. 2001
    ..Here, transcranial sonography (TCS) was used to test for differences in the susceptibility to NIP related to the echogenicity of the substantia nigra (SN) in different schizophrenic subforms...
  19. ncbi request reprint Early natural course of transient encephalopathy after coronary artery bypass grafting
    W Mullges
    Department of Neurology, Julius Maximilians University Hospital, Wurzburg, Germany
    Crit Care Med 28:1808-11. 2000
    ..A decline of neuropsychological performance is an unwanted side effect of coronary artery bypass grafting (CABG) with extracorporeal circulation. There is little data on the neuropsychological changes during the first 2 wks after CABG...
  20. ncbi request reprint Basal limbic system alteration in major depression: a hypothesis supported by transcranial sonography and MRI findings
    G Becker
    Neurologische Universitätsklinik Würzburg, Germany
    Int J Neuropsychopharmacol 4:21-31. 2001
    ..The similarity of findings in MD and depression in PD might reflect a relationship between MD and neurodegenerative disorders...
  21. ncbi request reprint Psychopathological symptoms of depression in Parkinson's disease compared to major depression
    U Merschdorf
    Department of Psychiatry, University of Wurzburg, Germany
    Psychopathology 36:221-5. 2003
    ..In conclusion, this investigation gives support to the assumption of a common neurobiological origin of depression in Parkinson's disease and major depression...
  22. ncbi request reprint Cerebral microembolus generation in different extracorporeal circulation systems
    W Mullges
    Department of Neurology, Julius Maximilians University Hospital, Wurzburg, Germany
    Cerebrovasc Dis 9:265-9. 1999
    ..Total counts did not differ significantly between the three groups. Intraoperative events in individual patients may lead to massive embolus generation overcoming positive properties of a distinct ECC system...
  23. doi request reprint Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany
    C B Lücking
    Department of Neurology, Ludwig Maximilians University, Marchioninistr 15, 81377 Munchen, Germany
    Neurobiol Aging 31:167-8. 2010
    ....
  24. ncbi request reprint Genetic analysis of immunomodulating factors in sporadic Parkinson's disease
    R Kruger
    Department of Molecular Human Genetics, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 107:553-62. 2000
    ..0097, p(c) = 0.048, chi2 = 6.69) with a relative risk reduced to 0.52. Our results suggest an involvement of immunomodulating factors in the pathogenesis of sporadic PD as revealed by a molecular genetic approach...
  25. ncbi request reprint Disturbance of iron metabolism in Parkinson's disease -- ultrasonography as a biomarker
    Daniela Berg
    Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Neurotox Res 9:1-13. 2006
    ..Future studies aim at substantiating the hypothesis that healthy subjects with SN hyperechogenicity indeed represent a population at risk for nigrostriatal degeneration, which would have a significant impact on therapeutical options...
  26. ncbi request reprint Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra
    Bettina Felletschin
    Institute for Human Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Neurosci Lett 352:53-6. 2003
    ....
  27. ncbi request reprint Transcranial brain parenchyma sonography in movement disorders: state of the art
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Ultrasound Med Biol 33:15-25. 2007
    ..As TCS is a quick and noninvasive method, using the same duplex-ultrasound machines as for investigation of intracranial vessels, applicable even in agitated patients, this method has a great potential to be more widely used...
  28. ncbi request reprint Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease
    Katherine J Schweitzer
    Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
    J Neurol 254:613-6. 2007
    ..As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD...
  29. ncbi request reprint Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: implications for idiopathic and monogenetic forms
    Daniela Berg
    Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Neurochem Res 32:1646-54. 2007
    ..Moreover, early detection of subjects at risk is essential for the application of therapeutic strategies at a stage at which neuroprotection is still possible...
  30. ncbi request reprint Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain
    Julia Fuchs
    University of Tubingen, Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    FASEB J 22:1327-34. 2008
    ..In conclusion, we provide evidence that alpha-synuclein levels are influenced by genetic variability in the promoter and 3' region of the SNCA gene in vivo...
  31. doi request reprint Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT
    Marcus M Unger
    Department of Neurology, Philipps Universitat Marburg, Germany
    Mov Disord 23:596-9. 2008
    ..Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD...
  32. doi request reprint Multiregional brain iron deficiency in restless legs syndrome
    Jana Godau
    Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen, Germany
    Mov Disord 23:1184-7. 2008
    ..61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. (c) 2008 Movement Disorder Society...
  33. doi request reprint Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation
    Jügen Prestel
    Hertie Institute for Clinical Brain Research, Dept for Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    J Neurol 255:643-8. 2008
    ..MR spectroscopy revealed raised myoinositol levels in the basal ganglia of both patients, reflecting possible astroglial proliferation...
  34. doi request reprint Biomarkers for the early detection of Parkinson's and Alzheimer's disease
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurodegener Dis 5:133-6. 2008
    ....
  35. doi request reprint Substantia nigra hyperechogenicity assessed by transcranial sonography is related to neuropsychological impairment in the elderly population
    Inga Liepelt
    Center of Neurology, Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    J Neural Transm 115:993-9. 2008
    ..02). Binary logistic regression analysis revealed that, besides UPDRS-III (P<0.001) and positive family history for PD (P<0.01), LogII (P<0.05) seems to be independently associated with SN+...
  36. doi request reprint The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study
    Alexandra Gaenslen
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Lancet Neurol 7:417-24. 2008
    ..We aimed to determine the diagnostic value of TCS in the early stages of parkinsonian syndromes, when the clinical symptoms often do not enable a definite diagnosis to be made...
  37. ncbi request reprint Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model
    Walter Maetzler
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Otfried Mueller Strasse 27, 72076 Tuebingen, Germany
    Neurobiol Dis 25:473-82. 2007
    ..Loss of tyrosine-hydroxylase-positive cells in the SN and of dopaminergic fibers in the striatum was reduced 3 weeks after MPTP intoxication in OPN-null mice. These data suggest that OPN is involved in PD-associated neurodegeneration...
  38. ncbi request reprint Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease
    Petra Ruprecht-Dörfler
    Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Neuroimage 18:416-22. 2003
    ..This sign is associated with clinical findings and objective measurements, indicating some degree of impaired nigrostriatal function...
  39. ncbi request reprint Therapeutic strategies for Parkinson's disease based on data derived from genetic research
    Olaf Riess
    Department of Medical Genetics, University of Tubingen, Calwer Strasse 7, 72076 Tubingen, Germany
    J Neurol 250:I3-10. 2003
    ....
  40. ncbi request reprint Specification of 14-3-3 proteins in Lewy bodies
    Daniela Berg
    Ann Neurol 54:135. 2003
  41. ncbi request reprint Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)
    Robert Hering
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    Hum Mutat 24:321-9. 2004
    ....
  42. ncbi request reprint Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease
    Daniela Berg
    Institute for Medical Genetics, University of Tubingen, Tubingen, Germany
    Mov Disord 20:383-5. 2005
    ..In conjunction with earlier findings in children and adolescents, this evidence indicates that, from late adolescence onward, this ultrasound finding is a trait marker for nigrostriatal vulnerability...
  43. ncbi request reprint Postnatal decrease in substantia nigra echogenicity. Implications for the pathogenesis of Parkinson's disease
    Alexander Iova
    Saint Petersburg Medical Academy of Postgraduate Education, Department of Child Neurology and Neurosurgery, St Petersburg, Russia
    J Neurol 251:1451-4. 2004
    ..As SN echogenicity is related to the tissue iron content in adults our findings suggest a failure in SN iron metabolism in some children with increased echogenicity during development which can be disclosed by TCS...
  44. ncbi request reprint In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage
    Luigi Zecca
    Institute of Biomedical Technologies CNR, Segrate Milano, Italy
    Mov Disord 20:1278-85. 2005
    ....
  45. ncbi request reprint Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease
    Katherine J Schweitzer
    Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, and Department of Neurology, University Hospital, Cologne, Germany
    Mov Disord 21:94-8. 2006
    ..It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD...
  46. ncbi request reprint Functional relevance of ceruloplasmin mutations in Parkinson's disease
    Helmine Hochstrasser
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    FASEB J 19:1851-3. 2005
    ..Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD...
  47. ncbi request reprint Iron metabolism in Parkinsonian syndromes
    Daniela Berg
    Hertie Institute of Clinical Brain Research and Department of Medical Genetics, University of Tubingen, Germany
    Mov Disord 21:1299-310. 2006
    ....
  48. ncbi request reprint Predictive value of transcranial sonography in the diagnosis of Parkinson's disease
    Jürgen Prestel
    Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Mov Disord 21:1763-5. 2006
    ..7% and a negative predictive value of 82.9% in the diagnosis of PD solely by interpreting the results of TCS, indicating that TCS is a valuable additional tool in the diagnosis of PD...
  49. ncbi request reprint Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra
    Nilgün Akbas
    Institute of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Neurosci Lett 407:16-9. 2006
    ..Future studies are necessary to reveal a possible functional relevance of these mutations for PD. Our results indicate that mutations in the HFE gene are not a common cause for PD with increased iron levels of the SN...
  50. ncbi request reprint Substantia nigra hyperechogenicity correlates with subtle motor dysfunction in tap dancers
    Petra Ruprecht-Dörfler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Parkinsonism Relat Disord 13:362-4. 2007
    ....
  51. ncbi request reprint Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome
    Jana Godau
    Hertie Institute of Clinical Brain Research, Division of Neurodegeneration, University of Tubingen, Germany
    Mov Disord 22:187-92. 2007
    ..Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications...
  52. ncbi request reprint Evidence for shoulder girdle dystonia in selected patients with cervical disc prolapse
    Georg Becker
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Germany
    Mov Disord 17:710-6. 2002
    ..This suggests a link between both disorders. A peripheral trauma to the nerve roots may precipitate dystonic movements in susceptible patients and chronic dystonic muscle contraction would account for the persistent nuchal pain...