D Berg

Summary

Country: Germany

Publications

  1. ncbi request reprint Multiple regions of alpha-synuclein are associated with Parkinson's disease
    Jakob C Mueller
    Institute for Human Genetics, GSF National Research Centre for Environment and Health, Neuherberg, Germany
    Ann Neurol 57:535-41. 2005
  2. doi request reprint Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body disease
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 22:933-8. 2010
  3. doi request reprint Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases
    Walter Maetzler
    Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 26:176-81. 2011
  4. doi request reprint Place value of transcranial sonography in early diagnosis of Parkinson's disease
    Daniela Berg
    Department of Neurodegeneration, German Center for Neurodegenerative Diseases, Hertie Institute of Clinical Brain Research and University of Tübingen, Tubingen, Germany
    Neurodegener Dis 7:291-9. 2010
  5. doi request reprint A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Neurobiol Aging 32:548.e9-18. 2011
  6. doi request reprint The PRIPS study: screening battery for subjects at risk for Parkinson's disease
    D Berg
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Eur J Neurol 20:102-8. 2013
  7. doi request reprint Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, University of Tubingen, 72070 Tübingen, Germany
    Lancet Neurol 12:514-24. 2013
  8. doi request reprint Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 28:216-9. 2013
  9. doi request reprint Defining at-risk populations for Parkinson's disease: lessons from ongoing studies
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center of Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany
    Mov Disord 27:656-65. 2012
  10. doi request reprint Biomarkers for the early detection of Parkinson's and Alzheimer's disease
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurodegener Dis 5:133-6. 2008

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Multiple regions of alpha-synuclein are associated with Parkinson's disease
    Jakob C Mueller
    Institute for Human Genetics, GSF National Research Centre for Environment and Health, Neuherberg, Germany
    Ann Neurol 57:535-41. 2005
    ..These findings indicate locus heterogeneity for the pathogenesis of Parkinson's disease in different genetic or physiological environments, related to sex and age...
  2. doi request reprint Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body disease
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 22:933-8. 2010
    ..Serum NEP activity levels were not significantly different between the groups. We conclude that, in Lewy body disease, CSF NEP activity levels are associated with dementia, probably via the Aβ pathway...
  3. doi request reprint Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases
    Walter Maetzler
    Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 26:176-81. 2011
    ..We hypothesize that alterations of the glutathione system occur in a very early stage of the disease or may even represent a risk marker for LBD...
  4. doi request reprint Place value of transcranial sonography in early diagnosis of Parkinson's disease
    Daniela Berg
    Department of Neurodegeneration, German Center for Neurodegenerative Diseases, Hertie Institute of Clinical Brain Research and University of Tübingen, Tubingen, Germany
    Neurodegener Dis 7:291-9. 2010
    ..In this review, the additional diagnostic value of TCS in the early diagnosis of PD as well as limitations of the method are being discussed...
  5. doi request reprint A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Neurobiol Aging 32:548.e9-18. 2011
    ..This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide...
  6. doi request reprint The PRIPS study: screening battery for subjects at risk for Parkinson's disease
    D Berg
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Eur J Neurol 20:102-8. 2013
    ..Screening batteries to narrow down a target-at-risk population are essential for trials testing neuroprotective compounds aiming to delay or prevent onset of Parkinson's disease (PD)...
  7. doi request reprint Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, University of Tubingen, 72070 Tübingen, Germany
    Lancet Neurol 12:514-24. 2013
    ..Specific advances in each tier, bridged by neuroimaging and biochemical data, will eventually lead to a redefinition of Parkinson's disease...
  8. doi request reprint Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 28:216-9. 2013
    ..Recently, we reported a 17.4-fold increased risk for PD in individuals with SN+ older than 50 years within 3 years...
  9. doi request reprint Defining at-risk populations for Parkinson's disease: lessons from ongoing studies
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center of Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany
    Mov Disord 27:656-65. 2012
    ..Although there is still a long way to go, studies designed according to these concepts might eventually provide sufficient data to form the basis for future screening programs for PD risk to be applied at a population level...
  10. doi request reprint Biomarkers for the early detection of Parkinson's and Alzheimer's disease
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurodegener Dis 5:133-6. 2008
    ....
  11. ncbi request reprint Application of transcranial sonography in extrapyramidal disorders: updated recommendations
    D Berg
    Hertie Institute for Clinical Brain Research and Institute for Medical Genetics, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Ultraschall Med 27:12-9. 2006
    ..This article provides an overview of these principles and typical findings in distinct extrapyramidal disorders...
  12. ncbi request reprint Disturbance of iron metabolism in Parkinson's disease -- ultrasonography as a biomarker
    Daniela Berg
    Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Neurotox Res 9:1-13. 2006
    ..Future studies aim at substantiating the hypothesis that healthy subjects with SN hyperechogenicity indeed represent a population at risk for nigrostriatal degeneration, which would have a significant impact on therapeutical options...
  13. doi request reprint Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderly
    Daniela Berg
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 25:1464-9. 2010
    ..Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow-up investigations...
  14. ncbi request reprint In vivo detection of iron and neuromelanin by transcranial sonography--a new approach for early detection of substantia nigra damage
    D Berg
    Hertie Institute for Clinical Brain Research and Department of Medical Genetics, University of Tubingen, Germany
    J Neural Transm 113:775-80. 2006
    ....
  15. ncbi request reprint Iron metabolism in Parkinsonian syndromes
    Daniela Berg
    Hertie Institute of Clinical Brain Research and Department of Medical Genetics, University of Tubingen, Germany
    Mov Disord 21:1299-310. 2006
    ....
  16. doi request reprint Hyperechogenicity of the substantia nigra: pitfalls in assessment and specificity for Parkinson's disease
    Daniela Berg
    Hertie Institute of Clinical Brain Research and German Center for Neurodegenerative Diseases, Department of Neurodegeneration, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    J Neural Transm 118:453-61. 2011
    ....
  17. doi request reprint Transcranial ultrasound as a risk marker for Parkinson's disease
    Daniela Berg
    Department of Neurodegeneration, Center of Neurology and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Mov Disord 24:S677-83. 2009
    ....
  18. ncbi request reprint Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: implications for idiopathic and monogenetic forms
    Daniela Berg
    Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Neurochem Res 32:1646-54. 2007
    ..Moreover, early detection of subjects at risk is essential for the application of therapeutic strategies at a stage at which neuroprotection is still possible...
  19. doi request reprint Transcranial sonography in movement disorders
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Lancet Neurol 7:1044-55. 2008
    ..Thus, this neuroimaging method could be recommended for general application in the diagnosis and differential diagnosis of PD...
  20. doi request reprint Ultrasound in the (premotor) diagnosis of Parkinson's disease
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Parkinsonism Relat Disord 13:S429-33. 2007
    ..Ongoing longitudinal studies test the hypothesis that SN hyperechogenicity is a risk marker for nigrostriatal vulnerability...
  21. doi request reprint Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: yes
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center for Neurodegenerative Diseases DZNE, University of Tuebingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    J Neural Transm 118:613-9. 2011
    ..Taken together, there is encouraging evidence to implement TCS in a screening battery to identify subjects at risk for the development of PD...
  22. doi request reprint Milestones in magnetic resonance imaging and transcranial sonography of movement disorders
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany
    Mov Disord 26:979-92. 2011
    ..Investigations are currently under way to evaluate the value of this technique in other movement disorders...
  23. doi request reprint Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: a 37-month 3-center study of 1847 older persons
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center of Neurodegenerative Diseases, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Arch Neurol 68:932-7. 2011
    ..To evaluate whether enlarged substantia nigra hyperechogenicity (SN+) is associated with an increased risk for Parkinson disease (PD) in a healthy elderly population...
  24. ncbi request reprint Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease
    Daniela Berg
    Institute for Medical Genetics, University of Tubingen, Tubingen, Germany
    Mov Disord 20:383-5. 2005
    ..In conjunction with earlier findings in children and adolescents, this evidence indicates that, from late adolescence onward, this ultrasound finding is a trait marker for nigrostriatal vulnerability...
  25. ncbi request reprint 14-3-3 proteins in the nervous system
    Daniela Berg
    Institute for Human Genetics, Department of Medical Genetics, University of Tubingen, Calwerstrasse 7, 72076 Tubingen, Germany
    Nat Rev Neurosci 4:752-62. 2003
  26. doi request reprint Is pre-motor diagnosis possible? The European experience
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany
    Parkinsonism Relat Disord 18:S195-8. 2012
    ..Establishing sensitivity, specificity, predictive value and progression of markers in yet healthy individuals are hoped to lay the basis for future interventional trials before the onset of motor-PD...
  27. ncbi request reprint Redox imbalance
    Daniela Berg
    Institute for Medical Genetics, University of Tuebingen and Hertie Institute for Clinical Brain Research, 72076 Tubingen, Germany
    Cell Tissue Res 318:201-13. 2004
    ..These consequences become even more harmful when genetic variations impair the normal degradation of altered proteins. Therefore, therapeutic strategies must aim at reducing free-radical formation and scavenging free-radicals...
  28. doi request reprint Microglia activation is related to substantia nigra echogenicity
    D Berg
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, and German Center for Neurodegenerative Diseases DZNE, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    J Neural Transm 117:1287-92. 2010
    ..46, p = 0.008) after correction for iron and neuromelanin content. These findings strengthen the hypothesis of a close pathophysiological connection between SN hyperechogenicity and PD pathology...
  29. ncbi request reprint Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease
    H Hochstrasser
    Institute for Medical Genetics, University of Tuebingen, Germany
    Neurology 63:1912-7. 2004
    ..However, sequence variations in genes involved in iron metabolism have been linked to basal ganglia disorders. One of these is ceruloplasmin (Cp), which is vitally involved in iron transport across the cell membrane...
  30. ncbi request reprint Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)
    Robert Hering
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    Hum Mutat 24:321-9. 2004
    ....
  31. doi request reprint Relation of risk factors and putative premotor markers for Parkinson's disease
    I Liepelt-Scarfone
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    J Neural Transm 118:579-85. 2011
    ....
  32. ncbi request reprint The transcription factor PITX3 is associated with sporadic Parkinson's disease
    Julia Fuchs
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Neurobiol Aging 30:731-8. 2009
    ..004) with PD. The C-allele appears to be a recessive risk allele with an estimated population frequency of 83%. An allele-dependent dysregulation of PITX3 expression might contribute to the susceptibility to PD...
  33. pmc The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations
    M Sharma
    Hertie Institute for Clinical Brain Research, Department for Neurodegenerative Diseases, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    J Med Genet 43:557-62. 2006
    ..Recently, a haplotype across the sepiapterin reductase (SPR) gene, which is located in the PARK3 linkage region, was shown to modulate age of onset of Parkinson's disease in sibships from North America...
  34. doi request reprint Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation
    Jügen Prestel
    Hertie Institute for Clinical Brain Research, Dept for Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    J Neurol 255:643-8. 2008
    ..MR spectroscopy revealed raised myoinositol levels in the basal ganglia of both patients, reflecting possible astroglial proliferation...
  35. ncbi request reprint Comprehensive association analysis of the NOS2A gene with Parkinson disease
    C Schulte
    Hertie Institute for Clinical Brain Research, Section for Neurodegenerative Diseases, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Neurology 67:2080-2. 2006
    ..A replication study of 340 German patients and 680 controls showed no significant association between 12 genotyped polymorphisms and PD. NOS2A is therefore not a major susceptibility locus in our relatively young sample population...
  36. pmc Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tuebingen, Germany
    J Neurol 256:1337-42. 2009
    ....
  37. ncbi request reprint Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model
    Walter Maetzler
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Otfried Mueller Strasse 27, 72076 Tuebingen, Germany
    Neurobiol Dis 25:473-82. 2007
    ..Loss of tyrosine-hydroxylase-positive cells in the SN and of dopaminergic fibers in the striatum was reduced 3 weeks after MPTP intoxication in OPN-null mice. These data suggest that OPN is involved in PD-associated neurodegeneration...
  38. ncbi request reprint [11C]PIB binding in Parkinson's disease dementia
    Walter Maetzler
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
    Neuroimage 39:1027-33. 2008
    ..Furthermore, we provide evidence that--in addition to nonspecific binding--PIB uptake in the brainstem may also reflect PDD related amyloid...
  39. doi request reprint Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease
    Manu Sharma
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Neurobiol Aging 30:1706-9. 2009
    ..In conclusion, our study did not lend support to the finding that the reported SNPs are directly influencing the susceptibility to sporadic form of PD at least in our population...
  40. doi request reprint Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PET
    Inga Liepelt
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
    Mov Disord 24:1504-11. 2009
    ..Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment...
  41. ncbi request reprint 14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta
    Andreas Ubl
    Department of Medical Genetics, Children s Hospital, University Rostock, Rembrandt Str 16 17, Germany
    Brain Res Mol Brain Res 108:33-9. 2002
    ..In accordance with these findings, there was no staining of substantia nigra Lewy bodies with antibodies specific for the 14-3-3 eta subunit...
  42. ncbi request reprint Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease
    R Hering
    Department of Medical Genetics, Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Neurology 62:1231-2. 2004
  43. ncbi request reprint The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies
    A Hofer
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    J Neural Transm 112:1249-54. 2005
    ..A triplication of the alpha-synuclein gene was found to cause autosomal dominant Lewy body disease in two distinct families...
  44. ncbi request reprint Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra
    Nilgün Akbas
    Institute of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Neurosci Lett 407:16-9. 2006
    ..Future studies are necessary to reveal a possible functional relevance of these mutations for PD. Our results indicate that mutations in the HFE gene are not a common cause for PD with increased iron levels of the SN...
  45. doi request reprint Novel ATP1A3 mutation in a sporadic RDP patient with minimal benefit from deep brain stimulation
    C Kamm
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Neurology 70:1501-3. 2008
  46. doi request reprint GBA-associated PD presents with nonmotor characteristics
    K Brockmann
    Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tü bingen, Tü bingen, Germany
    Neurology 77:276-80. 2011
    ..To evaluate whether there exists distinct characteristics in glucocerebrosidase (GBA)-associated Parkinson disease (PD) with regard to motor and nonmotor symptoms as well as imaging characteristics assessed by transcranial sonography (TCS)...
  47. doi request reprint Sonographic substantia nigra hypoechogenicity in polyneuropathy and restless legs syndrome
    Jana Godau
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 24:133-7. 2009
    ..2% of patients with idiopathic RLS exhibited SN hypoechogenicity. SN echogenicity did not differ significantly between PNP patients with and without RLS. Thus, TCS seems not suitable for the diagnosis of RLS in patients with PNP...
  48. doi request reprint Genetic analysis of coding SNPs in blood-brain barrier transporter MDR1 in European Parkinson's disease patients
    Claudia Funke
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    J Neural Transm 116:443-50. 2009
    ..However, genotyping of 300 PD patients and 302 healthy controls did not reveal a significant association between coding MDR1 gene polymorphisms and PD...
  49. doi request reprint Multiregional brain iron deficiency in restless legs syndrome
    Jana Godau
    Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen, Germany
    Mov Disord 23:1184-7. 2008
    ..61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. (c) 2008 Movement Disorder Society...
  50. doi request reprint A single-nucleotide polymorphism of the osteopontin gene may contribute to a susceptibility to Lewy body disease
    Walter Maetzler
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tubingen, Germany
    J Neural Transm 116:599-605. 2009
    ..61, 95% CI 0.66-3.91, P = 0.29). Genotype prevalence and OPN levels were not significantly related. These findings suggest that OPN is associated with the occurrence of Lewy body disease and SNP-66 may be a susceptibility factor...
  51. doi request reprint Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany
    Neurobiol Dis 34:107-12. 2009
    ..Motor symptoms were not associated with PIB binding. Thus, LBD patients with cortical beta-amyloid show characteristics usually observed in AD...
  52. doi request reprint Genetic analysis of heme oxygenase-1 (HO-1) in German Parkinson's disease patients
    Claudia Funke
    Department of Medical Genetics, Institute of Human Genetics, University of Tuebingen, Calwerstrasse 7, Tuebingen 72076, Germany
    J Neural Transm 116:853-9. 2009
    ..However, our analyses did not reveal a significant association of these genetic markers in the HO-1 gene with an increased susceptibility to PD...
  53. doi request reprint No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Otfried Muller Strasse 27, Tuebingen D 72076, Germany
    Neurobiol Dis 35:296-301. 2009
    ..These data confirm and extend previous results on the relationship between BChE gene and BuChE activity, and argue rather against a major impact of BuChE on LBD-associated pathologies...
  54. doi request reprint Role of transcranial ultrasound in the diagnosis of movement disorders
    Jana Godau
    Department of Neurodegeneration, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neuroimaging Clin N Am 20:87-101. 2010
    ..This article provides information about the ultrasound procedure, its specific diagnostic value, and its limitations. Pathophysiologic mechanisms leading to changes in the reflection of ultrasound waves are discussed...
  55. pmc Progressive secondary neurodegeneration and microcalcification co-occur in osteopontin-deficient mice
    Walter Maetzler
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, Tuebingen, Germany
    Am J Pathol 177:829-39. 2010
    ..In the case of secondary retrograde or transneuronal degeneration, OPN may have a protective role as intracellular actor...
  56. doi request reprint Increased serum insulin-like growth factor 1 in early idiopathic Parkinson's disease
    Jana Godau
    Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    J Neurol Neurosurg Psychiatry 81:536-8. 2010
    ..The aim of this study was to measure serum IGF-1 in patients with PD and assess its correlation with the clinical presentation...
  57. pmc The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease
    Alexandra Gaenslen
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, Tubingen, Germany
    Mov Disord 26:653-8. 2011
    ..This time be called the prodromal phase of PD...
  58. doi request reprint The CST3 BB genotype and low cystatin C cerebrospinal fluid levels are associated with dementia in Lewy body disease
    Walter Maetzler
    Department of Neurodegeneration, University of Tuebingen, Germany
    J Alzheimers Dis 19:937-42. 2010
    ..We conclude that, in Lewy body disease, the CST3 BB genotype and low CSF CysC levels are associated with dementia, possibly through a disturbed elimination of soluble Abeta(42)...
  59. doi request reprint Rivastigmine for the treatment of dementia in patients with progressive supranuclear palsy: Clinical observations as a basis for power calculations and safety analysis
    Iuga Liepelt
    Center of Neurology, Department of Neurodegeneration, and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Alzheimers Dement 6:70-4. 2010
    ..In subtests, meaningful results can be obtained with even lower numbers (five patients for a verbal fluency test, and 14 patients for a logical memory task)...
  60. doi request reprint The regional distribution of T2-relaxation times in MR images of the substantia nigra and crus cerebri
    Constantin Mänz
    Department of Diagnostic and Interventional Neuroradiology, University of Tubingen, Hope Seyler Str 3, 72076, Tubingen, Germany
    Neuroradiology 52:745-50. 2010
    ..The purpose of our study was to evaluate the depiction of the SN and the CC on calculated R2 maps by analyzing the regional distribution of T2 values in both regions...
  61. doi request reprint Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease
    Anne S Soehn
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Neurogenetics 11:203-15. 2010
    ..Searching for mutations in the periphilin gene, we detected a K69E substitution in two patients of a PD family. Taken together, these findings support for the first time an involvement of periphilin in PD...
  62. doi request reprint Progression of Parkinson's disease in the clinical phase: potential markers
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Lancet Neurol 8:1158-71. 2009
    ..In addition to routine clinical rating scales, new quantitative assessments of motor and non-motor symptoms, which should be more broadly available, reasonably priced, and easy-to-use, are needed...
  63. doi request reprint Poor effect of guideline based treatment of restless legs syndrome in clinical practice
    Jana Godau
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and Centre of Neurology, University of Tubingen, Germany
    J Neurol Neurosurg Psychiatry 81:1390-5. 2010
    ..In contrast, epidemiological data demonstrate generally insufficient RLS treatment in clinical practice...
  64. ncbi request reprint Mutation analysis of the neurofilament M gene in Parkinson's disease
    Rejko Kruger
    Department of Neurology, Neurodegeneration Laboratory, University of Tubingen, Hoppe Seyler Strasse 3, D 72076, Tubingen, Germany
    Neurosci Lett 351:125-9. 2003
    ..However, rare variants of the NF-M gene may act as susceptibility factors for PD and functional analyses of the identified variations are warranted to decipher possible mechanisms in neurodegeneration...
  65. doi request reprint Genetic factors influencing age at onset in LRRK2-linked Parkinson disease
    Yulia Golub
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Parkinsonism Relat Disord 15:539-41. 2009
    ....
  66. ncbi request reprint Cerebrotendinous xanthomatosis
    Ludger Schols
    Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Neurology 67:E20. 2006
  67. ncbi request reprint Functional relevance of ceruloplasmin mutations in Parkinson's disease
    Helmine Hochstrasser
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    FASEB J 19:1851-3. 2005
    ..Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD...
  68. ncbi request reprint Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease
    Katherine J Schweitzer
    Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, and Department of Neurology, University Hospital, Cologne, Germany
    Mov Disord 21:94-8. 2006
    ..It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD...
  69. ncbi request reprint Treatment of dementia in parkinsonian syndromes with cholinesterase inhibitors
    Inga Liepelt
    Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Dement Geriatr Cogn Disord 23:351-67. 2007
    ..The effect of treatment with cholinesterase inhibitors in progressive supranuclear palsy and corticobasal degeneration warrants carefully designed studies including a sufficient number of patients and symptom-adopted dementia scales...
  70. ncbi request reprint Sonographic abnormalities of brainstem structures in restless legs syndrome
    Jana Godau
    Hertie Institute for Clinical Brain Research and Center of Neurology, Department of Neurodegeneration, Hoppe Seyler Str 3, University of Tuebingen, 72076 Tuebingen, Germany
    Sleep Med 9:782-9. 2008
    ..The aim of this study was to validate SN hypoechogenicity as a morphological marker for RLS in a large patient cohort and to investigate further RLS-associated brain abnormalities using TCS...
  71. ncbi request reprint Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain
    Julia Fuchs
    University of Tubingen, Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    FASEB J 22:1327-34. 2008
    ..In conclusion, we provide evidence that alpha-synuclein levels are influenced by genetic variability in the promoter and 3' region of the SNCA gene in vivo...
  72. ncbi request reprint Predictive value of transcranial sonography in the diagnosis of Parkinson's disease
    Jürgen Prestel
    Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Mov Disord 21:1763-5. 2006
    ..7% and a negative predictive value of 82.9% in the diagnosis of PD solely by interpreting the results of TCS, indicating that TCS is a valuable additional tool in the diagnosis of PD...
  73. ncbi request reprint Therapeutic strategies for Parkinson's disease based on data derived from genetic research
    Olaf Riess
    Department of Medical Genetics, University of Tubingen, Calwer Strasse 7, 72076 Tubingen, Germany
    J Neurol 250:I3-10. 2003
    ....
  74. doi request reprint Nutrition and the risk for Parkinson's disease: review of the literature
    Alexandra Gaenslen
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, Tubingen, Germany
    J Neural Transm 115:703-13. 2008
    ..However, dietary factors are difficult to assess. This review gives an overview on epidemiological studies addressing a possible relation of dietary compounds and the risk for PD...
  75. doi request reprint Substantia nigra hyperechogenicity assessed by transcranial sonography is related to neuropsychological impairment in the elderly population
    Inga Liepelt
    Center of Neurology, Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    J Neural Transm 115:993-9. 2008
    ..02). Binary logistic regression analysis revealed that, besides UPDRS-III (P<0.001) and positive family history for PD (P<0.01), LogII (P<0.05) seems to be independently associated with SN+...
  76. ncbi request reprint Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra
    Bettina Felletschin
    Institute for Human Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Neurosci Lett 352:53-6. 2003
    ....
  77. ncbi request reprint Cross-sectional study discloses a positive family history for Parkinson's disease and male gender as epidemiological risk factors for substantia nigra hyperechogenicity
    K J Schweitzer
    Center of Neurology, Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany
    J Neural Transm 114:1167-71. 2007
    ..Among all variables assessed only family history of PD and male gender proved to be significantly associated with SN hyperechogenicity, indicating a genetic predisposition for the ultrasound marker...
  78. ncbi request reprint Screening for mutations of the IRP2 gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra
    J Deplazes
    Institute for Human Genetics, University of Tubingen, Germany
    J Neural Transm 111:515-21. 2004
    ..In one patient a -74C > T variation was found which was not present in the control group. Our data indicate that mutations in the IRP2 gene are not a common cause of PD associated with SN iron accumulation...
  79. doi request reprint A polymorphism in the gene encoding AdipoR1 affects olfactory recognition
    M Guthoff
    Internal Medicine IV, Department of Endocrinology and Diabetes, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University, Tubingen, Germany
    Int J Obes (Lond) 35:873-6. 2011
    ..In conclusion, the presence of a genetic variation in AdipoR1 is associated with decreased olfactory recognition in healthy subjects. Adiponectin signalling may have an important role in olfactory function and regulation of appetite...
  80. ncbi request reprint [Treatment for dementia in parkinsonian syndromes. Efficacy of cholinesterase inhibitors]
    I Liepelt
    Abteilung Neurologie mit Schwerpunkt Neurodegenerative Erkrankungen, Hertie Institut für Klinische Hirnforschung, 72076, Tubingen
    Nervenarzt 79:36-9, 42-6. 2008
    ..The effect of treatment with cholinesterase inhibitors in PSP and CBD warrants more carefully designed studies including sufficient numbers of patients...
  81. doi request reprint Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair
    Oliver Rothfuss
    Department for Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Hum Mol Genet 18:3832-50. 2009
    ..Our data indicate a novel role for parkin in directly supporting mitochondrial function and protecting mitochondrial genomic integrity from oxidative stress...
  82. pmc High-throughput homogeneous mass cleave assay technology for the diagnosis of autosomal recessive Parkinson's disease
    CHRISTOPHER SCHROEDER
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    J Mol Diagn 10:217-24. 2008
    ..In conclusion, this is the first study using matrix-assisted laser desorption ionization/time of flight mass spectrometry and homogeneous mass cleave assay for high-throughput mutation screening...
  83. ncbi request reprint Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome
    Jana Godau
    Hertie Institute of Clinical Brain Research, Division of Neurodegeneration, University of Tubingen, Germany
    Mov Disord 22:187-92. 2007
    ..Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications...
  84. doi request reprint Effect of genetic variation in Kv1.3 on olfactory function
    Martina Guthoff
    Medical Clinic, Department of Diabetes, Endocrinology, Nephrology and Angiology, Clinical Chemistry, Eberhard Karls University, Tuebingen, Germany
    Diabetes Metab Res Rev 25:523-7. 2009
    ..Furthermore, the function of this channel is associated with olfaction in mice and with glucose metabolism in mice and men. We therefore hypothesized that a functionally relevant polymorphism in Kv1.3 might alter olfactory function...
  85. doi request reprint The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study
    Alexandra Gaenslen
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Lancet Neurol 7:417-24. 2008
    ..We aimed to determine the diagnostic value of TCS in the early stages of parkinsonian syndromes, when the clinical symptoms often do not enable a definite diagnosis to be made...
  86. ncbi request reprint Role of iron in neurodegenerative disorders
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain, University of Tubingen, Tubingen, Germany
    Top Magn Reson Imaging 17:5-17. 2006
    ....
  87. ncbi request reprint Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration
    Daniela Rosenkranz
    Department of Cellular Neurology, Tubingen, Germany
    J Neuroimmunol 188:117-27. 2007
    ..The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients...
  88. ncbi request reprint The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease
    Frank P Marx
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    FASEB J 21:1759-67. 2007
    ..Our data suggest a direct interaction of synphilin-1 with the regulatory complex of the proteasome modulating proteasomal function...
  89. ncbi request reprint Alpha-synuclein and Parkinson's disease: implications from the screening of more than 1,900 patients
    Daniela Berg
    Institute for Medical Genetics, University of Tubingen, Germany
    Mov Disord 20:1191-4. 2005
    ..A53T mutation. These results demonstrate that mutations in the alpha-synuclein gene are rare and suggest that other factors contribute to alpha-synuclein aggregation in the majority of PD patients...
  90. doi request reprint The influence of Nordic Walking training on sit-to-stand transfer in Parkinson patients
    B Fritz
    Medical Clinic, Department of Sports Medicine, University of Tuebingen, Silcherstrasse 5, 72076 Tuebingen, Germany
    Gait Posture 34:234-8. 2011
    ..The effects of Nordic Walking as an easy, economic and low-risk intervention on STS in PD depend on the degree of PD. Our findings may help scientists, patients, and therapists to adjust sport-physiological interventions...
  91. doi request reprint Differentiation of Progressive Supranuclear Palsy: clinical, imaging and laboratory tools
    R M Liscic
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany German Center for Neurodegenerative Diseases DZNE, University of Tuebingen, Tuebingen, Germany
    Acta Neurol Scand 127:362-70. 2013
    ....
  92. ncbi request reprint Perspectives of B-mode transcranial ultrasound
    Daniela Berg
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Germany
    Neuroimage 15:463-73. 2002
    ..As new application and processing techniques are being developed transcranial color coded sonography will gain increasing impact on both diagnosis and research of neurological disorders...
  93. ncbi request reprint Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury
    Daniela Berg
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Arch Neurol 59:999-1005. 2002
    ..The same echo feature of the SN can be identified in 9% of healthy adults...
  94. ncbi request reprint Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease
    Petra Ruprecht-Dörfler
    Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Neuroimage 18:416-22. 2003
    ..This sign is associated with clinical findings and objective measurements, indicating some degree of impaired nigrostriatal function...
  95. ncbi request reprint Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease
    Katherine J Schweitzer
    Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
    J Neurol 254:613-6. 2007
    ..As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD...
  96. ncbi request reprint Specification of 14-3-3 proteins in Lewy bodies
    Daniela Berg
    Ann Neurol 54:135. 2003
  97. doi request reprint Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT
    Marcus M Unger
    Department of Neurology, Philipps Universitat Marburg, Germany
    Mov Disord 23:596-9. 2008
    ..Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD...
  98. pmc Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease
    Esti Liani
    Department of Pharmacology, The B Rappaport Institute of Medical Research, Technion Israel Institute of Technology, Haifa 31096, Israel
    Proc Natl Acad Sci U S A 101:5500-5. 2004
    ..In vitro experiments show that SIAH-2 monoubiquitylates alpha-synuclein. Further evidence that SIAH proteins may play a role in inclusion formation comes from the demonstration of SIAH immunoreactivity in Lewy bodies of PD patients...
  99. ncbi request reprint Postnatal decrease in substantia nigra echogenicity. Implications for the pathogenesis of Parkinson's disease
    Alexander Iova
    Saint Petersburg Medical Academy of Postgraduate Education, Department of Child Neurology and Neurosurgery, St Petersburg, Russia
    J Neurol 251:1451-4. 2004
    ..As SN echogenicity is related to the tissue iron content in adults our findings suggest a failure in SN iron metabolism in some children with increased echogenicity during development which can be disclosed by TCS...
  100. ncbi request reprint Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes
    Claudia Schmidt
    Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany
    Mov Disord 22:2123-6. 2007
    ..4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes...
  101. ncbi request reprint In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage
    Luigi Zecca
    Institute of Biomedical Technologies CNR, Segrate Milano, Italy
    Mov Disord 20:1278-85. 2005
    ....