C Belka

Summary

Country: Germany

Publications

  1. pmc Counting colonies of clonogenic assays by using densitometric software
    Maximilian Niyazi
    CCC Tübingen, Department of Radiation Oncology, Hoppe Seyler Str, 3, 72076 Tubingen, Germany
    Radiat Oncol 2:4. 2007
  2. pmc Surgery vs. radiotherapy in localized prostate cancer. Which is best?
    Stefan Welz
    Department of Radiation Oncology, Ludwig Maximilians University, Munich, Germany
    Radiat Oncol 3:23. 2008
  3. pmc The role of PDGF in radiation oncology
    Minglun Li
    Department of Radiation Oncology, University Hospital Tuebingen, Germany
    Radiat Oncol 2:5. 2007
  4. pmc Isobologram analysis of triple therapies
    Maximilian Niyazi
    CCC Tübingen, Department of Radiation Oncology, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Radiat Oncol 1:39. 2006
  5. pmc Intensity modulated radiotherapy for high risk prostate cancer based on sentinel node SPECT imaging for target volume definition
    Ute Ganswindt
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    BMC Cancer 5:91. 2005
  6. pmc Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis
    Patrizia Marini
    Department of Radiation Oncology, University of Tubingen, Experimental Radiation Oncology, Hoppe Seyler Str, 3, D 72076 Tubingen, Germany
    BMC Cancer 5:5. 2005
  7. pmc Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    BMC Cancer 6:14. 2006
  8. ncbi request reprint [Death inducing ligands in combination with ionizing radiation: objective and current knowledge]
    Claus Belka
    Klinik für Radioonkologie, Universitat Tubingen, Germany
    Strahlenther Onkol 179:141-51. 2003
  9. ncbi request reprint The tyrosine kinase Lck is involved in regulation of mitochondrial apoptosis pathways
    Claus Belka
    Department of Radiation Oncology, University of Tubingen, Germany
    Oncogene 22:176-85. 2003
  10. ncbi request reprint The fate of irradiated tumor cells
    C Belka
    Department of Radiation Oncology, University Tübingen, Tubingen, Germany
    Oncogene 25:969-71. 2006

Collaborators

Detail Information

Publications99

  1. pmc Counting colonies of clonogenic assays by using densitometric software
    Maximilian Niyazi
    CCC Tübingen, Department of Radiation Oncology, Hoppe Seyler Str, 3, 72076 Tubingen, Germany
    Radiat Oncol 2:4. 2007
    ..This software is made freely available by us with a detailed description how to use and install the necessary features...
  2. pmc Surgery vs. radiotherapy in localized prostate cancer. Which is best?
    Stefan Welz
    Department of Radiation Oncology, Ludwig Maximilians University, Munich, Germany
    Radiat Oncol 3:23. 2008
    ..Thus, the data provided do not support the strong conclusion issued by the authors. Based on the data available, surgery and radiotherapy still have to be considered as equally effective...
  3. pmc The role of PDGF in radiation oncology
    Minglun Li
    Department of Radiation Oncology, University Hospital Tuebingen, Germany
    Radiat Oncol 2:5. 2007
    ..This review introduces the structural and functional properties of PDGF and PDGF receptors and discusses the role and mechanism of PDGF signaling in normal and tumor tissues under different conditions in radiation oncology...
  4. pmc Isobologram analysis of triple therapies
    Maximilian Niyazi
    CCC Tübingen, Department of Radiation Oncology, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Radiat Oncol 1:39. 2006
    ..The present work introduces a new method for an evaluation of triple therapies and provides some graphical examples in order to visualize the results...
  5. pmc Intensity modulated radiotherapy for high risk prostate cancer based on sentinel node SPECT imaging for target volume definition
    Ute Ganswindt
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    BMC Cancer 5:91. 2005
    ..To overcome this limitation, we tested the feasibility of an intensity modulated radiation therapy (IMRT) protocol, taking under consideration the individual pelvic sentinel node drainage pattern by SPECT functional imaging...
  6. pmc Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis
    Patrizia Marini
    Department of Radiation Oncology, University of Tubingen, Experimental Radiation Oncology, Hoppe Seyler Str, 3, D 72076 Tubingen, Germany
    BMC Cancer 5:5. 2005
    ..Additionally, little is known about the effect of TRAIL combined with radiation on normal tissues...
  7. pmc Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    BMC Cancer 6:14. 2006
    ....
  8. ncbi request reprint [Death inducing ligands in combination with ionizing radiation: objective and current knowledge]
    Claus Belka
    Klinik für Radioonkologie, Universitat Tubingen, Germany
    Strahlenther Onkol 179:141-51. 2003
    ..In this regard, different areas of biological research may be distinguished: prediction, development of new cytotoxic agents, improvement of the tolerance of normal tissue and the optimisation of radiochemotherapy...
  9. ncbi request reprint The tyrosine kinase Lck is involved in regulation of mitochondrial apoptosis pathways
    Claus Belka
    Department of Radiation Oncology, University of Tubingen, Germany
    Oncogene 22:176-85. 2003
    ..We conclude that the Lck deficiency influences early steps during radiation-induced mitochondrial alterations...
  10. ncbi request reprint The fate of irradiated tumor cells
    C Belka
    Department of Radiation Oncology, University Tübingen, Tubingen, Germany
    Oncogene 25:969-71. 2006
    ..The demonstration that caffeine treatment can abrogate this G2 arrest, and that the cells go on to die, has implications for overcoming treatment resistance imposed by radiation-induced upregulation of p21CIP/WAF1...
  11. ncbi request reprint [Recurrence of prostate cancer--value of salvage radiotherapy]
    C Belka
    Klinik für Radioonkologie, Universitatsklinikum, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Urologe A 45:1266-70. 2006
    ..Taken together, radiotherapy is the only treatment option with curative potential in situations where a local failure is highly likely...
  12. ncbi request reprint Anti-apoptotic Bcl-2 proteins: structure, function and relevance for radiation biology
    C Belka
    Department of Radiation Oncology, University Tübingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Int J Radiat Biol 78:643-58. 2002
    ..The reasons for this obvious contradiction are not understood...
  13. ncbi request reprint Ionizing radiation and the activation of caspase-8 in highly apoptosis-sensitive lymphoma cells
    C Belka
    Department of Radiation Oncology, University of Tuebingen, Germany
    Int J Radiat Biol 75:1257-64. 1999
    ..Since contributing molecules for radiation-induced apoptosis and their exact order have not been analyzed in greater detail, the involvement of caspase-8 for radiation-induced apoptosis in human lymphoma cell lines was studied...
  14. ncbi request reprint MEK1 and Erk1/2 kinases as targets for the modulation of radiation responses
    C Belka
    Department of Radiotherapy, University of Tuebingen, Germany
    Anticancer Res 20:3243-9. 2000
    ..The cascade is also anti-apoptotic by modulation of Bcl-2, Bcl-xL and BAD function. The impact of MEK-1 on radiation resistance and the role of drugs targeting MEK-1 for the modulation of resistance is unclear...
  15. ncbi request reprint Radiation sensitivity and apoptosis in human lymphoma cells
    J Rudner
    Department of Radiotherapy, , Germany
    Int J Radiat Biol 77:1-11. 2001
    ..The execution phase had no influence on survival, whereas the initiation/decision phase controls immediate survival. However, abrogation of both phases did not influence radiation sensitivity...
  16. ncbi request reprint Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis
    J Rudner
    Department of Radiation Oncology, , Hoppe-Seyler Str. 3, , Germany
    J Cell Sci 114:4161-72. 2001
    ..By contrast, Bcl-2 in either subcellular position did not influence CD95- or TRAIL-mediated apoptosis...
  17. ncbi request reprint Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL
    C Belka
    Department of Radiation Oncology, , Hoppe-Seyler Str. 3, , Germany
    Oncogene 20:2190-6. 2001
    ..In addition, a strong effect of TRAIL on radiation induced clonogenic cell death was found. In conclusion, TRAIL seems to be of high potential value for a combination with ionizing radiation in tumor therapy...
  18. doi request reprint Toxicity and outcome of pelvic IMRT for node-positive prostate cancer
    A C Müller
    Department of Radiooncology, Eberhard Karls University, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Strahlenther Onkol 188:982-9. 2012
    ..This study reports on the treatment techniques, toxicity, and outcome of pelvic intensity-modulated radiotherapy (IMRT) for lymph node-positive prostate cancer (LNPPC, T1-4, c/pN1 cM0)...
  19. ncbi request reprint Chemotherapy in the treatment of recurrent glioblastoma multiforme: ifosfamide versus temozolomide
    F Paulsen
    Department of Radiotherapy, University of Tubingen, Germany
    J Cancer Res Clin Oncol 125:411-8. 1999
    ..In vitro analysis revealed activity for ifosfamide and temozolomide. The usefulness of these agents in recurrent disease was investigated...
  20. doi request reprint Radiotherapy with and without temozolomide in elderly patients with glioblastoma
    M Niyazi
    Department of Radiation Oncology, Ludwig Maximilian University Munich, Marchioninistrasse 15, Munich, Germany
    Strahlenther Onkol 188:154-9. 2012
    ..We conducted a retrospective analysis in 43 consecutive elderly patients with glioblastoma who either underwent radiotherapy (RT) or radiotherapy plus concomitant temozolomide (TMZ)...
  21. ncbi request reprint Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo
    P Marini
    CCC Tübingen, Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    Oncogene 25:5145-54. 2006
    ..We postulate that HGS-ETR1 and HGS-ETR2 will be very promising new agents in the field of molecular targeted multi-modality anticancer therapy...
  22. ncbi request reprint Bcl-2 mediated inhibition of erucylphosphocholine-induced apoptosis depends on its subcellular localisation
    R Handrick
    Department of Radiation Oncology, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Biochem Pharmacol 70:837-50. 2005
    ..The finding that ER-targeted Bcl-2 interferes with ErPC-induced mitochondrial damage points to an involvement of the ER in apoptosis signaling upstream of the mitochondria and to a crosstalk between both compartments...
  23. ncbi request reprint Reirradiation alternating with docetaxel and cisplatin in inoperable recurrence of head-and-neck cancer: a prospective phase I/II trial
    Thomas Hehr
    Department of Radiation Oncology, Eberhard Karls University, Tubingen, Germany
    Int J Radiat Oncol Biol Phys 61:1423-31. 2005
    ..The latter may provide a particular advantage for recurrent, potentially radiation resistant tumors. The feasibility and efficacy of a full-dose docetaxel containing alternating chemoradiation schedule was tested...
  24. doi request reprint Combination of the pro-apoptotic TRAIL-receptor antibody mapatumumab with ionizing radiation strongly increases long-term tumor control under ambient and hypoxic conditions
    Patrizia Marini
    Department of Radiation Oncology, CCC Tübingen, University of Tubingen, Tubingen, Germany
    Int J Radiat Oncol Biol Phys 75:198-202. 2009
    ..Because it remained unclear in how far these effects influence local tumor control, long-term experiments using a colorectal xenograft model were undertaken...
  25. pmc Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids
    A Lepple-Wienhues
    Department of Physiology I, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 96:13795-800. 1999
    ..The block of CRAC by sphingomyelinase metabolites adds a function to the repertoire of the CD95 receptor inhibiting T cell activation signals...
  26. ncbi request reprint Molecular requirements for the combined effects of TRAIL and ionising radiation
    Patrizia Marini
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    Radiother Oncol 68:189-98. 2003
    ..In the present study the minimal molecular prerequisites for the efficacy of a combined treatment were determined...
  27. ncbi request reprint Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways
    Martin Weinmann
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    FASEB J 18:1906-8. 2004
    ..In summary, it could be demonstrated that hypoxic stress confers a selection pressure on mitochondrial apoptotic pathways and, consecutively, to an increased resistance toward mitochondrial death triggers...
  28. doi request reprint Long-term outcome of mitomycin C- and 5-FU-based primary radiochemotherapy for esophageal cancer
    Maria Wolf
    Department of Radiation Oncology, University Hospital Munich, LMU, Munich, Germany
    Strahlenther Onkol 186:374-81. 2010
    ..By contrast, most patients treated at the University Hospital, LMU Munich, Germany, received 5-fluorouracil/mitomycin C. The objective of this retrospective analysis was to determine the value of 5-fluorouracil/mitomycin-C-based therapy...
  29. ncbi request reprint Influence of hypoxia on TRAIL-induced apoptosis in tumor cells
    Martin Weinmann
    Department of Radiation Oncology, University of Tubingen, Hoppe Seylerstrasse 3, 72076 Tubingen, Germany
    Int J Radiat Oncol Biol Phys 58:386-96. 2004
    ..The impact of hypoxia on TRAIL-induced apoptosis was examined in this study...
  30. ncbi request reprint Soluble levels of CD-95, CD 95-L and various cytokines after exposing human leukocytes to ionizing radiation
    M Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    Anticancer Res 20:1813-8. 2000
    ..Local radiotherapy induces systemic effects and influences the immune system. Some of these effects can hardly be explained by direct cellular reactions, but might be triggered by humoral factors...
  31. ncbi request reprint Cystosarcoma phyllodes malignum: a case report of a successive triple modality treatment
    F Paulsen
    Department of Radiotherapy, University of Tubingen, Germany
    Int J Hyperthermia 16:319-24. 2000
    ..Toxicity was mild. Resection of the tumour bed revealed a pathologically complete response with an actual disease free follow-up of 48 months...
  32. doi request reprint The additional loss of Bak and not the lack of the protein tyrosine kinase p56/Lck in one JCaM1.6 subclone caused pronounced apoptosis resistance in response to stimuli of the intrinsic pathway
    J Rudner
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    Apoptosis 14:711-20. 2009
    ....
  33. ncbi request reprint Celecoxib activates a novel mitochondrial apoptosis signaling pathway
    Verena Jendrossek
    Department of Radiation Oncology, Experimental Radiotherapy Group, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    FASEB J 17:1547-9. 2003
    ..In conclusion, Celecoxib induces apoptosis via a novel apoptosome-dependent but Bcl-2-independent mitochondrial pathway...
  34. ncbi request reprint Efficacy of triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin
    Maximilian Niyazi
    CCC Tübingen, Department of Radiation Oncology, 72076 Tubingen, Germany
    Oncol Rep 21:1455-60. 2009
    ..Our data suggest that targeted agents can be effectively added to existing multimodal therapy approaches which might open new perspectives in radiation oncology...
  35. doi request reprint Feasibility of 6-month maintenance cetuximab after adjuvant concurrent chemoradiation plus cetuximab in squamous cell carcinoma of the head and neck
    C Matuschek
    Medical Faculty, Department of Radiation Oncology, Heinrich Heine University of Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Strahlenther Onkol 189:625-31. 2013
    ..Ppreliminary results on feasibility and acute toxicity on skin and mucosa are presented in this article...
  36. doi request reprint Radiation treatment parameters for re-irradiation of malignant glioma
    M Niyazi
    Department of Radiation Oncology, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    Strahlenther Onkol 188:328-33. 2012
    ..However, only limited data are presently available allowing for a precise selection of patients suitable for re-treatment with regard to safety and efficacy...
  37. ncbi request reprint 70 Gy or more: which dose for which prostate cancer?
    U Ganswindt
    Department of Radiation Oncology, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    J Cancer Res Clin Oncol 131:407-19. 2005
    ..In order to evaluate available data on radiation dose response relationships, in prostate cancer, a thorough and critical literature analysis was performed...
  38. ncbi request reprint Optimized coverage of high-risk adjuvant lymph node areas in prostate cancer using a sentinel node-based, intensity-modulated radiation therapy technique
    Ute Ganswindt
    Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Int J Radiat Oncol Biol Phys 67:347-55. 2007
    ..To account for the highly individual lymphatic drainage pattern we tested an intensity-modulated radiation therapy (IMRT) approach based on the determination of pelvic sentinel lymph nodes (SN)...
  39. doi request reprint Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockade
    Maximilian Niyazi
    Department of Radiation Oncology, CCC Tübingen, Tubingen, Germany
    Strahlenther Onkol 185:8-18. 2009
    ....
  40. ncbi request reprint Type I and type II reactions in TRAIL-induced apoptosis -- results from dose-response studies
    Justine Rudner
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Str 3, Tuebingen D 72076, Germany
    Oncogene 24:130-40. 2005
    ..Thus, the requirement of the mitochondrial pathway for death receptor-induced apoptosis in type II cells should be reconsidered, since the protective effect of Bcl-2 is limited to lower TRAIL doses or early observation time points...
  41. ncbi request reprint Increased cytotoxicity of ionizing radiation in combination with membrane-targeted apoptosis modulators involves downregulation of protein kinase B/Akt-mediated survival-signaling
    Rene Handrick
    Department of Radiation Oncology, Experimental Radiation Oncology, University of Tubingen, Tubingen, Germany
    Radiother Oncol 80:199-206. 2006
    ..Aim of the present study was to elucidate molecular mechanisms of combined action...
  42. ncbi request reprint Involvement of tyrosine kinase p56/Lck in apoptosis induction by anticancer drugs
    Charlotte Gruber
    Department of Radiooncology, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Biochem Pharmacol 67:1859-72. 2004
    ....
  43. ncbi request reprint Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner
    Martin Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    Oncogene 23:3757-69. 2004
    ..Thus, in human tumors, hypoxia will mainly lead to the selection of hypoxia-resistant cells with defects in mitochondrial apoptosis signaling pathways...
  44. ncbi request reprint Immunosuppressive total lymphoid irradiation-based reconditioning regimens enable engraftment after graft rejection or graft failure in patients treated with allogeneic hematopoietic stem cell transplantation
    Frank Heinzelmann
    Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Int J Radiat Oncol Biol Phys 70:523-8. 2008
    ..To retrospectively evaluate the efficacy of total lymphoid irradiation (TLI)-based reconditioning regimens in patients with graft failure or graft rejection after allogeneic hematopoietic stem cell transplantation...
  45. pmc A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck
    W Budach
    Department of Radiation Oncology, University Hospital Dusseldorf, Germany
    BMC Cancer 6:28. 2006
    ....
  46. pmc Radiation induced CNS toxicity--molecular and cellular mechanisms
    C Belka
    Department of Radiation Oncology, , Hoppe Seyler Str 3,
    Br J Cancer 85:1233-9. 2001
    ..The article reviews the currently available data on the cellular and molecular basis of radiation induced CNS side effects...
  47. pmc Mitomycin C in combination with radiotherapy as a potent inhibitor of tumour cell repopulation in a human squamous cell carcinoma
    Wilfried Budach
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    Br J Cancer 86:470-6. 2002
    ..018). Mitomycin C significantly reduces the risk of local recurrence and inhibits tumour cell repopulation in combination with fractionated irradiation in vivo in the tested tumour model...
  48. ncbi request reprint New insights in the role of Bcl-2 Bcl-2 and the endoplasmic reticulum
    J Rudner
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    Apoptosis 7:441-7. 2002
    ..Current data on the function of Bcl-2 at the ER, its role for the modulation of calcium fluxes and its influence on caspase activation at the ER are reviewed...
  49. ncbi request reprint Clinical impact of predictive assays for acute and late radiation morbidity
    W Budach
    Abteilung für Strahlentherapie, Eberhard Karls Universitat Tubingen
    Strahlenther Onkol 174:20-4. 1998
    ..The following review evaluates whether fibroblast or lymphocyte radiation sensitivity measured in vitro correlates with the degree of acute and late radiation induced morbidity...
  50. ncbi request reprint Radiation-induced gastrointestinal toxicity. Pathophysiology, approaches to treatment and prophylaxis
    J Classen
    Abteilung für Strahlentherapie der Universität Tübingen
    Strahlenther Onkol 174:82-4. 1998
    ..The proposed pathophysiology of radiation enteritis is complex and a variety of different treatment strategies have been suggested for the management of acute radiation-induced diarrhea...
  51. ncbi request reprint [Quantitative assessment of therapy related effects after breast conserving therapy with dynamic MRI of the breast]
    A Wersebe
    Abteilung für Radiologische Diagnostik, Universitatsklinikum Tubingen, Germany
    Rofo 173:1109-17. 2001
    ..To quantify therapy related effects after breast conservation therapy (BCT) with dynamic MRI of the breast...
  52. pmc [68Ga]-DOTATOC-PET/CT for meningioma IMRT treatment planning
    Barbara Gehler
    Department of Radiation Oncology, LMU Munchen, Marchioninistr, 15, 81377 Munchen, Germany
    Radiat Oncol 4:56. 2009
    ....
  53. ncbi request reprint Death receptor ligands: new strategies for combined treatment with ionizing radiation
    Patrizia Marini
    Klinik für Radioonkologie, Universitat Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Curr Med Chem Anticancer Agents 3:334-42. 2003
    ..The present article reviews this novel biological strategy for optimized radiotherapy based on the combination of ionizing irradiation and death receptor triggered cell death...
  54. ncbi request reprint Retransplantation with stem cells from mismatched related donors after graft rejection in pediatric patients
    Peter Lang
    Department of Pediatric Oncology, University Children s Hospital, Eberhard Karl s University, Tubingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Blood Cells Mol Dis 40:33-9. 2008
    ..The use of different donors may contribute to avoid a second rejection...
  55. doi request reprint [A special radiation shielding for the radiotherapy of a pregnant patient]
    Markus Buchgeister
    Bereich Medizinische Physik, Universitätsklinik für Radioonkologie, Tubingen, Deutschland
    Strahlenther Onkol 184:80-5. 2008
    ..Measurement of the radiation dose of different radiotherapy techniques with a phantom at the position of the uterus of a pregnant patient with and without a special radiation shielding...
  56. pmc Definitive radiotherapy and single-agent radiosensitizing ifosfamide in patients with localized, irresectable soft tissue sarcoma: a retrospective analysis
    Franziska Eckert
    Eberhard Karls University Tuebingen, Department of Radiooncology, Tuebingen, Germany
    Radiat Oncol 5:55. 2010
    ..For primary radiotherapy local control rates of 30-45% have been reported. We analyzed retrospectively 11 cases of radiochemotherapy with single-agent ifosfamide in patients with macroscopic soft-tissue sarcomas...
  57. doi request reprint Reirradiation with alternating docetaxel-based chemotherapy for recurrent head and neck squamous cell carcinoma: update of a single-center prospective phase II protocol
    Bernhard Berger
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    Strahlenther Onkol 186:255-61. 2010
    ....
  58. doi request reprint Hypofractionated reirradiation for recurrent malignant glioma
    Guido Henke
    Department of Radiooncology, University Hospital, Tubingen, Germany
    Strahlenther Onkol 185:113-9. 2009
    ..In order to further define the role of short-term radiotherapy as retreatment option for selected patients, we analyzed outcomes after treatment with a hypofractionated radiation...
  59. ncbi request reprint Intracellular mediators of erucylphosphocholine-induced apoptosis
    Verena Jendrossek
    Department of Radiation Oncology, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Oncogene 22:2621-31. 2003
    ..Thus, ErPC triggers apoptosis via a Bcl-2-dependent mitochondrial but death receptor-independent pathway...
  60. pmc Choline PET based dose-painting in prostate cancer--modelling of dose effects
    Maximilian Niyazi
    Department of Radiation Oncology, Ludwig Maximilians University Munchen, Marchioninistr, 15, 81377 Munchen, Germany
    Radiat Oncol 5:23. 2010
    ..In order to assess potential effects of a dose escalation in certain sub-volumes based on choline PET imaging a mathematical dose-response model was developed...
  61. pmc Apoptotic response of Chang cells to infection with Pseudomonas aeruginosa strains PAK and PAO-I: molecular ordering of the apoptosis signaling cascade and role of type IV pili
    Verena Jendrossek
    Department of Physiology, University of Tubingen, 72076 Tubingen, Germany
    Infect Immun 71:2665-73. 2003
    ..In addition, only the piliated wild-type strains induced caspase-1-mediated activation of interleukin-1 beta. Thus, pili are necessary for distinct infection-induced cellular responses of human epithelial cells...
  62. ncbi request reprint Experimental thermoradiotherapy in malignant hepatocellular carcinoma
    Thomas Hehr
    Department of Radiation Oncology, Eberhard Karls University, Tubingen, Germany
    Int J Radiat Oncol Biol Phys 55:1374-80. 2003
    ..We therefore developed an experimental model for combined radiotherapy and hyperthermia of the liver in transplantable rat Morris hepatoma 3924A...
  63. pmc Pharmacokinetics and biodistribution of Erufosine in nude mice--implications for combination with radiotherapy
    Guido Henke
    Department of Radiooncology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Radiat Oncol 4:46. 2009
    ..In view of a possible combination of Erufosine and radiotherapy in vivo we determined the pharmacokinetics and bioavailability as well as the tolerability of Erufosine in nude mice...
  64. pmc Combined treatment with lexatumumab and irradiation leads to strongly increased long term tumour control under normoxic and hypoxic conditions
    Patrizia Marini
    CCC Tübingen, Dept of Radiation Oncology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Radiat Oncol 4:49. 2009
    ..To clarify the relevance of these effects on local tumour control long-term experiments using a colorectal xenograft model were conducted...
  65. ncbi request reprint Renal toxicity of adjuvant chemoradiotherapy with cisplatin in gastric cancer
    Stefan Welz
    Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Int J Radiat Oncol Biol Phys 69:1429-35. 2007
    ..On the basis of previously reported results of a Phase II trial using a more aggressive, cisplatin-containing chemoradiotherapy schedule, we investigated the effects of this approach on long-term renal function...
  66. ncbi request reprint First experiences of radiation treatment planning with PET/CT
    Frank Paulsen
    Clinic for Radiation Oncology, University of Tuebingen, Germany
    Strahlenther Onkol 182:369-75. 2006
    ..Its value for modern radiation treatment planning is under investigation...
  67. ncbi request reprint Novel chemotherapeutic agents for the treatment of glioblastoma multiforme
    Verena Jendrossek
    Department of Radiation Oncology, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Expert Opin Investig Drugs 12:1899-924. 2003
    ....
  68. ncbi request reprint Apoptosis-modulating agents in combination with radiotherapy-current status and outlook
    Claus Belka
    Department of Radiation Oncology, Experimental Radiation Oncology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Int J Radiat Oncol Biol Phys 58:542-54. 2004
    ..In this regard, several signaling systems have proved to be of high potential value...
  69. ncbi request reprint Palliative percutaneous radiotherapy in non-small-cell lung cancer
    Wilfried Budach
    Klinik für Radioonkologie, Universitatsklinikum Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Lung Cancer 45:S239-45. 2004
    ..For patients with good performance status the choice of the optimal radiation schedule is less clear. Schedules with total doses between 30 and 45 Gy in 2.5-3.0 Gy fractions should be preferred in these situations...
  70. ncbi request reprint CT-guided percutaneous drainage of intra-abdominal abscesses: APACHE III score stratification of 1-year results. Acute Physiology, Age, Chronic Health Evaluation
    Angelika Betsch
    Department of Radiation Oncology, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Eur Radiol 12:2883-9. 2002
    ..The percutaneous drainage of intra-abdominal abscesses shows good long-term results as long as abscesses are singular, small (<200 cm(3)), and located in well accessible regions in combination with low APACHE scores (<30)...
  71. ncbi request reprint Irradiation-induced pneumonitis mediated by the CD95/CD95-ligand system
    Frank Heinzelmann
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    J Natl Cancer Inst 98:1248-51. 2006
    ..This report demonstrates for the first time, to our knowledge, that the CD95/CD95L system is important for the development of irradiation-induced pneumonitis...
  72. ncbi request reprint A normal tissue dose response model of dynamic repair processes
    Markus Alber
    Universitatsklinikum Tubingen, Radioonkologische Uniklinik, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Phys Med Biol 51:153-72. 2006
    ..The three-parameter model lends a new perspective to the equivalent uniform dose formalism and the established serial and parallel complication models. Its implications for dose optimization are discussed...
  73. doi request reprint Chemoradiotherapy duration correlates with overall survival in limited disease SCLC patients with poor initial performance status who successfully completed multimodality treatment
    F Manapov
    Department of Radiation Oncology, Ludwig Maximilians University Munich, Marchioninistra 15, 81377, Munich, Germany
    Strahlenther Onkol 188:29-34. 2012
    ..Limited data concerning treatment-related prognostic factors in limited disease (LD) small-cell lung cancer (SCLC) patients with poor initial performance status (PS) who successfully completed chemoradiotherapy (CRT) are available...
  74. ncbi request reprint Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours
    M Weinmann
    Klinik für Radioonkologie, Universitat Tubingen, Germany
    Onkologie 27:83-90. 2004
    ..This article reviews in brief the specific pathophysiology of tumour oxygenation and its implications for prognosis, tumour treatment and biology...
  75. ncbi request reprint Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation
    F Lang
    Department for Physiology, University of Tubingen, Germany
    Pflugers Arch 440:902-7. 2000
    ..This effect contributes to CD95-induced cytosolic acidification, DNA fragmentation and cell shrinkage...
  76. doi request reprint Targeting death-receptors in radiation therapy
    Olivier Niemöller
    Department of Radiation Oncology, Ludwig Maximilians Universitat Munich, Marchioninistr 15, 81377 Munich, Germany
    Results Probl Cell Differ 49:219-39. 2009
    ..It is important to note that TRAIL and TRAIL receptor agonistic antibodies, either as single..
  77. ncbi request reprint Array-based comparative gene expression analysis of tumor cells with increased apoptosis resistance after hypoxic selection
    Martin Weinmann
    Department of Radiation Oncology, University of Tuebingen, Germany
    Oncogene 24:5914-22. 2005
    ..Most importantly, hypoxic selection was not associated with changes of single apoptosis relevant genes, but with alterations in gene expression levels of a wide variety of genes indicating a more complex adaptation process...
  78. ncbi request reprint Treatment-outcome for synchronous head-and-neck and oesophageal squamous cell carcinoma
    Stefan Welz
    Department of Radiation Oncology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Radiother Oncol 77:267-70. 2005
    ..Although head & neck and oesophageal carcinomas occur synchronously in up to 12%, almost no data on feasibility and outcome after radiotherapy are available...
  79. doi request reprint Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on celecoxib-induced apoptosis
    Justine Rudner
    University of Tubingen, Department of Radiation Oncology, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Biochem Pharmacol 79:10-20. 2010
    ....
  80. ncbi request reprint Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal
    Kirsten Lauber
    Department of Internal Medicine I, University of Tubingen, Tubingen, Germany
    Cell 113:717-30. 2003
    ..These data suggest that in addition to eat-me signals, apoptotic cells display attraction signals to ensure the efficient removal of apoptotic cells and prevent postapoptotic necrosis...
  81. ncbi request reprint Risk of second malignancies after prostate irradiation?
    Arndt Christian Müller
    Department of Radiooncology, University of Tubingen, Germany
    Strahlenther Onkol 183:605-9. 2007
    ..Several recent SEER- (Surveillance, Epidemiology and End Results-) analyses gave rise to a highly controversial discussion in how far radiotherapy for prostate cancer is associated with an increased risk of secondary neoplasms...
  82. doi request reprint Secondary hormonal manipulation
    Axel S Merseburger
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    Front Radiat Ther Oncol 41:93-102. 2008
    ..We discuss the emerging concept of secondary hormonal manipulation on the basis of the current literature and demonstrate prospective alternative treatment modalities...
  83. ncbi request reprint Total-body irradiation--role and indications: results from the German Registry for Stem Cell Transplantation (DRST)
    Frank Heinzelmann
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Strahlenther Onkol 182:222-30. 2006
    ..The exact role of TBI as part of the conditioning regimen is largely unclear. In order to determine the relevance of TBI, the status of TBI utilization was analyzed on the basis of a nationwide registry...
  84. doi request reprint Adjuvant radiotherapy for patients with locally advanced prostate cancer--a new standard?
    Ute Ganswindt
    Department of Radiation Oncology, Ludwig Maximilians University Munchen, Marchioninistr 15, 81373 München, Germany
    Eur Urol 54:528-42. 2008
    ..After radical prostatectomy (RPE) pathologically advanced disease is detected in 38% to 52% of patients. Retrospective data on the role of postoperative radiotherapy (RT) are controversial...
  85. doi request reprint Identification of urinary modified nucleosides and ribosylated metabolites in humans via combined ESI-FTICR MS and ESI-IT MS analysis
    Dino Bullinger
    Department of Clinical Pharmacology, Institute of Pharmacology and Toxicology, University Hospital Tubingen, Tubingen, Germany
    J Am Soc Mass Spectrom 19:1500-13. 2008
    ....
  86. pmc Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids
    K Lauber
    Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany
    Cell Death Differ 20:1230-40. 2013
    ..Thus, MFG-E8-dependent promotion of apoptotic cell clearance is a novel anti-inflammatory facet of GC treatment and renders MFG-E8 a prospective target for future therapeutic interventions in SLE. ..
  87. doi request reprint Combined action of celecoxib and ionizing radiation in prostate cancer cells is independent of pro-apoptotic Bax
    Rene Handrick
    Department of Radiation Oncology, University of Tubingen, Germany
    Radiother Oncol 90:413-21. 2009
    ..The aim of the present study was to analyze cytotoxic efficacy of celecoxib in combination with irradiation on human prostate cancer cell lines and to define the importance of pro-apoptotic Bax in this process...
  88. doi request reprint Analysis of complex protein kinase B signalling pathways in human prostate cancer samples
    Verena Jendrossek
    CCC Tübingen, Center of Urogenital Oncology, Department of Radiation Oncology, Essen, Germany
    BJU Int 102:371-82. 2008
    ..To provide a rational basis for targeted treatment approaches in prostate cancer deregulation of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB/Akt) system was analysed...
  89. doi request reprint Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways
    Minglun Li
    Department of Radiation Oncology, University Hospital Munich, Germany
    Biochem Pharmacol 79:122-9. 2010
    ..Thus ZM-induced apoptosis depends not only on polyploidization, but also on the intracellular apoptotic signaling...
  90. doi request reprint Evidence-based radiation oncology: oesophagus
    Bernhard Berger
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    Radiother Oncol 92:276-90. 2009
    ..Aim of this educational review is to summarize the available evidence and to define the role of radiation-based treatment options for oesophageal cancer...
  91. ncbi request reprint Disruption of cell death signaling in cancer: impact on disease prognosis and response to therapy
    Dilek Güner
    Dept Radiation Oncology, University Medical Center Charite, Campus Chárite, Humboldt University, Berlin, Germany
    Curr Med Chem Anticancer Agents 3:319-26. 2003
    ..Apart from the direct genetic events, these signaling cascades are subject to epigenetic modulations implied by the tumor microenvironment...
  92. ncbi request reprint TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway
    Jana Wendt
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Humboldt University, Berlin, Germany
    Oncogene 24:4052-64. 2005
    ..These data clearly establish distinct roles for Bax and Bak in linking the TRAIL death receptor pathway to the mitochondrial apoptosis signaling cascade upon DNA damage by IR...
  93. ncbi request reprint Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis
    Alessio Nencioni
    Massachusetts Institute of Technology, Department of Biology, Center for Cancer Research, Cambridge, MA, USA
    Blood 105:3255-62. 2005
    ..Pharmacologic or genetic approaches targeting Mcl-1, including therapeutic RNAi, may increase the effectiveness of these compounds...
  94. ncbi request reprint Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway
    Antje Klöpfer
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Campus Berlin Buch, Humboldt University, Berlin, Germany
    Oncogene 23:9408-18. 2004
    ....
  95. ncbi request reprint Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway
    Clarissa von Haefen
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Humboldt University, Berlin
    Oncogene 23:8320-32. 2004
    ....
  96. ncbi request reprint Guardians of cell death: the Bcl-2 family proteins
    Peter T Daniel
    Molecular Hematology and Oncology, Charité Campus Berlin Buch, Humboldt University, Lindenberger Weg 80, 13125 Berlin Buch, Germany
    Essays Biochem 39:73-88. 2003
    ..g. in cancer therapy...
  97. ncbi request reprint Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells
    Alessio Nencioni
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Clin Cancer Res 11:4259-65. 2005
    ..Here, we evaluated whether Bcl-2 overexpression affects the cytotoxic activity of proteasome inhibitors taken alone or in association with conventional anticancer drugs or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)...
  98. doi request reprint Importance of Bak for celecoxib-induced apoptosis
    Arndt Christian Müller
    Department of Radiation Oncology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Biochem Pharmacol 76:1082-96. 2008
    ..Taken together our data clearly show for the first time the functional relevance of Bak for celecoxib-induced apoptosis in Bax-deficient Jurkat T-lymphoma cells...
  99. ncbi request reprint Tributyltin (TBT) induces ultra-rapid caspase activation independent of apoptosome formation in human platelets
    Christoph P Berg
    Department of Internal Medicine I, University of Tubingen, Germany
    Oncogene 22:775-80. 2003
    ..Thus, these data implicate that TBT induces the activation of caspase-9 by a mechanism not involving the formation of the apoptosome...