M Beller

Summary

Country: Germany

Publications

  1. Dong K, Sang R, Wei Z, Liu J, Dühren R, Spannenberg A, et al. Cooperative catalytic methoxycarbonylation of alkenes: uncovering the role of palladium complexes with hemilabile ligands. Chem Sci. 2018;9:2510-2516 pubmed publisher
    ..Comparing CH3OD and CH3OH as nucleophiles suggests the involvement of (de)protonation in the rate-determining step. ..
  2. Papa V, Cabrero Antonino J, Alberico E, Spanneberg A, Junge K, Junge H, et al. Efficient and selective hydrogenation of amides to alcohols and amines using a well-defined manganese-PNN pincer complex. Chem Sci. 2017;8:3576-3585 pubmed publisher
    ..For the first time, more challenging substrates like primary aromatic amides including an actual herbicide can also be hydrogenated using this earth-abundant metal-based pincer catalyst. ..
  3. Murugesan K, Senthamarai T, Sohail M, Alshammari A, Pohl M, Beller M, et al. Cobalt-based nanoparticles prepared from MOF-carbon templates as efficient hydrogenation catalysts. Chem Sci. 2018;9:8553-8560 pubmed publisher
    ..The synthetic and practical utility of this novel non-noble metal-based hydrogenation protocol is demonstrated by upscaling several reactions to multigram-scale and recycling of the catalyst. ..
  4. Sahoo B, Kreyenschulte C, Agostini G, Lund H, Bachmann S, Scalone M, et al. A robust iron catalyst for the selective hydrogenation of substituted (iso)quinolones. Chem Sci. 2018;9:8134-8141 pubmed publisher
    ..As such this methodology constitutes the first heterogeneous iron-catalyzed hydrogenation of substituted (iso)quinolones with synthetic importance. ..
  5. Rosas Hernandez A, Alsabeh P, Barsch E, Junge H, Ludwig R, Beller M. Highly active and selective photochemical reduction of CO2 to CO using molecular-defined cyclopentadienone iron complexes. Chem Commun (Camb). 2016;52:8393-6 pubmed publisher
    ..Turnover numbers (TON) of ca. 600 (1 h) with initial turnover frequencies (TOF) up to 22.2 min(-1) were observed. Operando FTIR measurements allowed for the proposal of a plausible mechanism for catalyst activation. ..
  6. Cabrero Antonino J, Adam R, Papa V, Holsten M, Junge K, Beller M. Unprecedented selective homogeneous cobalt-catalysed reductive alkoxylation of cyclic imides under mild conditions. Chem Sci. 2017;8:5536-5546 pubmed publisher
    ..The present protocol opens the way to the development of new base-metal processes for the straightforward synthesis of functionalized N-heterocyclic compounds of pharmaceutical and biological interest. ..
  7. Chen F, Sahoo B, Kreyenschulte C, Lund H, Zeng M, He L, et al. Selective cobalt nanoparticles for catalytic transfer hydrogenation of N-heteroarenes. Chem Sci. 2017;8:6239-6246 pubmed publisher
  8. Cabrero Antonino J, Alberico E, Junge K, Junge H, Beller M. Towards a general ruthenium-catalyzed hydrogenation of secondary and tertiary amides to amines. Chem Sci. 2016;7:3432-3442 pubmed publisher
    ..Control experiments indicate that, after the initial reduction of the amide carbonyl group, the reaction proceeds through the reductive amination of the alcohol with the amine arising from collapse of the intermediate hemiaminal. ..
  9. Mellmann D, Sponholz P, Junge H, Beller M. Formic acid as a hydrogen storage material - development of homogeneous catalysts for selective hydrogen release. Chem Soc Rev. 2016;45:3954-88 pubmed publisher
    ..In addition to the development of catalysts for H2 generation, reversible H2 storage including continuous H2 production from formic acid is highlighted. Special focus is put on recent progress in non-noble metal catalysts. ..

More Information

Publications47

  1. request reprint
    Ziccarelli I, Neumann H, Kreyenschulte C, Gabriele B, Beller M. Pd-Supported on N-doped carbon: improved heterogeneous catalyst for base-free alkoxycarbonylation of aryl iodides. Chem Commun (Camb). 2016;52:12729-12732 pubmed
    ..Notably, no metal contamination (detection limit < 0.5 ppm) in the final products was observed. ..
  2. Cabrero Antonino J, Adam R, Junge K, Beller M. Cobalt-catalysed reductive C-H alkylation of indoles using carboxylic acids and molecular hydrogen. Chem Sci. 2017;8:6439-6450 pubmed publisher
    ..This new protocol enables the direct functionalization of indoles with readily available and stable carboxylic acids using a non-precious metal based catalyst and hydrogen as reductant. ..
  3. Ryabchuk P, Agapova A, Kreyenschulte C, Lund H, Junge H, Junge K, et al. Heterogeneous nickel-catalysed reversible, acceptorless dehydrogenation of N-heterocycles for hydrogen storage. Chem Commun (Camb). 2019;55:4969-4972 pubmed publisher
  4. Liu J, Dong K, Franke R, Neumann H, Jackstell R, Beller M. Development of efficient palladium catalysts for alkoxycarbonylation of alkenes. Chem Commun (Camb). 2018;54:12238-12241 pubmed publisher
    ..Similar transformation is obtained using tertiary ether as showcased in the carbonylation of MTBE to the corresponding linear ester in high yield and selectivity. ..
  5. Senthamarai T, Murugesan K, Schneidewind J, Kalevaru N, Baumann W, Neumann H, et al. Simple ruthenium-catalyzed reductive amination enables the synthesis of a broad range of primary amines. Nat Commun. 2018;9:4123 pubmed publisher
    ..Furthermore, in situ NMR studies were performed for the identification of active catalytic species. Based on these studies a mechanism for Ru-catalyzed reductive amination is proposed. ..
  6. Yang J, Liu J, Jackstell R, Beller M. Palladium-catalyzed aerobic oxidative carbonylation of alkynes with amines: a general access to substituted maleimides. Chem Commun (Camb). 2018;54:10710-10713 pubmed publisher
    ..This novel transformation proceeds in the presence of palladium chloride without the need for expensive ligands or additives and has a broad substrate scope affording a variety of maleimides in good to high yields. ..
  7. Li Y, Sorribes I, Vicent C, Junge K, Beller M. Convenient Reductive Methylation of Amines with Carbonates at Room Temperature. Chemistry. 2015;21:16759-63 pubmed publisher
    ..Mechanistic insights on intermediates formed during the reaction pathway were obtained by using ESI mass spectrometry. ..
  8. Pospech J, Lennox A, Beller M. Rhodium-catalysed alkoxylation/acetalization of diazo compounds: one-step synthesis of highly functionalised quaternary carbon centres. Chem Commun (Camb). 2015;51:14505-8 pubmed publisher
    ..The concomitant C-O/C-C bond formation reaction gives products with unique quaternary carbon centers, substituted by groups of different oxidation level (ester, protected aldehyde and alkoxide). ..
  9. Li H, Dong K, Neumann H, Beller M. Palladium-Catalyzed Hydroamidocarbonylation of Olefins to Imides. Angew Chem Int Ed Engl. 2015;54:10239-43 pubmed publisher
    ..The synthetic potential of the method is highlighted by the synthesis of Aniracetam by intramolecular hydroamidocarbonylation. ..
  10. Cui X, Li Y, Topf C, Junge K, Beller M. Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols. Angew Chem Int Ed Engl. 2015;54:10596-9 pubmed publisher
    ..Key to success is the use of a combination of Ru(acac)3, triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced. ..
  11. Peña López M, Neumann H, Beller M. Ruthenium pincer-catalyzed synthesis of substituted γ-butyrolactones using hydrogen autotransfer methodology. Chem Commun (Camb). 2015;51:13082-5 pubmed publisher
    ..This regioselective domino-process takes place through catalytic C-C bond formation, followed by intramolecular transesterification. Herein, we show the Ru-MACHO-BH complex as a valuable catalyst in hydrogen autotransfer reactions. ..
  12. Li Y, Li H, Junge H, Beller M. Selective ruthenium-catalyzed methylation of 2-arylethanols using methanol as C1 feedstock. Chem Commun (Camb). 2014;50:14991-4 pubmed publisher
    ..The desired domino transformation takes place via so-called borrowing hydrogen methodology, which constitutes an ideal example of green chemistry. ..
  13. Wu L, Liu Q, Spannenberg A, Jackstell R, Beller M. Highly regioselective osmium-catalyzed hydroformylation. Chem Commun (Camb). 2015;51:3080-2 pubmed publisher
    ..The combination of Os3(CO)12 and imidazoyl-substituted phosphine ligands allows n-selective (up to 99%) hydroformylation of bulk aliphatic as well as functional alkenes in good yields (64-87%). ..
  14. Dong K, Fang X, Jackstell R, Beller M. A novel rhodium-catalyzed domino-hydroformylation-reaction for the synthesis of sulphonamides. Chem Commun (Camb). 2015;51:5059-62 pubmed publisher
    ..Various olefins and sulphonamides are converted into the desired products in good yields and with excellent selectivities in the presence of a rhodium/Naphos catalyst. ..
  15. Werkmeister S, Neumann J, Junge K, Beller M. Pincer-Type Complexes for Catalytic (De)Hydrogenation and Transfer (De)Hydrogenation Reactions: Recent Progress. Chemistry. 2015;21:12226-50 pubmed publisher
    ..Aside from noble-metal-based pincer complexes, the corresponding base metal complexes are also highlighted and their applications summarized. ..
  16. Das S, Li Y, Bornschein C, Pisiewicz S, Kiersch K, Michalik D, et al. Selective rhodium-catalyzed reduction of tertiary amides in amino acid esters and peptides. Angew Chem Int Ed Engl. 2015;54:12389-93 pubmed publisher
    ..This convenient hydrosilylation reaction proceeds at ambient conditions and is operationally safe because no air-sensitive reagents or highly reactive metal hydrides are needed. ..
  17. Bheeter C, Chowdhury A, Adam R, Jackstell R, Beller M. Efficient Rh-catalyzed C-H borylation of arene derivatives under photochemical conditions. Org Biomol Chem. 2015;13:10336-40 pubmed publisher
    ..Applying trans-[Rh(PMe3)2(CO)Cl] as an active photocatalyst and HBPin as an boron source, we achieved high TON. A catalytic cycle that relies on a Rh(I)-Rh(III) interconversion is proposed. ..
  18. Li H, Neumann H, Beller M. Palladium-Catalyzed Aminocarbonylation of Allylic Alcohols. Chemistry. 2016;22:10050-6 pubmed publisher
    ..Mechanistic studies and control experiments revealed a tandem allylic alcohol amination/C-N bond carbonylation reaction sequence. ..
  19. Peña López M, Neumann H, Beller M. (Enantio)selective Hydrogen Autotransfer: Ruthenium-Catalyzed Synthesis of Oxazolidin-2-ones from Urea and Diols. Angew Chem Int Ed Engl. 2016;55:7826-30 pubmed publisher
    ..While this transformation is already highly chemo- and regioselective, we also developed the first asymmetric version of this method using (R)-(+)-MeO-BIPHEP as the chiral ligand. ..
  20. Pews Davtyan A, Jackstell R, Spannenberg A, Beller M. Zwitterionic phosphonium ligands: synthesis, characterization and application in telomerization of 1,3-butadiene. Chem Commun (Camb). 2016;52:7568-71 pubmed publisher
    ..Optimal results are obtained in the presence of cyclohexyl-substituted ligands under mild conditions and at metal loadings as low as 0.001 mol%. ..
  21. Li H, Fang X, Jackstell R, Neumann H, Beller M. Palladium-catalysed hydroamidocarbonylation of 1,3-dienes. Chem Commun (Camb). 2016;52:7142-5 pubmed publisher
    ..g. isoprene, 1,3-butadiene), are shown to be compatible with our established method (28 examples, 40-99% yield), which leads to the corresponding ?,?-unsaturated imides in a highly efficient and atom-economic fashion. ..
  22. He L, Weniger F, Neumann H, Beller M. Synthesis, Characterization, and Application of Metal Nanoparticles Supported on Nitrogen-Doped Carbon: Catalysis beyond Electrochemistry. Angew Chem Int Ed Engl. 2016;55:12582-94 pubmed publisher
    ..Furthermore, the effects of nitrogen incorporation on the different catalytic systems are highlighted. ..
  23. Peña López M, Neumann H, Beller M. Iron-Catalyzed Reaction of Urea with Alcohols and Amines: A Safe Alternative for the Synthesis of Primary Carbamates. ChemSusChem. 2016;9:2233-8 pubmed publisher
    ..These atom-economical transformations provide a direct and selective access to valuable compounds from cheap and readily available urea using a simple Lewis-acidic iron(II) catalyst. ..
  24. Pospech J, Ferraccioli R, Neumann H, Beller M. Rhodium(II)-Catalyzed Annulation of Azavinyl Carbenes Through Ring-Expansion of 1,3,5-Trioxane: Rapid Access to Nine-Membered 1,3,5,7-Trioxazonines. Chem Asian J. 2015;10:2624-30 pubmed publisher
    ..The synthesis of trioxazonine derivatives was achieved through a one-pot, two-step procedure from 1-mesylazide and a terminal alkyne by combining Cu(I)-catalyzed 1,3-dipolar cycloaddition and rhodium-catalyzed transformations. ..
  25. Adam R, Cabrero Antonino J, Junge K, Jackstell R, Beller M. Esters, Including Triglycerides, and Hydrogen as Feedstocks for the Ruthenium-Catalyzed Direct N-Alkylation of Amines. Angew Chem Int Ed Engl. 2016;55:11049-53 pubmed publisher
    ..Notably, plant oil can be efficiently applied in this single-step process. Moreover, a variety of other methyl esters can be used as N-alkylation agents in the presence of hydrogen for the synthesis of more advanced building blocks. ..
  26. Lennox A, Fischer S, Jurrat M, Luo S, Rockstroh N, Junge H, et al. Copper-Based Photosensitisers in Water Reduction: A More Efficient In Situ Formed System and Improved Mechanistic Understanding. Chemistry. 2016;22:1233-8 pubmed publisher
    ..The in situ method has been used to screen a range of ligands for the active PS, which has led to the identification a number of structural features important to longevity and performance. ..
  27. Natte K, Jagadeesh R, He L, Rabeah J, Chen J, Taeschler C, et al. Palladium-Catalyzed Trifluoromethylation of (Hetero)Arenes with CF3 Br. Angew Chem Int Ed Engl. 2016;55:2782-6 pubmed publisher
    ..As examples, trifluoromethylations of biologically important molecules, such as melatonin, theophylline, caffeine, and pentoxifylline, are showcased. ..
  28. Adam R, Alberico E, Baumann W, Drexler H, Jackstell R, Junge H, et al. NNP-Type Pincer Imidazolylphosphine Ruthenium Complexes: Efficient Base-Free Hydrogenation of Aromatic and Aliphatic Nitriles under Mild Conditions. Chemistry. 2016;22:4991-5002 pubmed publisher
    ..With its stable Ru-BH4 analogue, in which chloride is replaced by BH4, a broad range of (hetero)aromatic and aliphatic nitriles, including industrially interesting adiponitrile, has been hydrogenated under mild and base-free conditions. ..
  29. Natte K, Jagadeesh R, Sharif M, Neumann H, Beller M. Synthesis of nitriles from amines using nanoscale Co3O4-based catalysts via sustainable aerobic oxidation. Org Biomol Chem. 2016;14:3356-9 pubmed publisher
    ..Key to success for this transformation is the application of reusable cobalt oxide-based nanocatalysts. The resulting nitriles constitute key precursors and central intermediates in organic synthesis. ..
  30. Das S, Li Y, Lu L, Junge K, Beller M. A General and Selective Rhodium-Catalyzed Reduction of Amides, N-Acyl Amino Esters, and Dipeptides Using Phenylsilane. Chemistry. 2016;22:7050-3 pubmed publisher
    ..The catalyst shows excellent chemoselectivity in the presence of different sensitive functional moieties. ..
  31. Liu J, Li H, Spannenberg A, Franke R, Jackstell R, Beller M. Selective Palladium-Catalyzed Aminocarbonylation of Olefins to Branched Amides. Angew Chem Int Ed Engl. 2016;55:13544-13548 pubmed publisher
    ..Bulk industrial and functionalized olefins react with various aliphatic amines, including amino-acid derivatives, to give the corresponding branched amides generally in good yields (up to 99?%) and regioselectivities (b/l up to 99:1). ..
  32. Cabrero Antonino J, Sorribes I, Junge K, Beller M. Selective Ruthenium-Catalyzed Reductive Alkoxylation and Amination of Cyclic Imides. Angew Chem Int Ed Engl. 2016;55:387-91 pubmed publisher
    ..As an example, intramolecular reductive couplings to afford tricyclic compounds are presented for the first time. ..
  33. Dong K, Sang R, Soulé J, Bruneau C, Franke R, Jackstell R, et al. Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones. Chemistry. 2015;21:18033-7 pubmed publisher
    ..Key to success is the use of a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of an N-heterocyclic carbene. ..
  34. Rosas Hernandez A, Steinlechner C, Junge H, Beller M. Photo- and Electrochemical Valorization of Carbon Dioxide Using Earth-Abundant Molecular Catalysts. Top Curr Chem (Cham). 2017;376:1 pubmed publisher
    ..In addition, with the aim of aiding in the design of more robust and efficient non-noble metal-based catalysts, we discuss the lessons learned from the corresponding mechanistic studies...
  35. Natte K, Neumann H, Jagadeesh R, Beller M. Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines. Nat Commun. 2017;8:1344 pubmed publisher
  36. Jagadeesh R, Murugesan K, Alshammari A, Neumann H, Pohl M, Radnik J, et al. MOF-derived cobalt nanoparticles catalyze a general synthesis of amines. Science. 2017;358:326-332 pubmed publisher
  37. Wang L, Neumann H, Spannenberg A, Beller M. Practical in situ-generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters. Chem Commun (Camb). 2017;53:7469-7472 pubmed publisher
    ..Through this method, ligand optimization can be performed in a more efficient manner and the desired products could be obtained with good yields and selectivity. ..
  38. Piehl P, Peña López M, Frey A, Neumann H, Beller M. Hydrogen autotransfer and related dehydrogenative coupling reactions using a rhenium(i) pincer catalyst. Chem Commun (Camb). 2017;53:3265-3268 pubmed publisher
    ..In addition, the first examples of rhenium-catalysed synthesis of pyrroles are described by dehydrogenative coupling of diols, amines and ketones. ..