Eric Beitz

Summary

Country: Germany

Publications

  1. ncbi Adenylyl cyclase type 7 is the predominant isoform in the bovine retinal pigment epithelium
    E Beitz
    Institute of Pharmacy, University of Tubingen, Germany
    Acta Anat (Basel) 162:157-62. 1998
  2. ncbi Aquaporin water and solute channels from malaria parasites and other pathogenic protozoa
    Eric Beitz
    Department of Pharmaceutical Chemistry, University of Tubingen, Auf der Morgenstelle 8, 72076 Tubingen, Germany
    ChemMedChem 1:587-92. 2006
  3. pmc Subfamily logos: visualization of sequence deviations at alignment positions with high information content
    Eric Beitz
    Dept of Pharmaceutical Chemistry, University of Tubingen, Morgenstelle 8, 72076 Tubingen, Germany
    BMC Bioinformatics 7:313. 2006
  4. pmc Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons
    Eric Beitz
    Department of Pharmaceutical Biochemistry, University of Tubingen, Morgenstelle 8, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 103:269-74. 2006
  5. pmc Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis
    Eric Beitz
    Department of Pharmaceutical Biochemistry, University of Tubingen, Morgenstelle 8, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 101:1153-8. 2004
  6. ncbi Aquaporin-mediated fluid regulation in the inner ear
    Eric Beitz
    Department of Pharmaceutical Biochemistry, School of Pharmacy, University of Tubingen, 72076 Tubingen, Germany
    Cell Mol Neurobiol 23:315-29. 2003
  7. ncbi TEXshade: shading and labeling of multiple sequence alignments using LATEX2 epsilon
    E Beitz
    Faculty of Chemistry and Pharmacy, University of Tubingen, Germany
    Bioinformatics 16:135-9. 2000
  8. ncbi T(E)Xtopo: shaded membrane protein topology plots in LAT(E)X2epsilon
    E Beitz
    Faculty of Chemistry and Pharmacy, University of Tubingen, Morgenstelle 8, 72076 Tubingen, Germany
    Bioinformatics 16:1050-1. 2000
  9. ncbi A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins
    Slavica Pavlovic-Djuranovic
    Department of Pharmaceutical Chemistry, University of Tubingen, Morgenstelle 8, D 72076, Tubingen, Germany
    FEBS Lett 555:500-4. 2003
  10. ncbi Cloning, heterologous expression, and characterization of three aquaglyceroporins from Trypanosoma brucei
    Nestor L Uzcategui
    Biochemical Institute, Department of Pharmaceutical Biochemistry, and Institute of Physiology, University of Tubingen, 72076 Tübingen Germany
    J Biol Chem 279:42669-76. 2004

Collaborators

Detail Information

Publications22

  1. ncbi Adenylyl cyclase type 7 is the predominant isoform in the bovine retinal pigment epithelium
    E Beitz
    Institute of Pharmacy, University of Tubingen, Germany
    Acta Anat (Basel) 162:157-62. 1998
    ..We cloned AC type 7 from a cDNA library established with fresh bovine RPE, expressed this isoform in eukaryotic cells and characterized some of its properties...
  2. ncbi Aquaporin water and solute channels from malaria parasites and other pathogenic protozoa
    Eric Beitz
    Department of Pharmaceutical Chemistry, University of Tubingen, Auf der Morgenstelle 8, 72076 Tubingen, Germany
    ChemMedChem 1:587-92. 2006
  3. pmc Subfamily logos: visualization of sequence deviations at alignment positions with high information content
    Eric Beitz
    Dept of Pharmaceutical Chemistry, University of Tubingen, Morgenstelle 8, 72076 Tubingen, Germany
    BMC Bioinformatics 7:313. 2006
    ..Interesting residues at highly conserved positions can then be mutated and experimentally analyzed. However, identification of such sites is tedious because automated approaches are scarce...
  4. pmc Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons
    Eric Beitz
    Department of Pharmaceutical Biochemistry, University of Tubingen, Morgenstelle 8, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 103:269-74. 2006
    ..The data indicate that the ar/R constriction is a major checkpoint for solute permeability, and that the exquisite electrostatic proton barrier in AQPs comprises both the NPA constriction as well as the ar/R constriction...
  5. pmc Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis
    Eric Beitz
    Department of Pharmaceutical Biochemistry, University of Tubingen, Morgenstelle 8, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 101:1153-8. 2004
    ..This unequivocally proves the proximity of the couple W124/E125 close to the pore mouth. We conclude that in the Plasmodium aquaglyceroporin the electrostatic environment at the extracellular pore entry regulates water permeability...
  6. ncbi Aquaporin-mediated fluid regulation in the inner ear
    Eric Beitz
    Department of Pharmaceutical Biochemistry, School of Pharmacy, University of Tubingen, 72076 Tubingen, Germany
    Cell Mol Neurobiol 23:315-29. 2003
    ..6. Further, a working model is presented of how the endolymphatic sac may contribute to inner ear fluid regulation...
  7. ncbi TEXshade: shading and labeling of multiple sequence alignments using LATEX2 epsilon
    E Beitz
    Faculty of Chemistry and Pharmacy, University of Tubingen, Germany
    Bioinformatics 16:135-9. 2000
    ..Hence, a flexible alignment shading package was designed for both calculated and manual shading, using the macro language of the scientific typesetting software LATEX2 epsilon...
  8. ncbi T(E)Xtopo: shaded membrane protein topology plots in LAT(E)X2epsilon
    E Beitz
    Faculty of Chemistry and Pharmacy, University of Tubingen, Morgenstelle 8, 72076 Tubingen, Germany
    Bioinformatics 16:1050-1. 2000
    ..The plot can be shaded automatically to emphasize conserved residues or functional properties of the residue sidechains. The addition of rich decorations, such as labels, annotations and legends, is easily accomplished...
  9. ncbi A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins
    Slavica Pavlovic-Djuranovic
    Department of Pharmaceutical Chemistry, University of Tubingen, Morgenstelle 8, D 72076, Tubingen, Germany
    FEBS Lett 555:500-4. 2003
    ..Furthermore, we identified hydroxyurea, an antineoplastic agent with inhibitory effects on parasite proliferation, as a permeant of this channel...
  10. ncbi Cloning, heterologous expression, and characterization of three aquaglyceroporins from Trypanosoma brucei
    Nestor L Uzcategui
    Biochemical Institute, Department of Pharmaceutical Biochemistry, and Institute of Physiology, University of Tubingen, 72076 Tübingen Germany
    J Biol Chem 279:42669-76. 2004
    ..brucei. This function and especially the so far not investigated transport of dihydroxyacetone may be pivotal for the survival of the parasite survival under non-aerobic or osmotic stress conditions...
  11. ncbi Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation
    Slavica Pavlovic-Djuranovic
    Department of Pharmaceutical Biochemistry, University of Tubingen, Morgenstelle 8, D 72076 Tubingen, Germany
    Biochim Biophys Acta 1758:1012-7. 2006
    ..5 mM for 20 h. Treatment with 2.5 mM dihydroxyacetone, however, abolished PfGAPDH activity within 6 h. Aquaglyceroporin permeability for glycolytic metabolites may thus be of physiological significance...
  12. ncbi Aquaporins from pathogenic protozoan parasites: structure, function and potential for chemotherapy
    Eric Beitz
    Department of Pharmaceutical Chemistry, University of Tubingen, Morgenstelle 8, D 72076 Tubingen, Germany
    Biol Cell 97:373-83. 2005
    ..Furthermore, possible physiological roles in osmotic protection and metabolism are discussed. Finally, the potential of protozoan aquaporins for use as a target or entry pathway for chemotherapeutic compounds is reviewed...
  13. doi The aquaporin gene family of the ectomycorrhizal fungus Laccaria bicolor: lessons for symbiotic functions
    Sandra Dietz
    Interfaculty Institute of Microbiology and Infection Medicine, Physiological Ecology of Plants, University of Tubingen, Tubingen, Germany
    New Phytol 190:927-40. 2011
    ..This indicates that these proteins are an integral part of ectomycorrhizal fungus-based plant nitrogen nutrition in symbiosis...
  14. ncbi A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites
    Martin Hansen
    Department of Pharmaceutical Biochemistry, University of Tubingen, Morgenstelle 8, Tubingen D 72076, Germany
    J Biol Chem 277:4874-82. 2002
    ..Its unique bi-functionality indicates functions in the protection from osmotic stress and efficiently provides access to the serum glycerol pool for the use in ATP generation and primarily in the phospholipid synthesis...
  15. pmc Jammed traffic impedes parasite growth
    Eric Beitz
    Department of Pharmaceutical Chemistry, University of Kiel, Gutenbergstrasse 76, D 24118 Kiel, Germany
    Proc Natl Acad Sci U S A 104:13855-6. 2007
  16. ncbi Limited genetic diversity of the Plasmodium falciparum aquaglyceroporin gene
    Noemi Bahamontes-Rosa
    University of Tubingen, Department of Parasitology, Tubingen, Germany
    Mol Biochem Parasitol 156:255-7. 2007
    ..The lack of functionally variability suggests an invariable protein core, which may restrict parasite populations from evading therapeutic pressure if PfAQP inhibitors will be found...
  17. ncbi N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system
    Jürke Kotthaus
    Department of Pharmaceutical Chemistry, Pharmaceutical Institute, Christian Albrechts University of Kiel, Gutenbergstr 76 78, D 24118 Kiel, Germany
    Bioorg Med Chem 16:2305-12. 2008
    ..This hydroxylated intermediate, however, was detected to be a potent inhibitor of bovine liver arginase with a K(i) of 17.1+/-2.2 microM...
  18. ncbi Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells
    Eric Beitz
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biol Cell 98:101-9. 2006
    ..The intracellular distribution indicates that AQP6 has a function distinct from trans-epithelial water movement...
  19. ncbi Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63
    Masahiro Ikeda
    Departments of Physiology, Biological Chemistry, Medicine, and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 277:39873-9. 2002
    ....
  20. ncbi Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei
    Thomas Zeuthen
    Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Mol Microbiol 61:1598-608. 2006
    ..Ammonia permeability was similarly established for the aquaglyceroporins from Toxoplasma gondii and Trypanosoma brucei. Apparently, these aquaglyceroporins are important for the release of ammonia derived from amino acid breakdown...
  21. ncbi Microwave-assisted ring opening of epoxides: a general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities
    Aelig Robin
    Manchester Interdisciplinary Biocentre MIB, The University of Manchester, 131 Princess Street, Manchester M1 7ND, UK
    J Med Chem 50:4243-9. 2007
    ..Most of the compounds showed micromolar potency against malaria, with seven of them having IC50 values between 1 and 10 microM against both Plasmodium falciparum strains...
  22. ncbi A yeast-based phenotypic screen for aquaporin inhibitors
    Binghua Wu
    Pharmaceutical Chemistry, University of Kiel, Gutenbergstrasse 76, Kiel, Germany
    Pflugers Arch 456:717-20. 2008
    ..Specific inhibition of the aquaporin directly correlates to reduced cell proliferation...