Affiliation: Beiersdorf AG
- Assessing the risk of skin damage due to femtosecond laser irradiationFrank Fischer
Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany
J Biophotonics 1:470-7. 2008..Based on these results we are giving a risk assessment. The results show that multi photon imaging using the parameters described here is in the ballpark of damaging occurring from every day sun exposure...
- Risk estimation of skin damage due to ultrashort pulsed, focused near-infrared laser irradiation at 800 nmFrank Fischer
Research Microscopy, Beiersdorf AG, Unnastrasse 48, D 20245 Hamburg, Germany
J Biomed Opt 13:041320. 2008..6 minimal erythemal dose (MED). The 1-micron irradiation regime was comparable to 0.45 MED. Under these experimental conditions, the risk of DNA damage due to fs-laser irradiation on skin is in the range of natural UV-exposure...
- Approach to quantify human dermal skin aging using multiphoton laser scanning microscopyStefan Puschmann
Beiersdorf AG, Research and Development, Unnastrasse 48, 20245 Hamburg, Germany
J Biomed Opt 17:036005. 2012..Based on the MPLSM technology, we introduce the ELCOR parameter as a new means to quantify accurately age-associated alterations in the extracellular matrix...
- A tissue-engineered human dermal construct utilizing fibroblasts and transforming growth factor β1 to promote elastogenesisNadine Sommer
Research and Development, Beiersdorf AG, Unnastrasse, Hamburg, Germany
Biotechnol J 8:317-26. 2013..This tissue-engineered dermal construct may prove to be an effective template for the development of medicinal approaches in regenerative soft skin tissue reconstruction through TGF-β1 induction...
- Impact of collagen crosslinking on the second harmonic generation signal and the fluorescence lifetime of collagen autofluorescenceVivien Lutz
Research and Development, Beiersdorf AG, Hamburg, Germany
Skin Res Technol 18:168-79. 2012..In photodamaged skin, a decrease of the mature collagen crosslink histidinohydroxylysino-norleucine was reported. In this study, we investigated the consequences and measurability of the reduced crosslinking...
- Folic acid and creatine improve the firmness of human skin in vivoFrank Fischer
Research and Development, Skin Research, Beiersdorf AG, Hamburg, Germany
J Cosmet Dermatol 10:15-23. 2011..The decrease in firmness is a hallmark of skin aging. Accelerated by chronic sun exposure, fundamental changes occur within the dermal extracellular matrix over the years, mainly impairing the collagenous network...