Research Topics
Genomes and Genes
| Johannes BeckersSummaryCountry: Germany Publications
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Detail Information
Publications
"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?Sabine M Hoelter
Institute of Developmental Genetics, Helmholtz Center Munich German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany
Front Biosci 13:5810-23. 2008..These results emphasize the importance of comprehensive behavioural and physiological phenotyping...
Pleiotropic effects in Eya3 knockout miceTorben Soker
Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
BMC Dev Biol 8:118. 2008..The functions of its mammalian orthologs Eya1-4 are only partially understood and no mouse model exists for Eya3. Therefore, we characterized the phenotype of a new Eya3 knockout mouse mutant...
Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modellingJohannes Beckers
Institute of Experimental Genetics, Helmholtz Zentrum Munchen, GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
Nat Rev Genet 10:371-80. 2009....- Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral jointsIngeborg Teppner
GSF National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Neuherberg, Germany
BMC Dev Biol 7:68. 2007..We did this by overexpressing a functional copy of the Dll1 gene throughout the paraxial mesoderm, in particular in anterior somite compartments, during somitogenesis in transgenic mice... - Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillationKoustav Ganguly
Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
Respir Res 12:94. 2011..To test whether CNP-induced inflammation is affected by declined lung function, we exposed JF1/Msf (JF1) mice with lower than normal pulmonary function to CNP and studied the pulmonary inflammation and its resolution... - From dynamic expression patterns to boundary formation in the presomitic mesodermHendrik B Tiedemann
Institute of Experimental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
PLoS Comput Biol 8:e1002586. 2012..In conclusion, we have built a comprehensive model of somitogenesis with HES7 as core oscillator that is able to reproduce many experimentally observed data in mice... - Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processesIsabel Rubio-Aliaga
Institute of Experimental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
PLoS ONE 4:e6054. 2009..The role of the Notch ligands is less well understood. Loss-of-function of Dll1 leads to embryonic lethality, but reduction of Delta-like 1 protein levels has not been studied in adult stage... - A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouseIsabel Rubio-Aliaga
Institute of Experimental Genetics, GSF Research Center for Environment and Health, 85764 Neuherberg, Germany
Genetics 175:1451-63. 2007..These mutant mouse lines provide excellent in vivo tools for studying the role of Notch signaling in kidney and liver function, cholesterol and iron metabolism, cell-fate decisions, and during maturation of T cells in the immune system... - Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1Sabine Pfister
GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
J Mol Biol 333:229-35. 2003..Further, we found that expression of Acvrinp1 is altered in Dll1 loss-of-function mouse embryos... - Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) miceMichael Rosemann
Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
Mamm Genome 21:13-27. 2010..It is the first mouse mutant carrying a point mutation within the coding region of Pitx3... - Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patientsMartin Irmler
Helmholtz Zentrum Munchen, National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
Acta Neuropathol 124:187-97. 2012..The UBB(+1) expression pattern in humans is consistent with the contribution of bronchopneumonia as a cause of death in AD patients... - Mouse phenotypingHelmut Fuchs
Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 München Neuherberg, Germany
Methods 53:120-35. 2011..mousclinic.de; [1]). The GMC is a member of the EUMODIC consortium which created the European standard workflow EMPReSSslim for the systemic phenotyping of mouse models (http://www.eumodic.org/[2])... - Cell-based simulation of dynamic expression patterns in the presomitic mesodermHendrik B Tiedemann
Institute of Experimental Genetics, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
J Theor Biol 248:120-9. 2007..Furthermore, our program is able to synchronise Hes1 oscillations in thousands of cells through simulated Delta-Notch signalling interactions... - Systematic gene expression profiling of mouse model series reveals coexpressed genesMarion Horsch
Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Experimental Genetics, Neuherberg, Germany
Proteomics 8:1248-56. 2008..We identify the recurring regulation of particular genes and groups of coexpressed genes in apparently unrelated MMLs... - Innovations in phenotyping of mouse models in the German Mouse ClinicHelmut Fuchs
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg Munich, Germany
Mamm Genome 23:611-22. 2012..Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs)... - Assessment of a systematic expression profiling approach in ENU-induced mouse mutant linesMatthias Seltmann
GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstaedter Landstr. 1, Neuherberg, D-85764, Germany
Mamm Genome 16:1-10. 2005..We demonstrate the feasibility to detect transcriptionally affected organs employing RNA expression profiling as a tool for molecular phenotyping... - Requirement of the RNA-editing enzyme ADAR2 for normal physiology in miceMarion Horsch
Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
J Biol Chem 286:18614-22. 2011..Our extended phenotypic analysis covering ∼320 parameters identified significant changes related to absence of ADAR2 in behavior, hearing ability, allergy parameters and transcript profiles of brain... - Use of chemical mutagenesis in mouse embryonic stem cellsSonja Becker
Institute of Experimental Genetics, Ingolstaedter Landstr, Neuherberg, Germany
Methods Mol Biol 329:397-407. 2006..Whereas one set of samples is cryopreserved for archiving and subsequent generation of germline chimeras by means of blastocyst injection, the second set is used for genotype- or phenotype-driven screens to identify mutant alleles... - Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesisBastian Hoesel
Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, Neuherberg, Germany
Gene Expr Patterns 10:265-73. 2010..5 dpc. This suggests that these miRNAs could possibly target the Dll1 3'UTR in these regions. The other miRNAs are not expressed or below the detection limit and thus are unlikely to regulate Dll1 at the analyzed embryonic stages... - GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degenerationPatricia Del Río
Department of Protein Science, Helmholtz Zentrum Munchen, Neuherberg, Germany
Glia 59:821-32. 2011..Our findings suggest that RMG-derived OPN is a novel candidate protein that transmits part of the GDNF-induced neuroprotective activity of RMG to PR cells... - Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytomaSara Molatore
Department of Pathology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
Proc Natl Acad Sci U S A 107:18493-8. 2010..These studies reveal clues to the molecular pathways involved in rat and human pheochromocytoma and identify previously unexplored biomarkers for clinical use... - Cell line dependent RNA expression profiles of prion-infected mouse neuronal cellsAlex D Greenwood
Institute of Molecular Virology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
J Mol Biol 349:487-500. 2005..The results illustrate that prion infection differs in effect depending on cell type, which could be exploited for diagnostic or therapeutic intervention... - Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applicationsAndrea Beyerle
Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, and Institute of Experimental Genetics, Helmholtz Zentrum Munchen, Germany
Mol Pharm 7:727-37. 2010..Thus further optimization of the PEI-based vector systems is still needed for pulmonary application... - Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysisLuisa Pinto
Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Stem Cell Research, Ingolstadter Landstr 1, 85764 Neuherberg Munich, Germany
Mol Cell Neurosci 38:15-42. 2008..This analysis therefore identifies, for the first time, the lineage origin of basal progenitors and the molecular differences of this lineage in comparison to directly neurogenic and gliogenic radial glia... - An approach to handling and interpretation of ambiguous data in transcriptome and proteome comparisonsMartin Irmler
Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Experimental Genetics, Neuherberg, Germany
Proteomics 8:1165-9. 2008..We show here, that this can be complemented by the inspection of physical properties of genes, transcripts, and proteins... - Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesisJohannes Beckers
GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Neuherberg, Germany
Int J Cancer 114:590-7. 2005..Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html.).. - Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in miceKoustav Ganguly
Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, Neuherberg Munich, D85764, Germany
Part Fibre Toxicol 6:31. 2009..abstract:.. - Node and midline defects are associated with left-right development in Delta1 mutant embryosGerhard K H Przemeck
GSF, Institute of Experimental Genetics, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
Development 130:3-13. 2003..Based on expression analysis in wild-type and mutant embryos, we suggest a model, in which Notch signalling is required for the proper differentiation of node cells and node morphology... - Large-scale mutational analysis for the annotation of the mouse genomeJohannes Beckers
Institute of Experimental Genetics, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
Curr Opin Chem Biol 6:17-23. 2002..Beyond gene annotation, it will be necessary to understand how gene functions are integrated into the complex network of regulatory interactions in the cell... - Specificity assessment from fractionation experiments (SAFE): a novel method to evaluate microarray probe specificity based on hybridisation stringenciesAlexei L Drobyshev
Institute of Experimental Genetics, GSF-National Research Centre for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
Nucleic Acids Res 31:E1-1. 2003....