Johannes Beckers

Summary

Country: Germany

Publications

  1. ncbi request reprint "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?
    Sabine M Hoelter
    Institute of Developmental Genetics, Helmholtz Center Munich German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany
    Front Biosci 13:5810-23. 2008
  2. pmc Pleiotropic effects in Eya3 knockout mice
    Torben Soker
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    BMC Dev Biol 8:118. 2008
  3. doi request reprint Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling
    Johannes Beckers
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen, GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Nat Rev Genet 10:371-80. 2009
  4. pmc Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints
    Ingeborg Teppner
    GSF National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    BMC Dev Biol 7:68. 2007
  5. pmc Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation
    Koustav Ganguly
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
    Respir Res 12:94. 2011
  6. pmc From dynamic expression patterns to boundary formation in the presomitic mesoderm
    Hendrik B Tiedemann
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Comput Biol 8:e1002586. 2012
  7. pmc Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes
    Isabel Rubio-Aliaga
    Institute of Experimental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 4:e6054. 2009
  8. ncbi request reprint Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1
    Sabine Pfister
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    J Mol Biol 333:229-35. 2003
  9. ncbi request reprint Assessment of a systematic expression profiling approach in ENU-induced mouse mutant lines
    Matthias Seltmann
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstaedter Landstr 1, Neuherberg, D 85764, Germany
    Mamm Genome 16:1-10. 2005
  10. ncbi request reprint Cell-based simulation of dynamic expression patterns in the presomitic mesoderm
    Hendrik B Tiedemann
    Institute of Experimental Genetics, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Theor Biol 248:120-9. 2007

Detail Information

Publications33

  1. ncbi request reprint "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?
    Sabine M Hoelter
    Institute of Developmental Genetics, Helmholtz Center Munich German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany
    Front Biosci 13:5810-23. 2008
    ..These results emphasize the importance of comprehensive behavioural and physiological phenotyping...
  2. pmc Pleiotropic effects in Eya3 knockout mice
    Torben Soker
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    BMC Dev Biol 8:118. 2008
    ..The functions of its mammalian orthologs Eya1-4 are only partially understood and no mouse model exists for Eya3. Therefore, we characterized the phenotype of a new Eya3 knockout mouse mutant...
  3. doi request reprint Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling
    Johannes Beckers
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen, GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Nat Rev Genet 10:371-80. 2009
    ....
  4. pmc Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints
    Ingeborg Teppner
    GSF National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    BMC Dev Biol 7:68. 2007
    ..We did this by overexpressing a functional copy of the Dll1 gene throughout the paraxial mesoderm, in particular in anterior somite compartments, during somitogenesis in transgenic mice...
  5. pmc Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation
    Koustav Ganguly
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
    Respir Res 12:94. 2011
    ..To test whether CNP-induced inflammation is affected by declined lung function, we exposed JF1/Msf (JF1) mice with lower than normal pulmonary function to CNP and studied the pulmonary inflammation and its resolution...
  6. pmc From dynamic expression patterns to boundary formation in the presomitic mesoderm
    Hendrik B Tiedemann
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Comput Biol 8:e1002586. 2012
    ..In conclusion, we have built a comprehensive model of somitogenesis with HES7 as core oscillator that is able to reproduce many experimentally observed data in mice...
  7. pmc Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes
    Isabel Rubio-Aliaga
    Institute of Experimental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 4:e6054. 2009
    ..The role of the Notch ligands is less well understood. Loss-of-function of Dll1 leads to embryonic lethality, but reduction of Delta-like 1 protein levels has not been studied in adult stage...
  8. ncbi request reprint Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1
    Sabine Pfister
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    J Mol Biol 333:229-35. 2003
    ..Further, we found that expression of Acvrinp1 is altered in Dll1 loss-of-function mouse embryos...
  9. ncbi request reprint Assessment of a systematic expression profiling approach in ENU-induced mouse mutant lines
    Matthias Seltmann
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstaedter Landstr 1, Neuherberg, D 85764, Germany
    Mamm Genome 16:1-10. 2005
    ..We demonstrate the feasibility to detect transcriptionally affected organs employing RNA expression profiling as a tool for molecular phenotyping...
  10. ncbi request reprint Cell-based simulation of dynamic expression patterns in the presomitic mesoderm
    Hendrik B Tiedemann
    Institute of Experimental Genetics, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Theor Biol 248:120-9. 2007
    ..Furthermore, our program is able to synchronise Hes1 oscillations in thousands of cells through simulated Delta-Notch signalling interactions...
  11. pmc A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse
    Isabel Rubio-Aliaga
    Institute of Experimental Genetics, GSF Research Center for Environment and Health, 85764 Neuherberg, Germany
    Genetics 175:1451-63. 2007
    ..These mutant mouse lines provide excellent in vivo tools for studying the role of Notch signaling in kidney and liver function, cholesterol and iron metabolism, cell-fate decisions, and during maturation of T cells in the immune system...
  12. doi request reprint Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice
    Michael Rosemann
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Mamm Genome 21:13-27. 2010
    ..It is the first mouse mutant carrying a point mutation within the coding region of Pitx3...
  13. ncbi request reprint Use of chemical mutagenesis in mouse embryonic stem cells
    Sonja Becker
    Institute of Experimental Genetics, Ingolstaedter Landstr, Neuherberg, Germany
    Methods Mol Biol 329:397-407. 2006
    ..Whereas one set of samples is cryopreserved for archiving and subsequent generation of germline chimeras by means of blastocyst injection, the second set is used for genotype- or phenotype-driven screens to identify mutant alleles...
  14. pmc Rapamycin extends murine lifespan but has limited effects on aging
    Frauke Neff
    Institute of Pathology, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    J Clin Invest 123:3272-91. 2013
    ..Therefore, our data largely dissociate rapamycin's longevity effects from effects on aging itself. ..
  15. pmc Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients
    Martin Irmler
    Helmholtz Zentrum Munchen, National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
    Acta Neuropathol 124:187-97. 2012
    ..The UBB(+1) expression pattern in humans is consistent with the contribution of bronchopneumonia as a cause of death in AD patients...
  16. doi request reprint Mouse phenotyping
    Helmut Fuchs
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 München Neuherberg, Germany
    Methods 53:120-35. 2011
    ..mousclinic.de; [1]). The GMC is a member of the EUMODIC consortium which created the European standard workflow EMPReSSslim for the systemic phenotyping of mouse models (http://www.eumodic.org/[2])...
  17. doi request reprint Systematic gene expression profiling of mouse model series reveals coexpressed genes
    Marion Horsch
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    Proteomics 8:1248-56. 2008
    ..We identify the recurring regulation of particular genes and groups of coexpressed genes in apparently unrelated MMLs...
  18. pmc Innovations in phenotyping of mouse models in the German Mouse Clinic
    Helmut Fuchs
    German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Mamm Genome 23:611-22. 2012
    ..Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs)...
  19. pmc Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice
    Marion Horsch
    Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    J Biol Chem 286:18614-22. 2011
    ..Our extended phenotypic analysis covering ∼320 parameters identified significant changes related to absence of ADAR2 in behavior, hearing ability, allergy parameters and transcript profiles of brain...
  20. doi request reprint Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis
    Bastian Hoesel
    Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, Neuherberg, Germany
    Gene Expr Patterns 10:265-73. 2010
    ..5 dpc. This suggests that these miRNAs could possibly target the Dll1 3'UTR in these regions. The other miRNAs are not expressed or below the detection limit and thus are unlikely to regulate Dll1 at the analyzed embryonic stages...
  21. ncbi request reprint Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells
    Alex D Greenwood
    Institute of Molecular Virology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    J Mol Biol 349:487-500. 2005
    ..The results illustrate that prion infection differs in effect depending on cell type, which could be exploited for diagnostic or therapeutic intervention...
  22. ncbi request reprint Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis
    Johannes Beckers
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Neuherberg, Germany
    Int J Cancer 114:590-7. 2005
    ..Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html.)..
  23. pmc Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Acta Neuropathol 126:137-50. 2013
    ..Our studies reveal clues about the molecular mechanisms driving rat and human gonadotroph adenomas development, and may help identify previously unexplored biomarkers for clinical use...
  24. pmc Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma
    Sara Molatore
    Department of Pathology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 107:18493-8. 2010
    ..These studies reveal clues to the molecular pathways involved in rat and human pheochromocytoma and identify previously unexplored biomarkers for clinical use...
  25. doi request reprint GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration
    Patricia Del Río
    Department of Protein Science, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Glia 59:821-32. 2011
    ..Our findings suggest that RMG-derived OPN is a novel candidate protein that transmits part of the GDNF-induced neuroprotective activity of RMG to PR cells...
  26. doi request reprint Cytokine response of primary human myotubes in an in vitro exercise model
    Mika Scheler
    Institute of Experimental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany
    Am J Physiol Cell Physiol 305:C877-86. 2013
    ....
  27. doi request reprint Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications
    Andrea Beyerle
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, and Institute of Experimental Genetics, Helmholtz Zentrum Munchen, Germany
    Mol Pharm 7:727-37. 2010
    ..Thus further optimization of the PEI-based vector systems is still needed for pulmonary application...
  28. doi request reprint Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysis
    Luisa Pinto
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Stem Cell Research, Ingolstadter Landstr 1, 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 38:15-42. 2008
    ..This analysis therefore identifies, for the first time, the lineage origin of basal progenitors and the molecular differences of this lineage in comparison to directly neurogenic and gliogenic radial glia...
  29. doi request reprint An approach to handling and interpretation of ambiguous data in transcriptome and proteome comparisons
    Martin Irmler
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    Proteomics 8:1165-9. 2008
    ..We show here, that this can be complemented by the inspection of physical properties of genes, transcripts, and proteins...
  30. pmc Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice
    Koustav Ganguly
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, Neuherberg Munich, D85764, Germany
    Part Fibre Toxicol 6:31. 2009
    ..abstract:..
  31. ncbi request reprint Node and midline defects are associated with left-right development in Delta1 mutant embryos
    Gerhard K H Przemeck
    GSF, Institute of Experimental Genetics, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    Development 130:3-13. 2003
    ..Based on expression analysis in wild-type and mutant embryos, we suggest a model, in which Notch signalling is required for the proper differentiation of node cells and node morphology...
  32. ncbi request reprint Large-scale mutational analysis for the annotation of the mouse genome
    Johannes Beckers
    Institute of Experimental Genetics, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Curr Opin Chem Biol 6:17-23. 2002
    ..Beyond gene annotation, it will be necessary to understand how gene functions are integrated into the complex network of regulatory interactions in the cell...
  33. pmc Specificity assessment from fractionation experiments (SAFE): a novel method to evaluate microarray probe specificity based on hybridisation stringencies
    Alexei L Drobyshev
    Institute of Experimental Genetics, GSF National Research Centre for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Nucleic Acids Res 31:E1-1. 2003
    ....