G Schmuck

Summary

Affiliation: Bayer AG
Country: Germany

Publications

  1. ncbi Determination of the excitatory potencies of fluoroquinolones in the central nervous system by an in vitro model
    G Schmuck
    Bayer AG, Institute of Toxicology, Wuppertal, Germany
    Antimicrob Agents Chemother 42:1831-6. 1998
  2. ncbi Rat cortical neuron cultures: an in vitro model for differentiating mechanisms of chemically induced neurotoxicity
    G Schmuck
    Bayer AG, Pharma Research Centre, Wuppertal, Germany
    In Vitr Mol Toxicol 13:37-50. 2000
  3. ncbi [The importance of standardised cell culture methods for the routine toxicology in pharmaceutical companies]
    G Schmuck
    Bayer AG, D Wuppertal
    ALTEX 18:79-80. 2001
  4. ncbi Neurotoxic mode of action of artemisinin
    Gabriele Schmuck
    Pharma Research Center, Bayer AG, D 42096, Wuppertal, Germany
    Antimicrob Agents Chemother 46:821-7. 2002
  5. ncbi Effects of the dithiocarbamate fungicide propineb in primary neuronal cell cultures and skeletal muscle cells of the rat
    Gabriele Schmuck
    Bayer AG, Pharma Research Centre, Aprather Weg, 42096 Wuppertal, Germany
    Arch Toxicol 76:414-22. 2002
  6. ncbi Effects of the carbamates fenoxycarb, propamocarb and propoxur on energy supply, glucose utilization and SH-groups in neurons
    Gabriele Schmuck
    Bayer AG, Aprather Weg 18a, 42096 Wuppertal, Germany
    Arch Toxicol 78:330-7. 2004
  7. ncbi Effects of the new herbicide fentrazamide on the glucose utilization in neurons and erythrocytes in vitro
    Gabriele Schmuck
    Bayer AG, PH PD Toxicology, Aprather Weg 18a, D 42096 Wuppertal, Germany
    Neurotoxicology 24:55-64. 2003
  8. ncbi An in vitro model for toxicological investigations of environmental neurotoxins in primary neuronal cell cultures
    G Schmuck
    Bayer Pharma Research Center, Wuppertal, Germany
    Toxicol Ind Health 12:683-96. 1996
  9. ncbi c-fos mRNA expression in rat cortical neurons during glutamate-mediated excitotoxicity
    A Rogers
    Bayer HealthCare, Pharma Research Centre, Aprather Weg, 42096 Wuppertal, Germany
    Toxicol Sci 82:562-9. 2004
  10. ncbi Developmental and reproductive toxicity studies on artemisone
    G Schmuck
    Bayer HealthCare AG, Pharma Research Center, Wuppertal, Germany
    Birth Defects Res B Dev Reprod Toxicol 86:131-43. 2009

Detail Information

Publications14

  1. ncbi Determination of the excitatory potencies of fluoroquinolones in the central nervous system by an in vitro model
    G Schmuck
    Bayer AG, Institute of Toxicology, Wuppertal, Germany
    Antimicrob Agents Chemother 42:1831-6. 1998
    ..These investigations pointed to the N-methyl-D-aspartate receptor as the probable target of the fluoroquinolone effects...
  2. ncbi Rat cortical neuron cultures: an in vitro model for differentiating mechanisms of chemically induced neurotoxicity
    G Schmuck
    Bayer AG, Pharma Research Centre, Wuppertal, Germany
    In Vitr Mol Toxicol 13:37-50. 2000
    ..Damage of the cytoskeleton may be considered as an endpoint mechanistically related to degenerative neuropathic effects...
  3. ncbi [The importance of standardised cell culture methods for the routine toxicology in pharmaceutical companies]
    G Schmuck
    Bayer AG, D Wuppertal
    ALTEX 18:79-80. 2001
    ..The central question of toxicology is the risk assessment. Here, the in vitro toxicology will provide important information by a comparison between human and animal cell cultures under the same conditions...
  4. ncbi Neurotoxic mode of action of artemisinin
    Gabriele Schmuck
    Pharma Research Center, Bayer AG, D 42096, Wuppertal, Germany
    Antimicrob Agents Chemother 46:821-7. 2002
    ..Copper-zinc superoxide dismutase and glutathione peroxidase, two other antioxidant enzymes that were investigated, did not show any changes in their mRNA expression in all three cell types after exposure to artemisinin...
  5. ncbi Effects of the dithiocarbamate fungicide propineb in primary neuronal cell cultures and skeletal muscle cells of the rat
    Gabriele Schmuck
    Bayer AG, Pharma Research Centre, Aprather Weg, 42096 Wuppertal, Germany
    Arch Toxicol 76:414-22. 2002
    ..In conclusion, the toxicity of propineb is not comparable to disulfiram, diethyldithiocarbamate or CS(2) neurotoxicity. In regard to these findings, a direct reversible effect of propineb on skeletal muscle cells seems to be more likely...
  6. ncbi Effects of the carbamates fenoxycarb, propamocarb and propoxur on energy supply, glucose utilization and SH-groups in neurons
    Gabriele Schmuck
    Bayer AG, Aprather Weg 18a, 42096 Wuppertal, Germany
    Arch Toxicol 78:330-7. 2004
    ..The prevention by pyruvate and acetylcysteine pointed to these biochemical endpoints...
  7. ncbi Effects of the new herbicide fentrazamide on the glucose utilization in neurons and erythrocytes in vitro
    Gabriele Schmuck
    Bayer AG, PH PD Toxicology, Aprather Weg 18a, D 42096 Wuppertal, Germany
    Neurotoxicology 24:55-64. 2003
    ..It is concluded that this effect of fentrazamide in rats poses no specific risk under the exposure conditions relevant to humans...
  8. ncbi An in vitro model for toxicological investigations of environmental neurotoxins in primary neuronal cell cultures
    G Schmuck
    Bayer Pharma Research Center, Wuppertal, Germany
    Toxicol Ind Health 12:683-96. 1996
    ..Therefore, the determination of cell-specific end points is necessary to detect the neurotoxic potency and quality of a compound, whereas the cytotoxicity assay limited the tested concentration range...
  9. ncbi c-fos mRNA expression in rat cortical neurons during glutamate-mediated excitotoxicity
    A Rogers
    Bayer HealthCare, Pharma Research Centre, Aprather Weg, 42096 Wuppertal, Germany
    Toxicol Sci 82:562-9. 2004
    ..In view of the high levels of expression of c-fos mRNA, the rat cortical cell system may also be used as a more sensitive model than mCGCs for investigations into early markers of excitotoxicity...
  10. ncbi Developmental and reproductive toxicity studies on artemisone
    G Schmuck
    Bayer HealthCare AG, Pharma Research Center, Wuppertal, Germany
    Birth Defects Res B Dev Reprod Toxicol 86:131-43. 2009
    ....
  11. ncbi The influence of oxidative stress on catalase and MnSOD gene transcription in astrocytes
    E Röhrdanz
    Institute of Toxicology, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, D 40225, Dusseldorf, Germany
    Brain Res 900:128-36. 2001
    ..These results indicate transcriptional regulation of MnSOD and post-transcriptional regulation of catalase gene expression after oxidative stress in primary rat astrocytes...
  12. ncbi Artemisone--a highly active antimalarial drug of the artemisinin class
    Richard K Haynes
    Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China
    Angew Chem Int Ed Engl 45:2082-8. 2006
  13. ncbi Critical analysis of potential body temperature confounders on neurochemical endpoints caused by direct dosing and maternal separation in neonatal mice: a study of bioallethrin and deltamethrin interactions with temperature on brain muscarinic receptors
    Jürgen Pauluhn
    Institute of Toxicology, Bayer AG, 42096 Wuppertal, Germany
    J Appl Toxicol 23:9-18. 2003
    ..However, owing to their higher ventilation, under such conditions the pups may receive dosages at least double those of the dams...
  14. ncbi Improvements in an in-vitro assay for excitotoxicity by measurement of early gene (c-fos mRNA) levels
    Annamarie Rogers
    Bayer HealthCare, Pharma Research Centre, Aprather Weg, 42096, Wuppertal, Germany
    Arch Toxicol 79:129-39. 2005
    ..Furthermore, this test has the potential for application in screening newly-designed excitatory amino acid receptor antagonists in the search for clinically relevant drugs to treat a variety of neuropathologies...