Peter Jeschke

Summary

Affiliation: Bayer CropScience
Country: Germany

Publications

  1. doi Neonicotinoids-from zero to hero in insecticide chemistry
    Peter Jeschke
    Bayer CropScience AG, Research Insecticides Chemistry Insecticides, Building 6240, Alfred Nobel Str 50, D 40789 Monheim am Rhein, Germany
    Pest Manag Sci 64:1084-98. 2008
  2. ncbi Cyclohexadepsipeptides (CHDPs) with improved anthelmintical efficacy against the gastrointestinal nematode (Haemonchus contortus) in sheep
    P Jeschke
    Bayer CropScience AG, Research and Development Chemistry Insecticides, Alfred Nobel Strasse 50, Monheim am Rhein, Germany
    Parasitol Res 97:S17-21. 2005
  3. ncbi Synthesis and anthelmintic activity of cyclohexadepsipeptides with cyclohexylmethyl side chains
    Peter Jeschke
    Bayer CropScience AG, Research Insecticides, Chemistry Insecticides, Monheim am Rhein, Germany
    Bioorg Med Chem Lett 17:3690-5. 2007
  4. ncbi Synthesis and anthelmintic activity of substituted (R)-phenyllactic acid containing cyclohexadepsipeptides
    Peter Jeschke
    Bayer CropScience AG, Research and Development, Chemistry Insecticides, Monheim am Rhein, Germany
    Bioorg Med Chem Lett 16:4410-5. 2006
  5. ncbi Influence of the cyclooctadepsipeptides PF1022A and PF1022E as natural products on the design of semi-synthetic anthelmintics such as emodepside
    R Jeschke
    Bayer CropScience AG, Research and Development, Chemistry lnsecticides, Alfred Nobel Strasse 50, Monheim am Rhein, Germany
    Parasitol Res 97:S11-6. 2005
  6. ncbi Synthesis and anthelmintic activity of 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6,8(7H)-diones
    Peter Jeschke
    Bayer CropScience AG, Research Monheim, Global Chemistry Insecticides, Building 6240, Alfred Nobel Str 50, D 40789 Monheim am Rhein, Germany
    Bioorg Med Chem Lett 15:2375-9. 2005
  7. doi The unique role of halogen substituents in the design of modern agrochemicals
    Peter Jeschke
    Bayer CropScience AG, Research Insecticides Chemistry Insecticides, Monheim am Rhein, Germany
    Pest Manag Sci 66:10-27. 2010
  8. ncbi The unique role of fluorine in the design of active ingredients for modern crop protection
    Peter Jeschke
    Bayer CropScience AG, BCS R GCI, Building 6240, Alfred Nobel Strasse 50, 40789 Monheim am Rhein, Germany
    Chembiochem 5:571-89. 2004
  9. ncbi Synthesis and anthelmintic activity of cyclohexadepsipeptides with (S,S,S,R,S,R)-configuration
    Peter Jeschke
    Bayer CropScience AG, Research Monheim, Global Chemistry Insecticides, Building Q18, D 51368 Leverkusen, Germany
    Bioorg Med Chem Lett 13:3285-8. 2003
  10. doi Overview of the status and global strategy for neonicotinoids
    Peter Jeschke
    Research Insecticides Chemistry Insecticides, Building 6240, Bayer CropScience AG, Alfred Nobel Strasse 50, D 40789 Monheim am Rhein, Germany
    J Agric Food Chem 59:2897-908. 2011

Collaborators

Detail Information

Publications17

  1. doi Neonicotinoids-from zero to hero in insecticide chemistry
    Peter Jeschke
    Bayer CropScience AG, Research Insecticides Chemistry Insecticides, Building 6240, Alfred Nobel Str 50, D 40789 Monheim am Rhein, Germany
    Pest Manag Sci 64:1084-98. 2008
    ..This review comprehensively describes particularly the origin, structure and bonding as well as associated properties of neonicotinoid insecticides...
  2. ncbi Cyclohexadepsipeptides (CHDPs) with improved anthelmintical efficacy against the gastrointestinal nematode (Haemonchus contortus) in sheep
    P Jeschke
    Bayer CropScience AG, Research and Development Chemistry Insecticides, Alfred Nobel Strasse 50, Monheim am Rhein, Germany
    Parasitol Res 97:S17-21. 2005
    ..It may be assumed that the identified inflexible region of the major conformers might mimic the active conformation of these CHDPs, which could be helpful for rational design of anthelmintics with less complicated structures...
  3. ncbi Synthesis and anthelmintic activity of cyclohexadepsipeptides with cyclohexylmethyl side chains
    Peter Jeschke
    Bayer CropScience AG, Research Insecticides, Chemistry Insecticides, Monheim am Rhein, Germany
    Bioorg Med Chem Lett 17:3690-5. 2007
    ..Here we report on a simple total synthesis of the precursors for this type of CHDPs and an efficient chemical transformation of the benzylic into the corresponding cyclohexylmethyl side chains...
  4. ncbi Synthesis and anthelmintic activity of substituted (R)-phenyllactic acid containing cyclohexadepsipeptides
    Peter Jeschke
    Bayer CropScience AG, Research and Development, Chemistry Insecticides, Monheim am Rhein, Germany
    Bioorg Med Chem Lett 16:4410-5. 2006
    ..Here we report on a simple total synthetic pathway of the precursor for this particular type of CHDPs and an efficient modification of the benzylic side chain (R-PhLac(2))...
  5. ncbi Influence of the cyclooctadepsipeptides PF1022A and PF1022E as natural products on the design of semi-synthetic anthelmintics such as emodepside
    R Jeschke
    Bayer CropScience AG, Research and Development, Chemistry lnsecticides, Alfred Nobel Strasse 50, Monheim am Rhein, Germany
    Parasitol Res 97:S11-6. 2005
    ....
  6. ncbi Synthesis and anthelmintic activity of 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6,8(7H)-diones
    Peter Jeschke
    Bayer CropScience AG, Research Monheim, Global Chemistry Insecticides, Building 6240, Alfred Nobel Str 50, D 40789 Monheim am Rhein, Germany
    Bioorg Med Chem Lett 15:2375-9. 2005
    ..The absolute configuration of the most anthelmintically active (4aS,5aS,8aS,8bR)-enantiomer was determined by single crystal X-ray analysis using its stable (4aS,5aS,8aS,8bR)-enantiomer-CuCl2 (2:1)-complex...
  7. doi The unique role of halogen substituents in the design of modern agrochemicals
    Peter Jeschke
    Bayer CropScience AG, Research Insecticides Chemistry Insecticides, Monheim am Rhein, Germany
    Pest Manag Sci 66:10-27. 2010
    ....
  8. ncbi The unique role of fluorine in the design of active ingredients for modern crop protection
    Peter Jeschke
    Bayer CropScience AG, BCS R GCI, Building 6240, Alfred Nobel Strasse 50, 40789 Monheim am Rhein, Germany
    Chembiochem 5:571-89. 2004
    ..Therefore, it is still difficult to predict the sites in a molecule at which fluorine substitution will result in optimal desired effects...
  9. ncbi Synthesis and anthelmintic activity of cyclohexadepsipeptides with (S,S,S,R,S,R)-configuration
    Peter Jeschke
    Bayer CropScience AG, Research Monheim, Global Chemistry Insecticides, Building Q18, D 51368 Leverkusen, Germany
    Bioorg Med Chem Lett 13:3285-8. 2003
    ..A correlation between the major conformer and its anthelmintic activity was found. Here, we report on a simple total synthetic pathway for this particular type of CHDPs...
  10. doi Overview of the status and global strategy for neonicotinoids
    Peter Jeschke
    Research Insecticides Chemistry Insecticides, Building 6240, Bayer CropScience AG, Alfred Nobel Strasse 50, D 40789 Monheim am Rhein, Germany
    J Agric Food Chem 59:2897-908. 2011
    ..Innovative concepts for life-cycle management, jointly with the introduction of generic products, have made neonicotinoids the most important chemical class for the insecticide market...
  11. ncbi Synthesis of anthelmintically active N-methylated amidoxime analogues of the cyclic octadepsipeptide PF1022A
    Peter Jeschke
    Bayer AG, Bayer CropScience, Research Global Chemistry Insecticides, Alfred Nobel Str 50, D 40789 Monheim, Germany
    Pest Manag Sci 58:1205-15. 2002
    ..Here we report on a specific modification at the N-methyl amide linkage by using the mono-thionated PF1022A, resulting in novel anthelmintically active backbone analogues of PF 1022A...
  12. ncbi alpha-fluorinated ethers as "exotic" entity in medicinal chemistry
    Peter Jeschke
    aBayer CropScience AG, BCS R I Chemistry Insecticides, Building 6240, Alfred Nobel Strasse 50, D 40789 Monheim, Germany
    Mini Rev Med Chem 7:1027-34. 2007
    ..The present review will give an overlook of its use in medicinal chemistry...
  13. ncbi Synthesis and anthelmintic activity of thioamide analogues of cyclic octadepsipeptides such as PF1022A
    P Jeschke
    Bayer AG, Crop Protection Business Group, Agricultural Centre Monheim, D 51368 Leverkusen, Germany
    Pest Manag Sci 57:1000-6. 2001
    ..Here we report on two different and simple synthetic pathways for this new class of thionated cyclic octadepsipeptides...
  14. doi Nicotinic acetylcholine receptor agonists: a milestone for modern crop protection
    Peter Jeschke
    Bayer CropScience AG, BCS AG R and D SMR PC PCC C2, Alfred Nobel Strasse 50, Building 6510, 40789 Monheim am Rhein, Germany
    Angew Chem Int Ed Engl 52:9464-85. 2013
    ..The global economic success of synthetic nAChR agonists as insecticides renders the nicotinic acetylcholine receptor still one of the most attractive target sites for exploration in insecticide discovery. ..
  15. ncbi Alpha-fluorinated ethers, thioethers, and amines: anomerically biased species
    Frederic Leroux
    Laboratoire de Stéréochimie associé au CNRS UMR 7008, Université Louis Pasteur ECPM, 25 rue Becquerel, F 67087 Strasbourg, France
    Chem Rev 105:827-56. 2005
  16. ncbi PF1022A and related cyclodepsipeptides - a novel class of anthelmintics
    Jurgen Scherkenbeck
    Bayer AG, Leverkusen, Germany
    Curr Top Med Chem 2:759-77. 2002
    ....
  17. doi Alkaloids from stems and leaves of Stemona japonica and their insecticidal activities
    Chun Ping Tang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People s Republic of China
    J Nat Prod 71:112-6. 2008
    ....