Affiliation: Bayer HealthCare AG
- Novel whole-cell antibiotic biosensors for compound discoveryAndreas Urban
Pharma Research and Development, Discovery Europe, Bayer HealthCare AG, D 42096 Wuppertal, Germany
Appl Environ Microbiol 73:6436-43. 2007..For instance, we show that the mechanistically underexplored antibiotic ferrimycin A1 selectively inhibits protein biosynthesis...
- Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activityChristoph Freiberg
Institute of Anti infectives Research, Institute of Chemistry Research, and Institute of Cardiovascular Research, Pharma Research, Bayer HealthCare AG, D 42096 Wuppertal, Germany
J Biol Chem 279:26066-73. 2004....
- Pyrrolidinedione derivatives as antibacterial agents with a novel mode of actionJens Pohlmann
Department of Medicinal Chemistry, Bayer HealthCare AG, D-42096 Wuppertal, Germany
Bioorg Med Chem Lett 15:1189-92. 2005....
- Discovering antibiotic efficacy biomarkers: toward mechanism-specific high content compound screeningChristoph Freiberg
Pharma Global Drug Discovery, European Research Center, Bayer HealthCare AG, D-42096 Wuppertal, Germany
Mol Cell Proteomics 5:2326-35. 2006..The general approach is also applicable to drug discovery for medical indications other than infectious diseases...
- Total synthesis and initial structure-activity relationships of longicatenamycin AFranz von Nussbaum
Bayer HealthCare, Global Drug Discovery, 42096 Wuppertal, Germany
ChemMedChem 3:619-26. 2008..This first total synthesis of longicatenamycin A provided new congeners of the natural product (deacetyllongicatenamycin, dechlorolongicatenamycin, and longicatenamycin-A-amide)...
- Functional genomics in antibacterial drug discoveryChristoph Freiberg
Bayer HealthCare AG, Antibacterial Research, 42096 Wuppertal, Germany
Drug Discov Today 10:927-35. 2005..Functional genomics supports antibacterial drug discovery by improving knowledge on gene function, bacterial physiology and virulence and the effects of antibiotics on bacterial metabolism...
- The impact of transcriptome and proteome analyses on antibiotic drug discoveryChristoph Freiberg
Antibacterial Research (PH-R-EU-AI, Bayer HealthCare AG, 42096 Wuppertal, Germany
Curr Opin Microbiol 7:451-9. 2004..In addition, such compendia open up ways for novel cell-based drug screening approaches...
- The role of peptide deformylase in protein biosynthesis: a proteomic studyJulia Elisabeth Bandow
Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat, Greifswald, Germany
Proteomics 3:299-306. 2003..Eight of these protein pairs were also present on 2-D gels of exponentially growing B. subtilis, where the more acidic, still formylated protein species represented the smaller parts...
- Prediction of mechanisms of action of antibacterial compounds by gene expression profilingBernd Hutter
GPC Biotech AG, Microbiology, Munich, Germany
Antimicrob Agents Chemother 48:2838-44. 2004..A database of this kind may facilitate the prioritization of novel antibacterial entities in drug discovery programs. Potential applications and limitations are discussed...
- Applications of transcriptional profiling in antibiotics discovery and developmentHans Peter Fischer
Genedata AG, Postfach 254, 4016 Basel, Switzerland
Prog Drug Res 64:21, 23-47. 2007..Microarrays will continue to be a workhorse of anti-infectives discovery programs ranging from efficacy assessments of antibiotics ('forward pharmacology') to drug safety evaluations ('toxicogenomics')...
- Identification of antibiotic stress-inducible promoters: a systematic approach to novel pathway-specific reporter assays for antibacterial drug discoveryHans Peter Fischer
Genedata AG, Postfach 254, CH 4016, Basel, Switzerland
Genome Res 14:90-8. 2004..In a proof-of-principle experiment, this assay was shown to enable screening for new small-molecule inhibitors of bacterial growth...
- Staphylococcus aureus NfrA (SA0367) is a flavin mononucleotide-dependent NADPH oxidase involved in oxidative stress responseKarin Streker
Institut für Molekulare Infektionsbiologie, Rontgenring 11, D 97070 Wurzburg, Germany
J Bacteriol 187:2249-56. 2005..The observations presented here suggest that NfrA is a nonessential NADPH oxidoreductase which may play a role in the oxidative stress response of S. aureus, especially in keeping thiol-disulfide stress in balance...