Ralf Baumeister

Summary

Country: Germany

Publications

  1. ncbi request reprint The worm in us - Caenorhabditis elegans as a model of human disease
    Ralf Baumeister
    Trends Biotechnol 20:147-8. 2002
  2. pmc An optimized split-ubiquitin cDNA-library screening system to identify novel interactors of the human Frizzled 1 receptor
    Dietmar Dirnberger
    Bio3 Bioinformatics and Molecular Genetics Faculty of Biology, Center for Biochemistry and Molecular Cell Research ZBMZ, Faculty of Medicine, University of Freiburg, ZBSA Center for Systems Biology, Martinsried, Germany
    Nucleic Acids Res 36:e37. 2008
  3. pmc SnAvi--a new tandem tag for high-affinity protein-complex purification
    Ursula Schäffer
    Bioinformatics and Molecular Genetics, ZBMZ, Institute for Biology, ZBSA Center for Systems Biology, Albert Ludwigs Universitaet Freiburg, 79104 Freiburg, Germany
    Nucleic Acids Res 38:e91. 2010
  4. pmc Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response
    Eva D Runkel
    Spemann Graduate School of Biology and Medicine, Albert Ludwigs University of Freiburg, Freiburg, Germany
    PLoS Genet 9:e1003346. 2013
  5. pmc Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans
    Wenjing Qi
    Faculty of Biology, Bioinformatics, and Molecular Genetics, Center for Biochemistry and Molecular Cell Research, Freiburg, Germany
    PLoS Genet 8:e1002836. 2012
  6. pmc Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans
    Shu Liu
    Laboratory for Bioinformatics and Molecular Genetics, Faculty of Biology, Albert Ludwigs University of Freiburg, Freiburg, Germany
    PLoS ONE 7:e32360. 2012
  7. ncbi request reprint Endocrine signaling in Caenorhabditis elegans controls stress response and longevity
    Ralf Baumeister
    Bio 3, Bioinformatics and Molecular Genetics, University of Freiburg, Germany
    J Endocrinol 190:191-202. 2006
  8. ncbi request reprint Genes, longevity, and technology: meeting report from the 2nd conference on functional genomics of aging in Crete
    Ralf Baumeister
    Laboratory of Bioinformatics and Molecular Genetics, Institute of Biology 3, Albert Ludwig University of Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Sci Aging Knowledge Environ 2004:pe37. 2004
  9. ncbi request reprint C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
    Maren Hertweck
    BioIII, Bioinformatics and Molecular Genetics, University of Freiburg, D 79104 Freiburg, Germany
    Dev Cell 6:577-88. 2004
  10. pmc SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans
    Elke Neumann-Haefelin
    Bioinformatics and Molecular Genetics Faculty of Biology, Center for Biochemistry and Molecular Cell Research Faculty of Medicine, University of Freiburg, D 79104 Freiburg, Germany
    Genes Dev 22:2721-35. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The worm in us - Caenorhabditis elegans as a model of human disease
    Ralf Baumeister
    Trends Biotechnol 20:147-8. 2002
  2. pmc An optimized split-ubiquitin cDNA-library screening system to identify novel interactors of the human Frizzled 1 receptor
    Dietmar Dirnberger
    Bio3 Bioinformatics and Molecular Genetics Faculty of Biology, Center for Biochemistry and Molecular Cell Research ZBMZ, Faculty of Medicine, University of Freiburg, ZBSA Center for Systems Biology, Martinsried, Germany
    Nucleic Acids Res 36:e37. 2008
    ..The present work is the first example of a split-ubiquitin interaction screen using an in-situ expressed receptor of the serpentine class, emphasizing the suitability of the described improvements in the screening protocol...
  3. pmc SnAvi--a new tandem tag for high-affinity protein-complex purification
    Ursula Schäffer
    Bioinformatics and Molecular Genetics, ZBMZ, Institute for Biology, ZBSA Center for Systems Biology, Albert Ludwigs Universitaet Freiburg, 79104 Freiburg, Germany
    Nucleic Acids Res 38:e91. 2010
    ..elegans for tandem affinity purification of protein complexes, western blotting and also for the in vivo sub-cellular localization of labelled proteins...
  4. pmc Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response
    Eva D Runkel
    Spemann Graduate School of Biology and Medicine, Albert Ludwigs University of Freiburg, Freiburg, Germany
    PLoS Genet 9:e1003346. 2013
    ..This suggests that both UPRs may share a common membrane associated mechanism...
  5. pmc Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans
    Wenjing Qi
    Faculty of Biology, Bioinformatics, and Molecular Genetics, Center for Biochemistry and Molecular Cell Research, Freiburg, Germany
    PLoS Genet 8:e1002836. 2012
    ..Our data suggest that a functional balance of DAF-16 activities in different tissues determines longevity and reveals a novel, cell-nonautonomous role of FOXO/DAF-16 to affect stem cells...
  6. pmc Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans
    Shu Liu
    Laboratory for Bioinformatics and Molecular Genetics, Faculty of Biology, Albert Ludwigs University of Freiburg, Freiburg, Germany
    PLoS ONE 7:e32360. 2012
    ..In this work, we investigate neurological and molecular aspects of thermonociception using genetic, cell biological and physiological approaches...
  7. ncbi request reprint Endocrine signaling in Caenorhabditis elegans controls stress response and longevity
    Ralf Baumeister
    Bio 3, Bioinformatics and Molecular Genetics, University of Freiburg, Germany
    J Endocrinol 190:191-202. 2006
    ....
  8. ncbi request reprint Genes, longevity, and technology: meeting report from the 2nd conference on functional genomics of aging in Crete
    Ralf Baumeister
    Laboratory of Bioinformatics and Molecular Genetics, Institute of Biology 3, Albert Ludwig University of Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Sci Aging Knowledge Environ 2004:pe37. 2004
    ..At a recent conference in Hersonissos, Crete, around 200 internationally renowned experts gathered to discuss techniques and emerging results as the science of aging undergoes a shift toward systems biology...
  9. ncbi request reprint C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
    Maren Hertweck
    BioIII, Bioinformatics and Molecular Genetics, University of Freiburg, D 79104 Freiburg, Germany
    Dev Cell 6:577-88. 2004
    ..Our data also suggest the existence of a second pathway from DAF-2 to DAF-16 that does not depend on AKT-1, AKT-2, and SGK-1...
  10. pmc SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans
    Elke Neumann-Haefelin
    Bioinformatics and Molecular Genetics Faculty of Biology, Center for Biochemistry and Molecular Cell Research Faculty of Medicine, University of Freiburg, D 79104 Freiburg, Germany
    Genes Dev 22:2721-35. 2008
    ..elegans SHC-1 as a critical scaffold that directly cross-connects the two parallel JNK and IIS pathways and help to explain how these signaling cascades cooperate to ascertain normal stress response and life span in C. elegans...
  11. ncbi request reprint A mutation in CHN-1/CHIP suppresses muscle degeneration in Caenorhabditis elegans
    Oyunbileg Nyamsuren
    Bio 3, Bioinformatics and Molecular Genetics Faculty of Biology, Schaenzlestr 1, D 79104 Freiburg, Germany
    Dev Biol 312:193-202. 2007
    ..This suggests a critical role of CHIP/CHN-1-mediated ubiquitylation in the control of muscle wasting and degeneration and identifies a potential new drug target for the treatment of this disease...
  12. doi request reprint Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity
    Chronis Fatouros
    Institute of Biology III, University of Freiburg, 79104 Freiburg, Germany
    Hum Mol Genet 21:3587-603. 2012
    ..Our study establishes a new C. elegans model of Tau aggregation-mediated toxicity and supports the emerging notion that inhibiting the nucleation of Tau aggregation can be neuroprotective...
  13. pmc Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth
    Julia Sämann
    Bioinformatics and Molecular Genetics, Faculty of Biology, Albert Ludwigs Universitaet Freiburg, Freiburg, Germany
    J Biol Chem 284:16482-91. 2009
    ....
  14. pmc Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis
    Nicola Wanner
    Renal Division, University Hospital Freiburg, Freiburg, Germany
    PLoS ONE 6:e23598. 2011
    ....
  15. ncbi request reprint Automated assays to study longevity in C. elegans
    Maren Hertweck
    Bio3 Bioinformatics and Molecular Genetics, Albert Ludwigs University of Freiburg, Schänzlestr 1, D 79104 Freiburg, Germany
    Mech Ageing Dev 126:139-45. 2005
    ..elegans. Here, we discuss several methodological approaches to automate longevity assays in the nematode...
  16. ncbi request reprint Caenorhabditis elegans as a model system for Parkinson's disease
    Enrico Schmidt
    Bioinformatics and Molecular Genetics Faculty of Biology, Center for Biochemistry, University of Freiburg, Freiburg, Germany
    Neurodegener Dis 4:199-217. 2007
    ..In this review we describe that C. elegans can be used to advance our understanding of the genetic mechanisms implicated in these disorders...
  17. ncbi request reprint Presenilin function in Caenorhabditis elegans
    Agata Smialowska
    Bio3 Bioinformatics and Molecular Genetics, University of Freiburg, Freiburg, Germany
    Neurodegener Dis 3:227-32. 2006
    ..Mutations in spr-1, spr-3, spr-4 and spr-5 genes suppress the egg-laying phenotype of sel-12 loss of function mutants by derepressing the expression of the second C. elegans presenilin gene, hop-1...
  18. ncbi request reprint Targeted Purification of SnAvi-Tagged Proteins
    Ursula Schäffer
    Institute for Biology 3, University of Freiburg, Schänzlestr 4, 79104, Freiburg, Germany
    Methods Mol Biol 1177:163-74. 2014
    ..Due to its modular composition, this tag is multifunctional and facilitates among others the in vivo visualization of tagged proteins and their cell type specific activation. ..
  19. ncbi request reprint The genetics of synapse formation and function in Caenorhabditis elegans
    Mark Seifert
    Bio 3, Bioinformatics and Molecular Genetics, University of Freiburg, Schaenzlestrasse 1, 79104 Freiburg Brsg, Germany
    Cell Tissue Res 326:273-85. 2006
    ..elegans will be outlined briefly. In addition, we summarize new findings that have added to our understanding of NMJs during the last few years...
  20. ncbi request reprint Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background
    Tim Wolf
    Faculty of Biology, Institute of Biology III, Albert Ludwigs University, D 79104 Freiburg, Germany
    Exp Gerontol 56:114-22. 2014
    ....
  21. doi request reprint Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells
    Kathrin Thedieck
    Faculty of Biology, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany
    Cell 154:859-74. 2013
    ..Importantly, we show that in cancer cells, apoptosis suppression during stress depends on astrin. Being frequently upregulated in tumors, astrin is a potential clinically relevant target to sensitize tumors to apoptosis...
  22. doi request reprint Perception of UV-B by the Arabidopsis UVR8 protein
    Luca Rizzini
    Faculty of Biology, Institute of Biology II, University of Freiburg, D 79104 Freiburg, Germany
    Science 332:103-6. 2011
    ..Thereby this signaling cascade controlled by UVR8 mediates UV-B photomorphogenic responses securing plant acclimation and thus promotes survival in sunlight...
  23. ncbi request reprint C. elegans, a model for aging with high-throughput capacity
    Maren Hertweck
    ABI Molecular Neurogenetics, Ludwig Maximilians University Munich, Schillerstr 44, D 80336 Munich, Germany
    Exp Gerontol 38:345-6. 2003
    ..High-throughput analyses have been devised that allow large-scale analysis to identify additional genes, as well as compounds that affect life-span...
  24. ncbi request reprint Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans
    Bernard Lakowski
    ABI, Department of Biochemistry, Laboratory of Molecular Neurogenetics, Ludwig Maximilians Universitaet, Schillerstr 44, D 80336 Munich, Germany
    Development 130:2117-28. 2003
    ....
  25. ncbi request reprint Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans
    Barbara Meissner
    Acolph Butenandt Institute Molecular Neurogenetics, Ludwig Maximilians University of Munich, D 80336 Munich, Germany
    J Biol Chem 279:36739-45. 2004
    ....
  26. ncbi request reprint ceh-16/engrailed patterns the embryonic epidermis of Caenorhabditis elegans
    Giuseppe Cassata
    ABI Molecular Neurogenetics, LMU Munich, 80336 Munich, Germany
    Development 132:739-49. 2005
    ....
  27. pmc Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    Jennifer M A Tullet
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center Department of Pathology, Harvard Medical School Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
    Cell 132:1025-38. 2008
    ..Furthermore, SKN-1 that is constitutively active increases life span independently of DAF-16. Our findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of IIS...
  28. ncbi request reprint A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress
    Wolfdieter Springer
    ABI Molecular Neurogenetics, University of Munich, Germany
    Hum Mol Genet 14:3407-23. 2005
    ..Due to high-throughput capacity of C. elegans, this model is particularly well suited to identify genetic and chemical modifiers of toxicity...
  29. ncbi request reprint Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping
    Britta Spanier
    ABI Molecular Neurogenetics, Ludwig Maximilians University, Munich, Germany
    J Mol Biol 352:429-37. 2005
    ..elegans FLP-8), indicating that NEP-1 is a central component that controls the neuronal innervation of pharyngeal pumping in C.elegans...
  30. ncbi request reprint The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function
    Stefan Eimer
    ABI, Department of Biochemistry, Laboratory of Molecular Neurogenetics, Ludwig Maximilians Universitaet Munich, Schillerstrasse 44, Munich D 80336, Germany
    Dev Biol 251:178-92. 2002
    ....
  31. ncbi request reprint Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling
    Susanne Klumpp
    Institute for Medicinal Chemistry, Westfalische Wilhelms University, Munster, Germany
    J Cereb Blood Flow Metab 22:1420-4. 2002
    ..In Caenorhabditis elegans, the homolog of this histidine phosphatase was exclusively expressed in neurons, suggesting a distinct role of reversible histidine phosphorylation in neuronal functions...
  32. ncbi request reprint Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans
    Thorsten Hoppe
    Department of Molecular Neurogenetics, Adolph Butenandt Institute, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    Cell 118:337-49. 2004
    ..These results identify CHN-1 and UFD-2 as a functional E3/E4 complex and UNC-45 as its physiologically relevant substrate...
  33. doi request reprint A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein
    Susanne Schöbel
    Center for Integrated Protein Science and the Adolf Butenandt Institut, Ludwig Maximilians University, Munich, Germany
    J Biol Chem 283:14257-68. 2008
    ....
  34. ncbi request reprint Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence
    Jörg Höflich
    ABI Molecular Neurogenetics, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 279:30440-8. 2004
    ..We propose that the inability of Yersinia biofilms and M. nematophilum to adhere to the nematode cuticle is due to an altered glycoconjugate surface composition of the srf-3 mutant...
  35. ncbi request reprint A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans
    Assunta Croce
    IFOM Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Nat Cell Biol 6:1173-9. 2004
    ..Therefore, nematode genetics allowed not only the unmasking of distinct EPS-8-linked phenotypes, but also the definition of a novel function for this molecule in actin dynamics...
  36. ncbi request reprint Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings
    Evelyn Braungart
    PIERIS Proteolab AG, Freising Weihenstephan, Wurzburg, Germany
    Neurodegener Dis 1:175-83. 2004
    ..elegans with a variety of pharmacologically active components used in PD treatment reduced the MPP+-induced defects. Our data suggest that the C. elegans MPTP/MPP+ model can be used for the quantitative evaluation of anti-PD drugs...