Michael Baumann

Summary

Country: Germany

Publications

  1. ncbi Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC)
    M Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital C G Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 100:76-85. 2011
  2. ncbi CD44: a cancer stem cell-related biomarker with predictive potential for radiotherapy
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Clin Cancer Res 16:5091-3. 2010
  3. ncbi Exploring the role of cancer stem cells in radioresistance
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, and Michael Baumann is also at the University Cancer Center, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Rev Cancer 8:545-54. 2008
  4. ncbi Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation
    Ala Yaromina
    OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 96:116-22. 2010
  5. ncbi Epidermal growth factor receptor inhibitors for radiotherapy: biological rationale and preclinical results
    Daniel Zips
    Department of Radiation Oncology and OncoRay Centre for Radiation Research, Medical Faculty and University Hospital, Technische Universitat Dresden, Germany
    J Pharm Pharmacol 60:1019-28. 2008
  6. ncbi Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma
    Christina Schütze
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 183:256-64. 2007
  7. ncbi Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies
    Ala Yaromina
    Department of Radiation Oncology, OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 92:460-5. 2009
  8. ncbi EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: differential response of cancer stem cells and nontumourigenic cells?
    Mechthild Krause
    Department of Radiation Oncology, University of Technology Dresden, Germany
    Radiother Oncol 83:316-25. 2007
  9. ncbi Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas
    Daniel Zips
    Department of Radiation Oncology, OncoRay Centre for Radiation Research, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse, Germany
    Radiother Oncol 92:405-10. 2009
  10. ncbi Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?
    Ala Yaromina
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Radiother Oncol 76:206-12. 2005

Collaborators

Detail Information

Publications77

  1. ncbi Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC)
    M Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital C G Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 100:76-85. 2011
    ..Nevertheless high local failure rates call for radiation dose escalation. We report here the final results of the multicentric CHARTWEL trial (CHART weekend less, ARO 97-1)...
  2. ncbi CD44: a cancer stem cell-related biomarker with predictive potential for radiotherapy
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Clin Cancer Res 16:5091-3. 2010
    ..For the first time, a CSC-related marker has been functionally validated for radiotherapy in patients. CD44 expression bears the potential to predict the outcome of radiotherapy by assessment of CSC density...
  3. ncbi Exploring the role of cancer stem cells in radioresistance
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, and Michael Baumann is also at the University Cancer Center, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Rev Cancer 8:545-54. 2008
    ....
  4. ncbi Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation
    Ala Yaromina
    OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 96:116-22. 2010
    ....
  5. ncbi Epidermal growth factor receptor inhibitors for radiotherapy: biological rationale and preclinical results
    Daniel Zips
    Department of Radiation Oncology and OncoRay Centre for Radiation Research, Medical Faculty and University Hospital, Technische Universitat Dresden, Germany
    J Pharm Pharmacol 60:1019-28. 2008
    ..In summary, the data suggest that different classes of EGFR inhibitors may have a different potential to improve local tumour control after fractionated irradiation...
  6. ncbi Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma
    Christina Schütze
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 183:256-64. 2007
    ....
  7. ncbi Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies
    Ala Yaromina
    Department of Radiation Oncology, OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 92:460-5. 2009
    ..We aimed to establish a core needle biopsy technique to investigate the impact on outcome of irradiation of the microenvironment in individual experimental tumours...
  8. ncbi EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: differential response of cancer stem cells and nontumourigenic cells?
    Mechthild Krause
    Department of Radiation Oncology, University of Technology Dresden, Germany
    Radiother Oncol 83:316-25. 2007
    ....
  9. ncbi Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas
    Daniel Zips
    Department of Radiation Oncology, OncoRay Centre for Radiation Research, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse, Germany
    Radiother Oncol 92:405-10. 2009
    ..To test the effect of BIBF 1120, a novel small molecule inhibitor of multiple angiogenic receptor tyrosine kinases, on the hypoxia and radiation response of tumours...
  10. ncbi Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?
    Ala Yaromina
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Radiother Oncol 76:206-12. 2005
    ..The present study evaluates heterogeneity in pimonidazole binding within and between tumours and relates the results to the heterogeneity of radiation response in the same tumour cell line...
  11. ncbi Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo
    Kristin Gurtner
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat, Dresden, Germany
    Radiother Oncol 102:444-9. 2012
    ....
  12. ncbi Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining
    Apostolos Menegakis
    Department of Radiation Oncology, OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Int J Radiat Biol 85:1032-41. 2009
    ..To assess the potential of using the residual phosphorylation of histone H2AX (gammaH2AX) after irradiation as a marker of radiosensitivity in vitro...
  13. ncbi Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Res 5:863-72. 2007
    ..The data provide new differential insight into the importance of K-RAS mutation in the context of PI3K-AKT-mediated radioresistance of EGFR-overexpressing or EGFR-mutated tumors...
  14. ncbi Effect of cetuximab and fractionated irradiation on tumour micro-environment
    Alina Santiago
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 97:322-9. 2010
    ....
  15. ncbi Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts
    Ala Yaromina
    Department of Radiation Oncology, OncoRay Center for Radiation Research in Oncology, Medical Faculty C G Carus, Technische Universitat, Dresden, Germany
    Int J Radiat Biol 85:972-80. 2009
    ..To examine relationships between tumour hypoxia, perfusion and metabolic microenvironment at the microregional level in three different human squamous cell carcinomas (hSCC)...
  16. ncbi Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression
    Kristin Gurtner
    OncoRay National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 99:323-30. 2011
    ....
  17. ncbi Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation
    Mechthild Krause
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Radiother Oncol 76:162-7. 2005
    ..CONCLUSIONS: Our study provides evidence that both decreased repopulation as well as increased reoxygenation contribute to the improvement of local control after targeting of EGFR by C225 during fractionated irradiation of FaDu tumours...
  18. ncbi Monitoring PAI-1 and VEGF levels in 6 human squamous cell carcinoma xenografts during fractionated irradiation
    Christine Bayer
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Int J Radiat Oncol Biol Phys 84:e409-17. 2012
    ..The aim of this study was to determine in vivo whether changes in PAI-1 and VEGF during fractionated irradiation could predict for radiation resistance...
  19. ncbi Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
    Mahmoud Toulany
    Divison of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Clin Cancer Res 12:4119-26. 2006
    ..CONCLUSION: Targeting of the EGFR-dependent PI3K-AKT pathway in K-RAS-mutated A549 cells significantly affects postradiation survival by affecting the activation of DNA-PKcs, resulting in a decreased DSB repair capacity...
  20. ncbi EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms
    Michael Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Radiother Oncol 83:238-48. 2007
    ....
  21. ncbi Early FDG PET at 10 or 20 Gy under chemoradiotherapy is prognostic for locoregional control and overall survival in patients with head and neck cancer
    Maria Hentschel
    Clinic and Polyclinic of Nuclear Medicine, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, 01307 Dresden, Germany
    Eur J Nucl Med Mol Imaging 38:1203-11. 2011
    ....
  22. ncbi Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice
    Daniel Zips
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology-Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Int J Radiat Oncol Biol Phys 61:908-14. 2005
    ....
  23. ncbi Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany
    Radiother Oncol 76:143-50. 2005
    ....
  24. ncbi PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, Tuebingen, Germany
    DNA Repair (Amst) 7:1746-56. 2008
    ..Likewise, potential of IR-induced XRCC1 expression depends on its basal expression level...
  25. ncbi Recovery from sublethal damage during fractionated irradiation of human FaDu SCC
    Cordula Petersen
    Clinic of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Fetscherstr. 74, 01307 Dresden, Germany
    Radiother Oncol 74:331-6. 2005
    ..Therefore, an increased repair capacity as an explanation for the pronounced time factor of fractionated irradiation in this tumour can be ruled out...
  26. ncbi Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer
    Daniel Zips
    Medical Faculty and University Hospital Carl Gustav Carus, Dresden, Germany
    Radiother Oncol 105:21-8. 2012
    ..To explore in a prospective trial the prognostic value of hypoxia imaging before and during radiochemotherapy in patients with locally advanced head and neck cancer...
  27. ncbi Cancer stem cells: targets and potential biomarkers for radiotherapy
    Mechthild Krause
    Department of Radiation Oncology, OncoRay National Center for Radiation Research in Oncology, University Hospital, Dresden, Germany
    Clin Cancer Res 17:7224-9. 2011
    ....
  28. ncbi Tumour-infiltrating CD11b+ myelomonocytes and response to fractionated irradiation of human squamous cell carcinoma (hSCC) xenografts
    Karolina Zaleska
    Experimental Radiotherapy, Technische Universitat Dresden, Germany
    Radiother Oncol 101:80-5. 2011
    ..Here we investigated in a panel of well characterised hSCC tumour models the number of tumour-infiltrating CD11b+ cells and the association with response to clinically relevant fractionated irradiation...
  29. ncbi Comparison of [18F]FDG uptake and distribution with hypoxia and proliferation in FaDu human squamous cell carcinoma (hSCC) xenografts after single dose irradiation
    Kerstin Bruechner
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74, Dresden, Germany
    Int J Radiat Biol 85:772-80. 2009
    ....
  30. ncbi Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours
    Apostolos Menegakis
    Department of Radiation Oncology, Technische Universitat Dresden, Germany
    Radiother Oncol 100:137-44. 2011
    ..Micromilieu-dependent quantification of γH2AX after irradiation in vivo and correlation with local tumour control...
  31. ncbi Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: differences between antibodies and TK inhibitors
    Mechthild Krause
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Int J Radiat Biol 85:943-54. 2009
    ....
  32. ncbi Quantitative modifications of TNM staging, clinical staging and therapeutic intent by FDG-PET/CT in patients with non small cell lung cancer scheduled for radiotherapy--a retrospective study
    Andrij Abramyuk
    OncoRay National Center for Radiation Research in Oncology, Biological and Molecular Imaging, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Germany
    Lung Cancer 78:148-52. 2012
    ....
  33. ncbi Additional PET/CT in week 5-6 of radiotherapy for patients with stage III non-small cell lung cancer as a means of dose escalation planning?
    Charles Gillham
    OncoRay, Centre for Radiation Research in Oncology, Technische Universitat Dresden, Germany
    Radiother Oncol 88:335-41. 2008
    ..The present study was designed to test the hypothesis that a reduction in disease volume during radiotherapy detected by FDG PET/CT would facilitate radiation dose escalation, whilst remaining within normal tissue constraints...
  34. ncbi Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts
    Ala Yaromina
    OncoRay National Centre for Radiation Research in Oncology, Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Int J Radiat Oncol Biol Phys 80:1205-13. 2011
    ..To explore the prognostic value of microenvironmental parameters for local tumor control determined before and during fractionated irradiation...
  35. ncbi Usefulness of dynamic contrast enhanced computed tomography in patients with non-small-cell lung cancer scheduled for radiation therapy
    Kornelia Szluha Lazanyi
    OncoRay Center for Radiation Research in Oncology, Biological and Molecular Imaging, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Germany
    Lung Cancer 70:280-5. 2010
    ....
  36. ncbi PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha
    Iris Eke
    OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, Germany
    J Clin Invest 120:2516-27. 2010
    ....
  37. ncbi Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy
    Mechthild Krause
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Radiother Oncol 80:112-22. 2006
    ..This calls for radiotherapy specific research strategies in the preclinical testing of novel anti-cancer drugs, which in many aspects are different from research approaches for medical oncology...
  38. ncbi Molecular targeting in radiotherapy of lung cancer
    Michael Baumann
    Dept of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Lung Cancer 45:S187-97. 2004
    ..This review summarises the current status of preclinical and clinical research on combined radiation with examples of molecular targeting substances relevant for the treatment of NSCLC (EGFR, COX-2, VEGFR, KGF, TGF-beta, BBI)...
  39. ncbi Effect of the hypoxic cell sensitizer isometronidazole on local control of two human squamous cell carcinomas after fractionated irradiation
    Andreas Schreiber
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 180:375-82. 2004
    ....
  40. ncbi GTV differentially impacts locoregional control of non-small cell lung cancer (NSCLC) after different fractionation schedules: Subgroup analysis of the prospective randomized CHARTWEL trial
    Maher Soliman
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, Technische Universitat Dresden, Germany Department of Oncology, Alexandria University, Egypt
    Radiother Oncol 106:299-304. 2013
    ..To evaluate the impact of fractionation schedule on the size of the gross tumour volume (GTV) effect on tumour control after radiotherapy of NSCLC...
  41. ncbi A number of bone marrow mesenchymal stem cells but neither phenotype nor differentiation capacities changes with age of rats
    Sergey V Tokalov
    OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cells 24:255-60. 2007
    ..At the same time, neither change in phenotype no in differentiation capacities of MSC was registered. Age-related changes of the number of MSC should be taken into account whenever MSC are intended to be used for investigations...
  42. ncbi New anticancer agents: in vitro and in vivo evaluation
    Daniel Zips
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    In Vivo 19:1-7. 2005
    ..A step-wise procedure from in vitro to in vivo experiments using non-functional, functional non-clonogenic and, if applicable, clonogenic assays allows reduction of the number of promising agents for further clinical testing...
  43. ncbi Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard-Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Radiother Oncol 74:117-29. 2005
    ..CONCLUSIONS: Enhancement of radiation sensitivity by the specific EGFR-tyrosine kinase inhibitor BIBX1382BS is not generally achieved in human tumor cells, but depends most likely on the Ras genotype of the cell lines tested...
  44. ncbi PAI-1 levels predict response to fractionated irradiation in 10 human squamous cell carcinoma lines of the head and neck
    Christine Bayer
    Department of Radiation Oncology, Technical University of Munich, Munich, Germany
    Radiother Oncol 86:361-8. 2008
    ..To investigate the relationships between hypoxia, VEGF and components of the plasminogen activation system (PAS) and to determine their influence on local tumour control after fractionated radiotherapy...
  45. ncbi Individualization of cancer treatment from radiotherapy perspective
    Ala Yaromina
    Department of Radiation Oncology, OncoRay National Center for Radiation Research in Oncology, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Mol Oncol 6:211-21. 2012
    ....
  46. ncbi Clinical biomarkers of kinase activity: examples from EGFR inhibition trials
    Mechthild Krause
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Cancer Metastasis Rev 27:387-402. 2008
    ....
  47. ncbi Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the radiotherapy coo
    Volker Budach
    Department of Radiation Oncology, University Hospitals Charité, Berlin, Germany
    J Clin Oncol 23:1125-35. 2005
    ..6 Gy) to hyperfractionated accelerated radiation therapy alone (HART; 77.6 Gy)...
  48. ncbi Cancer stem cells and radiotherapy
    Michael Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitt Dresden, Germany
    Int J Radiat Biol 85:391-402. 2009
    ..In spite of many problems to be solved, the combination of stem cell markers with radiobiological assays bears considerable promise for advancing translational research in radiation oncology...
  49. ncbi ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway
    Mahmoud Toulany
    Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Radiother Oncol 97:338-45. 2010
    ..In the present study, we investigated the contribution of erbB2 as a heterodimerization partner of erbB1 in activation of Akt survival signaling after irradiation or EGF treatment...
  50. ncbi Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor control
    Daniel Zips
    Department of Radiation Oncology and OncoRay, National Center for Radiation Research in Oncology, Dresden, Germany
    Strahlenther Onkol 187:306-10. 2011
    ..Thus, the prognostic value of rHF determined during fractionated irradiation was investigated...
  51. ncbi Selection of genetically distinct, rapidly proliferating clones does not contribute to repopulation during fractionated irradiation in FaDu squamous cell carcinoma
    Daniel Zips
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Radiat Res 160:257-62. 2003
    ..The results indicate that selection of genetically distinct, rapidly proliferating clones does not contribute to the acceleration of repopulation during fractionated irradiation in poorly differentiated FaDu tumors...
  52. ncbi [Certified medical centers--A measurable benefit to patients?!]
    Maria Eberlein-Gonska
    Zentralbereich Qualitätsmanagement, Medizinische Fakultät und Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
    Z Arztl Fortbild Qualitatssich 101:173-9. 2007
    ..They have created fundamentals for measurable improvement of patient care and are able to present first results...
  53. ncbi Influence of connective tissue diseases on the expression of radiation side effects: a systematic review
    Tobias Hölscher
    Department of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 78:123-30. 2006
    ..The aim of this systematic review is to quantify the contribution of CTD to the risk of radiation related side effects...
  54. ncbi Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results
    Michael Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    Radiother Oncol 72:257-66. 2004
    ..This review presents the current status of knowledge and discusses radiobiological mechanisms which may underly the efficacy of EGFR inhibitors combined with irradiation...
  55. ncbi Cancer stem cells at the crossroads of current cancer therapy failures--radiation oncology perspective
    Ulrike Koch
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Semin Cancer Biol 20:116-24. 2010
    ..It is concluded that CSC-based endpoints and biomarkers are eventually expected to considerably improve tumour cure rates in the clinics through individualised tailoring of treatment...
  56. ncbi Experimental evaluation of functional imaging for radiotherapy
    Daniel Zips
    OncoRay - Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, , Germany
    Strahlenther Onkol 183:41-2. 2007
  57. ncbi Place of proton radiotherapy in future radiotherapy practice
    Daniel Zips
    Department of Radiation Oncology, Eberhard Karls University Tubingen, Tubingen, Germany
    Semin Radiat Oncol 23:149-53. 2013
    ..We describe the steps in health technology assessment and the potential design of preclinical and clinical trials to define the role of proton therapy in the future...
  58. ncbi Experimental study on different combination schedules of VEGF-receptor inhibitor PTK787/ZK222584 and fractionated irradiation
    Daniel Zips
    Department of Radiation Oncology, Medical Faculty C. G. Carus, University of Technology, Dresden, Germany
    Anticancer Res 23:3869-76. 2003
    ..Whether the effect of adjuvant VEGFR inhibition on growth delay translates into improved local tumor control after irradiation needs further investigation...
  59. ncbi Age-related changes in the frequency of mesenchymal stem cells in the bone marrow of rats
    Sergey V Tokalov
    OncoRay Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, 01307 Dresden, Germany
    Stem Cells Dev 16:439-46. 2007
    ....
  60. ncbi [Setting up an interdisciplinary cancer center between the poles of internal and external interests]
    Michael Baumann
    Michael Baumann, Universität KrebsCentrum, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden
    Z Arztl Fortbild Qualitatssich 101:153-8. 2007
    ..Consideration will be given to the interests of the different groups involved and to critical success factors such as its mission, interdisciplinary leadership structures, interfaces, responsibilities and quality management...
  61. ncbi Ultrafractionation in human malignant glioma xenografts
    Mechthild Krause
    Int J Cancer 107:333; author reply 334. 2003
  62. ncbi New targets for the modulation of radiation response--selective inhibition of the enzyme cyclooxygenase 2
    Cordula Petersen
    Clinic of Radiation Oncology, University Hospital Dresden, Germany
    Curr Med Chem Anticancer Agents 3:354-9. 2003
    ..In conclusion COX-2 might be a useful tool for cancer prevention and represents a potential molecular target for improving cancer treatment in combination with radiotherapy...
  63. ncbi Towards genetic prediction of radiation responses: ESTRO's GENEPI project
    Michael Baumann
    Radiother Oncol 69:121-5. 2003
  64. ncbi Impact of hypoxia and the metabolic microenvironment on radiotherapy of solid tumors. Introduction of a multi-institutional research project
    Daniel Zips
    Department of Radiotherapy and Radiation Oncology, Medical Faculty, University of Technology, Dresden, Germany
    Strahlenther Onkol 180:609-15. 2004
    ....
  65. ncbi Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro
    Iris Eke
    OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Int J Radiat Biol 83:793-802. 2007
    ..Previous studies have identified an antisurvival effect of ILK in irradiated cells. The aim of this study was to evaluate the role of EGFR tyrosine kinase (tk) activity for ILK-mediated radiosensitization...
  66. ncbi Low-dose hyperradiosensitivity of human glioblastoma cell lines in vitro does not translate into improved outcome of ultrafractionated radiotherapy in vivo
    Mechthild Krause
    Clinic for Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Int J Radiat Biol 81:751-8. 2005
    ..CONCLUSION: The results on human T98G and HGL21 glioblastoma do not support the hypothesis that HRS in vitro translates into improved outcome of ultrafractionated irradiation in vivo...
  67. ncbi Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice
    Verena Quennet
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Radiother Oncol 81:130-5. 2006
    ....
  68. ncbi TCP and NTCP: a basic introduction
    Michael Baumann
    Department of Radiotherapy and Radiation Oncology and OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Rays 30:99-104. 2005
    ..The impact of basic parameters of the fractionation schedules on these responses is described. Easy examples illustrate how Poisson statistics can be used to understand dose-response relationships in radiotherapy...
  69. ncbi Towards equity in turbulent Europe ESTRO, European cooperation and the European Commission
    Michael Baumann
    Radiother Oncol 75:251-2. 2005
  70. ncbi Ultrafractionation does not improve the results of radiotherapy in radioresistant murine DDL1 lymphoma
    Mechthild Krause
    Clinic for Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 181:540-4. 2005
    ....
  71. ncbi Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting
    Catharine M L West
    Academic Department of Radiation Oncology, The University of Manchester, Christie Hospital NHS Trust, Withington, Manchester, UK
    Int J Radiat Oncol Biol Phys 62:1264-73. 2005
    ..CONCLUSIONS: The next 5-10 years are likely to see the results of these and other correlative studies, and promising associations of profiles with response should be validated in larger definitive trials...
  72. ncbi Physical and technical quality assurance in the CHARTWEL-Bronchus trial
    Dietmar Lehmann
    Clinic of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Dresden, Germany
    Strahlenther Onkol 179:152-7. 2003
    ..On-site physical quality assurance (QA) was performed in the participating centers of the CHARTWEL-Bronchus trial to ensure that physical and technical treatment parameters correspond with the requirements of this trial...
  73. ncbi Keynote comment: Radiotherapy in the age of molecular oncology
    Michael Baumann
    Lancet Oncol 7:786-7. 2006
  74. ncbi Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation
    Ala Yaromina
    OncoRay Centre for Radiation Research in Oncology, University of Technology Dresden, Germany
    Radiother Oncol 83:304-10. 2007
    ..Therefore, these parameters were investigated using local control after single doses given under hypoxia, to predict the outcome of fractionated irradiation...
  75. ncbi TCP and NTCP in preclinical and clinical research in Europe
    Michael Baumann
    Department of Radiotherapy and Radiation Oncology and OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Rays 30:121-6. 2005
    ..These are controversial in many aspects and cannot be recommended for clinical routine practice but should rather be considered as a research tool...
  76. ncbi [Prolongation of latency or overall treatment time by unplanned radiation pauses. The clinical importance of compensation]
    Thomas Herrmann
    Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitatsklinikum Dresden, Fetscherstrasse 74, 01307 Dresden
    Strahlenther Onkol 181:65-76. 2005
    ..This study summarizes the evidence for an impact of delay and overall time of radiotherapy on locoregional tumor control...
  77. ncbi Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review
    David Pasquier
    Department of Radiotherapy, Centre Oscar Lambret, 59020 Lille, France
    Radiother Oncol 72:1-13. 2004
    ..The other treatment methods are also outlined for each location...