Michael Baumann

Summary

Country: Germany

Publications

  1. doi request reprint Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC)
    M Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital C G Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 100:76-85. 2011
  2. ncbi request reprint Exploring the role of cancer stem cells in radioresistance
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, and Michael Baumann is also at the University Cancer Center, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Rev Cancer 8:545-54. 2008
  3. doi request reprint CD44: a cancer stem cell-related biomarker with predictive potential for radiotherapy
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Clin Cancer Res 16:5091-3. 2010
  4. doi request reprint Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation
    Ala Yaromina
    OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 96:116-22. 2010
  5. doi request reprint Epidermal growth factor receptor inhibitors for radiotherapy: biological rationale and preclinical results
    Daniel Zips
    Department of Radiation Oncology and OncoRay Centre for Radiation Research, Medical Faculty and University Hospital, Technische Universitat Dresden, Germany
    J Pharm Pharmacol 60:1019-28. 2008
  6. ncbi request reprint Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma
    Christina Schütze
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 183:256-64. 2007
  7. doi request reprint Experimental evaluation of functional imaging for radiotherapy
    Daniel Zips
    OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Strahlenther Onkol 183:41-2. 2007
  8. doi request reprint Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies
    Ala Yaromina
    Department of Radiation Oncology, OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 92:460-5. 2009
  9. ncbi request reprint EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: differential response of cancer stem cells and nontumourigenic cells?
    Mechthild Krause
    Department of Radiation Oncology, University of Technology Dresden, Germany
    Radiother Oncol 83:316-25. 2007
  10. ncbi request reprint Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?
    Ala Yaromina
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Radiother Oncol 76:206-12. 2005

Detail Information

Publications85

  1. doi request reprint Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC)
    M Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital C G Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 100:76-85. 2011
    ..Nevertheless high local failure rates call for radiation dose escalation. We report here the final results of the multicentric CHARTWEL trial (CHART weekend less, ARO 97-1)...
  2. ncbi request reprint Exploring the role of cancer stem cells in radioresistance
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, and Michael Baumann is also at the University Cancer Center, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Rev Cancer 8:545-54. 2008
    ....
  3. doi request reprint CD44: a cancer stem cell-related biomarker with predictive potential for radiotherapy
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Clin Cancer Res 16:5091-3. 2010
    ..For the first time, a CSC-related marker has been functionally validated for radiotherapy in patients. CD44 expression bears the potential to predict the outcome of radiotherapy by assessment of CSC density...
  4. doi request reprint Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation
    Ala Yaromina
    OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 96:116-22. 2010
    ....
  5. doi request reprint Epidermal growth factor receptor inhibitors for radiotherapy: biological rationale and preclinical results
    Daniel Zips
    Department of Radiation Oncology and OncoRay Centre for Radiation Research, Medical Faculty and University Hospital, Technische Universitat Dresden, Germany
    J Pharm Pharmacol 60:1019-28. 2008
    ..In summary, the data suggest that different classes of EGFR inhibitors may have a different potential to improve local tumour control after fractionated irradiation...
  6. ncbi request reprint Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma
    Christina Schütze
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 183:256-64. 2007
    ....
  7. doi request reprint Experimental evaluation of functional imaging for radiotherapy
    Daniel Zips
    OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Strahlenther Onkol 183:41-2. 2007
  8. doi request reprint Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies
    Ala Yaromina
    Department of Radiation Oncology, OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 92:460-5. 2009
    ..We aimed to establish a core needle biopsy technique to investigate the impact on outcome of irradiation of the microenvironment in individual experimental tumours...
  9. ncbi request reprint EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: differential response of cancer stem cells and nontumourigenic cells?
    Mechthild Krause
    Department of Radiation Oncology, University of Technology Dresden, Germany
    Radiother Oncol 83:316-25. 2007
    ....
  10. ncbi request reprint Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?
    Ala Yaromina
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Radiother Oncol 76:206-12. 2005
    ..The present study evaluates heterogeneity in pimonidazole binding within and between tumours and relates the results to the heterogeneity of radiation response in the same tumour cell line...
  11. doi request reprint Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas
    Daniel Zips
    Department of Radiation Oncology, OncoRay Centre for Radiation Research, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse, Germany
    Radiother Oncol 92:405-10. 2009
    ..To test the effect of BIBF 1120, a novel small molecule inhibitor of multiple angiogenic receptor tyrosine kinases, on the hypoxia and radiation response of tumours...
  12. doi request reprint Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo
    Kristin Gurtner
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat, Dresden, Germany
    Radiother Oncol 102:444-9. 2012
    ....
  13. doi request reprint Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts
    Ala Yaromina
    Department of Radiation Oncology, OncoRay Center for Radiation Research in Oncology, Medical Faculty C G Carus, Technische Universitat, Dresden, Germany
    Int J Radiat Biol 85:972-80. 2009
    ..To examine relationships between tumour hypoxia, perfusion and metabolic microenvironment at the microregional level in three different human squamous cell carcinomas (hSCC)...
  14. doi request reprint Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining
    Apostolos Menegakis
    Department of Radiation Oncology, OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Int J Radiat Biol 85:1032-41. 2009
    ..To assess the potential of using the residual phosphorylation of histone H2AX (gammaH2AX) after irradiation as a marker of radiosensitivity in vitro...
  15. doi request reprint Effect of cetuximab and fractionated irradiation on tumour micro-environment
    Alina Santiago
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 97:322-9. 2010
    ....
  16. ncbi request reprint Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Res 5:863-72. 2007
    ..The data provide new differential insight into the importance of K-RAS mutation in the context of PI3K-AKT-mediated radioresistance of EGFR-overexpressing or EGFR-mutated tumors...
  17. doi request reprint Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression
    Kristin Gurtner
    OncoRay National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 99:323-30. 2011
    ....
  18. ncbi request reprint Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation
    Mechthild Krause
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Radiother Oncol 76:162-7. 2005
    ..Furthermore, the anti-EGFR monoclonal antibody C225 has been shown to significantly improve the results of fractionated irradiation in this tumour...
  19. doi request reprint Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation
    Linda Helbig
    OncoRay National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Int J Radiat Oncol Biol Phys 88:159-66. 2014
    ..To study the effects of BAY-84-7296, a novel orally bioavailable inhibitor of mitochondrial complex I and hypoxia-inducible factor 1 (HIF-1) activity, on hypoxia, microenvironment, and radiation response of tumors...
  20. doi request reprint Monitoring PAI-1 and VEGF levels in 6 human squamous cell carcinoma xenografts during fractionated irradiation
    Christine Bayer
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Int J Radiat Oncol Biol Phys 84:e409-17. 2012
    ..The aim of this study was to determine in vivo whether changes in PAI-1 and VEGF during fractionated irradiation could predict for radiation resistance...
  21. doi request reprint Comparison of [18F]FDG uptake and distribution with hypoxia and proliferation in FaDu human squamous cell carcinoma (hSCC) xenografts after single dose irradiation
    Kerstin Bruechner
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74, Dresden, Germany
    Int J Radiat Biol 85:772-80. 2009
    ....
  22. doi request reprint Early FDG PET at 10 or 20 Gy under chemoradiotherapy is prognostic for locoregional control and overall survival in patients with head and neck cancer
    Maria Hentschel
    Clinic and Polyclinic of Nuclear Medicine, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, 01307 Dresden, Germany
    Eur J Nucl Med Mol Imaging 38:1203-11. 2011
    ....
  23. ncbi request reprint EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms
    Michael Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Radiother Oncol 83:238-48. 2007
    ....
  24. ncbi request reprint Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice
    Daniel Zips
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Int J Radiat Oncol Biol Phys 61:908-14. 2005
    ..To test the latter hypothesis, local tumor control experiments were performed...
  25. ncbi request reprint Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
    Mahmoud Toulany
    Divison of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Clin Cancer Res 12:4119-26. 2006
    ..In the present study, we investigated whether impaired repair of DNA double-strand breaks (DSB) is responsible for the radiosensitizing effect of EGFR and PI3K inhibition in K-RAS mutated (K-RAS(mt)) cells...
  26. ncbi request reprint Effect of [(18)F]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice
    Christina Schütze
    OncoRay National Centre for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz Zentrum Dresden Rossendorf, Germany Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany German Cancer Consortium DKTK, Site Dresden and German Cancer Research Center DKFZ, Heidelberg, Germany
    Radiother Oncol 111:81-7. 2014
    ..To investigate the effect of radiation dose-escalation on local control in hypoxic versus non-hypoxic hypoxic tumours defined using [(18)F]fluoromisonidazole ([(18)F]FMISO) PET...
  27. doi request reprint GTV differentially impacts locoregional control of non-small cell lung cancer (NSCLC) after different fractionation schedules: subgroup analysis of the prospective randomized CHARTWEL trial
    Maher Soliman
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, Technische Universitat Dresden, Germany Department of Oncology, Alexandria University, Egypt
    Radiother Oncol 106:299-304. 2013
    ..To evaluate the impact of fractionation schedule on the size of the gross tumour volume (GTV) effect on tumour control after radiotherapy of NSCLC...
  28. doi request reprint Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer
    Daniel Zips
    Medical Faculty and University Hospital Carl Gustav Carus, Dresden, Germany
    Radiother Oncol 105:21-8. 2012
    ..To explore in a prospective trial the prognostic value of hypoxia imaging before and during radiochemotherapy in patients with locally advanced head and neck cancer...
  29. doi request reprint PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, Tuebingen, Germany
    DNA Repair (Amst) 7:1746-56. 2008
    ..Likewise, potential of IR-induced XRCC1 expression depends on its basal expression level...
  30. ncbi request reprint Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany
    Radiother Oncol 76:143-50. 2005
    ..In the context of EGFR-targeting strategies we investigated autocrine/paracrine factors leading to in vitro radioresistance of K-Ras mutated tumor cells through activation of EGFR mediated signal transduction...
  31. ncbi request reprint Recovery from sublethal damage during fractionated irradiation of human FaDu SCC
    Cordula Petersen
    Clinic of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Fetscherstr 74, 01307 Dresden, Germany
    Radiother Oncol 74:331-6. 2005
    ....
  32. doi request reprint Quantitative modifications of TNM staging, clinical staging and therapeutic intent by FDG-PET/CT in patients with non small cell lung cancer scheduled for radiotherapy--a retrospective study
    Andrij Abramyuk
    OncoRay National Center for Radiation Research in Oncology, Biological and Molecular Imaging, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Germany
    Lung Cancer 78:148-52. 2012
    ....
  33. doi request reprint Usefulness of dynamic contrast enhanced computed tomography in patients with non-small-cell lung cancer scheduled for radiation therapy
    Kornelia Szluha Lazanyi
    OncoRay Center for Radiation Research in Oncology, Biological and Molecular Imaging, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Germany
    Lung Cancer 70:280-5. 2010
    ....
  34. doi request reprint Tumour-infiltrating CD11b+ myelomonocytes and response to fractionated irradiation of human squamous cell carcinoma (hSCC) xenografts
    Karolina Zaleska
    Experimental Radiotherapy, Technische Universitat Dresden, Germany
    Radiother Oncol 101:80-5. 2011
    ..Here we investigated in a panel of well characterised hSCC tumour models the number of tumour-infiltrating CD11b+ cells and the association with response to clinically relevant fractionated irradiation...
  35. doi request reprint Cancer stem cells: targets and potential biomarkers for radiotherapy
    Mechthild Krause
    Department of Radiation Oncology, OncoRay National Center for Radiation Research in Oncology, University Hospital, Dresden, Germany
    Clin Cancer Res 17:7224-9. 2011
    ....
  36. doi request reprint Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: differences between antibodies and TK inhibitors
    Mechthild Krause
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Int J Radiat Biol 85:943-54. 2009
    ..Differences are obvious not only between different tumour entities, but also between different combination schedules and different classes of drugs. The underlying reasons are currently not well understood...
  37. doi request reprint Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours
    Apostolos Menegakis
    Department of Radiation Oncology, Technische Universitat Dresden, Germany
    Radiother Oncol 100:137-44. 2011
    ..Micromilieu-dependent quantification of γH2AX after irradiation in vivo and correlation with local tumour control...
  38. doi request reprint Additional PET/CT in week 5-6 of radiotherapy for patients with stage III non-small cell lung cancer as a means of dose escalation planning?
    Charles Gillham
    OncoRay, Centre for Radiation Research in Oncology, Technische Universitat Dresden, Germany
    Radiother Oncol 88:335-41. 2008
    ..The present study was designed to test the hypothesis that a reduction in disease volume during radiotherapy detected by FDG PET/CT would facilitate radiation dose escalation, whilst remaining within normal tissue constraints...
  39. doi request reprint Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts
    Ala Yaromina
    OncoRay National Centre for Radiation Research in Oncology, Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Int J Radiat Oncol Biol Phys 80:1205-13. 2011
    ..To explore the prognostic value of microenvironmental parameters for local tumor control determined before and during fractionated irradiation...
  40. pmc PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha
    Iris Eke
    OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, Germany
    J Clin Invest 120:2516-27. 2010
    ....
  41. ncbi request reprint Molecular targeting in radiotherapy of lung cancer
    Michael Baumann
    Dept of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Lung Cancer 45:S187-97. 2004
    ..This review summarises the current status of preclinical and clinical research on combined radiation with examples of molecular targeting substances relevant for the treatment of NSCLC (EGFR, COX-2, VEGFR, KGF, TGF-beta, BBI)...
  42. ncbi request reprint Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy
    Mechthild Krause
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Radiother Oncol 80:112-22. 2006
    ..This calls for radiotherapy specific research strategies in the preclinical testing of novel anti-cancer drugs, which in many aspects are different from research approaches for medical oncology...
  43. doi request reprint Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential
    Lydia Koi
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany OncoRay National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Helmholtz Zentrum Dresden Rossendorf, Germany
    Radiother Oncol 110:362-9. 2014
    ..The effect of radioimmunotherapy (RIT) using the therapeutic radionuclide Y-90 bound to the anti-EGFR antibody cetuximab combined with external beam irradiation (EBRT) (EBRIT) on permanent local tumor control in vivo was examined...
  44. doi request reprint Clinical biomarkers of kinase activity: examples from EGFR inhibition trials
    Mechthild Krause
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Cancer Metastasis Rev 27:387-402. 2008
    ....
  45. ncbi request reprint Effect of the hypoxic cell sensitizer isometronidazole on local control of two human squamous cell carcinomas after fractionated irradiation
    Andreas Schreiber
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 180:375-82. 2004
    ..The objective of the present study was to test the efficacy of the hypoxic cell sensitizer isometronidazole (ISO) during fractionated irradiation in two different human squamous cell carcinomas...
  46. ncbi request reprint New anticancer agents: in vitro and in vivo evaluation
    Daniel Zips
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    In Vivo 19:1-7. 2005
    ..A step-wise procedure from in vitro to in vivo experiments using non-functional, functional non-clonogenic and, if applicable, clonogenic assays allows reduction of the number of promising agents for further clinical testing...
  47. ncbi request reprint PAI-1 levels predict response to fractionated irradiation in 10 human squamous cell carcinoma lines of the head and neck
    Christine Bayer
    Department of Radiation Oncology, Technical University of Munich, Munich, Germany
    Radiother Oncol 86:361-8. 2008
    ..To investigate the relationships between hypoxia, VEGF and components of the plasminogen activation system (PAS) and to determine their influence on local tumour control after fractionated radiotherapy...
  48. ncbi request reprint A number of bone marrow mesenchymal stem cells but neither phenotype nor differentiation capacities changes with age of rats
    Sergey V Tokalov
    OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cells 24:255-60. 2007
    ..At the same time, neither change in phenotype no in differentiation capacities of MSC was registered. Age-related changes of the number of MSC should be taken into account whenever MSC are intended to be used for investigations...
  49. ncbi request reprint Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Radiother Oncol 74:117-29. 2005
    ..To investigate the cellular and molecular consequences of antagonizing radiation-induced EGFR-activation in vitro...
  50. doi request reprint Individualization of cancer treatment from radiotherapy perspective
    Ala Yaromina
    Department of Radiation Oncology, OncoRay National Center for Radiation Research in Oncology, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Mol Oncol 6:211-21. 2012
    ....
  51. ncbi request reprint Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the radiotherapy coo
    Volker Budach
    Department of Radiation Oncology, University Hospitals Charité, Berlin, Germany
    J Clin Oncol 23:1125-35. 2005
    ..6 Gy) to hyperfractionated accelerated radiation therapy alone (HART; 77.6 Gy)...
  52. doi request reprint Cancer stem cells and radiotherapy
    Michael Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitt Dresden, Germany
    Int J Radiat Biol 85:391-402. 2009
    ..An effort is made to differentiate clonogenicity from stemness of cancer cells...
  53. doi request reprint Place of proton radiotherapy in future radiotherapy practice
    Daniel Zips
    Department of Radiation Oncology, Eberhard Karls University Tubingen, Tubingen, Germany
    Semin Radiat Oncol 23:149-53. 2013
    ..We describe the steps in health technology assessment and the potential design of preclinical and clinical trials to define the role of proton therapy in the future...
  54. doi request reprint Residual γH2AX foci predict local tumour control after radiotherapy
    Ulrike Koch
    German Cancer Consortium DKTK, Dresden and German Cancer Research Center DKFZ, Heidelberg, Germany Department of Radiation Oncology and OncoRay National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 108:434-9. 2013
    ..Evaluation of micromilieu-dependent quantified γH2AX foci as a potential predictive biomarker in well-oxygenated tumour areas in 9 HNSCC xenograft models in vivo...
  55. doi request reprint ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway
    Mahmoud Toulany
    Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Radiother Oncol 97:338-45. 2010
    ..In the present study, we investigated the contribution of erbB2 as a heterodimerization partner of erbB1 in activation of Akt survival signaling after irradiation or EGF treatment...
  56. doi request reprint Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor control
    Daniel Zips
    Department of Radiation Oncology and OncoRay, National Center for Radiation Research in Oncology, Dresden, Germany
    Strahlenther Onkol 187:306-10. 2011
    ..Thus, the prognostic value of rHF determined during fractionated irradiation was investigated...
  57. ncbi request reprint [Certified medical centers--A measurable benefit to patients?!]
    Maria Eberlein-Gonska
    Zentralbereich Qualitätsmanagement, Medizinische Fakultät und Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
    Z Arztl Fortbild Qualitatssich 101:173-9. 2007
    ..They have created fundamentals for measurable improvement of patient care and are able to present first results...
  58. ncbi request reprint Selection of genetically distinct, rapidly proliferating clones does not contribute to repopulation during fractionated irradiation in FaDu squamous cell carcinoma
    Daniel Zips
    Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Radiat Res 160:257-62. 2003
    ..The results indicate that selection of genetically distinct, rapidly proliferating clones does not contribute to the acceleration of repopulation during fractionated irradiation in poorly differentiated FaDu tumors...
  59. doi request reprint Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation
    Mechthild Krause
    Department of Radiation Oncology, Technische Universitat Dresden, Germany OncoRay National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany German Cancer Consortium DKTK, Dresden, Heidelberg, Germany German Cancer Research Center dkfz, Heidelberg, Germany Helmholtz Zentrum Dresden Rossendorf Electronic address
    Radiother Oncol 108:422-8. 2013
    ..Aim of the current project was to evaluate the effect of the novel PLK1 inhibitor BI 6727 in combination with irradiation...
  60. doi request reprint Cancer stem cells at the crossroads of current cancer therapy failures--radiation oncology perspective
    Ulrike Koch
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Semin Cancer Biol 20:116-24. 2010
    ..It is concluded that CSC-based endpoints and biomarkers are eventually expected to considerably improve tumour cure rates in the clinics through individualised tailoring of treatment...
  61. ncbi request reprint Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results
    Michael Baumann
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    Radiother Oncol 72:257-66. 2004
    ..This review presents the current status of knowledge and discusses radiobiological mechanisms which may underly the efficacy of EGFR inhibitors combined with irradiation...
  62. doi request reprint Establishment of a small animal tumour model for in vivo studies with low energy laser accelerated particles
    Kerstin Brüchner
    Department of Radiation Oncology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstr, 74, 01307 Dresden, Germany
    Radiat Oncol 9:57. 2014
    ....
  63. doi request reprint Concept for individualized patient allocation: ReCompare--remote comparison of particle and photon treatment plans
    Armin Lühr
    OncoRay National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr, 74, PF 41, 01307 Dresden, Germany
    Radiat Oncol 9:59. 2014
    ..In this work, we want to contribute a practical concept that addresses these requirements...
  64. ncbi request reprint Influence of connective tissue diseases on the expression of radiation side effects: a systematic review
    Tobias Hölscher
    Department of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Germany
    Radiother Oncol 78:123-30. 2006
    ..The aim of this systematic review is to quantify the contribution of CTD to the risk of radiation related side effects...
  65. doi request reprint Clinical perspectives of cancer stem cell research in radiation oncology
    Rebecca Bütof
    Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany OncoRay National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany Institute of Radiation Oncology, a b Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitat Dresden, Germany, b c Helmholtz Zentrum Dresden Rossendorf, Germany
    Radiother Oncol 108:388-96. 2013
    ....
  66. ncbi request reprint Experimental study on different combination schedules of VEGF-receptor inhibitor PTK787/ZK222584 and fractionated irradiation
    Daniel Zips
    Department of Radiation Oncology, Medical Faculty C G Carus, University of Technology, Dresden, Germany
    Anticancer Res 23:3869-76. 2003
    ..The present experimental study compares the effect of neoadjuvant, concomitant and adjuvant treatment with PTK787/ZK222584, a specific inhibitor of the VEGFR, in combination with fractionated irradiation...
  67. ncbi request reprint Age-related changes in the frequency of mesenchymal stem cells in the bone marrow of rats
    Sergey V Tokalov
    OncoRay Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, 01307 Dresden, Germany
    Stem Cells Dev 16:439-46. 2007
    ....
  68. ncbi request reprint [Setting up an interdisciplinary cancer center between the poles of internal and external interests]
    Michael Baumann
    Michael Baumann, Universität KrebsCentrum, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden
    Z Arztl Fortbild Qualitatssich 101:153-8. 2007
    ..Consideration will be given to the interests of the different groups involved and to critical success factors such as its mission, interdisciplinary leadership structures, interfaces, responsibilities and quality management...
  69. ncbi request reprint TCP and NTCP in preclinical and clinical research in Europe
    Michael Baumann
    Department of Radiotherapy and Radiation Oncology and OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany
    Rays 30:121-6. 2005
    ..These are controversial in many aspects and cannot be recommended for clinical routine practice but should rather be considered as a research tool...
  70. ncbi request reprint Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation
    Ala Yaromina
    OncoRay Centre for Radiation Research in Oncology, University of Technology Dresden, Germany
    Radiother Oncol 83:304-10. 2007
    ..Therefore, these parameters were investigated using local control after single doses given under hypoxia, to predict the outcome of fractionated irradiation...
  71. ncbi request reprint Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review
    David Pasquier
    Department of Radiotherapy, Centre Oscar Lambret, 59020 Lille, France
    Radiother Oncol 72:1-13. 2004
    ..The other treatment methods are also outlined for each location...
  72. ncbi request reprint Low-dose hyperradiosensitivity of human glioblastoma cell lines in vitro does not translate into improved outcome of ultrafractionated radiotherapy in vivo
    Mechthild Krause
    Clinic for Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Int J Radiat Biol 81:751-8. 2005
    ..Low dose hyperradiosensitivity (HRS) has been observed in HGL21- and T98G human glioblastoma cells in vitro. The present study investigates whether these effects translate into improved outcome of ultrafractionated irradiation (UF) in vivo...
  73. ncbi request reprint Keynote comment: Radiotherapy in the age of molecular oncology
    Michael Baumann
    Lancet Oncol 7:786-7. 2006
  74. ncbi request reprint Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice
    Verena Quennet
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Radiother Oncol 81:130-5. 2006
    ....
  75. ncbi request reprint TCP and NTCP: a basic introduction
    Michael Baumann
    Department of Radiotherapy and Radiation Oncology and OncoRay Centre for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Rays 30:99-104. 2005
    ..The impact of basic parameters of the fractionation schedules on these responses is described. Easy examples illustrate how Poisson statistics can be used to understand dose-response relationships in radiotherapy...
  76. ncbi request reprint New targets for the modulation of radiation response--selective inhibition of the enzyme cyclooxygenase 2
    Cordula Petersen
    Clinic of Radiation Oncology, University Hospital Dresden, Germany
    Curr Med Chem Anticancer Agents 3:354-9. 2003
    ..In conclusion COX-2 might be a useful tool for cancer prevention and represents a potential molecular target for improving cancer treatment in combination with radiotherapy...
  77. ncbi request reprint Physical and technical quality assurance in the CHARTWEL-Bronchus trial
    Dietmar Lehmann
    Clinic of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Dresden, Germany
    Strahlenther Onkol 179:152-7. 2003
    ..On-site physical quality assurance (QA) was performed in the participating centers of the CHARTWEL-Bronchus trial to ensure that physical and technical treatment parameters correspond with the requirements of this trial...
  78. ncbi request reprint Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro
    Iris Eke
    OncoRay Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Int J Radiat Biol 83:793-802. 2007
    ..Previous studies have identified an antisurvival effect of ILK in irradiated cells. The aim of this study was to evaluate the role of EGFR tyrosine kinase (tk) activity for ILK-mediated radiosensitization...
  79. ncbi request reprint Towards equity in turbulent Europe ESTRO, European cooperation and the European Commission
    Michael Baumann
    Radiother Oncol 75:251-2. 2005
  80. ncbi request reprint Ultrafractionation does not improve the results of radiotherapy in radioresistant murine DDL1 lymphoma
    Mechthild Krause
    Clinic for Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Strahlenther Onkol 181:540-4. 2005
    ..e., application of very low doses per fraction, has been proposed to improve the effects of radiotherapy. The present study investigates ultrafractionation (UF) in radioresistant murine DDL1 T-cell lymphoma in mice...
  81. ncbi request reprint Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting
    Catharine M L West
    Academic Department of Radiation Oncology, The University of Manchester, Christie Hospital NHS Trust, Withington, Manchester, UK
    Int J Radiat Oncol Biol Phys 62:1264-73. 2005
    ..A meeting in Amsterdam was organized by the International Atomic Energy Agency to discuss this topic on an international basis...
  82. ncbi request reprint [Prolongation of latency or overall treatment time by unplanned radiation pauses. The clinical importance of compensation]
    Thomas Herrmann
    Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitatsklinikum Dresden, Fetscherstrasse 74, 01307 Dresden
    Strahlenther Onkol 181:65-76. 2005
    ..This study summarizes the evidence for an impact of delay and overall time of radiotherapy on locoregional tumor control...
  83. ncbi request reprint Towards genetic prediction of radiation responses: ESTRO's GENEPI project
    Michael Baumann
    Radiother Oncol 69:121-5. 2003
  84. ncbi request reprint Impact of hypoxia and the metabolic microenvironment on radiotherapy of solid tumors. Introduction of a multi-institutional research project
    Daniel Zips
    Department of Radiotherapy and Radiation Oncology, Medical Faculty, University of Technology, Dresden, Germany
    Strahlenther Onkol 180:609-15. 2004
    ..However, whether these new methods can predict radiobiological hypoxia and outcome after fractionated radiotherapy still awaits experimental evaluation...
  85. ncbi request reprint Ultrafractionation in human malignant glioma xenografts
    Mechthild Krause
    Int J Cancer 107:333; author reply 334. 2003