Michael Bauer

..Post-hoc analysis of the level of agreement between ChronoRecord and YMRS ratings was excellent or good in all cases using the kappa statistic. These data demonstrate concurrent validity between ChronoRecord and YMRS...

..Interdisciplinary knowledge transfer could help to increase our understanding of the pathophysiology of these disorders as well as provide grounds for better recognition and treatment of patients with manic and/or depressive symptoms...

..This will require prospective studies to determine the predictive power of the risk factors integrated into the scale...

..This study explores the frequency of brief depressive episodes, lasting 1 to 4 days, using daily self-reported mood ratings...

..The purpose of this manuscript is to review the evidence base of the available treatment options for bipolar depression within two frequent clinical scenarios...

..This study investigated the frequency of episodes and subsyndromal symptoms based on employment status in patients with bipolar disorder...

..Here, we review the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders...

..g. functional and quantitative MRI techniques applied to patients with hypothyroidism before and after hormone replacement therapy...

..This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self-reported adherence with taking a mood stabilizer...

..Frequency may be an important dimensional aspect of brief hypomania. Clinicians should regularly probe for brief hypomania...

..Therefore, there is a critical need for effective medication strategies that augment treatment with antidepressants...

..We also investigated the influence of latitude and seasonal climate variables on mood...

..This paper reviews the literature to examine the DSM-IV diagnostic criteria for rapid cycling in bipolar disorder...

..In conclusion, the prescribing of antidepressants varies by country, and the type of antidepressant chosen is influenced by physician- as well as patient-related factors...

..This study compared subgroups identified by cluster analysis and clinical observation by evaluating the association between the age of onset of bipolar disorder and self-reported daily mood ratings...

..More research in this field is warranted including both groups of symptomatic subjects and symptom-free persons, with and without a positive family history...

..Results indicate that comorbid anxiety symptoms have specific regional cerebral metabolic correlates in bipolar depression and cannot only be explained exclusively by the depressive state of the patients...

..Using daily mood ratings, pre-episode changes were detected before the episode onset. Further investigation to relate the pre-episode and pre-remission states to other clinical and biological data is indicated...

..Using daily self-reported mood ratings, we studied how changing the length requirement to that typical of recurrent brief depression (2-4 days) would impact the number of depressed episodes...

..To explore the measurement of subsyndromal mood symptoms in relation to studies of maintenance therapy for bipolar disorder...

..To determine thyroid gland volume and the prevalence of goiter in patients receiving long-term lithium treatment for affective disorders...

..They deal primarily with biological treatment (including antidepressants, other psychopharmacological and hormonal medications, electroconvulsive therapy, light therapy)...

..This single-center prospective study compared the efficacy and effects on treatment prescriptions of an algorithm-guided treatment regimen with treatment as usual (TAU) in depressed inpatients...

..Hypothyroidism is frequently associated with subtle behavioral and psychiatric symptoms. The consequences of inadequate thyroid hormone availability to brain metabolism are poorly understood...

..This 6-week, randomized, double-blind study evaluated efficacy and safety of adjunctive extended-release (XR) quetiapine in patients with major depressive disorder (MDD) and an inadequate response to >or= 1 antidepressant...

..This analysis further investigated whether sleep duration, sleep onset or sleep offset was the most useful sleep/wake parameter to monitor for an oncoming mood change...

..Additional post hoc analyses examined the efficacy of quetiapine XR against specific depressive symptoms including sleep...

..This study investigated the relation between median family income and self-reported mood symptoms in patients with bipolar disorder who reside in the United States...

..An online survey of European psychiatrists assessed awareness of the metabolic syndrome and its influence on the management of bipolar disorder...

..Results of this study should be confirmed in a larger study group...

..We aimed at detecting a set of clinical baseline variables for prediction of response and remission in 1014 naturalistically treated inpatients with major depressive episode treated for 53.62 ± 47.5 days...

....

..Most importantly, algorithm-guided antidepressive treatment showed a favorable response in those depressed patients who were treated according to the SSTR protocol...

..This is in contrast to the established decline of HPA system activity during treatment with tricyclic antidepressants...

..Of those who ultimately achieved response more than 40% did so within the first 2weeks. An individualized naturalistic inpatient treatment approach appears to be beneficial in terms of effectiveness...

..The primary difference in pattern between the groups was the time spent in depressed or normal mood, with minor daily mood variations...

..The objective of this study was a health economic evaluation of SSTR based on a cost effectiveness analysis (CEA)...

....

..Sleep disturbances are frequent warning signs of both mania and depression. This study used cross correlation analysis to characterize the relationship between mood, sleep and bedrest in longitudinal data...

..Using daily self-reported mood ratings, we studied the impact of changing the length requirement on the number of hypomanic episodes in patients with bipolar disorder...

..3; Hedges' g) but not in female PD patients. Although some possible confounders are not controlled here, our results support the need of monitoring depressive symptoms in the courses of PD, particularly in male patients...

..Here we studied neural correlates of gain and loss expectation in mania using functional magnetic resonance imaging (fMRI)...

..Because of strict inclusion and exclusion criteria, results drawn from placebo-controlled randomized antidepressant efficacy trials may not be transferable to real-world patients...

..This study aimed at exploring the role of thyroid function in lithium augmentation and used a prospective design that included a homogeneous sample of inpatients with unipolar major depressive disorder...

....

..It also examines hypotheses on the mode of action of lithium augmentation, with a focus on serotonin (5-HT) and neuroendocrine systems, and proposes recommendations for future research...

..A modern individualized antidepressant treatment in most cases is a well-tolerated and efficacious tool to minimize the negative impact of the otherwise devastating and life-threatening outcome of depressive disorders...

..Furthermore, the efficacy of algorithm-guided treatment versus treatment as usual in patients with anxious versus nonanxious depression was evaluated...

..91) and a decrease of 47% for the BDI baseline score (AUC: 0.78) best corresponded CGI response criteria. Our data largely confirmed currently used remission and response criteria in naturalistically treated patients...

..g. use of specific co-medications, supportive psychotherapy and continuous medical attendance by nursing staff) might be beneficial...

..Study data suggest that active medication should be maintained for at least 1 year after successful lithium augmentation in patients with unipolar major depressive disorder...

....

....

..This study investigates the association of the GSK3B -50T/C SNP and response to lithium augmentation in acutely depressed antidepressant nonresponders...

..In conclusion, adjunctive treatment with L-thyroxine in supraphysiological doses may be an effective strategy in the maintenance treatment of patients with prophylaxis-resistant affective disorders...

..Lithium augmentation is a well-established strategy for overcoming treatment resistance. In this study, the 5-HTTLPR allele variant's effect on lithium augmentation was analyzed in antidepressant-nonresponsive patients...

..These findings show that the neural mechanisms of emotion anticipation and processing are altered in patients with MDD and that these alterations are able to normalize after treatment with an antidepressant...

..e. augmentation or change of compound) are lacking. The aim of this publication is to review available direct and indirect evidence concerning dose increase of antidepressants after a medium-dose trial has failed...

..Automating data collection from patients can improve data quality, enhance compliance, and decrease costs in longitudinal studies. About half of all households in industrialized countries now have a home computer...

..These findings suggest that MDD patients show ventral striatal hyporesponsiveness during incentive cue processing, which normalizes after successful treatment...

..To investigate the long-term effects of supraphysiological, TSH suppressive doses of levothyroxine (TSDL) on bone mineral density (BMD) in patients with affective disorders during an average treatment duration of 69 months...

..This effect might be explained by the serotonergic effects of lithium...

..To compare the efficacy and safety of adjunctive treatment with paroxetine or amitriptyline in patients with bipolar disorder who relapsed into a depressive episode during lithium maintenance therapy...

..It may also tentatively suggest that sleep may be altered prior to the first manic episode in subjects at high risk...

..In the absence of well defined and disease specific biological markers for bipolar disorder, the recognition of premature stages must rely on combinations of risk factors that have been associated with later disease manifestation...

..Patients were treated with various antidepressants and co-medication according to the protocol based on evidence-based clinical guidelines...

..The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of the stimuli presented...

..Outcomes investigated included response rates and depression scale rates...

..In international treatment guidelines and algorithms, lithium augmentation is considered a first-line treatment strategy for patients with a major depressive episode who do not adequately respond to standard antidepressant treatment...

..Whether alterations in sleep occur parallel and as part of the disease process or whether they represent a trait existent before the onset of the disorder itself remains unclear...

..Therefore, duloxetine provides an alternative to current therapeutic options in the treatment of the different symptoms of depression...

..Meta-analysis of all available trials of Venlafaxine in the treatment of major depressive disorders, including treatment resistant depression and long-term relapse prevention...

..Ideas on pathophysiological causation and progression are translated into recommendations for patient management...

..A systematic review on empirical results of current guidelines and recommendations with focus on efficacy and tolerability of antidepressant pharmacological treatment options...

....

..234). The optimal cut-off value for detection of depression was 12 of 13 points. WHO-5 is a useful, brief, and easy instrument for identifying PD subjects with depression in daily practice...

..These findings suggest that male adults with ADHD show neural signs of abnormal reward processing. Future studies will have to investigate whether these dysfunctional patterns might be normalized by treatment...

..They also possess well documented antisuicidal effects. Second choice prophylactic treatments are carbamazepine and valproate, although evidence of their effectiveness is weaker...

..As there is very little research on the topic, we compared the frequency and the type hallucinations among hospitalized patients diagnosed with bipolar disorder (BPD) versus other major psychiatric illnesses...

..These trials suggest added benefit of combination treatment over use of either agent alone but also indicate the need for further studies...

..To examine the relation between baseline measurements of thyroid function and response to selective serotonin reuptake inhibitors (SSRIs) and to consider the effect of these antidepressants on thyroid hormone levels...

..To determine the effectiveness of lithium prophylaxis in unipolar major depressive disorder (MDD) and to identify predictors of outcome including comedication...

..To analyze new and reviewed findings to evaluate relations between treatment response and latency from onset of bipolar disorder (BD) to the start of mood-stabilizer prophylaxis...

..Therefore, it should be considered a first-line treatment strategy in patients with major depression who do not adequately respond to standard antidepressants...

..CONCLUSIONS: Rapid-cycling BD is associated with a latent hypofunction of the HPT system. This dysfunction becomes manifest with short-term lithium challenge...

....

....

..We assessed reproductive endocrine and metabolic markers in women treated for bipolar disorder over a 2-year time period, controlling for valproate use...

....

..Further investigation into factors associated with HRQoL in depression after treatment initiation is warranted...

..The objective was to compare the serotonin and norepinephrine reuptake inhibitors (SNRIs) duloxetine and venlafaxine using GBR assessment...

....

..Unexpectedly, only minimal side effects have been reported. The goal of the present study was to investigate whether healthy controls and depressed patients differ in their ability to tolerate supraphysiological doses of T(4)...

..The results are preliminary, and require replication in larger samples...