Patrick J Bastian

Summary

Country: Germany

Publications

  1. ncbi Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Eur Urol 51:665-74; discussion 674. 2007
  2. ncbi Modified ureterosigmoidostomy (Mainz Pouch II) in different age groups and with different techniques of ureteric implantation
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    BJU Int 94:345-9. 2004
  3. ncbi GSTP1 hypermethylation as a molecular marker in the diagnosis of prostatic cancer: is there a correlation with clinical stage, Gleason grade, PSA value or age?
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Eur J Med Res 9:523-7. 2004
  4. ncbi Health-related quality-of-life following modified ureterosigmoidostomy (Mainz Pouch II) as continent urinary diversion
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Urol 46:591-7. 2004
  5. ncbi Primary extragonadal germ cell tumor of the prostate in a young man
    Patrick J Bastian
    Department of Urology, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Int J Urol 11:671-3. 2004
  6. ncbi Local recurrence of a unilateral cystic nephroma
    Patrick J Bastian
    Abteilung für Urologie und Kinderurologie, St Josef Hospital Troisdorf, Bonn, Germany
    Int J Urol 11:329-31. 2004
  7. ncbi [Outpatient extracorporeal shock wave lithotripsy. Prospective evaluation of 2937 cases]
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn
    Urologe A 43:829-35. 2004
  8. ncbi [The modified ureterosigmoidostomy (Mainz pouch II) as a continent form of urinary diversion]
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn
    Urologe A 43:982-8. 2004
  9. ncbi [GSTP1 CpG island hypermethylation as a molecular marker of prostate cancer]
    P J Bastian
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Urologe A 43:573-9. 2004
  10. ncbi Papillary renal cell carcinoma within the wall of a solitary renal cyst
    P J Bastian
    Abteilung für Urologie und Kinderurologie, St Josef Hospital Troisdorf, Hospitalstr 40, 53840 Troisdorf, Germany
    Ann Urol (Paris) 37:221-2. 2003

Detail Information

Publications98

  1. ncbi Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Eur Urol 51:665-74; discussion 674. 2007
    ....
  2. ncbi Modified ureterosigmoidostomy (Mainz Pouch II) in different age groups and with different techniques of ureteric implantation
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    BJU Int 94:345-9. 2004
    ..To examine the outcome of Mainz Pouch II urinary diversion in different age groups and with different techniques of ureteric implantation...
  3. ncbi GSTP1 hypermethylation as a molecular marker in the diagnosis of prostatic cancer: is there a correlation with clinical stage, Gleason grade, PSA value or age?
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Eur J Med Res 9:523-7. 2004
    ..We present a real-time, methylation specific protocol to detect hypermethylation in the promoter region of the GSTP1 gene in benign hyperplasia and adenocarcinoma of the prostate...
  4. ncbi Health-related quality-of-life following modified ureterosigmoidostomy (Mainz Pouch II) as continent urinary diversion
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Urol 46:591-7. 2004
    ..The purpose of this study was to estimate the health-related quality of life (HRQoL) following modified ureterosigmoidostomy (Mainz Pouch II) urinary diversion...
  5. ncbi Primary extragonadal germ cell tumor of the prostate in a young man
    Patrick J Bastian
    Department of Urology, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Int J Urol 11:671-3. 2004
    ..During chemotherapy the patient suffered acute myocardial infarction and was treated with percutanous coronarangiography and stenting...
  6. ncbi Local recurrence of a unilateral cystic nephroma
    Patrick J Bastian
    Abteilung für Urologie und Kinderurologie, St Josef Hospital Troisdorf, Bonn, Germany
    Int J Urol 11:329-31. 2004
    ..Other renal lesions may not be differentiated preoperatively from cystic nephroma and thus require surgical exploration. Long-term follow-up is recommended to rule out local recurrence...
  7. ncbi [Outpatient extracorporeal shock wave lithotripsy. Prospective evaluation of 2937 cases]
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn
    Urologe A 43:829-35. 2004
    ..Extracorporeal shock wave lithotripsy (ESWL) is mainly performed on inpatient basis in Germany. It has yet to be considered if outpatient treatment in Germany is indicated when sufficient urological care is guaranteed...
  8. ncbi [The modified ureterosigmoidostomy (Mainz pouch II) as a continent form of urinary diversion]
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn
    Urologe A 43:982-8. 2004
    ....
  9. ncbi [GSTP1 CpG island hypermethylation as a molecular marker of prostate cancer]
    P J Bastian
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Urologe A 43:573-9. 2004
    ..Many studies have revealed multiple molecular alterations during prostate cancer carcinogenesis. GSTP1 CpG island hypermethylation is one of the molecular changes that occur during carcinogenesis...
  10. ncbi Papillary renal cell carcinoma within the wall of a solitary renal cyst
    P J Bastian
    Abteilung für Urologie und Kinderurologie, St Josef Hospital Troisdorf, Hospitalstr 40, 53840 Troisdorf, Germany
    Ann Urol (Paris) 37:221-2. 2003
    ..We report a case of a papillary renal cell carcinoma within the wall of a solitary renal cyst. Radiographic findings were not suspicious for malignancy, but histopathological examination revealed a papillary renal cell carcinoma...
  11. ncbi [Medizip surgical zipper: a new form of non-invasive wound closure with a surgical zipper]
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn
    Aktuelle Urol 34:398-401. 2003
    ..We describe the use of a new, non-invasive skin closure system (Medizip, Nycomed Pharma GmbH, Ismaning, Germany) in urological procedures...
  12. ncbi Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy
    Patrick J Bastian
    The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 13:5361-7. 2007
    ..We evaluated the association of preoperative serum cell-free circulating DNA concentration in men with clinically localized prostate cancer who underwent radical prostatectomy with prostate-specific antigen (PSA) recurrence...
  13. doi CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urology 71:161-7. 2008
    ..CpG island hypermethylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. We investigated its role at multiple gene sites during prostate carcinogenesis...
  14. doi CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie and Institut für Pathologie, Universitatsklinikum Bonn, Bonn, Germany
    J Urol 182:324-9. 2009
    ..DNA hypermethylation is a common cancer associated alteration. We analyzed methylation patterns of cell-free serum DNA in patients with testicular cancer...
  15. ncbi Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy
    Patrick J Bastian
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 11:4037-43. 2005
    ..We evaluated circulating cell-free DNA GSTP1 CpG island hypermethylation as a prognostic biomarker in the serum of men with prostate cancer...
  16. doi Analysis of sex differences in cancer-specific survival and perioperative mortality following radical cystectomy: results of a large German multicenter study of nearly 2500 patients with urothelial carcinoma of the bladder
    Wolfgang Otto
    Department of Urology, Caritas St Josef Medical Centre, University of Regensburg, Landshuterstrasse 65, Regensburg, Germany
    Gend Med 9:481-9. 2012
    ..Although overall incidence is higher in men, cancer-specific survival (CSS) has been suggested to be lower in women. Although the former effect is attributed to greater exposure to carcinogens in men, the latter has not been elucidated...
  17. doi External validation of postoperative nomograms for prediction of all-cause mortality, cancer-specific mortality, and recurrence in patients with urothelial carcinoma of the bladder
    Philipp Nuhn
    Department of Urology, Ludwig Maximilians Universitat, Munich, Germany
    Eur Urol 61:58-64. 2012
    ..The Bladder Cancer Research Consortium (BCRC) created nomograms to predict all-cause mortality (ACM), cancer-specific mortality (CSM), and recurrence after radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB)...
  18. doi Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 10065, USA
    J Urol 183:68-75. 2010
    ..We also assessed whether the combination of molecular markers is superior to any individual biomarker...
  19. ncbi Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ-confined TCC at radical cystectomy
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    Eur Urol 51:152-60. 2007
    ..The aim of this study was to assess whether presence of concomitant CIS has a detrimental effect on cancer control after radical cystectomy...
  20. ncbi Macroscopic, but not microscopic, perivesical fat invasion at radical cystectomy is an adverse predictor of recurrence and survival
    Patrick J Bastian
    The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    BJU Int 101:450-4. 2008
    ....
  21. ncbi Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Urol 176:2414-22; discussion 2422. 2006
    ..We present the characteristics and outcomes of a large, contemporary, consecutive series of patients treated with radical cystectomy and pelvic lymphadenectomy for transitional cell carcinoma of the bladder...
  22. pmc CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer
    Patrick J Bastian
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 179:529-34; discussion 534-5. 2008
    ..In this study we investigated the hypermethylation profile of several genes in the serum of men with localized and hormone refractory prostate cancer...
  23. doi Pathological upstaging detected in radical cystectomy procedures is associated with a significantly worse tumour-specific survival rate for patients with clinical T1 urothelial carcinoma of the urinary bladder
    Matthias May
    Department of Urology, St Elisabeth Klinikum Straubing, Straubing, Germany
    Scand J Urol Nephrol 45:251-7. 2011
    ..This study aimed to evaluate the frequency and prognosis of upstaging in patients undergoing RC due to UCB...
  24. ncbi Nomograms provide improved accuracy for predicting survival after radical cystectomy
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, and The Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    Clin Cancer Res 12:6663-76. 2006
    ....
  25. ncbi A delay in radical cystectomy of >3 months is not associated with a worse clinical outcome
    Matthew E Nielsen
    The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    BJU Int 100:1015-20. 2007
    ....
  26. doi Mitochondrial DNA in serum of patients with prostate cancer: a predictor of biochemical recurrence after prostatectomy
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    BJU Int 102:628-32. 2008
    ..To investigate the role of circulating mitochondrial DNA (mtDNA) in patients with localized prostate cancer, as recent reports show that patients with advanced cancer have increased levels of mtDNA...
  27. ncbi Discrepancy between clinical and pathologic stage: impact on prognosis after radical cystectomy
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Eur Urol 51:137-49; discussion 149-51. 2007
    ..We compared clinical and pathologic staging in a large, contemporary, consecutive series of patients who were treated with radical cystectomy and pelvic lymphadenectomy, and determined the effect of stage discrepancy on outcomes...
  28. doi Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    Cancer Invest 30:92-7. 2012
    ..H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis...
  29. doi p53 expression in patients with advanced urothelial cancer of the urinary bladder
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    BJU Int 105:489-95. 2010
    ..To test whether assessing p53 expression could improve the ability to predict disease recurrence and disease-specific survival in a multi-institutional cohort of patients with advanced urothelial carcinoma of the urinary bladder (UCB)...
  30. doi Complications of the AdVance transobturator male sling in the treatment of male stress urinary incontinence
    Ricarda M Bauer
    Department of Urology, Ludwig Maximilian University, Munich, Germany
    Urology 75:1494-8. 2010
    ..To evaluate prospectively the complication rate of the retrourethral transobturator sling (AdVance sling) for the functional treatment of male stress urinary incontinence (SUI)...
  31. ncbi CpG island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Prostate 68:42-9. 2008
    ..Our aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell-free serum DNA of prostate cancer (PCA) patients...
  32. ncbi Cell-free circulating DNA: Diagnostic value in patients with renal cell cancer
    Stefan Hauser
    Department of Urology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anticancer Res 30:2785-9. 2010
    ..To analyse the diagnostic and prognostic value of cell-free DNA in patients with renal cell carcinoma (RCC)...
  33. ncbi Advanced age is associated with poorer bladder cancer-specific survival in patients treated with radical cystectomy
    Matthew E Nielsen
    The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Eur Urol 51:699-706; discussion 706-8. 2007
    ..The aim of our study was to assess the impact of patient age on pathological characteristics and recurrence-free and disease-specific survival following RC...
  34. ncbi Clinical and pathologic outcome after radical prostatectomy for prostate cancer patients with a preoperative Gleason sum of 8 to 10
    Patrick J Bastian
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer 107:1265-72. 2006
    ....
  35. doi External validation of a risk model to predict recurrence-free survival after radical cystectomy in patients with pathological tumor stage T3N0 urothelial carcinoma of the bladder
    Matthias May
    Department of Urology, St Elisabeth Klinikum, Straubing, Germany
    J Urol 187:1210-4. 2012
    ..We present what is to our knowledge the first external validation of this risk model...
  36. doi Risk stratification of organ confined bladder cancer after radical cystectomy using cell cycle related biomarkers
    Shahrokh F Shariat
    Department of Urology, Weill Cornell Medical Center, New York, NY, USA
    J Urol 187:457-62. 2012
    ..We tested whether assessing the expression of cell cycle related proteins (p53, pRB, p21 and p27) could predict clinical outcomes after radical cystectomy in patients with organ confined urothelial carcinoma of the bladder...
  37. ncbi Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Int J Cancer 122:138-43. 2008
    ..We suggest that cancer-induced apoptosis of peripheral noncancerous tissues is relevant in many malignancies...
  38. ncbi Recurrence-free survival after radical cystectomy of patients downstaged by transurethral resection
    Matthew E Nielsen
    James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, USA
    Urology 70:1091-5. 2007
    ....
  39. doi DNA hypermethylation in papillary renal cell carcinoma
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    BJU Int 107:664-9. 2011
    ..To investigate the pattern of DNA CpG island hypermethylation in papillary renal cell carcinoma (pRCC)...
  40. doi Outcomes of patients with clinical T1 grade 3 urothelial cell bladder carcinoma treated with radical cystectomy
    Amit Gupta
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Urology 71:302-7. 2008
    ..The aim of the present study was to assess the pathologic features and clinical outcomes of patients with clinical T1 grade 3 urothelial cell bladder carcinoma (UCBC) treated with radical cystectomy...
  41. ncbi Clinical outcomes following radical cystectomy for primary nontransitional cell carcinoma of the bladder compared to transitional cell carcinoma of the bladder
    Craig G Rogers
    Bladder Cancer Research Consortium, James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, USA
    J Urol 175:2048-53; discussion 2053. 2006
    ..We conducted a multi-institutional retrospective study of patients with bladder cancer treated with radical cystectomy to assess the impact of nonTCC histology on bladder cancer specific outcomes...
  42. doi Multicenter evaluation of the prognostic value of pT0 stage after radical cystectomy due to urothelial carcinoma of the bladder
    Matthias May
    Department of Urology, St Elisabeth Klinikum, Straubing LMU München, Munchen, Germany
    BJU Int 108:E278-83. 2011
    ..To evaluate the characteristics and long-term outcome of patients with pT0 stage after radical cystectomy (RC) for urothelial carcinoma of the urinary bladder (UCB)...
  43. ncbi Cancer specific outcomes in patients with pT0 disease following radical cystectomy
    Ganesh S Palapattu
    James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Urol 175:1645-9; discussion 1649. 2006
    ..We assessed clinical outcomes in patients found to have no evidence of disease, ie pT0, in the cystectomy specimen following radical cystectomy for transitional cell carcinoma...
  44. doi Prognostic value of perinodal lymphovascular invasion following radical cystectomy for lymph node-positive urothelial carcinoma
    Hans Martin Fritsche
    Department of Urology, Caritas St Josef Medical Centre, University of Regensburg, Germany
    Eur Urol 63:739-44. 2013
    ..Perinodal lymphovascular invasion (pnLVI) has not yet been defined...
  45. pmc Alterations of global histone H4K20 methylation during prostate carcinogenesis
    Turang E Behbahani
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BMC Urol 12:5. 2012
    ..Our study was designed to assess global methylation levels of histone 4 lysine 20 (H4K20me1-3) at different stages of prostate cancer (PCA) carcinogenesis...
  46. doi Lymphovascular invasion is an independent predictor of oncological outcomes in patients with lymph node-negative urothelial bladder cancer treated by radical cystectomy: a multicentre validation trial
    Christian Bolenz
    Department of Urology, Mannheim Medical Centre, University of Heidelberg, Germany
    BJU Int 106:493-9. 2010
    ..To validate the association of lymphovascular invasion (LVI) with disease recurrence and cancer-specific survival (CSS) in a multicentre cohort of patients treated with radical cystectomy (RC) for urothelial bladder cancer (UBC)...
  47. doi Contrast-enhanced transrectal ultrasound (CE-TRUS) with cadence-contrast pulse sequence (CPS) technology for the identification of prostate cancer
    Michael Seitz
    Department of Urology, Hospital of the University of Munich Campus Grosshadern, Munich, Germany
    Urol Oncol 29:295-301. 2011
    ..In order to determine the ability of contrast-enhanced transrectal ultrasound (CE-TRUS) to identify CaP, we investigated patients scheduled for radical prostatectomy for CaP and radical cystoprostatectomy for bladder cancer...
  48. doi Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Int J Cancer 127:2360-6. 2010
    ..Our study on H3K4 methylation supports the concept of global histone modifications as potential cancer prognosis markers...
  49. doi Chronological age is not an independent predictor of clinical outcomes after radical nephroureterectomy
    Thomas F Chromecki
    Department of Urology, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, NY 10065, USA
    World J Urol 29:473-80. 2011
    ..The aim of the current study was to test this hypothesis in a large multicenter external validation cohort of patients treated with radical nephroureterectomy (RNU) while controlling for patient performance status...
  50. doi Global histone H4K20 trimethylation predicts cancer-specific survival in patients with muscle-invasive bladder cancer
    Ann Christin Schneider
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BJU Int 108:E290-6. 2011
    ..To determine the role of global histone methylation as a prognostic parameter in patients with bladder cancer...
  51. doi Association between the number of dissected lymph nodes during pelvic lymphadenectomy and cancer-specific survival in patients with lymph node-negative urothelial carcinoma of the bladder undergoing radical cystectomy
    Matthias May
    Department of Urology, St Elisabeth Klinikum Straubing, Straubing, Germany
    Ann Surg Oncol 18:2018-25. 2011
    ....
  52. doi Global levels of histone modifications predict prostate cancer recurrence
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    Prostate 70:61-9. 2010
    ..Our study was performed to evaluate histone lysine (H(x)K(y)) and histone acetyl (H(x)Ac) modifications in prostate tissue...
  53. doi p53 predictive value for pT1-2 N0 disease at radical cystectomy
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA
    J Urol 182:907-13. 2009
    ..We determined whether p53 expression would improve the prediction of disease progression after radical cystectomy for pT1-2N0M0 UCB...
  54. ncbi Renal cell carcinoma with tumor thrombus extension into the vena cava: prospective long-term followup
    Axel Haferkamp
    Department of Urology, University of Heidelberg, Heidelberg, Germany
    J Urol 177:1703-8. 2007
    ..We prospectively evaluated long-term survival in patients with renal cell carcinoma extending to the inferior vena cava...
  55. ncbi Lymphovascular invasion is independently associated with overall survival, cause-specific survival, and local and distant recurrence in patients with negative lymph nodes at radical cystectomy
    Yair Lotan
    Department of Urology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9110, USA
    J Clin Oncol 23:6533-9. 2005
    ..We hypothesized that bladder cancer patients with associated lymphovascular invasion (LVI) are at increased risk of occult metastases...
  56. doi High-risk prostate cancer: from definition to contemporary management
    Patrick J Bastian
    Department of Urology, Klinikum der Universität München Campus Großhadern, Ludwig Maximilians Universitat, Munich, Germany
    Eur Urol 61:1096-106. 2012
    ..It is clinically important to identify patients with high-risk PCa early on because they stand to benefit the most from curative therapy. Because of recent advances in PCa management, a multimodal approach may be advantageous...
  57. doi Circulating mitochondrial DNA in serum: a universal diagnostic biomarker for patients with urological malignancies
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    Urol Oncol 30:509-15. 2012
    ..Cell-free circulating mitochondrial DNA (mtDNA) has been proposed as universal diagnostic and prognostic biomarker in cancer patients...
  58. doi Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    BJU Int 104:48-52. 2009
    ..To analyse the diagnostic and prognostic value of cell-free mitochondrial (mt)DNA in patients with testicular cancer, as increased levels of cell-free circulating mtDNA have been reported in patients with cancer...
  59. doi Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: a prognostic entity
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Cancer Lett 264:274-80. 2008
    ..011) indicating that the AI is an independent prognostic factor. Thus, cell-free DNA seems to be a useful prognostic marker in patients with BCA...
  60. doi Radical cystectomy in the elderly patient: a contemporary comparison of perioperative complications in a single institution series
    Derya Tilki
    Department of Urology, Ludwig Maximilians University Munich, Campus Grosshadern, Marchioninistr 15, 81377, Munich, Germany
    World J Urol 28:445-50. 2010
    ..To report on our recent experience with peri- and postoperative morbidity of radical cystectomy in patients 75 years and older compared to younger patients...
  61. ncbi Molecular biomarker in prostate cancer: the role of CpG island hypermethylation
    Patrick J Bastian
    The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Eur Urol 46:698-708. 2004
    ..CpG island hypermethylation may serve as a useful molecular biomarker for the detection and diagnosis of patients with prostate cancer...
  62. doi Tyrosine kinase expression profile in clear cell renal cell carcinoma
    Turang E Behbahani
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    World J Urol 30:559-65. 2012
    ..To profile different tyrosine kinase (TK) expression patterns in clear cell renal carcinoma (ccRCC)...
  63. ncbi Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci
    Patrick J Bastian
    Klinik und Poliklinik für Urologie and Institut für Pathologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Clin Cancer Res 11:4097-106. 2005
    ..Our study was designed to evaluate promoter CpG island hypermethylation in the diagnosis and prognosis of prostate cancer...
  64. ncbi Relationship between primary Gleason pattern on needle biopsy and clinicopathologic outcomes among men with Gleason score 7 adenocarcinoma of the prostate
    Mark L Gonzalgo
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 67:115-9. 2006
    ..To examine the relationship among needle biopsy primary grade, prostatectomy grade, and postprostatectomy biochemical recurrence among men with Gleason score 7 disease...
  65. doi Outcomes of patients after aborted radical cystectomy for intraoperative findings of metastatic disease
    Thomas J Guzzo
    The Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
    BJU Int 102:1539-43. 2008
    ....
  66. ncbi High concordance of gene methylation in post-digital rectal examination and post-biopsy urine samples for prostate cancer detection
    Craig G Rogers
    The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 176:2280-4. 2006
    ....
  67. doi Volar onlay urethroplasty for reconstruction of female urethra in recurrent stricture disease
    Christian Gozzi
    Department of Urology, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    BJU Int 107:1964-6. 2011
    ..However, there is no consensus regarding the best way to reconstruct the female urethra in the case of stricture disease...
  68. ncbi Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    J Urol 179:346-52. 2008
    ..CpG island hypermethylation is a frequent event in bladder carcinogenesis and progression. We investigated the diagnostic and prognostic value of hypermethylation in cell-free serum DNA of patients with bladder cancer...
  69. doi Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    J Urol 181:363-71. 2009
    ..Increased levels of cell-free circulating DNA have been described in various malignancies as a diagnostic and prognostic biomarker. We analyzed the significance of cell-free DNA in patients with testicular cancer...
  70. doi The role of cell-free circulating DNA in the diagnosis and prognosis of prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urol Oncol 29:124-9. 2011
    ..The detection of increased DNA levels and tumor-specific DNA sequences may provide diagnostic and prognostic information. The recent findings in the emerging field of cell-free DNA will be discussed...
  71. doi [Prostate cancer research. Biomarkers as promising options for optimized diagnosis and treatment]
    J Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum, Bonn, Deutschland
    Urologe A 47:1190-2. 2008
    ..This should be the perfect breeding ground for future research in the field of prostate cancer...
  72. doi [Pediatric renal cell carcinoma. A rare differential diagnosis of Wilms' tumor]
    N Fischer
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Deutschland
    Urologe A 47:620-3. 2008
    ..Our objective is to discuss the difficulties in clinical diagnosis, prognosis, and therapy of this very rare disease in children and to provide a review of the current literature...
  73. ncbi [MR techniques for noninvasive diagnosis of prostate cancer]
    N Morakkabati-Spitz
    Radiologische Klinik, Klinikum, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105, Bonn
    Urologe A 45:702-5. 2006
    ..This article reviews the clinical indications for MRI of the prostate and summarizes new techniques such as high field strength (3 tesla) and dynamic contrast-enhanced MRI...
  74. ncbi [Epigenetic processes in prostate carcinoma. Study of cellular information carriers beyond DNA sequence]
    P J Bastian
    Klinik und Poliklinik fur Urologie, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105 Bonn
    Urologe A 46:1080-1. 2007
  75. ncbi Prostate cancer tissue is masked by bicalutamide: a case report
    J Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Med Res 12:212-5. 2007
    ..Despite of detailed histological work-up and immunohistochemistry cancer suspicious lesions were not found. We think that bicalutamide may be capable of masking prostate cancer cells...
  76. ncbi Surgical outcome following radical nephrectomy in cases with inferior vena cava tumour thrombus extension
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Eur J Surg Oncol 31:420-3. 2005
    ..To report our experience with extensive surgery in patients with and without metastatic renal cell carcinoma and gross venous tumour thrombus...
  77. ncbi [Abnormalities of the urachus]
    P J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn
    Aktuelle Urol 34:55-61. 2003
  78. ncbi Preoperative somatic symptoms are associated with disease progression in patients with bladder carcinoma after cystectomy
    Ganesh S Palapattu
    The James Buchanan Brady Urological Institute, The Johns Hopkins University, Baltimore, Maryland 21287 2101, USA
    Cancer 101:2209-13. 2004
    ..The purpose of the current study was to assess the association of psychologic factors measured preoperatively with bladder carcinoma progression after cystectomy...
  79. doi Quality of life and perioperative outcomes after retroperitoneoscopic radical nephrectomy (RN), open RN and nephron-sparing surgery in patients with renal cell carcinoma
    Christian Gratzke
    Department of Urology, Ludwig Maximilians University Munich, Germany
    BJU Int 104:470-5. 2009
    ....
  80. ncbi [The history of ureterosigmoidostomy]
    S C Muller
    Klinik und Poliklinik fur Urologie, Rheinische Friedrich Wilhelms Universitat, Bonn, Deutschland
    Urologe A 47:9-10, 12-7. 2008
    ..Today modified ureterosigmoidostomy has a strong place among the possibilities of urinary diversion...
  81. doi Predicting individual outcomes after radical cystectomy: an external validation of current nomograms
    Dirk Zaak
    Department of Urology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BJU Int 106:342-8. 2010
    ....
  82. ncbi Characteristics of insignificant clinical T1c prostate tumors. A contemporary analysis
    Patrick J Bastian
    The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer 101:2001-5. 2004
    ..Pathologic findings subsequently were analyzed for correlations with extent of disease in an attempt to validate the contemporary usefulness of existing parameters for predicting the 'significance' of prostate tumors...
  83. doi Functional magnetic resonance imaging in prostate cancer
    Michael Seitz
    Department of Urology, University of Munich Grosshadern Campus, Munich, Germany
    Eur Urol 55:801-14. 2009
    ....
  84. ncbi Prostate carcinogenesis and inflammation: emerging insights
    Ganesh S Palapattu
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Carcinogenesis 26:1170-81. 2005
    ..These emerging insights into chronic inflammation in the etiology of prostate carcinogenesis hold the promise of spawning new diagnostic and therapeutic modalities for men with prostate cancer...
  85. ncbi Adherens junctions of the human detrusor
    Nina Wagener
    Department of Urology, University of Heidelberg, Germany
    BJU Int 96:843-7. 2005
    ....
  86. doi Dynamic pelvic floor MR imaging at 3 T in patients with clinical signs of urinary incontinence-preliminary results
    Nuschin Morakkabati-Spitz
    Department of Radiology, University of Bonn, Bonn, Germany
    Eur Radiol 18:2620-7. 2008
    ..Dynamic pelvic floor MR imaging is feasible at 3.0 T. Our preliminary data indicate that evaluation of pelvic floor disease seems to be possible with 3.0 T equally well as compared to 1.5 T...
  87. ncbi A new form of noninvasive wound closure with a surgical zipper
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    J Urol 169:1785-6. 2003
    ..We describe the use of Medizip (Nycomed Pharma GmbH, Ismaning, Germany), a new form of noninvasive skin closure system, in urological procedures...
  88. ncbi Aggressive angiomyxoma of the prostate mimicking benign prostatic hyperplasia
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Eur J Med Res 11:167-9. 2006
    ..Only few cases in males have been reported in the literature. We describe what we think is the first case of an aggressive angiomyxoma arising in the prostate presenting with classical symptoms of benign prostatic hyperplasia...
  89. ncbi Abnormal DNA methylation, epigenetics, and prostate cancer
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Brady Urological Institute, Baltimore, MD 21231, USA
    Front Biosci 12:4254-66. 2007
    ..If sufficiently safe strategies for chromatin modulation can be discovered and developed, epigenetic alterations may become rational targets for both prostate cancer prevention and prostate cancer treatment...
  90. ncbi Soy isoflavone genistein in prevention and treatment of prostate cancer
    F G E Perabo
    Department of Urology, University Hospital, Bonn, Germany
    Prostate Cancer Prostatic Dis 11:6-12. 2008
    ..However, at present there is no convincing clinical proof or evidence that genistein might be useful in PCa therapy...
  91. ncbi MR imaging of the prostate at 3.0T with external phased array coil - preliminary results
    N Morakkabati-Spitz
    Department of Radiology, University of Bonn, Bonn, Germany
    Eur J Med Res 13:287-91. 2008
    ..0T enables to image the prostate without endorectal coil. Aim of this study was to evaluate the diagnostic accuracy of phased array coil 3.0T MRI in patients with suspicion of prostate cancer...
  92. doi [A critical assessment of phytotherapy for prostate cancer]
    F G E Perabo
    Klinik und Poliklinik fur Urologie, Universitatsklinikum, Sigmund Freud Strasse 25, 53105 Bonn
    Urologe A 48:270-1, 274-83. 2009
    ..The question about an improved immune function or quality of life remains open. Potentially the use of phytochemicals could play a role in a preventive setting...
  93. ncbi Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
    Philip Kahl
    Institute of Pathology, University Hospital Bonn Medical School, Germany
    Cancer Res 66:11341-7. 2006
    ..Our present study suggests that LSD1 and nuclear FHL2 may serve as novel biomarkers predictive for prostate cancer with aggressive biology and point to a role of LSD1 and FHL2 in constitutive activation of AR-mediated growth signals...
  94. doi Editorial comment on: placebo-controlled dose-ranging phase 2 study of subcutaneously administered LHRH antagonist cetrorelix in patients with symptomatic benign prostatic hyperplasia
    Patrick J Bastian
    Eur Urol 54:179-80. 2008
  95. ncbi Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder
    Pierre I Karakiewicz
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    J Urol 176:1354-61; discussion 1361-2. 2006
    ....
  96. ncbi Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignancies
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urology 68:257-62. 2006
    ..It is characterized by the expression of MIC2 and neural markers (eg, neuron-specific enolase, synaptophysin, S-100, vimentin, Leu-7), and the presence of the EWS-FLI1 translocation...
  97. ncbi Precystectomy nomogram for prediction of advanced bladder cancer stage
    Pierre I Karakiewicz
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    Eur Urol 50:1254-60; discussion 1261-2. 2006
    ..To evaluate precystectomy prediction of pT and pN stages at cystectomy...
  98. doi Adjuvant chemotherapy for bladder cancer does not alter cancer-specific survival after cystectomy in a matched case-control study
    Jochen Walz
    Cancer Prgonosis and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    BJU Int 101:1356-61. 2008
    ....