F A Barr

Summary

Country: Germany

Publications

  1. ncbi Signaling pathways regulating Golgi structure and function
    C Preisinger
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Sci STKE 2001:PE38. 2001
  2. pmc YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta
    Christian Preisinger
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152 Germany
    J Cell Biol 164:1009-20. 2004
  3. ncbi Golgins in the structure and dynamics of the Golgi apparatus
    Francis A Barr
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, Martinsried 82152, Germany
    Curr Opin Cell Biol 15:405-13. 2003
  4. ncbi Inheritance of the endoplasmic reticulum and Golgi apparatus
    Francis A Barr
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, Martinsried, 82152 Germany
    Curr Opin Cell Biol 14:496-9. 2002
  5. pmc Golgi positioning: are we looking at the right MAP?
    Francis A Barr
    Max Planck Institute of Biochemistry, Martinsried, 82152 Germany
    J Cell Biol 168:993-8. 2005
  6. pmc Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus
    F A Barr
    Department of Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 155:885-91. 2001
  7. pmc Golgi inheritance: shaken but not stirred
    Francis A Barr
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152 Germany
    J Cell Biol 164:955-8. 2004
  8. pmc A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic
    B Short
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried D 82152, Germany
    J Cell Biol 155:877-83. 2001
  9. ncbi COP sets TRAPP for vesicles
    Alexander K Haas
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Dev Cell 12:326-7. 2007
  10. ncbi Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome
    Martina Casenghi
    Max Planck Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Cell Sci 118:5101-8. 2005

Collaborators

Detail Information

Publications42

  1. ncbi Signaling pathways regulating Golgi structure and function
    C Preisinger
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Sci STKE 2001:PE38. 2001
    ..This includes the many stacks of the Golgi apparatus. Several kinases have been implicated in regulating Golgi disassembly during mitosis, but much about this process remains obscure...
  2. pmc YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta
    Christian Preisinger
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152 Germany
    J Cell Biol 164:1009-20. 2004
    ....
  3. ncbi Golgins in the structure and dynamics of the Golgi apparatus
    Francis A Barr
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, Martinsried 82152, Germany
    Curr Opin Cell Biol 15:405-13. 2003
    ..Current evidence therefore suggests that golgins function in a variety of membrane-membrane and membrane-cytoskeleton tethering events at the Golgi apparatus, and that all these are regulated by small GTPases of the Rab and Arl families...
  4. ncbi Inheritance of the endoplasmic reticulum and Golgi apparatus
    Francis A Barr
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, Martinsried, 82152 Germany
    Curr Opin Cell Biol 14:496-9. 2002
    ..Animal cells actively partition the endoplasmic reticulum and Golgi apparatus, but association with the mitotic spindle-rather than the actin cytoskeleton-appears to be the mechanism..
  5. pmc Golgi positioning: are we looking at the right MAP?
    Francis A Barr
    Max Planck Institute of Biochemistry, Martinsried, 82152 Germany
    J Cell Biol 168:993-8. 2005
    ..As such, the interesting question of how the Golgi interacts with MTs may well remain open to further investigation...
  6. pmc Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus
    F A Barr
    Department of Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 155:885-91. 2001
    ..These results suggest that one function of the Golgi matrix is to aid efficient retention or sequestration of p24 cargo receptors and other membrane proteins in the Golgi apparatus...
  7. pmc Golgi inheritance: shaken but not stirred
    Francis A Barr
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152 Germany
    J Cell Biol 164:955-8. 2004
    ..Rather than the Golgi contents being recycled through, or mixed with the ER, two recent studies taking complementary approaches, find that the contents of these organelles remain separate throughout mitosis...
  8. pmc A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic
    B Short
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried D 82152, Germany
    J Cell Biol 155:877-83. 2001
    ..These results demonstrate that GRASP55 and golgin-45 form a rab2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure...
  9. ncbi COP sets TRAPP for vesicles
    Alexander K Haas
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Dev Cell 12:326-7. 2007
    ..Recent work shows that in addition to its role in membrane-cargo selection, the COPII vesicle coat recruits TRAPPI, a cytosolic protein complex required for vesicle tethering...
  10. ncbi Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome
    Martina Casenghi
    Max Planck Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Cell Sci 118:5101-8. 2005
    ..These findings uncover a mechanism through which Plk1 helps to coordinate changes in MT organisation with cell cycle progression, by controlling the dynein-dynactin-dependent transport of centrosomal proteins...
  11. ncbi The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes
    Benjamin Short
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Curr Biol 12:1792-5. 2002
    ..Other Golgi Rabs do not bind to dynactin and are unable to support its recruitment to membranes. Rab6 therefore functions as a specificity or tethering factor controlling the recruitment of dynactin to membranes...
  12. pmc Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis
    Rüdiger Neef
    Intracellular Protein Transport, Independent Junior Research Group, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 162:863-75. 2003
    ..We propose that phosphorylation of MKlp2 by Plk1 is necessary for the spatial restriction of Plk1 to the central spindle during anaphase and telophase, and the complex of these two proteins is required for cytokinesis...
  13. ncbi Membrane traffic: exocyst III--makes a family
    Ben Short
    Department of Cell Biology Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152, Martinsried, Germany
    Curr Biol 12:R18-20. 2002
    ..New evidence suggests that at least some of these factors form related multimeric complexes that may help to explain the mechanism of vesicle docking...
  14. ncbi Membrane fusion: caught in a trap
    Benjamin Short
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152 Germany
    Curr Biol 14:R187-9. 2004
    ..Recent evidence points to the existence of an inhibitory class of SNAREs, i-SNAREs, which prevent incorrect fusions from occurring, adding a further layer of regulation to the process of membrane docking and fusion...
  15. ncbi Golgins and GTPases, giving identity and structure to the Golgi apparatus
    Benjamin Short
    Intracellular Protein Transport, Independent Junior Research Group, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany
    Biochim Biophys Acta 1744:383-95. 2005
    ..Together golgins and their regulatory GTPases form a complex network, commonly known as the Golgi matrix, which organizes Golgi membranes and regulates membrane trafficking...
  16. ncbi A GTPase-activating protein controls Rab5 function in endocytic trafficking
    Alexander K Haas
    Max Planck Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Nat Cell Biol 7:887-93. 2005
    ..RabGAP-5 therefore limits the amount of activated Rab5, and thereby regulates trafficking through endosomes...
  17. pmc KIF14 and citron kinase act together to promote efficient cytokinesis
    Ulrike Gruneberg
    Department of Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 172:363-72. 2006
    ..Atzori, E. Turco, R. Triolo, G.P. Dotto, et al. 2000. Neuron. 28:115-127), we find a general requirement for citron kinase in human cell division. Together, these findings identify a novel pathway required for efficient cytokinesis...
  18. ncbi Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1
    Rüdiger Neef
    Intracellular Protein Transport, Independent Junior Research Group, Max Planck Institute of Biochemistry, Martinsried, 82152 Germany
    Nat Cell Biol 9:436-44. 2007
    ..The activation state of Cdk1, therefore, controls the switch of Plk1 localization from centrosomes and kinetochores during metaphase, to the central spindle during anaphase...
  19. ncbi Membrane traffic: a glitch in the Golgi matrix
    Benjamin Short
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, Martinsried 82152, Germany
    Curr Biol 13:R311-3. 2003
    ..This model is brought into question by new evidence that two golgins, GM130 and golgin-84, contribute to but are not essential for protein transport and Golgi structure...
  20. pmc Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling
    Christian Preisinger
    Intracellular Protein Transport, Independent Junior Research Group, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 24:753-65. 2005
    ..These findings identify a Plk1-dependent signalling mechanism potentially linking Golgi structure and cell cycle control, but suggest that this may not be a cell cycle checkpoint in the classical sense...
  21. pmc Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
    Ulrike Gruneberg
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Cell Biol 166:167-72. 2004
    ..We propose that MKlp2 is involved in the localization of Plk1, Aurora B, and Cdc14A to the central spindle during anaphase, and that the integration of signaling by these proteins is necessary for proper cytokinesis...
  22. pmc Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
    Evelyn Fuchs
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    J Cell Biol 177:1133-43. 2007
    ..These results suggest that Shiga toxin trafficking to the Golgi is a multistep process controlled by several Rab GAPs and their target Rabs and that this process is discrete from ligand-induced EGF receptor trafficking...
  23. pmc Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis
    Anna Santamaria
    Department of Cell Biology and Intracellular Protein Transport, Independent Junior Research Group, Max Planck Institute of Biochemistry, Martinsried, 82152 Germany
    Mol Biol Cell 18:4024-36. 2007
    ..Finally, we show that Plk1 activity is essential for cleavage furrow formation and ingression, leading to successful cytokinesis...
  24. ncbi Cooperation between mitotic kinesins controls the late stages of cytokinesis
    Rüdiger Neef
    Intracellular Protein Transport Group, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Curr Biol 16:301-7. 2006
    ..Spatial restriction of Aurora B to the central spindle by MKlp2 therefore regulates MKlp1 during cytokinesis in human cells...
  25. pmc Functional dissection of Rab GTPases involved in primary cilium formation
    Shin ichiro Yoshimura
    University of Liverpool Cancer Research Centre, Liverpool, England, UK
    J Cell Biol 178:363-9. 2007
    ..7:517-524), and is the sole Rab enriched at primary cilia. These findings provide a basis for understanding how specific membrane trafficking pathways cooperate with the microtubule cytoskeleton to give rise to the primary cilia...
  26. ncbi Inheritance and biogenesis of organelles in the secretory pathway
    Martin Lowe
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Nat Rev Mol Cell Biol 8:429-39. 2007
    ..The different mechanisms by which organelles are inherited in yeasts, protozoa and metazoans probably reflect the differences in the structure and copy number of these organelles...
  27. ncbi Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells
    Alexander K Haas
    Cancer Research Centre, University of Liverpool, 200 London Road, Liverpool, L9 3AT, UK
    J Cell Sci 120:2997-3010. 2007
    ....
  28. ncbi Cytokinesis: placing and making the final cut
    Francis A Barr
    University of Liverpool, Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK
    Cell 131:847-60. 2007
    ..Here we will discuss recent advances in our understanding of the mechanisms of cytokinesis in animals, yeast, and plants...
  29. pmc The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic
    Rudy Behnia
    Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 2QH, England, UK
    J Cell Biol 176:255-61. 2007
    ....
  30. ncbi Assay and properties of rab6 interaction with dynein-dynactin complexes
    Evelyn Fuchs
    Methods Enzymol 403:607-18. 2005
    ..Standard protocols for yeast two-hybrid analysis, and biochemical assays for the analysis of the interactions between Rab6, Bicaudal-D, and the subunits of the dynein-dynactin complex are outlined...
  31. doi Analysis of Rab GTPase and GTPase-activating protein function at primary cilia
    Shin ichiro Yoshimura
    University of Liverpool, Cancer Research Centre, Liverpool, United Kingdom
    Methods Enzymol 439:353-64. 2008
    ..This chapter describes cell biological and biochemical methods for the analysis of Rab function and Rab GTPase-activating proteins during primary cilia formation...
  32. ncbi Dynamics of Golgi matrix proteins after the blockage of ER to Golgi transport
    Shin ichiro Yoshimura
    Molecular Biology Laboratory, Faculty of Pharmaceutical Sciences, and Cancer Research Institute, Kanazawa University, Kanazawa 920 0934
    J Biochem 135:201-16. 2004
    ..These results suggest that cis-Golgi matrix proteins resist retrograde transport flow and stay as true residents in Golgi remnants after the inhibition of ER to Golgi transport...
  33. pmc Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout
    Gilles R X Hickson
    The Henry Wellcome Laboratory of Cell Biology, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland
    Mol Biol Cell 14:2908-20. 2003
    ....
  34. pmc Alpine pathways of membrane traffic
    Martin Lowe
    School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    EMBO Rep 5:561-4. 2004
  35. ncbi Convergence of cell cycle regulation and growth factor signals on GRASP65
    Shin ichiro Yoshimura
    Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Japan
    J Biol Chem 280:23048-56. 2005
    ..The convergence of cell cycle regulation and growth factor signals on GRASP65 Ser-277 suggests that GRASP65 may function as a signal integrator controlling the cell growth...
  36. pmc Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis
    Jon D Lane
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Cell Biol 156:495-509. 2002
    ..Our results suggest that GRASP65 is an important structural component required for maintenance of Golgi apparatus integrity...
  37. ncbi The Golgi apparatus: going round in circles?
    Francis A Barr
    Trends Cell Biol 12:101-4. 2002
    ..I will discuss the evidence for these claims and consider whether or not they really disprove older ideas on how the Golgi apparatus is structured and performs its function...
  38. ncbi Purification and functional interactions of GRASP55 with Rab2
    Francis A Barr
    Methods Enzymol 403:391-401. 2005
    ....
  39. ncbi The UIM domain of Hrs couples receptor sorting to vesicle formation
    Sylvie Urbé
    Physiological Laboratory, University of Liverpool, Crown St, Liverpool L69 3BX, UK
    J Cell Sci 116:4169-79. 2003
    ..Our data suggest a role for the UIM-domain of Hrs in actively retaining EGFR at the limiting membrane of endosomes as a prelude to lumenal vesicle formation...
  40. ncbi Cilia--the masterplan
    Francis A Barr
    Cancer Research Centre, University of Liverpool, UK
    J Cell Sci 121:5-6. 2008
  41. ncbi I-proteins - a proposed switch in myotubularin function
    Michael J Clague
    Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Trends Biochem Sci 29:58-61. 2004
    ..We propose an alternate, or additional, function that is analogous to the G-protein family of phosphatases, which use nucleotide-dependent conformational changes to transduce signals or do mechanical work...
  42. ncbi Assay and functional properties of Rabkinesin-6/Rab6-KIFL/MKlp2 in cytokinesis
    Rüdiger Neef
    Methods Enzymol 403:618-28. 2005
    ..Protocols for the in vivo functional analysis of Rabkinesin-6/Rab6-KIFL/MKlp2 using depletion with small interfering RNA duplexes are described...