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Genomes and Genes | A BahnSummaryCountry: Germany Publications
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Publications
Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) geneA Bahn
Zentrum für Physiologie und Pathophysiologie, Humboldtallee 23, Gottingen, 37073, Germany
Biochem Biophys Res Commun 275:623-30. 2000..1-q13.2. Additionally, 600 bp of the 5' flanking region was analyzed, illustrating the probable transcription start site at nt -280, a NF-kappaB-site at nt -397 and several putative transcription factor binding sites...- Expression studies and functional characterization of renal human organic anion transporter 1 isoformsAndrew Bahn
Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
Drug Metab Dispos 32:424-30. 2004.... - Mutation of amino acid 475 of rat organic cation transporter 2 (rOCT2) impairs organic cation transportAndrew Bahn
Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
Biochimie 86:133-6. 2004..These data indicate that rOCT2 transports both ASP(+) and TEA and that aspartate at position 475 of rOCT2 plays a critical role in transport function... - Interaction of the metal chelator 2,3-dimercapto-1-propanesulfonate with the rabbit multispecific organic anion transporter 1 (rbOAT1)A Bahn
Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie, Universitat Gottingen, Gottingen, Germany
Mol Pharmacol 62:1128-36. 2002..In summary, rbOAT1 mediates basolateral uptake of DMPS into proximal tubule cells, implicating this process in the detoxification process of heavy metals in the kidneys... - Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expressionE Beery
Abteilung Nephrologie und Rheumatologie, Universitat Gottingen, 37073 Gottingen, Germany
Endocrinology 144:4519-26. 2003..The zonated distribution of transporters furthermore suggest that oatp1-3 and OCT2 may be important for the endocrine function of rat adrenocortical cells... - Characterization and identification of steroid sulfate transporters of human placentaBernhard Ugele
I Frauenklinik Innenstadt and Medizinische Klinik II Grosshadern, Klinikum der Universitat Munchen, D 80337 Munich, Germany
Am J Physiol Endocrinol Metab 284:E390-8. 2003..Our results indicate that uptake of steroid sulfates by isolated MT is mediated by OATP-B and OAT-4 and suggest a physiological role of both carrier proteins in placental uptake of fetal-derived steroid sulfates... - Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolitesAndrew Bahn
Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
Am J Physiol Cell Physiol 289:C1075-84. 2005..Consequently, they are crucial for the regulation of central nervous system tryptophan metabolite concentration... - Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transportersNadiya Bakhiya
German Institute of Human Nutrition Potsdam Rehbrucke, Department of Nutritional Toxicology, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
J Am Soc Nephrol 17:1414-21. 2006..This study indicates that OAT can mediate the basolateral uptake of reactive sulfuric acid esters into proximal tubule cells and thereby participate in kidney cell damage by these compounds... - Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormonesMarija Ljubojevic
Molecular Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
Am J Physiol Renal Physiol 292:F361-72. 2007..Therefore, OAT2 in rat (and mouse) kidney is localized to the BB of S3, exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation... - Human renal organic anion transporter 4 operates as an asymmetric urate transporterYohannes Hagos
Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
J Am Soc Nephrol 18:430-9. 2007..hOAT4 facilitates substantial uptake of [(14)C]urate, which was elevated 2.6-fold by intracellular HCTZ. Thus, hOAT4 is the long-postulated, low-affinity apical urate anion exchanger that facilitates HCTZ-associated hyperuricemia... - Gender differences in kidney functionIvan Sabolic
Molecular Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
Pflugers Arch 455:397-429. 2007.... - Torasemide transport by organic anion transporters contributes to hyperuricemiaYohannes Hagos
Abteilung Vegetative Physiologie und Pathophysiologie, , , Germany
J Am Soc Nephrol 18:3101-9. 2007 
Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)Andrew Bahn
Zentrum Physiologie und Pathophysiologie, Abteilung Vegetative Physiologie und Pathophysiologie, Humboldtallee 23, 37073 Gottingen, Germany
J Biol Chem 283:16332-41. 2008..Uricosurics, diuretics, and cyclosporine A showed substantial interactions with hOAT10, of which cyclosporine A enhanced [(14)C]urate uptake, providing the first molecular evidence for cyclosporine A-induced hyperuricemia...- Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cellsAbdul R Asif
Abt. Nephrologie und Rheumatologie, , , Germany
Pflugers Arch 450:88-95. 2005..Likewise, [3H]PAH uptake was cis-inhibited by estrone sulphate and trans-stimulated by preloading the cells with PAH, glutarate or cortisol, indicating functional expression of OATs in the plasma membrane of NCI-H295R cells... - Functional expression of pig renal organic anion transporter 3 (pOAT3)Yohannes Hagos
Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie, Humboldtallee 23, 37073 Gottingen, Germany
Biochimie 87:421-4. 2005..8 +/- 1.3 microM. Moreover, pOAT3 mediated [3H]estrone sulfate uptake was almost abolished by 0.5 mM of glutarate, dehydroepiandosterone sulfate, or probenecid consistent with the hallmarks of OAT3 function... - Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubuleXiaohong Zhang
Dept. of Physiology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
Am J Physiol Renal Physiol 287:F999-1010. 2004..Thus the fractional contribution of different OE transporters to renal secretion is influenced by their affinity for substrate and relative expression level in RPT... - Molecular characterization of the renal organic anion transporter 1Gerhard Burckhardt
Institute of Physiology, Georg August University, Gottingen, Germany
Cell Biochem Biophys 36:169-74. 2002..Anionic neurotransmitter metabolites and the heavy-metal chelator, 2,3-dimercaptopropane sulfonate, interacted with the rabbit renal OAT1, which is expressed in kidneys and the retina... - Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibitionMarija Ljubojevic
Unit of Molecular Toxicology, Institute for Medical Research and Occupational Health, HR-10001 Zagreb, Croatia
Am J Physiol Renal Physiol 287:F124-38. 2004.... - Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate fluxAdiya Bakhiya
Zentrum Physiologie und Pathophysiologie, Georg August Universitat, Gottingen
Cell Physiol Biochem 13:249-56. 2003..It would thus dissipate gradients established by OAT1 of common OAT1/OAT3 substrates. In the present study we therefore reinvestigated the driving forces of human OAT3... - Regulation of sodium-dicarboxylate cotransporter-3 from winter flounder kidney by protein kinase CYohannes Hagos
Zentrum Physiologie und Pathophysiologie, Abteilung Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
Am J Physiol Renal Physiol 286:F86-93. 2004..In conclusion, fNaDC-3 expressed in oocytes is downregulated by PMA through endocytosis. PKC consensus sites appear not to be important for this process... - RT-PCR-based evidence for the in vivo stimulation of renal tubularp-aminohippurate (PAH) transport by triiodothyronine (T3) or dexamethasone (DEXA) in kidney tissue of immature and adult ratsAndrew Bahn
Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, Germany
Exp Toxicol Pathol 54:367-73. 2003..Thus, this is the first evidence that T3 and DEXA pre-treatment induces the expression of OAT1... - Cloning of the pig renal organic anion transporter 1 (pOAT1)Yohannes Hagos
Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
Biochimie 84:1221-4. 2002..One splice form (pOAT1) showed typical functional characteristics of organic anion transporter 1, whereas the second form appears not to transport PAH... - Interaction of cysteine conjugates with human and rabbit organic anion transporter 1Carlotta E Groves
Department of Physiology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
J Pharmacol Exp Ther 304:560-6. 2003..Finally, preloading cells transfected with hOAT1 with BTC significantly trans-stimulated the uptake of PAH, consistent with the conclusion that BTC and, hence, other cysteine S-conjugates are substrates for hOAT1... - Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placentaBernhard Ugele
Klinikum der Universitat Munchen, Lindwurmstr 2a, D 80337 München, Germany
J Steroid Biochem Mol Biol 111:1-6. 2008..OATP2B1 seems not to be involved in de novo synthesis of placental estrogens but may contribute to the clearance of estrogen sulfates from foetal circulation...