M Bader

Summary

Country: Germany

Publications

  1. doi request reprint Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy
    Michael Bader
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Annu Rev Pharmacol Toxicol 50:439-65. 2010
  2. pmc Brain Renin-Angiotensin system in hypertension, cardiac hypertrophy, and heart failure
    Luciana Aparecida Campos
    Núcleo do Parque Tecnológico de São José dos Campos, Universidade Camilo Castelo Branco São Paulo, Brazil
    Front Physiol 2:115. 2011
  3. pmc Importin α7 is essential for zygotic genome activation and early mouse development
    Franziska Rother
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    PLoS ONE 6:e18310. 2011
  4. pmc Characterization of trophoblast and extraembryonic endoderm cell lineages derived from rat preimplantation embryos
    Ilya Chuykin
    Max Delbrupsilonck Center for Molecular Medicine, Berlin Buch, Germany
    PLoS ONE 5:e9794. 2010
  5. pmc Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown
    Katarina Kotnik
    Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    PLoS ONE 4:e5124. 2009
  6. ncbi request reprint ACE2, angiotensin-(1–7), and Mas: the other side of the coin
    Michael Bader
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Str 10, 13125 Berlin, Germany
    Pflugers Arch 465:79-85. 2013
  7. pmc Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats
    Swapna Upadhyay
    EPA NHEERL, Research Triangle Park, NC 27709, USA
    Part Fibre Toxicol 5:19. 2008
  8. pmc Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice
    Adriana C Dos Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    J Neuroinflammation 5:49. 2008
  9. pmc Restricted mobility of Dnmt1 in preimplantation embryos: implications for epigenetic reprogramming
    Maik Grohmann
    Department of Biology II, Ludwig Maximilians University Munich, Grosshadernerstr 2, 82152 Planegg Martinsried, Germany
    BMC Dev Biol 5:18. 2005
  10. doi request reprint Highlights of the 13th Annual Meeting of the European Council for Cardiovascular Research. 13th Annual Meeting of the European Council for Cardiovascular Research (ECCR). Nice, France, 10-12 October, 2008
    Michael Bader
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    Future Cardiol 5:23-5. 2009

Detail Information

Publications126 found, 100 shown here

  1. doi request reprint Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy
    Michael Bader
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Annu Rev Pharmacol Toxicol 50:439-65. 2010
    ..Novel components with mostly opposite actions to the classical renin-angiotensin-aldosterone systems have been described and need functional characterization to evaluate their suitability as novel drug targets...
  2. pmc Brain Renin-Angiotensin system in hypertension, cardiac hypertrophy, and heart failure
    Luciana Aparecida Campos
    Núcleo do Parque Tecnológico de São José dos Campos, Universidade Camilo Castelo Branco São Paulo, Brazil
    Front Physiol 2:115. 2011
    ..Therefore, targeting brain RAS with drugs such as renin or angiotensin converting enzyme inhibitors or receptor blockers having increased brain penetrability could be of advantage...
  3. pmc Importin α7 is essential for zygotic genome activation and early mouse development
    Franziska Rother
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    PLoS ONE 6:e18310. 2011
    ..We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes...
  4. pmc Characterization of trophoblast and extraembryonic endoderm cell lineages derived from rat preimplantation embryos
    Ilya Chuykin
    Max Delbrupsilonck Center for Molecular Medicine, Berlin Buch, Germany
    PLoS ONE 5:e9794. 2010
    ..We addressed the question, which kind of cell lineages are produced from rat preimplantation embryo under "classical" mouse ES conditions...
  5. pmc Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown
    Katarina Kotnik
    Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    PLoS ONE 4:e5124. 2009
    ..Our first transgenic rat line generated with this method represents an inducible model for diabetes mellitus...
  6. ncbi request reprint ACE2, angiotensin-(1–7), and Mas: the other side of the coin
    Michael Bader
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Str 10, 13125 Berlin, Germany
    Pflugers Arch 465:79-85. 2013
    ..Consequently, this novel RAS axis represents a promising therapeutic target for cardiovascular and metabolic diseases...
  7. pmc Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats
    Swapna Upadhyay
    EPA NHEERL, Research Triangle Park, NC 27709, USA
    Part Fibre Toxicol 5:19. 2008
    ..abstract:..
  8. pmc Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice
    Adriana C Dos Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    J Neuroinflammation 5:49. 2008
    ....
  9. pmc Restricted mobility of Dnmt1 in preimplantation embryos: implications for epigenetic reprogramming
    Maik Grohmann
    Department of Biology II, Ludwig Maximilians University Munich, Grosshadernerstr 2, 82152 Planegg Martinsried, Germany
    BMC Dev Biol 5:18. 2005
    ..A short isoform of the prevalent maintenance DNA methyltransferase (Dnmt1S) is found in the cytoplasm of preimplantation embryos and transiently enters the nucleus only at the 8-cell stage...
  10. doi request reprint Highlights of the 13th Annual Meeting of the European Council for Cardiovascular Research. 13th Annual Meeting of the European Council for Cardiovascular Research (ECCR). Nice, France, 10-12 October, 2008
    Michael Bader
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    Future Cardiol 5:23-5. 2009
    ..The content of these sessions, as well as other important contributions to the conference, are summarized in this article...
  11. ncbi request reprint Molecular interactions of vasoactive systems in cardiovascular damage
    M Bader
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Cardiovasc Pharmacol 38:S7-9. 2001
    ..This double action is utilized by drugs such as ACE inhibitors to provide unprecedented effectiveness in hypertension and associated cardiac and renal damage...
  12. doi request reprint Update on tissue renin-angiotensin systems
    Michael Bader
    Max Delbrück Centrum for Molecular Medicine MDC, Berlin, Germany
    J Mol Med (Berl) 86:615-21. 2008
    ..This review summarizes the recent findings on the importance of tissue RAS in the most relevant cardiovascular organs...
  13. ncbi request reprint Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
    M Bader
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, Berlin Buch, Germany
    J Mol Med (Berl) 79:76-102. 2001
    ..Comprehensiveness in such an endeavor is not possible. We focus largely on work from our own group, not because the work is necessarily worthy of such scrutiny but rather because of our own familiarity with the contents...
  14. ncbi request reprint Transgenic animals in cardiovascular disease research
    M Bader
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Exp Physiol 85:713-31. 2000
    ..In this review, some of the important new genetically modified animals (i.e. transgenic models) with alterations in hormone and second messenger systems involved in cardiovascular regulation are summarized...
  15. ncbi request reprint Regulation of renin: new evidence from cultured cells and genetically modified mice
    M Bader
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 78:130-9. 2000
    ..Transgenic technology will help to clarify the function of this isoform as well as some of the other unresolved aspects of renin regulation and function and may become the motor of the second century in renin research...
  16. ncbi request reprint Transgenic animal models for the functional analysis of vasoactive peptides
    M Bader
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    Braz J Med Biol Res 31:1171-83. 1998
    ..Moreover, in recent years gene-targeting technology was employed to produce mouse strains lacking these proteins. The established animal models as well as the main insights gained by their analysis are summarized in this review...
  17. ncbi request reprint Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models
    Michael Bader
    Max Delbrück Center for Molecular Medicine MDC, D 13092, Berlin Buch, Germany
    J Mol Cell Cardiol 34:1455-62. 2002
    ..Thus, we have shown that local synthesis of this protein is involved but not essential in the development of cardiac hypertrophy and fibrosis...
  18. ncbi request reprint The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy
    O Baltatu
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 35:409-12. 2000
    ..However, the hypertensive and hypertrophic effects of subpressor angiotensin II are at least in part mediated by the brain renin-angiotensin system...
  19. ncbi request reprint Alterations in blood pressure and heart rate variability in transgenic rats with low brain angiotensinogen
    O Baltatu
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 37:408-13. 2001
    ..Furthermore, these data indicate that a permanent deficiency in the brain renin-angiotensin system alters the reflex control of heart rate in rats...
  20. ncbi request reprint Alterations of the renin-angiotensin system at the RVLM of transgenic rats with low brain angiotensinogen
    O Baltatu
    Max Delbruck Center for Molecular Medicine, D 13092 Berlin Buch, Germany
    Am J Physiol Regul Integr Comp Physiol 280:R428-33. 2001
    ....
  21. ncbi request reprint Differential gene expression of renin and angiotensinogen in the TGR(mREN-2)27 transgenic rat
    M A Lee
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 25:570-80. 1995
    ..Reversal of cardiovascular damage with the converting enzyme inhibitor but not dihydralazine suggests that angiotensin II generated locally may be involved in the pathogenesis of hypertension and structural changes in TGR(mREN-2)27 rats...
  22. doi request reprint Excessive hypertension and end-organ damage in a transgenic mouse line carrying the rat angiotensinogen gene
    Ping Xu
    Department of Cardiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Cardiovasc Pharmacol 53:38-43. 2009
    ..Thus, this line TGM(rAOGEN)102 provides a new model to study hypertension-mediated end-organ damage and to evaluate new antihypertensive or cardioprotective drugs...
  23. ncbi request reprint Sex specific behavioural alterations in Mas-deficient mice
    T Walther
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Behav Brain Res 107:105-9. 2000
    ..This implicates that the lack of Mas protein influences spatial learning and anxiety in a sex-specific manner...
  24. ncbi request reprint Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis
    Ningling Kang
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin Buch, Germany
    J Mol Med (Berl) 80:359-66. 2002
    ..Our results support an important role of local AOGEN expression in hypertension-induced end-organ damage but not in the development of the kidney...
  25. ncbi request reprint Learning and anxiety in angiotensin-deficient mice
    T Walther
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Behav Brain Res 100:1-4. 1999
    ..In both tests no differences were found between control mice and angiotensin-deficient mice. This implicates that angiotensin does not influence learning and anxiety-related behaviour in mice under normal conditions...
  26. ncbi request reprint Alcohol consumption is controlled by angiotensin II
    B Maul
    Institute of Molecular Pharmacology, Berlin, Germany Genome Research, Hypertension Research, Max Delbrueck Center for Molecular Medicine, Berlin Buch, Germany
    FASEB J 15:1640-2. 2001
  27. ncbi request reprint Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice
    O von Bohlen und Halbach
    Johannes Müller Institute of Physiology Charité, Humboldt University, Tucholskystrasse 2, D 10117, Berlin, Germany
    Regul Pept 99:209-16. 2001
    ..These results show the contrary effects of both angiotensin receptors on cell growth and represent the first demonstration of their action on neuronal cell development evidenced in the adult mouse brain...
  28. ncbi request reprint Genetic targeting of the brain renin-angiotensin system in transgenic rats: impact on stress-induced renin release
    O Baltatu
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Acta Physiol Scand 181:579-84. 2004
    ....
  29. ncbi request reprint Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene
    T Walther
    Max Delbruck Center for Molecular Medicine, Free University of Berlin, Berlin, Germany
    Braz J Med Biol Res 33:1-9. 2000
    ..The marked alterations detected in Mas-deficient mice of both genders suggest that the Mas-protooncogene is an important determinant of heart rate and blood pressure variability...
  30. ncbi request reprint Effects of angiotensin II and IV on geniculate activity in nontransgenic and transgenic rats
    D Albrecht
    Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    Eur J Pharmacol 332:53-63. 1997
    ..There were no significant differences in the effects of angiotensins in the various strains of rats, except for the latencies of the neuronal responses to the iontophoretic ejection of angiotensins...
  31. doi request reprint Increased blood pressure and water intake in transgenic mice expressing rat tonin in the brain
    Cibele C Cardoso
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Biol Chem 391:435-41. 2010
    ..In conclusion, tonin in the brain may represent an alternative pathway for angiotensin II generation with effects on the cardiovascular system...
  32. ncbi request reprint A unique central tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Biochem Pharmacol 66:1673-80. 2003
    ..In fact, there are two serotonin systems in vertebrates, independently regulated and with distinct functions...
  33. ncbi request reprint Androgen receptor independent cardiovascular action of the antiandrogen flutamide
    Radu Iliescu
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:420-7. 2003
    ..This response may contribute to the observed antihypertensive actions of flutamide...
  34. ncbi request reprint The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains
    Katja Tenner
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin, Germany
    Neurosci Lett 431:21-5. 2008
    ..These data indicate that the distinct behavioural characteristics of mouse strains are not due to differences in TPH2 activity, but to other variations in the genetic background...
  35. doi request reprint Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function
    Brit Rentzsch
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 52:967-73. 2008
    ..Thus, activation of the ACE2/angiotensin-(1-7) axis may be a novel therapeutic strategy in hypertension...
  36. ncbi request reprint Smooth-muscle contraction without smooth-muscle myosin
    I Morano
    Max Delbrück Center for Molecular Medicine MDC, Robert Rössle Strabe 10, D 13092 Berlin, Germany
    Nat Cell Biol 2:371-5. 2000
    ..We conclude that phase 1 becomes indispensable for survival and normal growth soon after birth, particularly for functions such as homeostasis and circulation...
  37. pmc Stem-cell research: the state of the art. Future regulations of embryonic-stem-cell research will be influenced more by economic interests and cultural history than by ethical concerns
    Sven Pompe
    Research Centre Julich, Germany
    EMBO Rep 6:297-300. 2005
  38. doi request reprint Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction
    Andrey C da Costa Goncalves
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Hypertension 53:387-92. 2009
    ..Our data suggest that db/db mice exhibit features found in humans with type 2 diabetic autonomic neuropathy and could serve as a model for this complication...
  39. ncbi request reprint Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model
    Ahmed Ihab Abdelaziz
    Max Delbrück Center for Molecular Medicine MDC, Molecular Muscle Physiology, Robert Rossle Strasse 10, 13125 Berlin, Germany
    J Mol Med (Berl) 82:265-74. 2004
    ..2 to 1,364 +/- 137.4 mmHg/s in the relaxation rate in the WKY and the TGR groups respectively. Characterizing the functional effects of hALC-1 at the whole organ level represents a step towards gene therapy of heart failure...
  40. ncbi request reprint Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene
    Ovidiu Baltatu
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    J Am Soc Nephrol 13:2681-7. 2002
    ..Our results indicate that androgens contribute not only to the development of hypertension, but even more importantly to end-organ damage in TGR(mREN2)27 rats...
  41. ncbi request reprint Brain renin-angiotensin system. Lessons from functional genomics
    Ovidiu Baltatu
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Neuroendocrinology 78:253-9. 2003
    ..During the last years, the development of transgenic technologies allowed to get further insight into the functionality and relevance of the brain RAS. This paper is attempting to summarize our recent experience from transgenic animals...
  42. ncbi request reprint Locally synthesized angiotensin modulates pineal melatonin generation
    Ovidiu Baltatu
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Neurochem 80:328-34. 2002
    ..Our results demonstrate that a local pineal RAS exerts a tonic modulation of indole synthesis by influencing the activity of TPH via AT1-receptors...
  43. ncbi request reprint Synthesis of serotonin by a second tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Science 299:76. 2003
  44. pmc Growth retardation and altered autonomic control in mice lacking brain serotonin
    Natalia Alenina
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Proc Natl Acad Sci U S A 106:10332-7. 2009
    ..These data confirm that the majority of central serotonin is generated by TPH2. TPH2-derived serotonin is involved in the regulation of behavior and autonomic pathways but is not essential for adult life...
  45. ncbi request reprint 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors
    Diego J Walther
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cancer 94:3135-40. 2002
    ..Therefore, there is still a need for more specific and potent chemotherapeutic agents in the fight against serotonin-producing tumors...
  46. ncbi request reprint Influence of human tryptophan hydroxylase 2 N- and C-terminus on enzymatic activity and oligomerization
    K Tenner
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Neurochem 102:1887-94. 2007
    ..These data identify a region between the C-terminal oligomerization domain and the catalytic domain, which is indispensable for TPH2 activity...
  47. pmc Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin
    V Mosienko
    Department of Molecular Biology of Peptide Hormones, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Transl Psychiatry 2:e122. 2012
    ..Our findings provide unequivocal evidence on the pivotal role of central serotonin in anxiety and aggression...
  48. pmc Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors
    J B Pesquero
    Molecular Biology of Peptide Hormones Group, and Growth Factors and Regeneration Group in the Department of Neuroscience, Max Delbruck Center for Molecular Medicine, D 13092 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 97:8140-5. 2000
    ..The B1 receptor therefore represents a useful pharmacological target especially for the treatment of inflammatory disorders and pain...
  49. ncbi request reprint Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization
    K Sugimura
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, Berlin Buch, D 13122, Germany
    Biochem Biophys Res Commun 247:466-72. 1998
    ..As this mRNA could be the source of soluble ACE, plasma ACE activity may be regulated on the level of mRNA processing...
  50. pmc Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload
    Anna N Panek
    Department of Cardiovascular and Metabolic Disease Research, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 4:e6743. 2009
    ..Moreover, it is involved in hypertrophy induction and cellular remodeling depending on the cardiac stress stimulus. Our new transgenic animals are valuable models for reconsideration of CTGF's profibrotic function in the heart...
  51. pmc Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy
    Dirk Westermann
    Department of Cardiology and Pneumology, Charité Universitä tsmedizinBerlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1373-81. 2009
    ..The underlying pathology of this disease is still under discussion. We studied the role of the kinin B1 receptor on the development of experimental diabetic cardiomyopathy...
  52. pmc Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B
    Thomas H Langenickel
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    Proc Natl Acad Sci U S A 103:4735-40. 2006
    ..The hypertrophic phenotype is further enhanced in chronic volume overload-induced congestive heart failure. Thus, this study provides evidence linking NPR-B signaling to the control of cardiac growth...
  53. ncbi request reprint Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress
    Stefan Donath
    Department of Cardiology, Campus Virchow Clinic, Charite, Humboldt University, HELIOS GmbH, Berlin, Germany
    Circulation 113:1203-12. 2006
    ..In this study we attempted to elucidate the physiological role of ARC and to understand pathophysiological consequences resulting from its deletion...
  54. ncbi request reprint Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  55. doi request reprint Rat models of cardiovascular diseases
    Michael Bader
    Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    Methods Mol Biol 597:403-14. 2010
    ..One of these tools is transgenic technology, which has allowed the creation of even more disease models in the rat. This review summarizes the experimental, genetic, and transgenic rat models for cardiovascular diseases...
  56. ncbi request reprint Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680
    Jörg Peter Voigt
    Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany
    Brain Res 1046:145-56. 2005
    ..5-1 mg/kg IP) was more pronounced in TGR(ASrAOGEN)680. The data suggest an anxious phenotype in rats with low brain angiotensinogen, possibly related to secondary dysfunctions of the brain serotonergic system...
  57. ncbi request reprint Alterations in gene expression in the testis of angiotensin-(1-7)-receptor Mas-deficient mice
    Ping Xu
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Str 10, D 13125 Berlin, Germany
    Regul Pept 138:51-5. 2007
    ..Three of these genes, coding for proteins involved in mitochondrial function and steroidogenesis, become henceforth targets for our continuing search for the physiological function of Mas in testis...
  58. doi request reprint Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation
    Andrey C da Costa-Goncalves
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 52:702-7. 2008
    ..The elevated blood pressure in SPL(-/-) mice was associated with attenuated baroreflex sensitivity and decreased parasympathetic activity. Our study is the first to show a role for the spinophilin gene in blood pressure regulation...
  59. ncbi request reprint Genetically altered animal models for Mas and angiotensin-(1-7)
    Natalia Alenina
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Exp Physiol 93:528-37. 2008
    ..In conclusion, the angiotensin-(1-7)-Mas axis has important functional implications for vascular regulation and blood pressure control, particularly in pathophysiological situations...
  60. ncbi request reprint Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
    Sebastian Bachmann
    Medical Faculty of the Charite, Department of Anatomy, Franz Volhard Clinic, HELIOS Clinics and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Am J Physiol Renal Physiol 288:F559-67. 2005
    ..Our data raise the hypothesis that THP plays an important regulatory role in the kidney...
  61. pmc Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation
    Nils Paulmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Biol 7:e1000229. 2009
    ....
  62. ncbi request reprint The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice
    Virginia S Lemos
    Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil, and Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University, Berlin, Germany
    J Cardiovasc Pharmacol 46:274-9. 2005
    ..Our results show that Ang(1-7) and AVE 0991 produced an NO-dependent vasodilator effect in the mouse aorta that is mediated by the G protein-coupled receptor Mas...
  63. ncbi request reprint Mouse knockout models of hypertension
    Michael Bader
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Methods Mol Med 108:17-32. 2005
    ..The blastocysts are then transferred into the uterus of a pseudopregnant foster mother giving birth to chimeras, which are bred to yield heterozygous and finally homozygous mutant mice for the targeted gene...
  64. ncbi request reprint Central angiotensin II controls alcohol consumption via its AT1 receptor
    Björn Maul
    Institute of Molecular Pharmacology, Berlin, Germany
    FASEB J 19:1474-81. 2005
    ..Our results indicate that a distinct drug-mediated control of the central RAS could be a promising therapy for alcohol disease...
  65. ncbi request reprint Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy
    Carsten Tschope
    Department of Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 19:2057-9. 2005
    ..These insights might have therapeutic implications also for human diabetic cardiomyopathy...
  66. ncbi request reprint Serotonin synthesis in murine embryonic stem cells
    D J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Str 10, D 13092, Berlin Buch, Germany
    Brain Res Mol Brain Res 68:55-63. 1999
    ..Furthermore, TPH protein was detected in mouse zygotes after fertilization. These results indicate that ES cells may be useful for the investigation of neurotransmitters in pre-nervous embryos and their actions during ontogeny...
  67. ncbi request reprint Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene
    T Walther
    Max Delbrück Center for Molecular Medicine MDC, D 13122 Berlin Buch, Germany
    J Biol Chem 273:11867-73. 1998
    ..Thus, Mas is an important modulating factor in the electrophysiology of the hippocampus and is involved in behavioral pathways in the adult brain...
  68. ncbi request reprint Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension
    Cecile Cayla
    Max Delbruck Center for Molecular Medicine, D 13092 Berlin Buch, Germany
    FASEB J 21:1689-98. 2007
    ..These results clearly demonstrate a pivotal role of kinins and their receptors in hypotension induced by endotoxemia in mice...
  69. doi request reprint Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart
    Jens Buttgereit
    Max Delbrück Center for Molecular Medicine MDC, Campus Berlin Buch, Berlin, Germany
    Regul Pept 161:51-7. 2010
    ..In conclusion, VILIP-1 deficiency may be responsible for the reduced efficiency of the natriuretic peptide system in cardiac hypertrophy and heart failure and may therefore serve as pharmacological target...
  70. doi request reprint Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice
    Ping Xu
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin Buch, Germany
    Hypertension 51:574-80. 2008
    ....
  71. pmc SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2
    Juliane Reiche
    Max Delbruck Center for Molecular Medicine, Charite, Universitatsmedizin, 13125 Berlin, Germany
    Mol Cell Biol 30:3027-37. 2010
    ..Our data suggest a novel regulatory pathway whereby intracellular trafficking of SPAK by the sorting receptor SORLA is crucial for proper NKCC2 activation and for maintenance of renal ion balance...
  72. ncbi request reprint Production of transgenic models in hypertension
    Elena Popova
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Methods Mol Med 108:33-50. 2005
    ....
  73. doi request reprint Increased susceptibility to endotoxic shock in transgenic rats with endothelial overexpression of kinin B(1) receptors
    Vanessa F Merino
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, Berlin Buch, Berlin, 13125, Germany
    J Mol Med (Berl) 86:791-8. 2008
    ..Thus, the transgenic rats overexpressing kinin B(1) receptors exclusively in the endothelium generated in this study support an important role of this receptor in the vasculature during the pathogenesis of endotoxic shock...
  74. doi request reprint Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system
    Ulf Schulze-Topphoff
    Cecilie Vogt Klinik, Charite University Hospital Berlin, Max Delbrueck Center for Molecular Medicine and NeuroCure Research Center, Berlin, Germany
    Nat Med 15:788-93. 2009
    ....
  75. doi request reprint Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
    Sandra Feldt
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum, Berlin Buch, Germany
    Hypertension 51:682-8. 2008
    ..Aliskiren has no (P)RR blocking effect and did not inhibit ERK 1/2 phosphorylation or kinase activity. Finally, we found no evidence that HRP affects renin or prorenin binding and signaling...
  76. ncbi request reprint Generation and characterization of a GFP transgenic rat line for embryological research
    Elena Popova
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Str 10, 13092, Berlin Buch, Germany
    Transgenic Res 17:955-63. 2008
    ....
  77. pmc The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation
    Herbert Schulz
    Max Delbrück Center for Molecular Medicine Berlin Buch, Berlin, Germany
    PLoS ONE 4:e6804. 2009
    ..The FunGenES database provides a comprehensive resource for studies into the biology of ES cells...
  78. ncbi request reprint Forced homodimerization by site-directed mutagenesis alters guanylyl cyclase activity of natriuretic peptide receptor B
    Thomas Langenickel
    Max Delbrueck Center for Molecular Medicine, Berlin Buch, Berlin, Germany
    Hypertension 43:460-5. 2004
    ..Localization of the crosslink in relation to the cell membrane is important for configuration of the extracellular domain and the consecutive signal transduction...
  79. ncbi request reprint Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
    Jens Uwe Peter
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195, Berlin, Germany
    Mol Cell Biochem 295:205-15. 2007
    ..Therefore, this Tph1-specific miniribozyme may provide a novel and effective form of gene therapy that may be applicable to a variety of thrombotic diseases...
  80. doi request reprint The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex
    Max Werth
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Development 137:3835-45. 2010
    ..Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation...
  81. ncbi request reprint Cell type-specific expression of the Mas proto-oncogene in testis
    Natalia Alenina
    Department of Cardiology, University Hospital Benjamin Franklin, Berlin Buch, Germany
    J Histochem Cytochem 50:691-6. 2002
    ..The strong ontogenetically controlled and cell type-specific expression of this membrane-bound receptor in testis implicates a role for the Mas proto-oncogene in testis maturation and function...
  82. ncbi request reprint Imprinting of the murine MAS protooncogene is restricted to its antisense RNA
    Natalia Alenina
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    Biochem Biophys Res Commun 290:1072-8. 2002
    ..Our results strongly suggest that Mas is not imprinted in mice but that an antisense RNA probably starting in the neighboring Igf2r gene is maternally imprinted in both embryos and adult organs...
  83. doi request reprint Tryptophan hydroxylase as novel target for the treatment of depressive disorders
    Susann Matthes
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Pharmacology 85:95-109. 2010
    ..This paper summarizes the data which support TPH2 as novel drug target and discusses strategies for its pharmacological exploitation...
  84. ncbi request reprint Dynamics of DNA-demethylation in early mouse and rat embryos developed in vivo and in vitro
    Ioulia Zaitseva
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    Mol Reprod Dev 74:1255-61. 2007
    ....
  85. pmc Alternative splicing and extensive RNA editing of human TPH2 transcripts
    Maik Grohmann
    Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e8956. 2010
    ..Finally, we present molecular and large-scale linkage data evidencing that deregulated alternative splicing and RNA editing is involved in the etiology of psychiatric diseases, such as suicidal behaviour...
  86. ncbi request reprint Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
    ..Thus, autocrine-paracrine serotonin signaling is an important regulator of mammary homeostasis and early involution...
  87. ncbi request reprint Plasma and kidney angiotensin II levels and renal functional responses to AT(1) receptor blockade in hypertensive Ren-2 transgenic rats
    Libor Kopkan
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 1958 9 Vídenská, CZ 140 21 Prague 4, Czech Republic
    J Hypertens 22:819-25. 2004
    ..The second aim was to investigate potential differences between TGR and HanSD in blood pressure (BP) and renal functional responses to either intravenous (i.v.), i.e. systemic, or intrarenal (i.r.) AT1 receptor blockade with candesartan...
  88. doi request reprint Aggravation of viral hepatitis by platelet-derived serotonin
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzberstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 14:756-61. 2008
    ..Thus, vasoactive serotonin supports virus persistence in the liver and aggravates virus-induced immunopathology...
  89. ncbi request reprint Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release
    Diego J Walther
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Cell 115:851-62. 2003
    ..Our data provides evidence for a receptor-independent signaling mechanism, termed herein as "serotonylation," which leads to alpha-granule exocytosis from platelets...
  90. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  91. ncbi request reprint Abolition of end-organ damage by antiandrogen treatment in female hypertensive transgenic rats
    Ovidiu Baltatu
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 41:830-3. 2003
    ..These results demonstrate that the androgen receptor antagonist Flutamide protects against hypertension and end-organ damage not only in male but also in female TGR(mREN2)27 rats...
  92. ncbi request reprint Detrimental implication of B1 receptors in myocardial ischemia: evidence from pharmacological blockade and gene knockout mice
    Caroline Lagneux
    Laboratoire du Stress Cardiovasculaire et Pathologies Associées, Universite Joseph Fourier, La Tronche, France
    Int Immunopharmacol 2:815-22. 2002
    ..The aim of this study was to evaluate the contribution of kinin B1 receptors in myocardial ischemia using both pharmacological blockade and gene knockout mice...
  93. ncbi request reprint Ischemic injury in experimental stroke depends on angiotensin II
    Thomas Walther
    Max Planck Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany
    FASEB J 16:169-76. 2002
    ..Our data, therefore, demonstrate a direct correlation between brain angiotensin II and the severity of ischemic injury in experimental stroke...
  94. ncbi request reprint Transgenic rat model of Huntington's disease
    Stephan von Horsten
    Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Hum Mol Genet 12:617-24. 2003
    ..This model allows longitudinal in vivo imaging studies and is therefore ideally suited for the evaluation of novel therapeutic approaches such as neurotransplantation...
  95. ncbi request reprint Tonin in rat heart with experimental hypertrophy
    Julio Cesar Borges
    Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil
    Am J Physiol Heart Circ Physiol 284:H2263-8. 2003
    ..Our results permit us to conclude that tonin may play a role in the process of heart hypertrophy in the rat...
  96. ncbi request reprint Autonomic control in rats with overactivity of tissue renin-angiotensin or kallikrein-kinin system
    José Marcio Ribeiro
    Physiology and Biophysic Department, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Regul Pept 129:155-9. 2005
    ....
  97. ncbi request reprint Differential effects of angiotensin II and angiotensin-(1-7) at the nucleus tractus solitarii of transgenic rats with low brain angiotensinogen
    Aurea S Couto
    Departamento de Fisiologia e Biofisica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    J Hypertens 20:919-25. 2002
    ..In this study, we investigated the effects of angiotensin II and angiotensin-(1-7) at the nucleus tractus solitarii (nTS) in transgenic rats with a severe deficit in brain angiotensinogen production, TGR(ASrAOGEN) (TGR)...
  98. pmc In vivo bradykinin B2 receptor activation reduces renal fibrosis
    Joost P Schanstra
    INSERM U388, Institut Louis Bugnard, Toulouse, France
    J Clin Invest 110:371-9. 2002
    ..Thus, in both mice and rats, bradykinin B2 receptor activation reduces renal tubulointerstitial fibrosis in vivo, most likely by increasing ECM degradation...
  99. pmc Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice
    Lei Xi
    Division of Cardiology, Box 980204, Virginia Commonwealth University, 1101 East Marshall Street, Room 7 042, Richmond, VA 23298 0204, USA
    Circulation 118:S32-7. 2008
    ..However, the exact subtypes of such receptors remain controversial or uninvestigated. To this context, the purpose of present study was to determine the definitive role of adenosine A(1) and bradykinin B(1) and B(2) receptors in PostC...
  100. ncbi request reprint Rat corin gene: molecular cloning and reduced expression in experimental heart failure
    Thomas H Langenickel
    Max Delbrueck Center for Molecular Medicine, Berlin 13092, Germany
    Am J Physiol Heart Circ Physiol 287:H1516-21. 2004
    ..566 +/- 0.014 AU, P < 0.001; left atrium: control 0.564 +/- 0.009 AU, shunt 0.464 +/- 0.009 AU, P < 0.001]. Downregulation of atrial corin mRNA expression may be a novel mechanism for the blunted ANP release in heart failure...
  101. ncbi request reprint Kinin B1 receptor participates in the control of cardiac function in mice
    Sandra Lauton-Santos
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Life Sci 81:814-22. 2007
    ..This result can be explained by the significant reduction of eNOS (NOS-3) expression in the aorta of B(1)(-/-) mice. Collectively, our results demonstrate that B(1) receptor exerts a fundamental role in the mammalian cardiac function...