E Neumann

Summary

Affiliation: Bad Nauheim
Country: Germany

Publications

  1. ncbi request reprint [Inflammation and bone metabolism]
    E Neumann
    Abteilung Innere Medizin und Rheumatologie, Justus Liebig Universität Gießen, Kerckhoff Klinik GmbH, Benekestr 2 8, 61231, Bad Nauheim, Deutschland
    Z Rheumatol 73:342-8. 2014
  2. doi request reprint Adiponectin isoforms: a potential therapeutic target in rheumatoid arthritis?
    Klaus W Frommer
    Department of Internal Medicine and Rheumatology Justus Liebig University Giessen Kerckhoff Klinik Benekestrasse 2 8 D 61231 Bad Nauheim, Germany
    Ann Rheum Dis 71:1724-32. 2012
  3. pmc Identification of differentially expressed genes in ileal Peyer's patch of scrapie-infected sheep using RNA arbitrarily primed PCR
    Lars Austbø
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033, Oslo, Norway
    BMC Vet Res 4:12. 2008
  4. pmc Developments in the synovial biology field 2006
    Anette Knedla
    Department for Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim, Benekestr, 2 8, D 61231 Bad Nauheim, Germany
    Arthritis Res Ther 9:209. 2007
  5. doi request reprint Rheumatoid arthritis progression mediated by activated synovial fibroblasts
    Elena Neumann
    Dept of Internal Medicine and Rheumatology, Justus Liebig University Giesen, Kerckhoff Klinik, Benekestr 2 8, D 61231 Bad Nauheim, Germany
    Trends Mol Med 16:458-68. 2010
  6. pmc Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts
    Elena Neumann
    Department of Internal Medicine and Rheumatology, University of Giessben, Kerckhoff Klinik, D 61231 Bad Nauheim, Benekestr, 2 8, Germany
    Arthritis Res Ther 12:R83. 2010
  7. doi request reprint Adiponectin-mediated changes in effector cells involved in the pathophysiology of rheumatoid arthritis
    Klaus W Frommer
    Justus Liebig University Giessen and Kerckhoff Klinik, Bad Nauheim, Germany
    Arthritis Rheum 62:2886-99. 2010
  8. ncbi request reprint Migratory potential of rheumatoid arthritis synovial fibroblasts: additional perspectives
    Elena Neumann
    Department of Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Klinik Bad Nauheim, Germany
    Cell Cycle 9:2286-91. 2010
  9. doi request reprint Native albumin for targeted drug delivery
    Elena Neumann
    Justus Liebig University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff Klinik Bad Nauheim, Benekestr 2 8, 61231 Bad Nauheim, Germany
    Expert Opin Drug Deliv 7:915-25. 2010
  10. ncbi request reprint [Adipocytokines as driving forces in rheumatoid arthritis]
    E Neumann
    Innere Medizin mit Schwerpunkt Rheumatologie, Justus Liebig Universitat Giessen, Kerckhoff Klinik, Bad Nauheim, Benekestr 2 8, 61231 Bad Nauheim
    Z Rheumatol 66:139-41. 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint [Inflammation and bone metabolism]
    E Neumann
    Abteilung Innere Medizin und Rheumatologie, Justus Liebig Universität Gießen, Kerckhoff Klinik GmbH, Benekestr 2 8, 61231, Bad Nauheim, Deutschland
    Z Rheumatol 73:342-8. 2014
    ..Usually, (chronic) inflammation results in increased bone loss. The molecular mechanisms and pathophysiological pathways of bone metabolism under the influence of inflammation are summarized in this review. ..
  2. doi request reprint Adiponectin isoforms: a potential therapeutic target in rheumatoid arthritis?
    Klaus W Frommer
    Department of Internal Medicine and Rheumatology Justus Liebig University Giessen Kerckhoff Klinik Benekestrasse 2 8 D 61231 Bad Nauheim, Germany
    Ann Rheum Dis 71:1724-32. 2012
    ....
  3. pmc Identification of differentially expressed genes in ileal Peyer's patch of scrapie-infected sheep using RNA arbitrarily primed PCR
    Lars Austbø
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033, Oslo, Norway
    BMC Vet Res 4:12. 2008
    ..In the present study, we have examined differential gene expression in ileal Peyer's patches and in laser microdissected follicles of sheep infected with scrapie...
  4. pmc Developments in the synovial biology field 2006
    Anette Knedla
    Department for Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim, Benekestr, 2 8, D 61231 Bad Nauheim, Germany
    Arthritis Res Ther 9:209. 2007
    ....
  5. doi request reprint Rheumatoid arthritis progression mediated by activated synovial fibroblasts
    Elena Neumann
    Dept of Internal Medicine and Rheumatology, Justus Liebig University Giesen, Kerckhoff Klinik, Benekestr 2 8, D 61231 Bad Nauheim, Germany
    Trends Mol Med 16:458-68. 2010
    ..Here, we review new findings regarding RASF activation and their altered behavior that contribute to matrix destruction and inflammation as well as their potential to spread RA...
  6. pmc Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts
    Elena Neumann
    Department of Internal Medicine and Rheumatology, University of Giessben, Kerckhoff Klinik, D 61231 Bad Nauheim, Benekestr, 2 8, Germany
    Arthritis Res Ther 12:R83. 2010
    ..We evaluated, whether passaging during culture and freezing has effects on gene expression and cell proliferation...
  7. doi request reprint Adiponectin-mediated changes in effector cells involved in the pathophysiology of rheumatoid arthritis
    Klaus W Frommer
    Justus Liebig University Giessen and Kerckhoff Klinik, Bad Nauheim, Germany
    Arthritis Rheum 62:2886-99. 2010
    ....
  8. ncbi request reprint Migratory potential of rheumatoid arthritis synovial fibroblasts: additional perspectives
    Elena Neumann
    Department of Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Klinik Bad Nauheim, Germany
    Cell Cycle 9:2286-91. 2010
    ....
  9. doi request reprint Native albumin for targeted drug delivery
    Elena Neumann
    Justus Liebig University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff Klinik Bad Nauheim, Benekestr 2 8, 61231 Bad Nauheim, Germany
    Expert Opin Drug Deliv 7:915-25. 2010
    ..Drug carriers such as albumin have been used to target specifically diseased and malignant cells, resulting in higher efficacy of treatment and reduced side effects...
  10. ncbi request reprint [Adipocytokines as driving forces in rheumatoid arthritis]
    E Neumann
    Innere Medizin mit Schwerpunkt Rheumatologie, Justus Liebig Universitat Giessen, Kerckhoff Klinik, Bad Nauheim, Benekestr 2 8, 61231 Bad Nauheim
    Z Rheumatol 66:139-41. 2007
  11. ncbi request reprint [New pathophysological relevant metabolic pathways in osteoporosis. Future innovative therapies?]
    E Neumann
    Abteilung für Innere Medizin mit Schwerpunkt Rheumatologie der Justus Liebig Universität Giessen, Abteilung für Rheumatologie und klinische Immunologie, Kerckhoff Klinik, Bad Nauheim
    Z Rheumatol 65:400, 402-6. 2006
    ..The RANK/RANKL/OPG-System is actively involved in the differentiation and function of osteoclasts and seems to play a central part in most pathophysiological mechanisms that are active in osteoporosis...
  12. doi request reprint The therapeutic use of osmotic minipumps in the severe combined immunodeficiency (SCID) mouse model for rheumatoid arthritis
    A Knedla
    Department of Internal Medicine and Rheumatology, Justus Liebig University of Giessen, Department of Rheumatology and Clinical Immunology, Kerckhoff Klinik Bad Nauheim, Germany
    Ann Rheum Dis 68:124-9. 2009
    ..As the production of viruses coding for bioactive proteins is cost and time intensive, we established an in vivo long-term release model using osmotic minipumps in the SCID mouse model for RA...
  13. doi request reprint A1.42 Adiponectin: modulation of bone remodelling in rheumatoid arthritis
    G Krumbholz
    Department of Internal Medicine and Rheumatology, Justus Liebig University Giesen, Kerckhoff Klinik Bad Nauheim
    Ann Rheum Dis 73:A18. 2014
    ..In this study, we therefore focussed on the influence of adiponectin on RA osteoblast and osteoclast activity, their differentiation as well as the immunomodulatory properties of adiponectin...
  14. doi request reprint A1.17 Analysis of two essential sub-processes of long distance migration of synovial fibroblasts from patients with rheumatoid arthritis
    B Zimmermann
    Department of Internal Medicine and Rheumatology, Justus Liebig University Giesen, Kerckhoff Klinik, Bad Nauheim, Germany
    Ann Rheum Dis 73:A7. 2014
    ..In this study, expression of the E-selectin ligand CD15s, interaction of RASF with EC via E-selectin as well as kinetics of vascular growth induced by RASF in the SCID mouse model were analysed...
  15. doi request reprint Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology
    M Geyer
    Department of Rheumatology and Clinical Immunology, Justus Liebig University Giessen, Kerckhoff Klinik, Bad Nauheim, Germany
    Osteoarthritis Cartilage 17:328-35. 2009
    ....
  16. doi request reprint A1.35 Adiponectin isoform-mediated effects on P38 MAPK and AMPK pathways in rheumatoid arthritis synovial fibroblasts
    K Khawaja
    Department of Internal Medicine and Rheumatology, Justus Liebig University, Giessen, Kerckhoff Klinik, Benekestrasse 2 8, D 61231 Bad Nauheim, Germany
    Ann Rheum Dis 73:A15. 2014
    ..The aim of the present study was to verify which signalling molecules are involved in the adiponectin-induced signalling in RASF and to analyse potential differences in the adiponectin isoform-mediated signalling...
  17. ncbi request reprint [Bone metabolism: molecular mechanisms]
    E Neumann
    Abteilung für Innere Medizin und Rheumatologie, Justus Liebig Universitat, Giessen
    Z Rheumatol 66:286-9. 2007
    ..Disturbances of this process lead via increased bone resorption to osteoporosis, and via increased synthesis to osteopetrosis. This contribution describes the known molecular mechanisms in this remodelling process...
  18. pmc Methotrexate (MTX) and albumin coupled with MTX (MTX-HSA) suppress synovial fibroblast invasion and cartilage degradation in vivo
    C Fiehn
    Department of Haematology, Oncology and Rheumatology, Clinic of Internal Medicine V, University of Heidelberg, Germany
    Ann Rheum Dis 63:884-6. 2004
    ..To investigate the effect of methotrexate (MTX) and albumin coupled with methotrexate (MTX-HSA) on cartilage invasion and induction of perichondrocytic degradation by rheumatoid arthritis synovial fibroblasts (RA SF) in vivo...
  19. pmc p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion
    C A Seemayer
    Centre of Experimental Rheumatology and WHO Collaborating Centre for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, Department of Rheumatology, University Hospital Zurich, Switzerland
    Ann Rheum Dis 62:1139-44. 2003
    ..To analyse the functional response of p53 in rheumatoid arthritis synovial fibroblasts (RASF) in vitro and in vivo and to investigate whether activation of p53 modulates the destructive process of RASF...
  20. ncbi request reprint Laser-mediated microdissection facilitates analysis of area-specific gene expression in rheumatoid synovium
    M Judex
    University of Regensburg, Regensburg, Germany
    Arthritis Rheum 48:97-102. 2003
    ..The present study was undertaken to establish parameters for this technique and assess its usefulness for gene expression analysis...
  21. ncbi request reprint Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway
    E Neumann
    Department of Internal Medicine I, University of Regensburg, Germany
    Gene Ther 9:1508-19. 2002
    ....
  22. ncbi request reprint Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed-polymerase chain reaction
    E Neumann
    University of Regensburg, Germany
    Arthritis Rheum 46:52-63. 2002
    ..A combination of RNA arbitrarily primed-polymerase chain reaction (RAP-PCR) and complementary DNA (cDNA) array with defined genes was used for a highly sensitive differential screening using small amounts of RNA...