Maiko Higuchi

Summary

Affiliation: Bad Nauheim
Country: Germany

Publications

  1. doi request reprint Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells
    Maiko Higuchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Cell Sci 126:745-55. 2013
  2. ncbi request reprint Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells
    Yasunori Mori
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Cell Struct Funct 29:101-10. 2004
  3. doi request reprint Scaffolding function of PAK in the PDK1-Akt pathway
    Maiko Higuchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 10:1356-64. 2008
  4. ncbi request reprint The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts
    Keisuke Onishi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 12:535-46. 2007
  5. pmc JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release
    Yasunori Mori
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    EMBO J 27:76-87. 2008
  6. ncbi request reprint The phosphatidylinositol-3 kinase (PI3K)-Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells
    Maiko Higuchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 8:657-69. 2003
  7. doi request reprint Mitochondrial localization of the antiviral signaling adaptor IPS-1 is important for its induction of caspase activation
    Tomohiko Okazaki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 18:493-501. 2013
  8. ncbi request reprint SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling
    Masahiro Shinohara
    Department of Applied Biological Chemistry, Faculty of Agricultural and Life Science, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Nature 416:759-63. 2002

Collaborators

Detail Information

Publications8

  1. doi request reprint Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells
    Maiko Higuchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Cell Sci 126:745-55. 2013
    ..This study has unveiled a novel function of Akt as an 'ignition kinase' of FAK in growth factor signaling and may shed light on the mechanism by which growth factors regulate integrin signaling...
  2. ncbi request reprint Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells
    Yasunori Mori
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Cell Struct Funct 29:101-10. 2004
    ....
  3. doi request reprint Scaffolding function of PAK in the PDK1-Akt pathway
    Maiko Higuchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 10:1356-64. 2008
    ..PAK differentially activates subpopulations of Akt. These findings reveal scaffolding functions of PAK that regulate the efficiency, localization and specificity of the PDK1-Akt pathway...
  4. ncbi request reprint The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts
    Keisuke Onishi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 12:535-46. 2007
    ....
  5. pmc JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release
    Yasunori Mori
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    EMBO J 27:76-87. 2008
    ..Furthermore, mutation of Ser135 abrogated enhancement of Ca2+-evoked release by Syt 4. These results provide a molecular basis for the effect of growth factors on Ca2+-mediated secretion...
  6. ncbi request reprint The phosphatidylinositol-3 kinase (PI3K)-Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells
    Maiko Higuchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 8:657-69. 2003
    ..However, the roles of the PI3K pathway in neurite branch formation were not fully understood. Also, it was not clear where the PI3K pathway is activated during branch formation...
  7. doi request reprint Mitochondrial localization of the antiviral signaling adaptor IPS-1 is important for its induction of caspase activation
    Tomohiko Okazaki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 18:493-501. 2013
    ..These results establish that the mitochondrial location of IPS-1 is essential to its ability to induce apoptosis...
  8. ncbi request reprint SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling
    Masahiro Shinohara
    Department of Applied Biological Chemistry, Faculty of Agricultural and Life Science, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Nature 416:759-63. 2002
    ..We conclude that SWAP-70 is a new type of Rac-GEF which, independently of Ras, transduces signals from tyrosine kinase receptors to Rac...