Armin Schneider

Summary

Affiliation: Axaron Bioscience AG
Country: Germany

Publications

  1. ncbi request reprint A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    Cell Cycle 4:1753-7. 2005
  2. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
  3. pmc An extended window of opportunity for G-CSF treatment in cerebral ischemia
    Armin Schneider
    Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Biol 4:36. 2006
  4. ncbi request reprint Identification of regulated genes during transient cortical ischemia in mice by restriction-mediated differential display (RMDD)
    Armin Schneider
    Department of Molecular Neurology and Technology, Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    Brain Res Mol Brain Res 124:20-8. 2004
  5. ncbi request reprint Restriction-mediated differential display (RMDD) identifies pip92 as a pro-apoptotic gene product induced during focal cerebral ischemia
    Armin Schneider
    Department of Molecular Neurology, Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    J Cereb Blood Flow Metab 24:224-36. 2004
  6. ncbi request reprint Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Neurochem 88:1114-26. 2004
  7. ncbi request reprint TorsinA, the gene linked to early-onset dystonia, is upregulated by the dopaminergic toxin MPTP in mice
    Rohini Kuner
    Pharmacology Institute, University of Heidelberg, Im Neunheimer Feld 366, 69120 Heidelberg, Germany
    Neurosci Lett 355:126-30. 2004
  8. ncbi request reprint Expression of hemoglobin in rodent neurons
    Dominik W Schelshorn
    Division of Systems Physiology, Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 29:585-95. 2009
  9. ncbi request reprint KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ
    Angela Vogt-Eisele
    Sygnis Bioscience, Heidelberg, Germany
    J Neurochem 128:686-700. 2014
  10. doi request reprint The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury
    Claudia Pitzer
    Sygnis Bioscience, Im Neuenheimer Feld, Heidelberg, Germany
    J Neurochem 113:930-42. 2010

Collaborators

Detail Information

Publications47

  1. ncbi request reprint A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    Cell Cycle 4:1753-7. 2005
    ....
  2. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
    ..We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases...
  3. pmc An extended window of opportunity for G-CSF treatment in cerebral ischemia
    Armin Schneider
    Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Biol 4:36. 2006
    ..In addition to these trophic effects, G-CSF is a potent neuroprotective factor reliably reducing infarct size in different stroke models...
  4. ncbi request reprint Identification of regulated genes during transient cortical ischemia in mice by restriction-mediated differential display (RMDD)
    Armin Schneider
    Department of Molecular Neurology and Technology, Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    Brain Res Mol Brain Res 124:20-8. 2004
    ..We discuss the identity of the regulated genes in view of their possible usefulness for pharmacological intervention in cerebral ischemia...
  5. ncbi request reprint Restriction-mediated differential display (RMDD) identifies pip92 as a pro-apoptotic gene product induced during focal cerebral ischemia
    Armin Schneider
    Department of Molecular Neurology, Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    J Cereb Blood Flow Metab 24:224-36. 2004
    ..In summary, restriction-mediated differential display has proven its suitability for screening complex samples such as brain to reliably identify regulated genes, which can uncover novel pathophysiological mechanisms...
  6. ncbi request reprint Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Neurochem 88:1114-26. 2004
    ..We conclude that the up-regulation of this kinase during focal ischaemia may represent an interesting new target for pharmacological intervention...
  7. ncbi request reprint TorsinA, the gene linked to early-onset dystonia, is upregulated by the dopaminergic toxin MPTP in mice
    Rohini Kuner
    Pharmacology Institute, University of Heidelberg, Im Neunheimer Feld 366, 69120 Heidelberg, Germany
    Neurosci Lett 355:126-30. 2004
    ..These results provide insights into the pathophysiology of early-onset dystonia and strengthen links between the dopaminergic system and dystonia...
  8. ncbi request reprint Expression of hemoglobin in rodent neurons
    Dominik W Schelshorn
    Division of Systems Physiology, Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 29:585-95. 2009
    ..We propose that neuronal hemoglobin expression is connected to facilitated oxygen uptake in neurons, and hemoglobin might serve as oxygen capacitator molecule...
  9. ncbi request reprint KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ
    Angela Vogt-Eisele
    Sygnis Bioscience, Heidelberg, Germany
    J Neurochem 128:686-700. 2014
    ..KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMζ levels. Our findings support a role for KIBRA in memory, and unveil a novel function for this protein. ..
  10. doi request reprint The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury
    Claudia Pitzer
    Sygnis Bioscience, Im Neuenheimer Feld, Heidelberg, Germany
    J Neurochem 113:930-42. 2010
    ..We show that G-CSF improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. We conclude that G-CSF constitutes a promising and feasible new therapy option for SCI...
  11. ncbi request reprint Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Neurochem 91:1007-17. 2004
    ..We propose that ee3 is a highly interesting new orphan GPCR with potential connections to erythropoietin and 5HT2a receptor signalling...
  12. pmc Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis
    Claudia Pitzer
    Sygnis Bioscience, Heidelberg, Germany
    Brain 131:3335-47. 2008
    ..We conclude that G-CSF is a novel neurotrophic factor for motoneurons that is an attractive and feasible drug candidate for the treatment of ALS...
  13. pmc G-CSF protects motoneurons against axotomy-induced apoptotic death in neonatal mice
    Alexandre Henriques
    Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Neurosci 11:25. 2010
    ..Here we studied whether G-CSF is able to protect motoneurons from purely apoptotic cell death induced by a monocausal paradigm, neonatal sciatic nerve axotomy...
  14. pmc Granulocyte-colony stimulating factor (G-CSF) improves motor recovery in the rat impactor model for spinal cord injury
    Tanjew Dittgen
    Sygnis Bioscience, Heidelberg, Germany
    PLoS ONE 7:e29880. 2012
    ..In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function...
  15. ncbi request reprint Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-kappaB
    Ming Fei Lang
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Neurosci Lett 430:138-41. 2008
    ..However, there was no difference in the infarct size in PGRP-S-deficient mice compared to controls. In summary, the data show that PGRP-S is induced in cerebral ischemia by RelA, but its role in ischemia is unclear...
  16. pmc Characterization of a novel SOD-1(G93A) transgenic mouse line with very decelerated disease development
    Alexandre Henriques
    Department of Molecular Neurology, Sygnis Bioscience, Heidelberg, Germany
    PLoS ONE 5:e15445. 2010
    ..The delayed development of disease may more closely mimic human pathophysiology, and studying drug effects in this model may yield added confidence for potential efficacy of ALS drug candidates...
  17. pmc The hematopoietic factor GM-CSF (granulocyte-macrophage colony-stimulating factor) promotes neuronal differentiation of adult neural stem cells in vitro
    Carola Krüger
    Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Neurosci 8:88. 2007
    ..We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotective in animal stroke models...
  18. ncbi request reprint Long-term gene expression changes in the cortex following cortical ischemia revealed by transcriptional profiling
    Carola Krüger
    Department of Molecular Neurology, Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    Exp Neurol 200:135-52. 2006
    ..Conclusively, our data highlight the degree of long-term transcriptional changes in the cortex after ischemia, and provide insight into functional pathways of relevance for compensatory recovery mechanisms in neural networks...
  19. pmc The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions
    Markus Krieger
    Sygnis Bioscience, Heidelberg, Germany
    Sci Rep 2:697. 2012
    ..Collectively, these results suggest that GM-CSF signalling plays a major role in structural plasticity relevant to learning and memory...
  20. pmc The receptor for granulocyte-colony stimulating factor (G-CSF) is expressed in radial glia during development of the nervous system
    Friederike Kirsch
    Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Dev Biol 8:32. 2008
    ..In addition, we found close co-localization of the G-CSF receptor and its ligand G-CSF. Here we have conducted a systematic expression analysis of G-CSF receptor and its ligand in the developing embryo...
  21. doi request reprint A novel flow cytometry-based technique to measure adult neurogenesis in the brain
    Robert Spoelgen
    Sygnis Bioscience, Im Neuenheimer Feld 515, Heidelberg, Germany
    J Neurochem 119:165-75. 2011
    ..We demonstrate the ability of the technique to detect increased neurogenesis in the hippocampus of animals which underwent physical exercise and received fluoxetine treatment...
  22. pmc CNS-targeted viral delivery of G-CSF in an animal model for ALS: improved efficacy and preservation of the neuromuscular unit
    Alexandre Henriques
    Department of Molecular Neurology, Sygnis Bioscience, Heidelberg, Germany
    Mol Ther 19:284-92. 2011
    ..Collectively, our results show that intraspinal delivery improves efficacy of G-CSF treatment in an ALS mouse model while minimizing the systemic load of G-CSF, suggesting a new therapeutic option for ALS treatment...
  23. ncbi request reprint Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia
    Wen Zhang
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 25:30-40. 2005
    ..In summary, the data show that NF-kappaB is activated in neurons and astrocytes during cerebral ischemia and that NF-kappaB activation in neurons contributes to the ischemic damage...
  24. ncbi request reprint Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone
    Martin H Maurer
    Department of Physiology and Pathophysiology, Division of Systems Physiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    J Proteome Res 6:1198-208. 2007
    ....
  25. ncbi request reprint TorsinA protects against oxidative stress in COS-1 and PC12 cells
    Rohini Kuner
    Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Neurosci Lett 350:153-6. 2003
    ..To our knowledge, this is the first demonstration that TorsinA protects against oxidative stress. We speculate that a loss of this cellular function in mutant TorsinA may be linked to the pathogenesis of early-onset dystonia...
  26. ncbi request reprint Neuronal co-expression of EGFP and beta-galactosidase in mice causes neuropathology and premature death
    Heinz E Krestel
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    Neurobiol Dis 17:310-8. 2004
    ..These compounds could protect neurons from EGFP and beta-gal-induced dysfunction, as demise of mice started after treatment was discontinued...
  27. pmc The functional genome of CA1 and CA3 neurons under native conditions and in response to ischemia
    Dieter Newrzella
    Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    BMC Genomics 8:370. 2007
    ..We have compared CA3 and CA1 gene expression in the uninjured brain, and after cerebral ischemia using laser microdissection (LMD), RNA amplification, and array hybridization...
  28. ncbi request reprint Yellow pages to the transcriptome
    Julia Scheel
    Axaron Bioscience AG, Im Neuenheimer Feld 515, D 69120 Heidelberg, Germany
    Pharmacogenomics 3:791-807. 2002
    ..Finally, a prognosis for future developments of the technologies is given...
  29. doi request reprint Initial lesion volume is an independent predictor of clinical stroke outcome at day 90: an analysis of the Virtual International Stroke Trials Archive (VISTA) database
    Gerhard Vogt
    Sygnis Bioscience, Heidelberg, Germany
    Stroke 43:1266-72. 2012
    ..We analyzed the Virtual International Stroke Trials Archive (VISTA) database to define the influence of infarct or hemorrhagic volume on clinical outcome after stroke...
  30. pmc Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?
    Alexandre Henriques
    Department of Molecular Neurology, SYGNIS Bioscience Heidelberg, Germany
    Front Neurosci 4:32. 2010
    ..In this review we discuss the rationale behind those factors, possible reasons for clinical failures, and argue for a renewal of hope in this powerful class of drugs for the treatment of ALS...
  31. ncbi request reprint Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany
    Neurosci Lett 327:181-4. 2002
    ..In conclusion, components of oxidative metabolism pathways were activated at the level of transcription which could be related to neuroprotective effects of EPO or could indicate compromised tissue...
  32. ncbi request reprint Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas
    Nikolaus Gassler
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Pathol 207:295-300. 2005
    ....
  33. ncbi request reprint Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease
    Katrin Meuer
    Department of Neurology, University of Gottingen, Waldweg 33, 37073 Gottingen, Germany
    J Neurochem 97:675-86. 2006
    ..Thus our data suggest that G-CSF is a novel therapeutic opportunity for the treatment of Parkinson's disease, because it is well-tolerated and already approved for the treatment of neutropenic conditions in humans...
  34. ncbi request reprint Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration
    Ioana Potrovita
    Department of Neurology, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 24:8237-44. 2004
    ..In summary, our data show that TWEAK induces neuronal cell death and is involved in neurodegeneration in vivo...
  35. ncbi request reprint Verge: a novel vascular early response gene
    Jean B Regard
    Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 24:4092-103. 2004
    ..This response is accompanied by reorganization of the actin cytoskeleton and the formation of paracellular gaps. These studies suggest that Verge functions as a dynamic regulator of endothelial cell signaling and vascular function...
  36. ncbi request reprint New targets for established proteins: exploring G-CSF for the treatment of stroke
    Wolf Rüdiger Schäbitz
    Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Trends Pharmacol Sci 28:157-61. 2007
    ..Several clinical trials have been initiated in stroke patients, mainly to demonstrate the safety of G-CSF in this setting...
  37. doi request reprint Meta-analysis of the efficacy of granulocyte-colony stimulating factor in animal models of focal cerebral ischemia
    Jens Minnerup
    Universitatsklinikum Munster, Klinik und Poliklinik fur Neurologie, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Stroke 39:1855-61. 2008
    ..To guide further development, a meta-analysis was performed to assess the effects of G-CSF on infarct size and sensorimotor deficits...
  38. ncbi request reprint A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)
    Wolf Rüdiger Schäbitz
    Department of Neurology, University of Munster, Munster, Germany
    J Cereb Blood Flow Metab 28:29-43. 2008
    ..Clinically, GM-CSF now broadens the repertoire of hematopoietic factors available as novel drug candidates for stroke and neurodegenerative diseases...
  39. ncbi request reprint Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis
    Wolf Rüdiger Schäbitz
    Department of Neurology, University of Munster, Germany
    Stroke 38:2165-72. 2007
    ..Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis...
  40. ncbi request reprint Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemia
    Oliver Herrmann
    Department of Neurology, University of Heidelberg Germany
    J Cereb Blood Flow Metab 23:406-15. 2003
    ..Neuroprotective properties apparently compensate for its pyretic action after MCAO and enhance the safety of this endogenous pyrogen...
  41. ncbi request reprint Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing
    Nikolaus Gassler
    Institute of Pathology, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Aachen, Germany
    Gastroenterology 133:587-98. 2007
    ..The aim of the present study was to examine underlying molecular mechanisms of the cell death at the villus tip...
  42. ncbi request reprint Granulocyte colony-stimulating factor and acute myocardial infarction
    Wolf Rüdiger Schäbitz
    JAMA 296:1967-8; author reply 1968-9. 2006
  43. ncbi request reprint Toward a multimodal neuroprotective treatment of stroke
    Andreas Rogalewski
    Department of Neurology, University of Muenster, Germany
    Stroke 37:1129-36. 2006
    ..Stroke remains a common medical problem with importance attributable to the demographic changes in industrialized societies...
  44. ncbi request reprint Developing granulocyte-colony stimulating factor for the treatment of stroke: current status of clinical trials
    Wolf Rüdiger Schäbitz
    Stroke 37:1654; author reply 1655. 2006
  45. ncbi request reprint Reduced oxidative damage in ALS by high-dose enteral melatonin treatment
    Jochen H Weishaupt
    Department of Neurology, Georg August University, Gottingen, Germany
    J Pineal Res 41:313-23. 2006
    ..This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS...
  46. ncbi request reprint Submucosal endoscopy: a novel approach to en bloc endoscopic mucosal resection (with videos)
    Stefan von Delius
    2nd Medical Department, Technical University of Munich, Munich, Germany
    Gastrointest Endosc 66:753-6. 2007
    ..The submucosal layer is of eminent importance for endoscopic mucosal resection (EMR) in the GI tract...
  47. ncbi request reprint Expression of calnexin reflects paneth cell differentiation and function
    Nikolaus Gassler
    Department of Pathology, Heidelberg University, Mannheim, Germany
    Lab Invest 82:1647-59. 2002
    ..In conclusion, calnexin probably reflects the status of Paneth cell differentiation and function. The results do not necessarily indicate that calnexin has a function in Paneth cell proliferation...