Research Topics
Genomes and Genes | Armin SchneiderSummaryAffiliation: Axaron Bioscience AG Country: Germany Publications
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Publications
The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesisArmin Schneider
Axaron Bioscience AG, Heidelberg, Germany
J Clin Invest 115:2083-98. 2005..We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases...- An extended window of opportunity for G-CSF treatment in cerebral ischemiaArmin Schneider
Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
BMC Biol 4:36. 2006..In addition to these trophic effects, G-CSF is a potent neuroprotective factor reliably reducing infarct size in different stroke models... 
A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous systemArmin Schneider
Axaron Bioscience AG, Heidelberg, Germany
Cell Cycle 4:1753-7. 2005....- Identification of regulated genes during transient cortical ischemia in mice by restriction-mediated differential display (RMDD)Armin Schneider
Department of Molecular Neurology and Technology, Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
Brain Res Mol Brain Res 124:20-8. 2004..We discuss the identity of the regulated genes in view of their possible usefulness for pharmacological intervention in cerebral ischemia... - Restriction-mediated differential display (RMDD) identifies pip92 as a pro-apoptotic gene product induced during focal cerebral ischemiaArmin Schneider
Department of Molecular Neurology, Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
J Cereb Blood Flow Metab 24:224-36. 2004..In summary, restriction-mediated differential display has proven its suitability for screening complex samples such as brain to reliably identify regulated genes, which can uncover novel pathophysiological mechanisms... - Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4Armin Schneider
Axaron Bioscience AG, Heidelberg, Germany
J Neurochem 88:1114-26. 2004..We conclude that the up-regulation of this kinase during focal ischaemia may represent an interesting new target for pharmacological intervention... 
Expression of hemoglobin in rodent neuronsDominik W Schelshorn
Division of Systems Physiology, Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
J Cereb Blood Flow Metab 29:585-95. 2009..We propose that neuronal hemoglobin expression is connected to facilitated oxygen uptake in neurons, and hemoglobin might serve as oxygen capacitator molecule...- TorsinA, the gene linked to early-onset dystonia, is upregulated by the dopaminergic toxin MPTP in miceRohini Kuner
Pharmacology Institute, University of Heidelberg, Im Neunheimer Feld 366, 69120 Heidelberg, Germany
Neurosci Lett 355:126-30. 2004..These results provide insights into the pathophysiology of early-onset dystonia and strengthen links between the dopaminergic system and dystonia... - The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injuryClaudia Pitzer
Sygnis Bioscience, Im Neuenheimer Feld, Heidelberg, Germany
J Neurochem 113:930-42. 2010..We show that G-CSF improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. We conclude that G-CSF constitutes a promising and feasible new therapy option for SCI... - Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptorMartin H Maurer
Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
J Neurochem 91:1007-17. 2004..We propose that ee3 is a highly interesting new orphan GPCR with potential connections to erythropoietin and 5HT2a receptor signalling... - Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosisClaudia Pitzer
Sygnis Bioscience, Heidelberg, Germany
Brain 131:3335-47. 2008..We conclude that G-CSF is a novel neurotrophic factor for motoneurons that is an attractive and feasible drug candidate for the treatment of ALS... - G-CSF protects motoneurons against axotomy-induced apoptotic death in neonatal miceAlexandre Henriques
Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
BMC Neurosci 11:25. 2010..Here we studied whether G-CSF is able to protect motoneurons from purely apoptotic cell death induced by a monocausal paradigm, neonatal sciatic nerve axotomy... - Granulocyte-colony stimulating factor (G-CSF) improves motor recovery in the rat impactor model for spinal cord injuryTanjew Dittgen
Sygnis Bioscience, Heidelberg, Germany
PLoS ONE 7:e29880. 2012..In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function... - Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-kappaBMing Fei Lang
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Neurosci Lett 430:138-41. 2008..However, there was no difference in the infarct size in PGRP-S-deficient mice compared to controls. In summary, the data show that PGRP-S is induced in cerebral ischemia by RelA, but its role in ischemia is unclear... - Long-term gene expression changes in the cortex following cortical ischemia revealed by transcriptional profilingCarola Krüger
Department of Molecular Neurology, Axaron Bioscience AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
Exp Neurol 200:135-52. 2006..Conclusively, our data highlight the degree of long-term transcriptional changes in the cortex after ischemia, and provide insight into functional pathways of relevance for compensatory recovery mechanisms in neural networks... - The hematopoietic factor GM-CSF (granulocyte-macrophage colony-stimulating factor) promotes neuronal differentiation of adult neural stem cells in vitroCarola Krüger
Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
BMC Neurosci 8:88. 2007..We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotective in animal stroke models... - Characterization of a novel SOD-1(G93A) transgenic mouse line with very decelerated disease developmentAlexandre Henriques
Department of Molecular Neurology, Sygnis Bioscience, Heidelberg, Germany
PLoS ONE 5:e15445. 2010..The delayed development of disease may more closely mimic human pathophysiology, and studying drug effects in this model may yield added confidence for potential efficacy of ALS drug candidates... - The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functionsMarkus Krieger
Sygnis Bioscience, Heidelberg, Germany
Sci Rep 2:697. 2012..Collectively, these results suggest that GM-CSF signalling plays a major role in structural plasticity relevant to learning and memory... - A novel flow cytometry-based technique to measure adult neurogenesis in the brainRobert Spoelgen
Sygnis Bioscience, Im Neuenheimer Feld 515, Heidelberg, Germany
J Neurochem 119:165-75. 2011..We demonstrate the ability of the technique to detect increased neurogenesis in the hippocampus of animals which underwent physical exercise and received fluoxetine treatment... - CNS-targeted viral delivery of G-CSF in an animal model for ALS: improved efficacy and preservation of the neuromuscular unitAlexandre Henriques
Department of Molecular Neurology, Sygnis Bioscience, Heidelberg, Germany
Mol Ther 19:284-92. 2011..Collectively, our results show that intraspinal delivery improves efficacy of G-CSF treatment in an ALS mouse model while minimizing the systemic load of G-CSF, suggesting a new therapeutic option for ALS treatment... - The receptor for granulocyte-colony stimulating factor (G-CSF) is expressed in radial glia during development of the nervous systemFriederike Kirsch
Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
BMC Dev Biol 8:32. 2008..In addition, we found close co-localization of the G-CSF receptor and its ligand G-CSF. Here we have conducted a systematic expression analysis of G-CSF receptor and its ligand in the developing embryo... - Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemiaWen Zhang
Department of Neurology, University of Heidelberg, Heidelberg, Germany
J Cereb Blood Flow Metab 25:30-40. 2005..In summary, the data show that NF-kappaB is activated in neurons and astrocytes during cerebral ischemia and that NF-kappaB activation in neurons contributes to the ischemic damage... - TorsinA protects against oxidative stress in COS-1 and PC12 cellsRohini Kuner
Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Neurosci Lett 350:153-6. 2003..To our knowledge, this is the first demonstration that TorsinA protects against oxidative stress. We speculate that a loss of this cellular function in mutant TorsinA may be linked to the pathogenesis of early-onset dystonia... - Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zoneMartin H Maurer
Department of Physiology and Pathophysiology, Division of Systems Physiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
J Proteome Res 6:1198-208. 2007.... - Neuronal co-expression of EGFP and beta-galactosidase in mice causes neuropathology and premature deathHeinz E Krestel
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
Neurobiol Dis 17:310-8. 2004..These compounds could protect neurons from EGFP and beta-gal-induced dysfunction, as demise of mice started after treatment was discontinued... - The functional genome of CA1 and CA3 neurons under native conditions and in response to ischemiaDieter Newrzella
Sygnis Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
BMC Genomics 8:370. 2007..We have compared CA3 and CA1 gene expression in the uninjured brain, and after cerebral ischemia using laser microdissection (LMD), RNA amplification, and array hybridization... - Yellow pages to the transcriptomeJulia Scheel
Axaron Bioscience AG, Im Neuenheimer Feld 515, D 69120 Heidelberg, Germany
Pharmacogenomics 3:791-807. 2002..Finally, a prognosis for future developments of the technologies is given... - Initial lesion volume is an independent predictor of clinical stroke outcome at day 90: an analysis of the Virtual International Stroke Trials Archive (VISTA) databaseGerhard Vogt
Sygnis Bioscience, Heidelberg, Germany
Stroke 43:1266-72. 2012..We analyzed the Virtual International Stroke Trials Archive (VISTA) database to define the influence of infarct or hemorrhagic volume on clinical outcome after stroke... - Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?Alexandre Henriques
Department of Molecular Neurology, SYGNIS Bioscience Heidelberg, Germany
Front Neurosci 4:32. 2010..In this review we discuss the rationale behind those factors, possible reasons for clinical failures, and argue for a renewal of hope in this powerful class of drugs for the treatment of ALS... - Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietinMartin H Maurer
Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany
Neurosci Lett 327:181-4. 2002..In conclusion, components of oxidative metabolism pathways were activated at the level of transcription which could be related to neuroprotective effects of EPO or could indicate compromised tissue... - Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomasNikolaus Gassler
Institute of Pathology, University of Heidelberg, Heidelberg, Germany
J Pathol 207:295-300. 2005.... - Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's diseaseKatrin Meuer
Department of Neurology, , Waldweg 33, , Germany
J Neurochem 97:675-86. 2006..Thus our data suggest that G-CSF is a novel therapeutic opportunity for the treatment of Parkinson's disease, because it is well-tolerated and already approved for the treatment of neutropenic conditions in humans... - Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegenerationIoana Potrovita
Department of Neurology, University of Heidelberg, D 69120 Heidelberg, Germany
J Neurosci 24:8237-44. 2004..In summary, our data show that TWEAK induces neuronal cell death and is involved in neurodegeneration in vivo... - Verge: a novel vascular early response geneJean B Regard
Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neurosci 24:4092-103. 2004..This response is accompanied by reorganization of the actin cytoskeleton and the formation of paracellular gaps. These studies suggest that Verge functions as a dynamic regulator of endothelial cell signaling and vascular function... - Meta-analysis of the efficacy of granulocyte-colony stimulating factor in animal models of focal cerebral ischemiaJens Minnerup
Universitatsklinikum Munster, Klinik und Poliklinik fur Neurologie, Albert Schweitzer Strasse 33, 48149 Munster, Germany
Stroke 39:1855-61. 2008..To guide further development, a meta-analysis was performed to assess the effects of G-CSF on infarct size and sensorimotor deficits... - New targets for established proteins: exploring G-CSF for the treatment of strokeWolf Rüdiger Schäbitz
Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
Trends Pharmacol Sci 28:157-61. 2007..Several clinical trials have been initiated in stroke patients, mainly to demonstrate the safety of G-CSF in this setting... - A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)Wolf Rüdiger Schäbitz
Department of Neurology, University of Munster, Munster, Germany
J Cereb Blood Flow Metab 28:29-43. 2008..Clinically, GM-CSF now broadens the repertoire of hematopoietic factors available as novel drug candidates for stroke and neurodegenerative diseases... - Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesisWolf Rüdiger Schäbitz
Department of Neurology, University of Munster, Germany
Stroke 38:2165-72. 2007..Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis... - Regulation of body temperature and neuroprotection by endogenous interleukin-6 in cerebral ischemiaOliver Herrmann
Department of Neurology, University of Heidelberg Germany
J Cereb Blood Flow Metab 23:406-15. 2003..Neuroprotective properties apparently compensate for its pyretic action after MCAO and enhance the safety of this endogenous pyrogen... - Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicingNikolaus Gassler
Institute of Pathology, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, Aachen, Germany
Gastroenterology 133:587-98. 2007..The aim of the present study was to examine underlying molecular mechanisms of the cell death at the villus tip... - Granulocyte colony-stimulating factor and acute myocardial infarctionWolf Rüdiger Schäbitz
JAMA 296:1967-8; author reply 1968-9. 2006 - Toward a multimodal neuroprotective treatment of strokeAndreas Rogalewski
Department of Neurology, University of Muenster, Germany
Stroke 37:1129-36. 2006..Here, we review such combination approaches, and outline how this concept could be developed into future stroke treatment... - Developing granulocyte-colony stimulating factor for the treatment of stroke: current status of clinical trialsWolf Rüdiger Schäbitz
Stroke 37:1654; author reply 1655. 2006 - Reduced oxidative damage in ALS by high-dose enteral melatonin treatmentJochen H Weishaupt
Department of Neurology, Georg August University, , Germany
J Pineal Res 41:313-23. 2006..This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS... - Submucosal endoscopy: a novel approach to en bloc endoscopic mucosal resection (with videos)Stefan von Delius
2nd Medical Department, Technical University of Munich, Munich, Germany
Gastrointest Endosc 66:753-6. 2007..The submucosal layer is of eminent importance for endoscopic mucosal resection (EMR) in the GI tract... - Expression of calnexin reflects paneth cell differentiation and functionNikolaus Gassler
Department of Pathology, Heidelberg University, Mannheim, Germany
Lab Invest 82:1647-59. 2002..In conclusion, calnexin probably reflects the status of Paneth cell differentiation and function. The results do not necessarily indicate that calnexin has a function in Paneth cell proliferation...