Daniela E Aust

Summary

Country: Germany

Publications

  1. doi request reprint Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria
    Daniela E Aust
    Institute for Pathology, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany
    Virchows Arch 457:291-7. 2010
  2. pmc Germline truncating-mutations in BRCA1 and MSH6 in a patient with early onset endometrial cancer
    Karin Kast
    Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    BMC Cancer 12:531. 2012
  3. doi request reprint [Histopathology of microscopic colitis]
    D E Aust
    Institut fur Pathologie, Universitatsklinikum Carl Gustav Carus, TU Dresden, Fetscherstr 74, 01307 Dresden
    Pathologe 33:221-4. 2012
  4. ncbi request reprint What can molecular pathology offer for optimal decision making?
    D E Aust
    Institute for Pathology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
    Ann Oncol 23:x63-70. 2012
  5. doi request reprint [Nonbacterial colitides]
    D E Aust
    Institut fur Pathologie, Universitätsklinikum Carl Gustav Carus der TU Dresden, Fetscherstr 74, 01307, Dresden, Deutschland
    Pathologe 32:379-83. 2011
  6. ncbi request reprint Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma
    Daniela E Aust
    Department of Pathology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany
    Int J Cancer 115:673-7. 2005
  7. doi request reprint [WHO classification 2010 for the lower gastrointestinal tract: what is new?]
    D E Aust
    Institut fur Pathologie, Universitatsklinikum Carl Gustav Carus, TU Dresden, Fetscherstr 74, 01307, Dresden, Deutschland
    Pathologe 32:326-31. 2011
  8. doi request reprint [Polyps of the colorectum: non-neoplastic and non-hamartomatous]
    D E Aust
    Institut fur Pathologie, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Fetscherstr 74, 01309, Dresden, Deutschland
    Pathologe 32:297-302. 2011
  9. ncbi request reprint Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy
    Christiane Jakob
    Institute for Pathology, University of Technology, Dresden, Germany
    Am J Surg Pathol 30:1169-74. 2006
  10. ncbi request reprint Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemorad
    Christiane Jakob
    Institute for Pathology, University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    Am J Surg Pathol 29:1304-9. 2005

Detail Information

Publications25

  1. doi request reprint Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria
    Daniela E Aust
    Institute for Pathology, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany
    Virchows Arch 457:291-7. 2010
    ....
  2. pmc Germline truncating-mutations in BRCA1 and MSH6 in a patient with early onset endometrial cancer
    Karin Kast
    Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    BMC Cancer 12:531. 2012
    ..Carriers of both germline mutations in breast cancer genes BRCA1 or BRCA2 and in mismatch repair (MMR) genes MLH1, MSH2, MSH6 or PMS2 are very rare...
  3. doi request reprint [Histopathology of microscopic colitis]
    D E Aust
    Institut fur Pathologie, Universitatsklinikum Carl Gustav Carus, TU Dresden, Fetscherstr 74, 01307 Dresden
    Pathologe 33:221-4. 2012
    ....
  4. ncbi request reprint What can molecular pathology offer for optimal decision making?
    D E Aust
    Institute for Pathology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
    Ann Oncol 23:x63-70. 2012
    ..Biomarkers with known implications in advanced CRC will be discussed in this paper...
  5. doi request reprint [Nonbacterial colitides]
    D E Aust
    Institut fur Pathologie, Universitätsklinikum Carl Gustav Carus der TU Dresden, Fetscherstr 74, 01307, Dresden, Deutschland
    Pathologe 32:379-83. 2011
    ..This manuscript will give an overview of the spectrum of pathogenic germs, the clinical symptoms, and pathological findings of the most important infections...
  6. ncbi request reprint Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma
    Daniela E Aust
    Department of Pathology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany
    Int J Cancer 115:673-7. 2005
    ..Disruption of the Raf/MEK/ERK (MAPK) kinase pathway-either through RAS or BRAF mutation-was detected in 27% of all UC-related cancers and thus plays an important role in UC-related carcinogenesis...
  7. doi request reprint [WHO classification 2010 for the lower gastrointestinal tract: what is new?]
    D E Aust
    Institut fur Pathologie, Universitatsklinikum Carl Gustav Carus, TU Dresden, Fetscherstr 74, 01307, Dresden, Deutschland
    Pathologe 32:326-31. 2011
    ..This manuscript will give an overview of the most important changes within the new WHO classification of colorectal tumors...
  8. doi request reprint [Polyps of the colorectum: non-neoplastic and non-hamartomatous]
    D E Aust
    Institut fur Pathologie, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Fetscherstr 74, 01309, Dresden, Deutschland
    Pathologe 32:297-302. 2011
    ..The etiology, endoscopic and histological appearance of these entities and their most important differential diagnoses are discussed...
  9. ncbi request reprint Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy
    Christiane Jakob
    Institute for Pathology, University of Technology, Dresden, Germany
    Am J Surg Pathol 30:1169-74. 2006
    ..Furthermore, measurement of posttherapeutical TS-gene expression may help to identify patients at higher risk for cancer recurrence...
  10. ncbi request reprint Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemorad
    Christiane Jakob
    Institute for Pathology, University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    Am J Surg Pathol 29:1304-9. 2005
    ..However, precise results can only be achieved if staining intensity as well as staining pattern within the tumors are evaluated...
  11. pmc Predictive value of Ki67 and p53 in locally advanced rectal cancer: correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy
    Christiane Jakob
    Institute for Pathology, University of Technology, Fetscherstr 74, D 01307 Dresden, Germany
    World J Gastroenterol 14:1060-6. 2008
    ..To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen...
  12. ncbi request reprint Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor
    Jens Plaschke
    Department of Surgical Research, Dresden University of Technology, Dresden, Germany
    Eur J Hum Genet 14:561-6. 2006
    ..Our data suggest considering biallelic mutations in MMR genes for patients who develop HNPCC-associated tumors at an unusually young age of onset, even without hematological or brain malignancies...
  13. doi request reprint Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation
    Jan Stoehlmacher
    Department of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Haematology and Medical Oncology, Fetscherstr 74, 01307 Dresden, Germany
    Cancer Lett 272:221-5. 2008
    ..We assessed the impact of standardized pre-operative CT/RT and intratumoural mRNA levels and polymorphisms of the TS gene on histopathological tumour regression...
  14. pmc Lymphangiogenesis in regional lymph nodes is an independent prognostic marker in rectal cancer patients after neoadjuvant treatment
    Christiane Jakob
    Institute of Pathology, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    PLoS ONE 6:e27402. 2011
    ..Furthermore, addition of VEGF-blocking agents to standardized neoadjuvant treatment schemes might be indicated in advanced rectal cancer...
  15. ncbi request reprint Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer
    Christiane Jakob
    Institute for Pathology, University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    J Pathol 204:562-8. 2004
    ..Moreover, intra-tumoural TS- and TP-gene expression in surgical rectal specimens after neo-adjuvant chemoradiotherapy correlates significantly with histopathological tumour regression when microdissection is applied...
  16. doi request reprint Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling
    Myriam Labelle
    Institute of Pathology, University of Dresden, Dresden, Germany
    Cancer Res 68:1388-97. 2008
    ..Our findings may have important implications for the clinical application of anti-VE-cadherin strategies...
  17. doi request reprint Intestinal microvascular malformations and congenital asplenia in an adolescent possibly expanding the phenotype of Ivemark syndrome
    Christiane Würfel
    Departments of Pediatrics, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Eur J Gastroenterol Hepatol 23:1258-61. 2011
    ..We therefore envison that in times of refined diagnostic techniques the phenotype of the Ivemark syndrome might be expanded by including microvascular malformations...
  18. ncbi request reprint Ten novel MSH2 and MLH1 germline mutations in families with HNPCC
    Stefan Kruger
    Department of Surgical Research, Universitatsklinikum Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Hum Mutat 24:351-2. 2004
    ..In the tumor from the patient with the missense mutation c.122A>G [p.D41G] a normal expression of the proteins coded by MLH1 and MSH2 was noticed...
  19. ncbi request reprint Characterization of macrophage subpopulations and microvessel density in carcinomas of the gastrointestinal tract
    Denise Sickert
    Institute for Physiological Chemistry, Medical Faculty Carl Gustav Carus, University of Technology Dresden, D 01307 Dresden, Germany
    Anticancer Res 27:1693-700. 2007
    ..The role of tumor associated macrophages (TAMs) in tumor angiogenesis and inflammation and the interactions between TAMs and tumor cells as well as lymphocytes appear to be critical factors in the development and progression of cancer...
  20. pmc Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density affymetrix 10K single nucleotide polymorphism mapping array
    Marieta I Toma
    Institute for Pathology, University of Technology Dresden, D 01307 Dresden, Germany
    Neoplasia 10:634-42. 2008
    ..Genome-wide SNP array analysis not only confirmed previously described large chromosomal aberrations but also detected novel microdeletions in genes potentially involved in tumor genesis of cc-RCC...
  21. ncbi request reprint Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy
    Torsten Liersch
    Department of General Surgery, University Medical Center, Gottingen, Germany
    J Clin Oncol 24:4062-8. 2006
    ..We assessed the impact of standardized preoperative CT/RT and intratumoral TS, TP, and DPD levels on patient outcome...
  22. ncbi request reprint High resolution analysis of chromosome 18 alterations in ulcerative colitis-related colorectal cancer
    Jonathan P Terdiman
    Cancer Center, University of California San Francisco, San Francisco, CA, USA
    Cancer Genet Cytogenet 136:129-37. 2002
    ..SMAD2 was retained in four tumors having loss of SMAD4 and DCC. Loss of SMAD4 alone was seen in one tumor. The present data indicate that the loss of SMAD4 and DCC occurs in the majority of colitis-related cancers...
  23. ncbi request reprint The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis
    Daniela E Aust
    Pathologisches Institut der Ludwig Maximilians Universität, Munchen, Germany
    Cancer 94:1421-7. 2002
    ..To elucidate the role of the APC-/beta-catenin pathway in UC-related carcinogenesis, the authors identified APC and beta-catenin mutations in a set of UC-related and sporadic colorectal carcinomas...
  24. ncbi request reprint Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study
    Annegret Müller
    Department of General Surgery, University of Gottingen, Gottingen, Germany
    Int J Colorectal Dis 21:632-41. 2006
    ..Therefore, screening for MMR deficiency should not be applied routinely in adenomas with the goal to identify HNPCC patients...
  25. pmc Matrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks
    Heiko Fensterer
    Department of Internal Medicine I, University of Ulm, Ulm, Germany
    BMC Cancer 7:58. 2007
    ..Multicentric clinical studies represent an ideal source of well documented archived material for this type of analyses...