H G Augustin

Summary

Country: Germany

Publications

  1. ncbi request reprint Angiopoietins: a link between angiogenesis and inflammation
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg 79106, Germany
    Trends Immunol 27:552-8. 2006
  2. ncbi request reprint Angiogenesis: molecular mechanisms and functional interactions--2nd Kloster Seeon Meeting of the German Priority Research Grant "Angiogenesis"
    Hellmut G Augustin
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Freiburg, Germany
    Thromb Haemost 89:190-7. 2003
  3. ncbi request reprint Translating angiogenesis research into the clinic: the challenges ahead
    H G Augustin
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, D 79106 Freiburg, Germany
    Br J Radiol 76:S3-10. 2003
  4. ncbi request reprint Judah Folkman
    Hellmut G Augustin
    DKFZ and University of Heidelberg
    Thromb Haemost 99:250. 2008
  5. doi request reprint Spheroid-based engineering of a human vasculature in mice
    Abdullah Alajati
    Joint Research Division Vascular Biology of the Medical Faculty Mannheim CBTM, University of Heidelberg, Ludolph Krehl Str 11 14, D 68167 Mannheim, Germany
    Nat Methods 5:439-45. 2008
  6. pmc Angiopoietin-2 is critical for cytokine-induced vascular leakage
    Andrew V Benest
    Division of Vascular Oncology and Metastasis, German Cancer Research Center DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 8:e70459. 2013
  7. doi request reprint Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    Hellmut G Augustin
    Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, University of Heidelberg, and German Cancer Research Center Heidelberg DKFZ ZMBH Alliance, Germany
    Nat Rev Mol Cell Biol 10:165-77. 2009
  8. ncbi request reprint EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis
    Hellmut G Augustin
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Str 117, 79106, Freiburg, Germany
    Cell Tissue Res 314:25-31. 2003
  9. ncbi request reprint [Angiogenesis research--quo vadis?]
    H G Augustin
    Abt für Vaskläre Biologie und Angiogeneseforshcung, Klinik für Tumorbiologie Freiburg
    Ophthalmologe 100:104-10. 2003
  10. ncbi request reprint Quantitating angiogenesis and assessing the causal relationship between angiogenesis and tumorigenesis: problems and progress
    H G Augustin
    Dept of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, Germany
    Ann Hematol 81:S68. 2002

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Angiopoietins: a link between angiogenesis and inflammation
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg 79106, Germany
    Trends Immunol 27:552-8. 2006
    ..This suggests that Ang-2 is the dynamic regulator of the Ang-Tie2 axis, thereby functioning as a built-in switch controlling the transition of the resting quiescent endothelium towards the activated responsive endothelium...
  2. ncbi request reprint Angiogenesis: molecular mechanisms and functional interactions--2nd Kloster Seeon Meeting of the German Priority Research Grant "Angiogenesis"
    Hellmut G Augustin
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Freiburg, Germany
    Thromb Haemost 89:190-7. 2003
    ..This report summarizes the key findings reported during the platform presentations of the meeting...
  3. ncbi request reprint Translating angiogenesis research into the clinic: the challenges ahead
    H G Augustin
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, D 79106 Freiburg, Germany
    Br J Radiol 76:S3-10. 2003
    ....
  4. ncbi request reprint Judah Folkman
    Hellmut G Augustin
    DKFZ and University of Heidelberg
    Thromb Haemost 99:250. 2008
  5. doi request reprint Spheroid-based engineering of a human vasculature in mice
    Abdullah Alajati
    Joint Research Division Vascular Biology of the Medical Faculty Mannheim CBTM, University of Heidelberg, Ludolph Krehl Str 11 14, D 68167 Mannheim, Germany
    Nat Methods 5:439-45. 2008
    ..Modifications make it possible to study human lymphangiogenic processes in vivo. EC spheroids can also be coimplanted with other cell types for tissue engineering purposes...
  6. pmc Angiopoietin-2 is critical for cytokine-induced vascular leakage
    Andrew V Benest
    Division of Vascular Oncology and Metastasis, German Cancer Research Center DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 8:e70459. 2013
    ..Additionally, recombinant human Ang-2 (rhAng-2) alone was unable to induce vascular leakage. In summary, we report here in a definite genetic setting that Ang-2 is critical for multiple vascular permeability-inducing cytokines. ..
  7. doi request reprint Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    Hellmut G Augustin
    Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, University of Heidelberg, and German Cancer Research Center Heidelberg DKFZ ZMBH Alliance, Germany
    Nat Rev Mol Cell Biol 10:165-77. 2009
    ..The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands provide unique insights into the functions of this vascular signalling system...
  8. ncbi request reprint EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis
    Hellmut G Augustin
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Str 117, 79106, Freiburg, Germany
    Cell Tissue Res 314:25-31. 2003
    ....
  9. ncbi request reprint [Angiogenesis research--quo vadis?]
    H G Augustin
    Abt für Vaskläre Biologie und Angiogeneseforshcung, Klinik für Tumorbiologie Freiburg
    Ophthalmologe 100:104-10. 2003
    ..The present article provides an overview of the field of angiogenesis research and summarizes ongoing efforts aimed at developing angiomanipulatory therapies...
  10. ncbi request reprint Quantitating angiogenesis and assessing the causal relationship between angiogenesis and tumorigenesis: problems and progress
    H G Augustin
    Dept of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, Germany
    Ann Hematol 81:S68. 2002
  11. ncbi request reprint Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering
    A Wenger
    Department of Plastic and Hand Surgery, University of Freiburg Medical Center, Freiburg, Germany
    Tissue Eng 10:1536-47. 2004
    ....
  12. doi request reprint Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin
    Simone Kutschera
    Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg, Im Neuenheimer Feld 280, Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 31:151-9. 2011
    ..To characterize the role of a vascular-expressed class 3 semaphorin (semaphorin 3G [Sema3G])...
  13. ncbi request reprint Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2
    Christine Piossek
    Cytos Biotechnology AG, Zurich, Switzwerland
    Thromb Haemost 90:501-10. 2003
    ..The rational design of potent and stable anti-angiogenic peptide inhibitors from their parent receptors provides a feasible route to develop novel leads for anti-angiogenic medicines...
  14. ncbi request reprint Endothelial ephrinB2 is controlled by microenvironmental determinants and associates context-dependently with CD31
    Thomas Korff
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, Germany
    Arterioscler Thromb Vasc Biol 26:468-74. 2006
    ..This study was aimed at identifying determinants of endothelial cell ephrinB2 expression...
  15. ncbi request reprint Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking
    Dennis Pfaff
    Department of Vascular Oncology and Metastasis, University of Heidelberg, Germany
    J Leukoc Biol 80:719-26. 2006
    ..This may also broaden the scope of vascular RTK-targeted therapies...
  16. pmc Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells
    Sven Christian
    Department of Vascular Oncology and Metastatis, University of Heidelberg, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Am J Pathol 172:486-94. 2008
    ....
  17. doi request reprint Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway
    Diana Klein
    Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Hepatology 47:1018-31. 2008
    ..Inhibition of Wnt signaling down-regulated VEGFR-2 messenger RNA and protein. Wnt2 siRNA knock-down confirmed Wnt2 specificity of VEGFR-2 regulation in HSECs...
  18. ncbi request reprint Eph receptor and ephrin ligand-mediated interactions during angiogenesis and tumor progression
    Melanie Heroult
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center Freiburg, Breisacher Str 117, D 79106 Freiburg, Germany
    Exp Cell Res 312:642-50. 2006
    ....
  19. ncbi request reprint Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function
    Tanja Veikkola
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, 00014 University of Helsinki, Finland
    FASEB J 17:2006-13. 2003
    ..Collectively, these data show intrinsic cell-specific differences of BEC and LEC responses to VEGFs and identify a pericellular regulatory mechanism for VEGFR-3 down-regulation in endothelial cells...
  20. ncbi request reprint Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells
    Tim Füller
    Department of Vascular Biology and Angiogenesis Research, Institute of Molecular Oncology, Tumor Biology Center, Breisacher Strasse 117, 79106 Freiburg, Germany
    J Cell Sci 116:2461-70. 2003
    ..Taken together, these data identify distinct propulsive and repulsive effector functions of endothelial ephrinB2 and EphB4 that mediate spatial positional signals during angiogenesis and vessel assembly...
  21. pmc The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms
    Athanasios N Athanasopoulos
    Experimental Immunology Branch, NCI, NIH, Center Dr, Rm 4B17, Bethesda, MD 20892, USA
    Blood 107:2720-7. 2006
    ..Eap may also serve as a lead compound for new anti-inflammatory and antiangiogenic therapies in several pathologies...
  22. ncbi request reprint Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies
    Thomas Korff
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, D 79106 Freiburg, Germany
    Exp Cell Res 297:415-23. 2004
    ....
  23. pmc Inhibition of tumor growth and angiogenesis by soluble EphB4
    Georg Martiny-Baron
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, University of Freiburg, Freiburg D 79106, Germany
    Neoplasia 6:248-57. 2004
    ..Taken together, the data identify dual effects of sEphB4 on the tumor and the vascular compartment that collectively inhibit tumor growth...
  24. doi request reprint Role of ephrinB2 expression in endothelial cells during arteriogenesis: impact on smooth muscle cell migration and monocyte recruitment
    Thomas Korff
    Institute of Physiology and Pathophysiology, Division of Cardiovascular Physiology, University of Heidelberg, Heidelberg, Germany
    Blood 112:73-81. 2008
    ..This stretch-induced ephrinB2 expression may be pivotal for arteriogenesis as it limits smooth muscle cell migration within defined borders and controls monocyte extravasation...
  25. doi request reprint Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
    Keizo Kanasaki
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 453:1117-21. 2008
    ....
  26. doi request reprint Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2 BP/90K
    Renate Becker
    Joint Research Division Vascular Biology of the Medical Faculty Mannheim, University of Heidelberg and the German Cancer Research Center, Heidelberg, Germany
    FASEB J 22:3059-67. 2008
    ..Taken together, the experiments identify a novel repulsive interaction between endosialin on stromal fibroblasts and Mac-2 BP/90K on tumor cells...
  27. pmc Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1
    Claudia Prahst
    Joint Research Division Vascular Biology of the Medical Faculty Mannheim CBTM, University of Heidelberg
    J Biol Chem 283:25110-4. 2008
    ..Taken together, the experiments have identified a novel mechanism of NP-1 interaction with VEGFR-2, which involves the cytoplasmic domain of NP-1...
  28. ncbi request reprint The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany
    Blood 103:4150-6. 2004
    ....
  29. ncbi request reprint Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements
    Anja Hegen
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, D 79106 Freiburg, Germany
    Arterioscler Thromb Vasc Biol 24:1803-9. 2004
    ..To examine the transcriptional regulation of Ang-2, we studied the Ang-2 promoter in endothelial cells and nonendothelial cells...
  30. ncbi request reprint Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model
    Andreas Stahl
    Department of Plastic Surgery, University of Freiburg Medical Center, D 79106 Freiburg, Germany
    Biochem Biophys Res Commun 322:684-92. 2004
    ..Collectively, the data demonstrate complex bi-directional gene regulation mechanisms between EC and OB that are likely to play a critical role during OB differentiation and in controlling the properties of angiogenic EC...
  31. ncbi request reprint Flow-dependent regulation of angiopoietin-2
    Winfried Goettsch
    Department of Vascular Endothelium and Microcirculation, University of Technology, Dresden, Germany
    J Cell Physiol 214:491-503. 2008
    ..These data suggest a new mechanism of flow-dependent regulation of vessel stability and differentiation...
  32. ncbi request reprint The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis
    Tanju G Nacak
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center Freiburg, 79106 Freiburg, Germany
    J Biol Chem 281:5065-71. 2006
    ..Taken together, our experiments identify LZTR-1 as the first BTB-kelch protein that exclusively localizes to the Golgi network, and the binding of LZTR-1 to the Golgi complex is mediated by its second BTB/POZ domain...
  33. pmc Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture
    Susanna M Müller
    Department of Immunology, University of Ulm, D 89081 Ulm, Germany
    Proc Natl Acad Sci U S A 102:10587-92. 2005
    ..These experiments provide insights into Foxn1-dependent and Foxn1-independent stromal cell development and demonstrate the value of this chimeric approach to analyzing gene function in thymus epithelium...
  34. ncbi request reprint Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg 79106, Germany
    Nat Med 12:235-9. 2006
    ..Ang-2 thereby acts as a switch of vascular responsiveness exerting a permissive role for the activities of proinflammatory cytokines...
  35. ncbi request reprint Down-regulation of endothelial ephrinB2 expression by laminar shear stress
    Winfried Goettsch
    Department of Vascular Endothelium and Microcirculation, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Dresden, Germany
    Endothelium 11:259-65. 2004
    ..The down-regulation of ephrinB2 in response to laminar shear stress may contribute to the differentiation of endothelial cells into a nonactivated phenotype...
  36. ncbi request reprint Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors
    Jelena Krneta
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center Freiburg, Freiburg, Germany
    Cancer Res 66:5686-95. 2006
    ....
  37. ncbi request reprint The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism
    Marion Scharpfenecker
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, 79106 Freiburg, Germany
    J Cell Sci 118:771-80. 2005
    ....
  38. ncbi request reprint The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis
    Tanju G Nacak
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg, Germany
    Circ Res 100:1155-63. 2007
    ..We conclude that the BTB-kelch protein KLEIP is a novel regulator of endothelial function during angiogenesis that controls the VEGF-induced activation of Rho GTPases...
  39. ncbi request reprint Semaphorin SEMA3F affects multiple signaling pathways in lung cancer cells
    Vincent A Potiron
    Division of Medical Oncology, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Cancer Res 67:8708-15. 2007
    ..These changes would be anticipated to contribute significantly to the observed antitumor activity of SEMA3F...
  40. pmc The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Strasse 117, D 79106 Freiburg, Germany
    Am J Pathol 168:1045-53. 2006
    ..The data warrant further exploration of CD34 in tumor-associated LECs as a prognostic tumor marker...