G Auerbach

Summary

Country: Germany

Publications

  1. ncbi Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization
    G Auerbach
    Max Planck Institut für Biochemie Abt Strukturforschung, 82152, Martinsried, Germany
    Structure 6:769-81. 1998
  2. ncbi Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability
    G Auerbach
    Max Planck Institut fur Biochemie, Abt Strukturforschung, 82152, Martinsried, Germany
    Structure 5:1475-83. 1997
  3. pmc The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters
    G Auerbach
    Max Planck Institut fur Biochemie, Abt Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 16:7219-30. 1997
  4. pmc Zinc plays a key role in human and bacterial GTP cyclohydrolase I
    G Auerbach
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 97:13567-72. 2000
  5. ncbi Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP
    G Bader
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, Martinsried, D 82152, Germany
    J Mol Biol 312:1051-7. 2001
  6. pmc Active site topology and reaction mechanism of GTP cyclohydrolase I
    H Nar
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Proc Natl Acad Sci U S A 92:12120-5. 1995
  7. ncbi Crystallographic analysis of phosphoglycerate kinase from the hyperthermophilic bacterium Thermotoga maritima
    G Auerbach
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Biol Chem 378:327-9. 1997
  8. ncbi Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase
    T Ploom
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, Martinsried, 82152, Germany
    J Mol Biol 286:851-60. 1999
  9. ncbi The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase
    G Auerbach
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Biol Chem 378:185-92. 1997
  10. pmc Tetrahydrobiopterin biosynthesis, regeneration and functions
    B Thony
    Division of Clinical Chemistry, University Children s Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochem J 347:1-16. 2000

Collaborators

Detail Information

Publications13

  1. ncbi Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization
    G Auerbach
    Max Planck Institut für Biochemie Abt Strukturforschung, 82152, Martinsried, Germany
    Structure 6:769-81. 1998
    ..It was hoped that the structure of TmLDH would serve as a model system to reveal strategies of protein stabilization at temperatures near the boiling point of water...
  2. ncbi Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability
    G Auerbach
    Max Planck Institut fur Biochemie, Abt Strukturforschung, 82152, Martinsried, Germany
    Structure 5:1475-83. 1997
    ..It adds to a series of four known crystal structures of PGKs from mesophilic via moderately thermophilic to a hyperthermophilic organism, allowing a detailed analysis of possible structural determinants of thermostability...
  3. pmc The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters
    G Auerbach
    Max Planck Institut fur Biochemie, Abt Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 16:7219-30. 1997
    ..The complex structure with N-acetyl serotonin suggests the possibility for a highly specific feedback regulatory mechanism between the formation of indoleamines and pteridines in vivo...
  4. pmc Zinc plays a key role in human and bacterial GTP cyclohydrolase I
    G Auerbach
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 97:13567-72. 2000
    ..It may also be involved in the hydrolytic release of formate from the intermediate, 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-triphosphate, and in the consecutive Amadori rearrangement of the ribosyl moiety...
  5. ncbi Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP
    G Bader
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, Martinsried, D 82152, Germany
    J Mol Biol 312:1051-7. 2001
    ..Kinetic investigations of human GTP cyclohydrolase I in complex with rat and human GFRP showed similar regulatory effects of both GFRP proteins...
  6. pmc Active site topology and reaction mechanism of GTP cyclohydrolase I
    H Nar
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Proc Natl Acad Sci U S A 92:12120-5. 1995
    ..The gamma-phosphate of GTP may be involved in the subsequent Amadori rearrangement of the carbohydrate side chain by activating the hydroxyl group of Ser-135...
  7. ncbi Crystallographic analysis of phosphoglycerate kinase from the hyperthermophilic bacterium Thermotoga maritima
    G Auerbach
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Biol Chem 378:327-9. 1997
    ....
  8. ncbi Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase
    T Ploom
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, Martinsried, 82152, Germany
    J Mol Biol 286:851-60. 1999
    ..Kinetic studies with dihydroneopterin monophosphate reveal that the triphosphate moiety of the substrate is necessary for enzyme specifity...
  9. ncbi The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase
    G Auerbach
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Biol Chem 378:185-92. 1997
    ..Here we review the structural and mechanistic information on the biosynthetic pathway from GTP to BH4 on the basis of the recently determined crystal structures of CYH and PTPS...
  10. pmc Tetrahydrobiopterin biosynthesis, regeneration and functions
    B Thony
    Division of Clinical Chemistry, University Children s Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochem J 347:1-16. 2000
    ..Furthermore, several neurological diseases, including Dopa-responsive dystonia, but also Alzheimer's disease, Parkinson's disease, autism and depression, have been suggested to be a consequence of restricted cofactor availability...
  11. ncbi The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability
    T Dams
    Institut fur Biophysik und Physikalische Biochemie, Regensburg, 93040, Germany
    J Mol Biol 297:659-72. 2000
    ..The active-site loop, which is known to play an important role in catalysis in mesophilic dihydrofolate reductase molecules, is rearranged, participating in the association of the subunits; it no longer participates in catalysis...
  12. pmc Extremely thermostable L(+)-lactate dehydrogenase from Thermotoga maritima: cloning, characterization, and crystallization of the recombinant enzyme in its tetrameric and octameric state
    R Ostendorp
    Institute of Biophysics and Physical Biochemistry, University of Regensburg, Germany
    Protein Sci 5:862-73. 1996
    ..Both the high optimal temperature and the pH optimum of the catalytic activity correspond to the growth conditions of T. maritima in its natural habitat...
  13. ncbi Homo-dimeric recombinant dihydrofolate reductase from Thermotoga maritima shows extreme intrinsic stability
    T Dams
    Institut fur Biophysik und Physikalische Biochemie, Universitat Regensburg, Germany
    Biol Chem 379:367-71. 1998
    ..The apoenzyme was crystallized and a data set was collected to a resolution of about 2 A...