Michael J Atkinson

Summary

Country: Germany

Publications

  1. doi request reprint Radiation treatment effects on the proteome of the tumour microenvironment
    Michael J Atkinson
    Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Institute of Radiation Biology, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Germany
    Adv Exp Med Biol 990:49-60. 2013
  2. pmc MiRNA expression patterns predict survival in glioblastoma
    Maximilian Niyazi
    Department of Radiation Oncology, Ludwig Maximilians University Munich, Marchioninistr, 15, 81377 Munich, Germany
    Radiat Oncol 6:153. 2011
  3. pmc Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors
    Sara Molatore
    Institute of Pathology, Helmholtz Zentrum Munchen, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Mol Cancer 9:116. 2010
  4. ncbi request reprint Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study
    Mayur V Bakshi
    Institute of Radiation Biology, German Research Center for Environmental Health, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Radiat Environ Biophys 52:451-61. 2013
  5. doi request reprint Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation
    Ramesh Yentrapalli
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    Proteomics 13:1096-107. 2013
  6. pmc The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation
    Ramesh Yentrapalli
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    PLoS ONE 8:e70024. 2013
  7. doi request reprint Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation
    Zarko Barjaktarovic
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Radiat Environ Biophys 52:87-98. 2013
  8. doi request reprint PPAR alpha: a novel radiation target in locally exposed Mus musculus heart revealed by quantitative proteomics
    Omid Azimzadeh
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    J Proteome Res 12:2700-14. 2013
  9. pmc Radiation resistance due to high expression of miR-21 and G2/M checkpoint arrest in breast cancer cells
    Natasa Anastasov
    Institute of Radiation Biology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Muenchen, Germany
    Radiat Oncol 7:206. 2012
  10. doi request reprint Rb1 haploinsufficiency promotes telomere attrition and radiation-induced genomic instability
    Iria Gonzalez-Vasconcellos
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Cancer Res 73:4247-55. 2013

Collaborators

Detail Information

Publications21

  1. doi request reprint Radiation treatment effects on the proteome of the tumour microenvironment
    Michael J Atkinson
    Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Institute of Radiation Biology, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Germany
    Adv Exp Med Biol 990:49-60. 2013
    ..Hopefully this will lead to the development of new therapeutic strategies to prevent long-term health implications of radiation exposure...
  2. pmc MiRNA expression patterns predict survival in glioblastoma
    Maximilian Niyazi
    Department of Radiation Oncology, Ludwig Maximilians University Munich, Marchioninistr, 15, 81377 Munich, Germany
    Radiat Oncol 6:153. 2011
    ..In order to define new prognostic subgroups in patients with glioblastoma a miRNA screen (> 1000 miRNAs) from paraffin tissues followed by a bio-mathematical analysis was performed...
  3. pmc Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors
    Sara Molatore
    Institute of Pathology, Helmholtz Zentrum Munchen, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Mol Cancer 9:116. 2010
    ....
  4. ncbi request reprint Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study
    Mayur V Bakshi
    Institute of Radiation Biology, German Research Center for Environmental Health, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Radiat Environ Biophys 52:451-61. 2013
    ..It will contribute to the understanding of the long-term consequences of radiation-induced injury and developmental alterations in the neonatal heart. ..
  5. doi request reprint Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation
    Ramesh Yentrapalli
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    Proteomics 13:1096-107. 2013
    ..This study contributes to the understanding of the increased risk of cardiovascular diseases seen in populations exposed to chronic low-dose irradiation...
  6. pmc The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation
    Ramesh Yentrapalli
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    PLoS ONE 8:e70024. 2013
    ..We postulate that a similar endothelial aging may contribute to the increased rate of CVD seen in populations chronically exposed to low-dose-rate radiation. ..
  7. doi request reprint Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation
    Zarko Barjaktarovic
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Radiat Environ Biophys 52:87-98. 2013
    ..The data presented here may facilitate the discovery of low-dose biomarkers of radiation-induced cardiovascular damage...
  8. doi request reprint PPAR alpha: a novel radiation target in locally exposed Mus musculus heart revealed by quantitative proteomics
    Omid Azimzadeh
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    J Proteome Res 12:2700-14. 2013
    ..This study suggests that persistent alteration of cardiac metabolism due to impaired PPAR alpha activity contributes to the heart pathology after radiation...
  9. pmc Radiation resistance due to high expression of miR-21 and G2/M checkpoint arrest in breast cancer cells
    Natasa Anastasov
    Institute of Radiation Biology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Muenchen, Germany
    Radiat Oncol 7:206. 2012
    ..We studied the regulation of cellular response to radiation treatment by miR-21-mediated modulation of cell cycle progression in breast cancer cells and analysed miR-21 expression in breast cancer tissue samples with long-term follow up...
  10. doi request reprint Rb1 haploinsufficiency promotes telomere attrition and radiation-induced genomic instability
    Iria Gonzalez-Vasconcellos
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Cancer Res 73:4247-55. 2013
    ....
  11. doi request reprint Ionising radiation induces persistent alterations in the cardiac mitochondrial function of C57BL/6 mice 40 weeks after local heart exposure
    Zarko Barjaktarovic
    Institute of Radiation Biology, German Research Center for Environmental Health, Neuherberg, Germany
    Radiother Oncol 106:404-10. 2013
    ..Radiotherapy of thoracic and chest-wall tumours increases the long-term risk of radiation-induced heart disease. The aim of this study was to investigate the long-term effect of local heart irradiation on cardiac mitochondria...
  12. pmc Cell survival following radiation exposure requires miR-525-3p mediated suppression of ARRB1 and TXN1
    Anne Kraemer
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    PLoS ONE 8:e77484. 2013
    ..Elucidation of critical radiation-regulated miRNAs and their target proteins offers a promising approach to identify new targets to increase the therapeutic effectiveness of the radiation treatment of cancer...
  13. doi request reprint Proteomics in radiation research: present status and future perspectives
    Omid Azimzadeh
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Radiat Environ Biophys 53:31-8. 2014
    ..The aim of this review is to introduce the most recent developments in the field of radiation proteomics. ..
  14. pmc Changes in circulating microRNAs after radiochemotherapy in head and neck cancer patients
    Isolde Summerer
    Research Unit Radiation Cytogenetics, Helmholtz Center Munich, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
    Radiat Oncol 8:296. 2013
    ....
  15. pmc UVA and UVB irradiation differentially regulate microRNA expression in human primary keratinocytes
    Anne Kraemer
    Institute of Radiation Biology, Helmholtz Center Munich, Neuherberg, Germany
    PLoS ONE 8:e83392. 2013
    ..This suggests that selective regulation of signaling pathways occurs in response to different UV energies. This may shed new light on miRNA-regulated carcinogenic processes involved in UV-induced skin carcinogenesis. ..
  16. doi request reprint Long-term effects of ionising radiation on the brain: cause for concern?
    Stefan J Kempf
    German Research Center for Environmental Health, Institute of Radiation Biology, Helmholtz Zentrum Munchen, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Radiat Environ Biophys 52:5-16. 2013
    ..This includes effects of oxidative stress and neuroinflammation-all fundamental players of neurodegenerative diseases...
  17. doi request reprint Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation
    Omid Azimzadeh
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    J Proteomics 75:2384-95. 2012
    ..The label-free approach enables the quantitative measurement of radiation-induced alterations in FFPE tissue and facilitates retrospective biomarker identification using clinical archives...
  18. pmc Secondary radiation-induced bone tumours demonstrate a high degree of genomic instability predictive of a poor prognosis
    Christine Rümenapp
    Institute of Radiation Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany Institute of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany Current adress Technische Universität München, Zentralinstitut für Medizintechnik IMETUM, Garching, Germany
    Curr Genomics 13:433-7. 2012
    ..We speculate that the high degree of genomic instability found in these tumours causes the poor prognosis irrespective of the initiating event...
  19. doi request reprint Proteomic analysis by SILAC and 2D-DIGE reveals radiation-induced endothelial response: four key pathways
    Arundhathi Sriharshan
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Research Unit of Radiation Cytogenetics, Neuherberg, Germany
    J Proteomics 75:2319-30. 2012
    ..We suggest that these alterations facilitate the repair processes needed to overcome the stress caused by irradiation and are indicative of the vascular damage leading to radiation-induced cardio- and cerebrovascular impairment...
  20. doi request reprint Poloxamer synperonic F108 improves cellular transduction with lentiviral vectors
    Ines Höfig
    Institute of Radiation Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    J Gene Med 14:549-60. 2012
    ..In the present study, we focus on the evaluation of two chemical classes with respect to their ability to increase lentiviral transduction without cytotoxicity...
  21. ncbi request reprint Differences in the susceptibility to iodine¹³¹-induced thyroid tumours amongst inbred mouse strains
    Claudia Dalke
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany
    J Radiat Res 53:343-52. 2012
    ..We conclude that genetic background, in particular the JF1 genotype, confer differences in susceptibility to the carcinogenic effects of radioiodine on the thyroid...