Gerd Assmann

Summary

Country: Germany

Publications

  1. ncbi request reprint Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: results of a nested case-control analysis of the Prospective Cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Leibniz Institut für Arterioskleroseforschung an der Universität Münster, Domagkstrasse 3, 48149 Munster, Germany
    Nutr Metab Cardiovasc Dis 16:13-21. 2006
  2. ncbi request reprint HDL cholesterol and protective factors in atherosclerosis
    Gerd Assmann
    Institute of Clinical Chemistry and Laboratory Medicine, Central Laboratory, Westphalian Wilhelms University, Munster, Germany
    Circulation 109:III8-14. 2004
  3. ncbi request reprint Cardiovascular risk assessment in metabolic syndrome: view from PROCAM
    Gerd Assmann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfäliche Wilhelms Universität, Muenster, Germany
    Endocrinol Metab Clin North Am 33:377-92, table of contents. 2004
  4. ncbi request reprint Implications of emerging risk factors for therapeutic intervention
    Gerd Assmann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Munster, Germany
    Nutr Metab Cardiovasc Dis 15:373-81. 2005
  5. ncbi request reprint Atheroprotective effects of high-density lipoproteins
    Gerd Assmann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Annu Rev Med 54:321-41. 2003
  6. ncbi request reprint Importance of arterial pulse pressure as a predictor of coronary heart disease risk in PROCAM
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Munster, Germany
    Eur Heart J 26:2120-6. 2005
  7. ncbi request reprint Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Germany
    Circulation 105:310-5. 2002
  8. ncbi request reprint Assessing risk of myocardial infarction and stroke: new data from the Prospective Cardiovascular Münster (PROCAM) study
    G Assmann
    Leibniz Institute of Arteriosclerosis Research, University of Munster, Germany
    Eur J Clin Invest 37:925-32. 2007
  9. ncbi request reprint Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia
    Gerd Assmann
    Leibniz Institute of Arteriosclerosis Research at the University of Münster, and Institute for Clinical Chemistry and Laboratory Medicine, University Clinics Münster, Munster, Germany
    Curr Med Res Opin 24:249-59. 2008
  10. doi request reprint Cardiovascular risk assessment in the metabolic syndrome: results from the Prospective Cardiovascular Munster (PROCAM) Study
    G Assmann
    Leibniz Institute of Arteriosclerosis Research, University of Munster, Munster, Germany
    Int J Obes (Lond) 32:S11-6. 2008

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: results of a nested case-control analysis of the Prospective Cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Leibniz Institut für Arterioskleroseforschung an der Universität Münster, Domagkstrasse 3, 48149 Munster, Germany
    Nutr Metab Cardiovasc Dis 16:13-21. 2006
    ..This study was conducted to evaluate if the modest sitosterol elevations seen in the general population are also associated with the occurrence of coronary events...
  2. ncbi request reprint HDL cholesterol and protective factors in atherosclerosis
    Gerd Assmann
    Institute of Clinical Chemistry and Laboratory Medicine, Central Laboratory, Westphalian Wilhelms University, Munster, Germany
    Circulation 109:III8-14. 2004
    ..However, HDL-C should be considered as part of the patient's overall profile of established risk factors in determining treatment strategies...
  3. ncbi request reprint Cardiovascular risk assessment in metabolic syndrome: view from PROCAM
    Gerd Assmann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfäliche Wilhelms Universität, Muenster, Germany
    Endocrinol Metab Clin North Am 33:377-92, table of contents. 2004
    ..This article reviews the progress that has been made toward reaching these goals based on the results of the PROspective Cardiovascular Münster (PROCAM) study...
  4. ncbi request reprint Implications of emerging risk factors for therapeutic intervention
    Gerd Assmann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Munster, Germany
    Nutr Metab Cardiovasc Dis 15:373-81. 2005
    ....
  5. ncbi request reprint Atheroprotective effects of high-density lipoproteins
    Gerd Assmann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Annu Rev Med 54:321-41. 2003
    ..This review summarizes current views on the molecular mechanism underlying these atheroprotective effects of HDL...
  6. ncbi request reprint Importance of arterial pulse pressure as a predictor of coronary heart disease risk in PROCAM
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Munster, Germany
    Eur Heart J 26:2120-6. 2005
    ..To investigate pulse pressure (PP) as an independent predictor of coronary heart disease (CHD) risk...
  7. ncbi request reprint Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Germany
    Circulation 105:310-5. 2002
    ..Although several scoring schemes have been suggested to calculate this profile, many omit information on important variables such as family history of coronary heart disease or LDL cholesterol...
  8. ncbi request reprint Assessing risk of myocardial infarction and stroke: new data from the Prospective Cardiovascular Münster (PROCAM) study
    G Assmann
    Leibniz Institute of Arteriosclerosis Research, University of Munster, Germany
    Eur J Clin Invest 37:925-32. 2007
    ....
  9. ncbi request reprint Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia
    Gerd Assmann
    Leibniz Institute of Arteriosclerosis Research at the University of Münster, and Institute for Clinical Chemistry and Laboratory Medicine, University Clinics Münster, Munster, Germany
    Curr Med Res Opin 24:249-59. 2008
    ..However, there is a paucity of published data concerning the effects of combined treatment using HMG-CoA reductase inhibitors (statins) and a cholesterol absorption inhibitor (ezetimibe) on these parameters...
  10. doi request reprint Cardiovascular risk assessment in the metabolic syndrome: results from the Prospective Cardiovascular Munster (PROCAM) Study
    G Assmann
    Leibniz Institute of Arteriosclerosis Research, University of Munster, Munster, Germany
    Int J Obes (Lond) 32:S11-6. 2008
    ....
  11. ncbi request reprint [Assessment of cardiovascular risk--PROCAM and new algorithms]
    G Assmann
    Leibniz Institut für Arterioskleroseforschung an der Universität Münster, Domagkstrasse 3, 48149 Munster
    Biomed Tech (Berl) 50:227-32. 2005
    ..This inference must however be substantiated by further studies before it becomes part of the general recommendations for treatment...
  12. ncbi request reprint Beyond statin therapy: why we need new thinking
    Gerd Assmann
    Institute of Clinical Chemistry and Laboratory Medicine, Westphalian Wilhelms University, Muenster, Germany
    Curr Med Res Opin 21:S3-8. 2005
    ..Lp(a) has not been specifically tested as a target for intervention, but it is included in the new guidelines where it is regarded as an important modifier of global risk...
  13. ncbi request reprint Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Lipid Res 47:794-803. 2006
    ..We conclude that ABCA1 transduces signals from apoA-I by complexing and activating Cdc42 and downstream kinases and, therefore, acts as a full apoA-I receptor...
  14. ncbi request reprint Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol
    Thomas Engel
    Leibniz Institute for Arteriosclerosis Research, Westphalian Wilhelms University, 48149 Muenster, Germany
    FEBS Lett 581:1673-80. 2007
    ..Our study points to detoxification as one of potential cellular functions of ABCG1. We assume that ABCG1 protects against 7beta-HC-induced cell death, an important role in prevention of neurodegenerative and cardiovascular disease...
  15. ncbi request reprint Cholesterol absorption inhibitor Ezetimibe blocks uptake of oxidized LDL in human macrophages
    Udo Seedorf
    Institute for Arteriosclerosis Research, Central Laboratory, Westphalian Wilhelms University Münster, Germany
    Biochem Biophys Res Commun 320:1337-41. 2004
    ....
  16. ncbi request reprint The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women
    Mario Kratz
    Institute of Arteriosclerosis Research, University of Muenster, Domagkstrasse 3, 48149 Muenster, Germany
    J Clin Endocrinol Metab 87:5008-14. 2002
    ..Thus, it is proposed that serum leptin levels were affected by the high amount of alpha-linolenic acid in rapeseed oil. However, questions remain as to why this diet differently affected serum leptin in men and women...
  17. ncbi request reprint Type 2 diabetes mellitus and risk of coronary heart disease: results of the 10-year follow-up of the PROCAM study
    Anette E Buyken
    Leibniz Institute of Arteriosclerosis Research at the University of Münster, Germany
    Eur J Cardiovasc Prev Rehabil 14:230-6. 2007
    ..We examined if this holds true for men in the Prospective Cardiovascular Münster Study (PROCAM)...
  18. ncbi request reprint Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Biochem Biophys Res Commun 340:751-7. 2006
    ..We conclude that activation of p38MAPK is required for the inhibitory effect of LDL on Na+/H+ antiport and thereby for LDL-dependent sensitization in human platelets...
  19. ncbi request reprint Relationship between phytosterol levels and components of the metabolic syndrome in the PROCAM study
    Gerd Assmann
    Leibniz Institute of Arteriosclerosis Research, University of Munster, Munster, Germany
    Eur J Cardiovasc Prev Rehabil 14:208-14. 2007
    ..Our aim was to determine if the indices of cholesterol synthesis and absorption show a graded relationship with severity of metabolic syndrome...
  20. ncbi request reprint ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export
    Thomas Engel
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Domagkstr 3, D 48149 Munster, Germany
    FEBS Lett 566:241-6. 2004
    ..This data is consistent with a model in which ARL7 is involved in transport between a perinuclear compartment and the plasma membrane apparently linked to the ABCA1-mediated cholesterol secretion pathway...
  21. ncbi request reprint Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Biochemistry 39:15199-207. 2000
    ..Apo A-I stimulates phosphatidylcholine breakdown and thereby facilitates cholesterol efflux, whereas LSF and SPC trigger PI-PLC activation and thereby stimulate cell proliferation...
  22. ncbi request reprint Associations of HDL phospholipids and paraoxonase activity with coronary heart disease in postmenopausal women
    M J Horter
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Acta Physiol Scand 176:123-30. 2002
    ..As HDL-SPM was previously shown to correlate with cholesterol efflux capacity of plasma, we conclude that reduced cholesterol efflux capacity is an important factor accounting for the inverse association between HDL-cholesterol and CHD...
  23. ncbi request reprint Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease
    Frank Fischer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Clin Endocrinol (Oxf) 61:595-602. 2004
    ..IGFs and their binding proteins (IGFBPs) are produced both systemically and locally by cells of the cardiovascular system. As growth promoters, they may play a role in atherosclerosis...
  24. ncbi request reprint Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, D 48129 Munster, Germany
    J Biol Chem 278:53055-62. 2003
    ..These results for the first time demonstrate activation of Rho family G proteins and stress kinases by apoA-I and implicate the involvement of Cdc42 and JNK in the apoA-I-induced cholesterol efflux...
  25. ncbi request reprint Cloning, expression and sequences of mouse sterol-carrier protein-x-encoding cDNAs and a related pseudogene
    U Seedorf
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Munster, Germany
    Gene 123:165-72. 1993
    ..Therefore, our results indicate that at least some of the multiple restriction fragments which are detected by Southern hybridization analyses with SCP-x cDNA-derived probes can be explained by cross-hybridization with a pseudogene...
  26. ncbi request reprint Structure-activity studies of human sterol carrier protein 2
    U Seedorf
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Munster, Germany
    J Biol Chem 269:2613-8. 1994
    ..Circular dichroism results showed that Leu20 and Asp70 may serve to stabilize the overall fold, whereas residue 104 appears to play a role in the specific lipid binding and/or transfer activity of SCP2...
  27. ncbi request reprint Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease)
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, D 48129 Munster, Germany
    J Biol Chem 279:34032-7. 2004
    ..The impaired release of the content of dense bodies may explain the defective activation of Tangier platelets by collagen and low concentrations of thrombin, but not by ADP...
  28. ncbi request reprint Expression and functional characterization of ABCG1 splice variant ABCG1(666)
    Thomas Engel
    Leibniz Institute of Arteriosclerosis Research, Westphalian Wilhelms University, Domagkstr 3, 48149 Muenster, Germany
    FEBS Lett 580:4551-9. 2006
    ..Our results support that ABCG1(666) may in fact be the most prominent form of functional ABCG1 expressed in the human...
  29. ncbi request reprint Prediction of risk of coronary events in middle-aged men in the Prospective Cardiovascular Münster Study (PROCAM) using neural networks
    Reinhard Voss
    Institute of Clinical Chemistry and Laboratory Medicine, Institute of Arteriosclerosis Research, University of Munster, Germany
    Int J Epidemiol 31:1253-62; discussion 1262-64. 2002
    ....
  30. ncbi request reprint FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Circulation 115:501-8. 2007
    ..The present study was undertaken to investigate whether modulation of S1P signaling would affect atherosclerosis in a murine model of disease...
  31. ncbi request reprint Harmonizing the definition of the metabolic syndrome: comparison of the criteria of the Adult Treatment Panel III and the International Diabetes Federation in United States American and European populations
    Gerd Assmann
    Leibniz Institute of Arteriosclerosis Research, University of Munster, Munster, Germany
    Am J Cardiol 99:541-8. 2007
    ..7%) than the IDF criteria (5.5%) had a cardiovascular event. In conclusion, although the prevalence of MS was higher when the IDF criteria were used in the German sample, the IDF criteria have lower predictive power for coronary events...
  32. ncbi request reprint A novel variant of lysosomal acid lipase (Leu336-->Pro) associated with acid lipase deficiency and cholesterol ester storage disease
    U Seedorf
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Germany
    Arterioscler Thromb Vasc Biol 15:773-8. 1995
    ....
  33. ncbi request reprint Tibolone lowers high density lipoprotein cholesterol by increasing hepatic lipase activity but does not impair cholesterol efflux
    Arnold von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Clin Endocrinol (Oxf) 58:49-58. 2003
    ..Tibolone lowers HDL-cholesterol by 20% but the clinical significance of this effect is unknown...
  34. pmc HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Clin Invest 113:569-81. 2004
    ..This mechanism may contribute to the vasoactive effect of HDL and represent a novel aspect of its antiatherogenic function...
  35. ncbi request reprint Individual serum triglyceride responses to high-fat and low-fat diets differ in men with modest and severe hypertriglyceridemia
    Birgitta Jacobs
    Institute of Arteriosclerosis Research, University of Muenster, Muenster, Germany
    J Nutr 134:1400-5. 2004
    ..5 mmol/L). However, a lower-fat diet is more suitable for some subjects with more distinctly elevated triglyceride concentrations...
  36. ncbi request reprint Gap between guidelines and practice: attainment of treatment targets in patients with primary hypercholesterolemia starting statin therapy. Results of the 4E-Registry (Efficacy Calculation and Measurement of Cardiovascular and Cerebrovascular Events Inclu
    Gerd Assmann
    Leibniz Institute of Arteriosclerosis Research at the University of Muenster, Muenster, Germany
    Eur J Cardiovasc Prev Rehabil 13:776-83. 2006
    ..The aim of this study was to determine the achievement of National Cholesterol Education Program Adult Treatment Panel III goals in patients with primary hypercholesterolemia starting statin therapy in clinical practice...
  37. ncbi request reprint Phytanic acid accumulation is associated with conduction delay and sudden cardiac death in sterol carrier protein-2/sterol carrier protein-x deficient mice
    Gerold Mönnig
    Department of Cardiology and Angiology, University Hospital Munster, Munster, Germany
    J Cardiovasc Electrophysiol 15:1310-6. 2004
    ....
  38. ncbi request reprint Dietary mono- and polyunsaturated fatty acids similarly increase plasma apolipoprotein A-IV concentrations in healthy men and women
    Mario Kratz
    Institute of Arteriosclerosis Research at the University of Münster, 48149 Munster, Germany
    J Nutr 133:1821-5. 2003
    ..In conclusion, diets rich in unsaturated fatty acids, independent of the degree of unsaturation, gender and apo A-IV genotype, increase plasma apo A-IV concentrations compared with a baseline diet rich in SFA in healthy men and women...
  39. ncbi request reprint Accumulation of cardiolipin and lysocardiolipin in fibroblasts from Tangier disease subjects
    M Fobker
    , , Germany
    FEBS Lett 500:157-62. 2001
    ..Altogether these data may indicate that the role of these phospholipids is a regulatory one rather than that of a bulk mediator of cholesterol solubilization in sterol trafficking and efflux...
  40. ncbi request reprint Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones
    G von Dehn
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Horm Metab Res 33:110-4. 2001
    ..In conclusion, the suppression of gonadotropins appears to have a moderate anti-atherogenic effect. The effect of testosterone appears to be either neutral or opposed by gonadotropins...
  41. ncbi request reprint Atheroprotective effects of high-density lipoprotein-associated lysosphingolipids
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Trends Cardiovasc Med 15:265-71. 2005
    ..In this review, we discuss the latest developments concerning the potential atheroprotective role of HDL-associated lysosphingolipids...
  42. ncbi request reprint Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1
    Yoshinari Uehara
    Institute of Clinical Chemistry and Laboratory Medicine, Central Laboratory, Westphalian Wilhelms University, Munster, Germany
    Diabetes 51:2922-8. 2002
    ..Downregulation of ABCA1 by unsaturated fatty acids and acetoacetate may contribute to low HDL cholesterol and increased cardiovascular risk of diabetic patients...
  43. ncbi request reprint Framingham risk function overestimates risk of coronary heart disease in men and women from Germany--results from the MONICA Augsburg and the PROCAM cohorts
    Hans Werner Hense
    Institute of Epidemiology and Social Medicine, University Muenster, D 48129, Muenster, Germany
    Eur Heart J 24:937-45. 2003
    ..However, differences in population risk levels compromise the external validity of these risk functions...
  44. ncbi request reprint Current understanding of the role of high-density lipoproteins in atherosclerosis and senescence
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweizer Str 33 D 48129, Munster, Germany
    Expert Rev Cardiovasc Ther 3:1071-86. 2005
    ..The purpose of this review is to summarize the novel functions of HDL that may protect from atherosclerosis and senescence...
  45. ncbi request reprint Atorvastatin therapy is associated with reduced levels of N-terminal prohormone brain natriuretic peptide and improved cardiac function in patients with heart failure
    Jörg Stypmann
    Department of Cardiology and Angiology, Leibniz Institute for Arteriosclerosis Research, University of Munster, Muster, Germany
    Clin Cardiol 31:478-81. 2008
    ..We analyzed plasma N-terminal prohormone brain natriuretic peptide (NT-proBNP) levels and cardiac function in patients with HF of various etiologies, and who were treated with or without statins...
  46. ncbi request reprint Testosterone up-regulates scavenger receptor BI and stimulates cholesterol efflux from macrophages
    Claus Langer
    Institut für Arterioskleroseforschung an der Universität Münster, Domagkstrasse 3, D 48149, Munster, Germany
    Biochem Biophys Res Commun 296:1051-7. 2002
    ..These data suggest that testosterone, despite lowering HDL cholesterol, intensifies reverse cholesterol transport and thereby exerts an anti-atherogenic rather than a pro-atherogenic effect...
  47. ncbi request reprint Electrocardiographic risk stratification in families with congenital long QT syndrome
    Gerold Mönnig
    Department of Cardiology and Angiology, Medizinische Klinik und Poliklinik C, University Hospital Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Eur Heart J 27:2074-80. 2006
    ..The QT interval in the surface ECG is one of the most often used risk stratifiers in families with congenital long QT syndrome (LQTS). The best ECG lead for clinical management of LQTS families remains unclear...
  48. ncbi request reprint The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies
    Klaus Berger
    Institute of Epidemiology and Social Medicine, University of Muenster, Domagkstr 3, Muenster 48149, Germany
    Hum Genet 121:169-78. 2007
    ..Using large sample sizes and a replication study approach, we found evidence for a role of a polymorphism in the nitric oxide synthase 3 gene in stroke onset...
  49. ncbi request reprint The mutagenically separated polymerase chain reaction is a rapid and reliable method for genotyping of the tumour necrosis factor-alpha promoter polymorphism (-308 G/A)
    Bernhard Schlüter
    Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Clin Chim Acta 320:135-8. 2002
    ..We developed a genotyping technique based on the mutagenically separated polymerase chain reaction (MS-PCR) which may be useful in the clinical risk assessment...
  50. ncbi request reprint Effect of the interleukin-6 promoter polymorphism (-174 G/C) on the incidence and outcome of sepsis
    Bernhard Schlüter
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital of Munster, Germany
    Crit Care Med 30:32-7. 2002
    ..Because IL-6 is excessively released into the circulation during sepsis and closely correlates with the clinical course, we studied whether this promoter polymorphism has an effect on the incidence and/or outcome of sepsis...
  51. ncbi request reprint The ATP binding cassette transporter A1 contributes to the secretion of interleukin 1beta from macrophages but not from monocytes
    Xiaoqin Zhou
    Institute of Arteriosclerosis Research, Domagkstrasse 3, Munster, D 48149, Germany
    Biochem Biophys Res Commun 291:598-604. 2002
    ..We conclude that IL-1beta is secreted from monocytes by an ABCA1-independent pathway and from macrophages by ABCA1-dependent and -independent pathways...
  52. ncbi request reprint The transforming growth factor-beta1 gene polymorphism (G915C) is not associated with systemic lupus erythematosus
    H Schotte
    Medizinische Klinik und Poliklinik B, Universitatsklinikum, Munster, Germany
    Lupus 12:86-92. 2003
    ..Further studies are needed to corroborate the pathogenic role of TGF-beta1 in SLE patients and to identify the precise genetic elements controlling its production...
  53. ncbi request reprint Extended haplotype analysis reveals an association of TNF polymorphisms with susceptibility to systemic lupus erythematosus beyond HLA-DR3
    H Schotte
    Department of Medicine B, Munster University Hospital, Germany
    Scand J Rheumatol 34:114-21. 2005
    ..To study the relative contribution of tumour necrosis factor (TNF) and HLA-DRB1 polymorphisms to the genetic susceptibility to systemic lupus erythematosus (SLE) via an extended haplotype analysis...
  54. pmc Interleukin 10 promoter microsatellite polymorphisms are associated with response to long term treatment with etanercept in patients with rheumatoid arthritis
    H Schotte
    Department of Medicine B, Munster University Hospital, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Ann Rheum Dis 64:575-81. 2005
    ..To analyse the association of interleukin 10 (IL10) promoter polymorphisms, which have been shown to be related to IL10 secretion capacity, with the response to long term treatment with etanercept in patients with rheumatoid arthritis (RA)...
  55. ncbi request reprint Interleukin-10 promoter microsatellite polymorphisms in systemic lupus erythematosus: association with the anti-Sm immune response
    H Schotte
    Medizinische Klinik, Universitatsklinikum Munster, Germany
    Rheumatology (Oxford) 43:1357-63. 2004
    ..We analysed the association of IL-10 promoter microsatellite polymorphisms with disease susceptibility and manifestations in German Caucasian patients with SLE...
  56. ncbi request reprint [Use of risk factors in determining individual coronary risk]
    P Cullen
    Leibniz Institut für Arterioskleroseforschung, Domagkstrasse 3, 48147 Münster
    Z Kardiol 94:IV/65-69. 2005
    ..Widespread use of this score would lead to massive over-treatment. For this reason, we cannot recommend this score for general use...
  57. ncbi request reprint Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Atherosclerosis 138:25-34. 1998
    ..Moreover, the lack of alpha-LpA-I in TD plasma together with its failure to convert exogenous apo A-I into an alpha-migrating particle provide specific tests for the diagnosis of TD...
  58. ncbi request reprint The Münster Heart Study (PROCAM): total mortality in middle-aged men is increased at low total and LDL cholesterol concentrations in smokers but not in nonsmokers
    P Cullen
    Institute of Arteriosclerosis Research, University of Munster, Germany
    Circulation 96:2128-36. 1997
    ..To investigate this question, we analyzed all deaths occurring among middle-aged men in the Münster Heart Study (PROCAM), one of the largest prospective epidemiological studies of coronary heart disease risk markers in Europe...
  59. ncbi request reprint Plasminogen activator inhibitor-1 4G/5G-polymorphism and factor V Q506 mutation are not associated with myocardial infarction in young men
    R Junker
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
    Blood Coagul Fibrinolysis 9:597-602. 1998
    ..In conclusion, in the present study neither homozygosity for the 4G allele of the PAI-1 4G/5G-polymorphism nor the FV:Q506 mutation led to an increased risk of myocardial infarction in young men...
  60. ncbi request reprint Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
    S Rust
    Institut für Arterioskleroseforschung an der Westfälischen Wilhelms Universität Münster, Germany
    Nat Genet 22:352-5. 1999
    ..An in-frame insertion-deletion in exon 12 was found in the second family. Our findings indicate that defects in ABC1, encoding a member of the ABC transporter superfamily, are the cause of TD...
  61. ncbi request reprint Strategies for the assessment of genetic coronary artery disease risk
    H Funke
    Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, Germany
    Curr Opin Lipidol 10:285-91. 1999
    ..In this paper we analyse the reasons for the current lack of predictive power of genetics-based algorithms and we speculate why future developments might open the door to a role for genetics in the clinical management of atherosclerosis...
  62. ncbi request reprint The biologic lower detection limit of six ultrasensitive PSA assays
    R Junker
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
    Anticancer Res 19:2625-8. 1999
    ....
  63. ncbi request reprint High risk strategies for atherosclerosis
    P Cullen
    Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, Germany
    Clin Chim Acta 286:31-45. 1999
    ..This is even more the case in patients with such evidence (secondary prevention). It appears that lowering of LDL-C also reduces all-cause mortality in secondary prevention...
  64. ncbi request reprint Measuring cholesterol in macrophages: comparison of high-performance liquid chromatography and gas-liquid chromatography with enzymatic fluorometry
    P Cullen
    Institut für Arterioskleroseforschung, Munster, Federal Republic of Germany
    Anal Biochem 251:39-44. 1997
    ..Second, the cells appeared to contain an intrinsic inhibitor of the enzymatic fluorometric method...
  65. ncbi request reprint c-erbB-2/EGFR as dominant heterodimerization partners determine a motogenic phenotype in human breast cancer cells
    B H Brandt
    Institut fur Klinische Chemie und Laboratoriumsmedizin, 48149 Munster, Germany Institut für Immunologie, Universitat Witten Herdecke, Witten 58453, Germany
    FASEB J 13:1939-49. 1999
    ....
  66. ncbi request reprint Detection of missense mutations in the genes for lipoprotein lipase and hepatic triglyceride lipase in patients with dyslipidemia undergoing coronary angiography
    G Moennig
    Department of Cardiology and Angiology, Westfalische Wilhelms University, Albert Schweitzer Str 33, D 48149, Munster, Germany
    Atherosclerosis 149:395-401. 2000
    ..Since this dyslipoproteinemia meets the criteria of LHDL/HTG, it is intriguing to speculate that missense mutations in HTGL may play a role in the pathogenesis of this atherogenic phenotype...
  67. ncbi request reprint [Knowledge about stroke among the German population]
    B M Weltermann
    Klinik und Poliklinik fur Neurologie, Westfalische Wilhelms Universitat Munster
    Dtsch Med Wochenschr 125:416-20. 2000
    ..US studies showed that only 57% of the population knew at least one stroke symptom. This is the first study about stroke knowledge among German populations...
  68. ncbi request reprint Intrinsic sterol- and phosphatidylcholine transfer activities of 17 beta-hydroxysteroid dehydrogenase type IV
    U Seedorf
    Institut für Arterioskeleroseforschung, Zentrallaboratorium, Westfalische Wilhelms Universitat, Munster, Germany
    J Steroid Biochem Mol Biol 55:549-53. 1995
    ..We conclude that the 80 kDa type IV 17 beta-HSD represents a potentially multifunctional protein with intrinsic in vitro sterol and phospholipid transfer activity in addition to its enzymatic activity...
  69. ncbi request reprint D609-phosphatidylcholine-specific phospholipase C inhibitor attenuates thapsigargin-induced sodium influx in human lymphocytes
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat, A Schweitzer Str 33, 48 149, Munster, Germany
    Cell Signal 12:289-96. 2000
    ..In conclusion, our results suggest that diacylglycerol released due to the PC-PLC activation contributes to the thapsigargin-induced Na(+) entry...
  70. ncbi request reprint Factor V Leiden mutation is a risk factor for cerebral venous thrombosis: a case-control study of 55 patients
    P Ludemann
    Department of Neurology, University of Münster Germany
    Stroke 29:2507-10. 1998
    ..To better define the relevance of the FVL mutation in conjunction with additional risk factors in CVT, we conducted the present case-control study...
  71. ncbi request reprint Hemostasis in normotensive and hypertensive men: results of the PROCAM study. The prospective cardiovascular Münster study
    R Junker
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
    J Hypertens 16:917-23. 1998
    ..The greater than normal cardiovascular risk of hypertensive patients could be partly due to an impairment of hemostatic balance found in such individuals...
  72. ncbi request reprint Coagulation factor VII and the risk of coronary heart disease in healthy men
    R Junker
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 17:1539-44. 1997
    ..We conclude that FVIIc is a risk factor for CHD, especially in the presence of additional risk factors, and must be taken into account when assessing cardiovascular risk in men...
  73. ncbi request reprint Translational research studies of erbB oncogenes: selection strategies for breast cancer treatment
    B H Brandt
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westf Wilh Universität Münster, Germany
    Cancer Lett 118:143-51. 1997
    ..6 and an intratumoral EGFR concentration of more than 56 fmol/mg, (b) an intratumoral p185c-erbB-2 concentration above 26 HNU/mg and (c) a quotient of egfr and c-erbB-2 average gene copy numbers of less than 0.15 and greater than 4.35...
  74. ncbi request reprint Absence of mutations in peripheral myelin protein-22, myelin protein zero, and connexin 32 in autosomal recessive Dejerine-Sottas syndrome
    F Stogbauer
    Klinik und Poliklinik fur Neurologie, Westfalische Wilhelms Universitat Munster, Germany
    Neurosci Lett 240:1-4. 1998
    ..We conclude that DSS also exists as a distinct genetic entity with autosomal recessive inheritance as originally defined by Dejerine and Sottas in 1893...
  75. pmc Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages
    P Cullen
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, 48149 Munster, Germany
    J Clin Invest 101:1670-7. 1998
    ..E4/4 macrophages secrete the most apoE but lack effective net cholesterol efflux due to enhanced surface binding and reuptake of cholesterol-rich particles...
  76. pmc Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function
    U Seedorf
    Institute for Arteriosclerosis Research, Westfalian Wilhelms University, D 48129 M unster, Germany
    Genes Dev 12:1189-201. 1998
    ..These results corresponded to high-affinity binding of phytanoyl-CoA to the recombinant rat SCP2 protein, as well as high 3-ketopristanoyl-CoA thiolase activity of the recombinant rat SCPx protein...
  77. ncbi request reprint Isolation of blood-borne epithelium-derived c-erbB-2 oncoprotein-positive clustered cells from the peripheral blood of breast cancer patients
    B Brandt
    Institute of Clinical Chemistry and Laboratory Medicine, Westfalische Wilhelms Universitat, Munster, Germany
    Int J Cancer 76:824-8. 1998
    ..We suggest that blood-borne epithelium-derived c-erbB-2-positive clustered cells are the possible precursor cells responsible for the formation of distant metastases and bone marrow micrometastases...
  78. ncbi request reprint Relationship between plasma viscosity and the severity of coronary heart disease
    R Junker
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 18:870-5. 1998
    ..On the whole, we can give further support to the hypothesis that cardiovascular risk factors and coronary heart disease may be linked by plasma viscosity...
  79. ncbi request reprint Downregulation of the selectin ligand-producing fucosyltransferases Fuc-TIV and Fuc-TVII during foam cell formation in monocyte-derived macrophages
    P Cullen
    Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 17:1591-8. 1997
    ..Transformation of macrophages into foam cells results in reduced expression of selectin-binding ligands on the surface of such cells...
  80. ncbi request reprint High density lipoproteins and reverse cholesterol transport: lessons from mutations
    A von Eckardstein
    Institut für Arterioskleroseforschung an der Universität Münster, Germany
    Atherosclerosis 137:S7-11. 1998
    ..Apo E and gamma-LpE are of special interest for reverse cholesterol transport since macrophages can produce apo E...
  81. ncbi request reprint Incidence and risk factors for stroke in an occupational cohort: the PROCAM Study. Prospective Cardiovascular Muenster Study
    K Berger
    Institute of Atherosclerosis Research, University of Muenster, Germany
    Stroke 29:1562-6. 1998
    ..The purpose of this study was to assess the incidence of stroke and the magnitude of classic stroke risk factors in an occupational cohort of white-collar and blue-collar workers...
  82. ncbi request reprint Assignment of Tangier disease to chromosome 9q31 by a graphical linkage exclusion strategy
    S Rust
    Institute of Arteriosclerosis Research, University of Munster, Germany
    Nat Genet 20:96-8. 1998
    ..05 at D9S1784). We also provide evidence that TD may be due to a loss-of-function defect...
  83. ncbi request reprint Prevalence of factor V Leiden mutation in young adults with cerebral ischaemia: a case-control study on 225 patients
    D G Nabavi
    Department of Neurology, University of Munster, Germany
    J Neurol 245:653-8. 1998
    ..However, our results suggest that this gene mutation plays an aetiological role in the subgroup of patients suffering from 'cryptogenic' ischaemic events...
  84. ncbi request reprint Involvement of phospholipase D in store-operated calcium influx in vascular smooth muscle cells
    M Walter
    Institut für Arterioskleroseforschung, Universitat Munster, Germany
    FEBS Lett 479:51-6. 2000
    ..These results suggest a regulatory role for PLD in store-operated Ca2+ entry in VSMC...
  85. ncbi request reprint Risk for diabetes mellitus in middle-aged Caucasian male participants of the PROCAM study: implications for the definition of impaired fasting glucose by the American Diabetes Association. Prospective Cardiovascular Münster
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    J Clin Endocrinol Metab 85:3101-8. 2000
    ..72 mmol/L glucose may help to reduce the previously reported discordance between impaired fasting glucose (American Diabetes Association) and impaired glucose tolerance (WHO) in diagnosis of the prediabetic state...
  86. ncbi request reprint Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms Universität and the Institut für Arterioskleroseforschung an der Universität Münster, 48129 Munster, Germany
    J Biol Chem 276:34480-5. 2001
    ....
  87. ncbi request reprint Clinical value of electrocardiographic parameters in genotyped individuals with familial long QT syndrome
    G Moennig
    Department of Cardiology and Angiology, Westfälische Wilhelms University Münster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Pacing Clin Electrophysiol 24:406-15. 2001
    ..QT dispersion and QT product might be helpful in finding LQTS mutation carriers and might serve as additional ECG tools to identify asymptomatic LQTS patients...
  88. ncbi request reprint High density lipoproteins induce cell cycle entry in vascular smooth muscle cells via mitogen activated protein kinase-dependent pathway
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Thromb Haemost 85:730-5. 2001
    ..The strong and specific mitogenic effect of HDL should be taken into account, when therapeutic strategies to elevate the plasma level of these lipoproteins are developed...
  89. ncbi request reprint [Obesity and cardiovascular risk]
    H Schulte
    Institut für Arterioskleroseforschung, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster
    Herz 26:170-7. 2001
    ..PROBANDS AND METHOD: In the Prospective Cardiovascular Münster (PROCAM) Study, 16,288 men aged 40.5 +/- 11.3 years (mean +/- SD) and 7,328 women aged 35.8 +/- 12.3 years were enrolled between 1979 and 1991...
  90. ncbi request reprint ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages
    A von Eckardstein
    Institute of Clinical Chemistry and Laboratory Medicine, Central Laboratory, Westphalian Wilhelms University, D 48129 Munster, Germany
    FASEB J 15:1555-61. 2001
    ..Inhibition of ABCA1 in HMDM prevented the occurrence of anti-apoE-immunoreactive granular structures in the plasma membrane. We conclude that ABCA1 and, to a lesser extent, ABC8 both promote secretion of apoE from human macrophages...
  91. ncbi request reprint Differential secretion of atrial and brain natriuretic peptide in critically ill patients
    E Berendes
    Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin and Institut für Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Anesth Analg 93:676-82. 2001
    ..The physiologic role of BNP, by contrast, is less clear. ANP and BNP are not predictors for the severity of illness and mortality in critically ill patients...
  92. ncbi request reprint Association of serum apolipoprotein A-I (but not high-density lipoprotein cholesterol) with healed myocardial infarction in men independent of serum insulin and C-peptide
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Am J Cardiol 88:723-6. 2001
    ..Thus, the combined measurement of apolipoprotein A-I and C-peptide may improve the identification of nondiabetic patients at increased risk for CHD...
  93. ncbi request reprint The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages
    T Engel
    Macrophage Metabolism, Institut für Arterioskleroseforschung, Westfalische Wilhelms Universitat, Domagkstrasse 3, 48149 Munster, Germany
    Biochem Biophys Res Commun 288:483-8. 2001
    ..6 kb in size on chromosome 11q23.3. Based on its structural features and an LXR/RXR-responsive regulation similar to the cellular lipid export protein ABCA1, we conclude that ABCG4 may be involved in macrophage lipid homeostasis...
  94. ncbi request reprint Lowering of HDL cholesterol in post-menopausal women by tibolone is not associated with changes in cholesterol efflux capacity or paraoxonase activity
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Strasse 33, D 48129, Munster, Germany
    Atherosclerosis 159:433-9. 2001
    ..We conclude that changes in insulin do not contribute to the lowering of HDL cholesterol by tibolone. Despite decreased HDL cholesterol, putatively anti-atherogenic activities of HDL remained unchanged...
  95. ncbi request reprint Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein
    M Kratz
    Institute of Arteriosclerosis Research at the University of Münster, Munster, Germany
    Eur J Clin Nutr 56:72-81. 2002
    ..The objective of this study was to compare the effects of dietary monounsaturated fatty acids (MUFA), n-6 and n-3 polyunsaturated fatty acids (PUFA) on LDL composition and oxidizability...
  96. ncbi request reprint Interleukin-6 promoter polymorphism (--174 G/C) in Caucasian German patients with systemic lupus erythematosus
    H Schotte
    Medizinische Klinik und Poliklinik B, Westfalische Wilhelms Universitat, Munster, Germany
    Rheumatology (Oxford) 40:393-400. 2001
    ..A biallelic polymorphism (--174 G/C) within the interleukin-6 (IL-6) promoter reportedly has functional importance through the modulation of IL-6 expression in vitro and in vivo...
  97. ncbi request reprint High density lipoproteins, reverse transport of cholesterol, and coronary artery disease. Insights from mutations
    G Assmann
    Institute of Clinical Chemistry and Laboratory Medicine, Westphalian Wilhelms University, Munster, Germany
    Circulation 87:III28-34. 1993
    ....
  98. ncbi request reprint High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 21:13-27. 2001
    ..Instead, the concentration of HDL subclasses, the mobilization of cellular lipids for efflux, and the kinetics of HDL metabolism are important determinants of RCT and the risk of atherosclerosis...
  99. ncbi request reprint Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system
    R Junker
    Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, Germany
    Thromb Haemost 85:280-6. 2001
    ..Therefore, the clinical significance of the present findings remains to be evaluated...
  100. ncbi request reprint Pro and con: high-density lipoprotein, triglycerides, and other lipid subfractions are the future of lipid management
    G Assmann
    Institute of Clinical Chemistry and Laboratory Medicine, , Germany
    Am J Cardiol 87:2B-7B. 2001
    ..Such individuals might derive preferential benefit from treatments targeting such risk factors...
  101. ncbi request reprint Acceleration of reverse cholesterol transport
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Curr Opin Cardiol 15:348-54. 2000
    ..It is suggested, however, that the serum level of HDL cholesterol does not necessarily reflect the efficacy of reverse cholesterol transport...