Wiebke Arlt

Summary

Country: Germany

Publications

  1. ncbi request reprint Dehydroepiandrosterone replacement in women with adrenal insufficiency
    W Arlt
    Department of Endocrinology, Medical University Hospital, Wuerzburg, Germany
    N Engl J Med 341:1013-20. 1999
  2. ncbi request reprint Gorham-Stout disease--stabilization during bisphosphonate treatment
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Wurzburg, Germany
    J Bone Miner Res 20:350-3. 2005
  3. ncbi request reprint Age-specific changes in sex steroid biosynthesis and sex development
    Nils Krone
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Best Pract Res Clin Endocrinol Metab 21:393-401. 2007
  4. ncbi request reprint Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion
    W Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University Hospital Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 86:4686-92. 2001
  5. ncbi request reprint Quality of life in Addison's disease--the case for DHEA replacement
    Wiebke Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Clin Endocrinol (Oxf) 56:573-4. 2002
  6. ncbi request reprint Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 92:3912-22. 2007
  7. ncbi request reprint Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:6283-9. 2005
  8. ncbi request reprint DHEA treatment: myth or reality?
    Bruno Allolio
    Dept Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Trends Endocrinol Metab 13:288-94. 2002
  9. ncbi request reprint Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 88:2760-6. 2003
  10. ncbi request reprint No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:3600-5. 2005

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Dehydroepiandrosterone replacement in women with adrenal insufficiency
    W Arlt
    Department of Endocrinology, Medical University Hospital, Wuerzburg, Germany
    N Engl J Med 341:1013-20. 1999
    ..Adrenal insufficiency leads to a deficiency of dehydroepiandrosterone; we therefore, investigated the effects of dehydroepiandrosterone replacement, in patients with adrenal insufficiency...
  2. ncbi request reprint Gorham-Stout disease--stabilization during bisphosphonate treatment
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Wurzburg, Germany
    J Bone Miner Res 20:350-3. 2005
    ..v. every 3 months) was initiated, leading to rapid disappearance of local pain. Follow-up over 24 months documented a stable clinical and radiological picture without evidence of progressive bone destruction...
  3. ncbi request reprint Age-specific changes in sex steroid biosynthesis and sex development
    Nils Krone
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Best Pract Res Clin Endocrinol Metab 21:393-401. 2007
    ....
  4. ncbi request reprint Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion
    W Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University Hospital Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 86:4686-92. 2001
    ..Thus, in contrast to previous findings in adrenal insufficiency, we found no obvious benefit of 4 months of dehydroepiandrosterone supplementation in healthy men with a physiological decline of dehydroepiandrosterone production...
  5. ncbi request reprint Quality of life in Addison's disease--the case for DHEA replacement
    Wiebke Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Clin Endocrinol (Oxf) 56:573-4. 2002
  6. ncbi request reprint Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 92:3912-22. 2007
    ..Here we evaluated the subjective health status in primary and secondary AI and the effect of concomitant disease...
  7. ncbi request reprint Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:6283-9. 2005
    ..In vitro DHEA has been shown to enhance IL-2 release from T lymphocytes, whereas it inhibits IL-6 secretion. Conversely, aging is associated with a decline in both DHEA and IL-2, whereas IL-6 increases...
  8. ncbi request reprint DHEA treatment: myth or reality?
    Bruno Allolio
    Dept Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Trends Endocrinol Metab 13:288-94. 2002
    ..Future research should focus on DHEA treatment for adrenal insufficiency, and DHEA administration in both patients receiving chronic glucocorticoid treatment and women with androgen deficiency...
  9. ncbi request reprint Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 88:2760-6. 2003
    ..05). Taken together, these data indicate enhanced peripheral 5 alpha-reductase activity in PCOS. Thus, not only ovary and adrenal, but also liver and peripheral target tissues, significantly contribute to steroid alterations in PCOS...
  10. ncbi request reprint No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:3600-5. 2005
    ..DHEAS does not seem to represent a circulating storage pool for DHEA regeneration, and therefore serum DHEAS is unlikely to reflect bioavailable DHEA...
  11. ncbi request reprint Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D
    Wiebke Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, Germany
    Eur J Endocrinol 146:215-22. 2002
    ..Only few studies have evaluated the efficacy of calcium/vitamin D treatment in hypoparathyroidism; the impact of chronic hypoparathyroid disease on well-being has not been investigated previously...
  12. pmc Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells
    Matthias Kroiss
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital, University of Würzburg Würzburg, Germany
    Front Endocrinol (Lausanne) 2:27. 2011
    ..Sunitinib exhibits anti-proliferative effects in vitro, and appears to specifically block adrenal steroidogenesis by down-regulation of HSD3B2, rendering it a promising option for treatment of ACC...
  13. ncbi request reprint Adrenal insufficiency
    Wiebke Arlt
    Division of Medical Sciences, University of Birmingham, Birmingham
    Clin Med 8:211-5. 2008
  14. doi request reprint Adult consequences of congenital adrenal hyperplasia
    Wiebke Arlt
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Horm Res 68:158-64. 2007
    ....
  15. ncbi request reprint Management of the androgen-deficient woman
    Wiebke Arlt
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    Growth Horm IGF Res 13:S85-9. 2003
    ..Thus, androgen replacement should not be routinely considered in postmenopausal women but should be reserved for women with established androgen deficiency and related symptoms...
  16. ncbi request reprint Dehydroepiandrosterone and ageing
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TH, UK
    Best Pract Res Clin Endocrinol Metab 18:363-80. 2004
    ....
  17. ncbi request reprint Dehydroepiandrosterone replacement therapy
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
    Semin Reprod Med 22:379-88. 2004
    ..However, DHEA may be a suitable option for androgen replacement in women with established androgen deficiency, for example, bilateral oophorectomy and premature menopause...
  18. ncbi request reprint Adrenal insufficiency
    Wiebke Arlt
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Lancet 361:1881-93. 2003
    ..Thus, long-term management of patients with adrenal insufficiency remains a challenge, requiring an experienced specialist. However, all doctors should know how to diagnose and manage suspected acute adrenal failure...
  19. doi request reprint Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  20. ncbi request reprint DHEA replacement in adrenal insufficiency
    Wiebke Arlt
    J Clin Endocrinol Metab 88:4001; author reply 4001-2. 2003
  21. ncbi request reprint Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature
    G Umberto Meduri
    University of Tennessee Health Science Center and Memphis VA Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Room H316, 956 Court Avenue, TN 38163, Memphis, USA
    Intensive Care Med 34:61-9. 2008
    ....
  22. ncbi request reprint Hormones and immune function: implications of aging
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, B15 2TT, UK
    Aging Cell 3:209-16. 2004
    ..As a step in this direction, the present review summarizes established facts on the physiology of secretion and function of hormones that, in most cases, decline with aging and that are likely to affect the immune system...
  23. ncbi request reprint Using corticosteroids in intensive care
    Paul E Marik
    Arch Surg 141:946-7; author reply 947. 2006
  24. ncbi request reprint Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock
    Wiebke Arlt
    Medical Research Council Senior Clinical Fellow, Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Room 233, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:2548-54. 2006
    ..However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels...
  25. ncbi request reprint Androgen therapy in women
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, Endocrinology, Room 233, University of Birmingham, Birmingham, B15 2TT, UK
    Eur J Endocrinol 154:1-11. 2006
    ..Currently, androgen replacement should be reserved for women with severe androgen deficiency due to an established cause and matching clinical signs and symptoms...
  26. ncbi request reprint Androgen replacement therapy in women
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, Endocrinology, Birmingham, UK
    Curr Opin Investig Drugs 6:1028-36. 2005
    ..Choosing both a convenient and efficient mode of androgen administration in women remains a challenge and currently none of the available preparations is officially approved for use in women...
  27. ncbi request reprint Dehydroepiandrosterone supplementation in elderly men: the role of estrogens versus androgens on the male skeleton
    Lorenz C Hofbauer
    J Clin Endocrinol Metab 87:4009; author reply 4009. 2002
  28. ncbi request reprint Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs. timed serum cortisol measurements
    Wiebke Arlt
    Division of Medical Sciences Institute of Biomedical Research IBR Endocrinology and Metabolism, The Medical School, University of Birmingham, Edgbaston, UK
    Clin Endocrinol (Oxf) 64:384-9. 2006
    ..Here we compared the results of a structured clinical assessment to the outcome of repeated, timed serum cortisol measurements...