Research Topics
Species | Wiebke ArltSummaryCountry: Germany Publications
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Publications
Gorham-Stout disease--stabilization during bisphosphonate treatmentFabian Hammer
Department of Medicine, Endocrine and Diabetes Unit, , , Germany
J Bone Miner Res 20:350-3. 2005..v. every 3 months) was initiated, leading to rapid disappearance of local pain. Follow-up over 24 months documented a stable clinical and radiological picture without evidence of progressive bone destruction...- Age-specific changes in sex steroid biosynthesis and sex developmentNils Krone
Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Best Pract Res Clin Endocrinol Metab 21:393-401. 2007.... - Dehydroepiandrosterone replacement in women with adrenal insufficiencyW Arlt
Department of Endocrinology, Medical University Hospital, Wuerzburg, Germany
N Engl J Med 341:1013-20. 1999..Adrenal insufficiency leads to a deficiency of dehydroepiandrosterone; we therefore, investigated the effects of dehydroepiandrosterone replacement, in patients with adrenal insufficiency... - Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretionW Arlt
Department of Medicine, Endocrine and Diabetes Unit, University Hospital Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
J Clin Endocrinol Metab 86:4686-92. 2001..Thus, in contrast to previous findings in adrenal insufficiency, we found no obvious benefit of 4 months of dehydroepiandrosterone supplementation in healthy men with a physiological decline of dehydroepiandrosterone production... - Quality of life in Addison's disease--the case for DHEA replacementWiebke Arlt
Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, Josef-Schneider-Strasse 2, 97080 Wuerzburg, Germany
Clin Endocrinol (Oxf) 56:573-4. 2002 - Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysisStefanie Hahner
Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
J Clin Endocrinol Metab 92:3912-22. 2007..Here we evaluated the subjective health status in primary and secondary AI and the effect of concomitant disease... - Sex steroid metabolism in human peripheral blood mononuclear cells changes with agingFabian Hammer
Department of Medicine, Endocrine and Diabetes Unit, , , Germany
J Clin Endocrinol Metab 90:6283-9. 2005..CONCLUSIONS: Our results provide evidence for significant changes in sex steroid metabolism by human PBMCs with aging, which may represent an endocrine link to immune senescence... - DHEA treatment: myth or reality?Bruno Allolio
Dept Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Trends Endocrinol Metab 13:288-94. 2002..Future research should focus on DHEA treatment for adrenal insufficiency, and DHEA administration in both patients receiving chronic glucocorticoid treatment and women with androgen deficiency... - Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndromeMartin Fassnacht
Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
J Clin Endocrinol Metab 88:2760-6. 2003..05). Taken together, these data indicate enhanced peripheral 5 alpha-reductase activity in PCOS. Thus, not only ovary and adrenal, but also liver and peripheral target tissues, significantly contribute to steroid alterations in PCOS... - No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studiesFabian Hammer
Department of Medicine, Endocrine and Diabetes Unit, , , Germany
J Clin Endocrinol Metab 90:3600-5. 2005..DHEAS does not seem to represent a circulating storage pool for DHEA regeneration, and therefore serum DHEAS is unlikely to reflect bioavailable DHEA... - Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin DWiebke Arlt
Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, Germany
Eur J Endocrinol 146:215-22. 2002..Future studies need to address the impact of more physiological treatment options like parathyroid hormone(1-34) or parathyroid transplantation on well-being and mood in these patients... 
Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma CellsMatthias Kroiss
Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital, University of Würzburg Würzburg, Germany
Front Endocrinol (Lausanne) 2:27. 2011..Sunitinib exhibits anti-proliferative effects in vitro, and appears to specifically block adrenal steroidogenesis by down-regulation of HSD3B2, rendering it a promising option for treatment of ACC...- Adrenal insufficiencyWiebke Arlt
Division of Medical Sciences, University of Birmingham, Birmingham
Clin Med 8:211-5. 2008 
Adult consequences of congenital adrenal hyperplasiaWiebke Arlt
Division of Medical Sciences, University of Birmingham, Birmingham, UK
Horm Res 68:158-64. 2007..It is very important that the adult CAH patient receive regular monitoring by a multidisciplinary team at the secondary- or tertiary-care level...- Management of the androgen-deficient womanWiebke Arlt
Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
Growth Horm IGF Res 13:S85-9. 2003..Thus, androgen replacement should not be routinely considered in postmenopausal women but should be reserved for women with established androgen deficiency and related symptoms... - Dehydroepiandrosterone and ageingWiebke Arlt
Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TH, UK
Best Pract Res Clin Endocrinol Metab 18:363-80. 2004.... - Dehydroepiandrosterone replacement therapyWiebke Arlt
Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
Semin Reprod Med 22:379-88. 2004..However, DHEA may be a suitable option for androgen replacement in women with established androgen deficiency, for example, bilateral oophorectomy and premature menopause... - Adrenal insufficiencyWiebke Arlt
Division of Medical Sciences, University of Birmingham, Birmingham, UK
Lancet 361:1881-93. 2003..Thus, long-term management of patients with adrenal insufficiency remains a challenge, requiring an experienced specialist. However, all doctors should know how to diagnose and manage suspected acute adrenal failure... - Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care MedicinePaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 36:1937-49. 2008..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients... - DHEA replacement in adrenal insufficiencyWiebke Arlt
J Clin Endocrinol Metab 88:4001; author reply 4001-2. 2003 - Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literatureG Umberto Meduri
University of Tennessee Health Science Center and Memphis VA Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Room H316, 956 Court Avenue, TN 38163, Memphis, USA
Intensive Care Med 34:61-9. 2008.... - Hormones and immune function: implications of agingWiebke Arlt
Division of Medical Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, B15 2TT, UK
Aging Cell 3:209-16. 2004..As a step in this direction, the present review summarizes established facts on the physiology of secretion and function of hormones that, in most cases, decline with aging and that are likely to affect the immune system... - Using corticosteroids in intensive carePaul E Marik
Arch Surg 141:946-7; author reply 947. 2006 - Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shockWiebke Arlt
Medical Research Council Senior Clinical Fellow, Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Room 233, Birmingham B15 2TT, United Kingdom
J Clin Endocrinol Metab 91:2548-54. 2006..However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels... - Androgen therapy in womenWiebke Arlt
Division of Medical Sciences, Institute of Biomedical Research, Endocrinology, Room 233, University of Birmingham, Birmingham, B15 2TT, UK
Eur J Endocrinol 154:1-11. 2006..Currently, androgen replacement should be reserved for women with severe androgen deficiency due to an established cause and matching clinical signs and symptoms... - Androgen replacement therapy in womenWiebke Arlt
Division of Medical Sciences, Institute of Biomedical Research, Endocrinology, Birmingham, UK
Curr Opin Investig Drugs 6:1028-36. 2005..Choosing both a convenient and efficient mode of androgen administration in women remains a challenge and currently none of the available preparations is officially approved for use in women... - Dehydroepiandrosterone supplementation in elderly men: the role of estrogens versus androgens on the male skeletonLorenz C Hofbauer
J Clin Endocrinol Metab 87:4009; author reply 4009. 2002 - Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs. timed serum cortisol measurementsWiebke Arlt
Division of Medical Sciences Institute of Biomedical Research IBR Endocrinology and Metabolism, The Medical School, University of Birmingham, Edgbaston, UK
Clin Endocrinol (Oxf) 64:384-9. 2006..Here we compared the results of a structured clinical assessment to the outcome of repeated, timed serum cortisol measurements...