Research Topics
| R G AndrzejakSummaryCountry: Germany Publications
| Collaborators |
Detail Information
Publications
The epileptic process as nonlinear deterministic dynamics in a stochastic environment: an evaluation on mesial temporal lobe epilepsyR G Andrzejak
Department of Epileptology, Medical Center, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
Epilepsy Res 44:129-40. 2001..In all investigated cases, this differentiation allowed to retrospectively determine the side of the epileptogenic zone in full agreement with results of the presurgical workup...
Indications of nonlinear deterministic and finite-dimensional structures in time series of brain electrical activity: dependence on recording region and brain stateR G Andrzejak
Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Phys Rev E Stat Nonlin Soft Matter Phys 64:061907. 2001..Strongest indications of nonlinear deterministic dynamics were found for seizure activity. Results of the other sets were found to be inbetween these two extremes...
Seizure prediction: any better than chance?Ralph G Andrzejak
Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain
Clin Neurophysiol 120:1465-78. 2009..For this purpose, analytical performance estimates and seizure predictor surrogates were introduced. We here extend the Monte Carlo framework of seizure predictor surrogates by introducing alarm times surrogates...
Improved spatial characterization of the epileptic brain by focusing on nonlinearityRalph G Andrzejak
John von Neumann Institute for Computing, Forschungszentrum Julich GmbH, Julich, Germany
Epilepsy Res 69:30-44. 2006..Focusing on nonlinearity by using a combination of nonlinear measures with surrogates appears as the key to a successful characterization of the spatial distribution of the epileptic process...
Nonlinear EEG analysis in epilepsy: its possible use for interictal focus localization, seizure anticipation, and preventionK Lehnertz
Department of Epileptology and Institute for Radiation and Nuclear Physics, University of Bonn, Germany
J Clin Neurophysiol 18:209-22. 2001..The unequivocal definition of such a state with a sufficient length would enable investigations of basic mechanisms leading to seizure initiation in humans, and development of adequate seizure prevention strategies...
Using bivariate signal analysis to characterize the epileptic focus: the benefit of surrogatesR G Andrzejak
Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain
Phys Rev E Stat Nonlin Soft Matter Phys 83:046203. 2011..The highest significance and accuracy is obtained for the surrogate-corrected nonlinear interdependence measure...
Discerning nonstationarity from nonlinearity in seizure-free and preseizure EEG recordings from epilepsy patientsChristoph Rieke
Department of Epileptology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
IEEE Trans Biomed Eng 50:634-9. 2003..These differences seem most prominent for recording sites within the seizure-generating area and for EEG segments less than one minute's length...
On the predictability of epileptic seizuresFlorian Mormann
Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Clin Neurophysiol 116:569-87. 2005..In this paper, we evaluate the predictability of seizures by comparing the predictive performance of a variety of univariate and bivariate measures comprising both linear and non-linear approaches...
Seizure anticipation: Do mathematical measures correlate with video-EEG evaluation?Florian Mormann
Epilepsia 46:1335-6; author reply 1336-7. 2005
A distributed computing system for multivariate time series analyses of multichannel neurophysiological dataAndy Müller
Department of Epileptology, Neurophysics Group, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
J Neurosci Methods 152:190-201. 2006..Results indicate that for most of the currently available analysis techniques, calculations can be performed in real time, which, in principle, allows on-line analyses at relatively low cost...
Seizure prediction by nonlinear EEG analysisKlaus Lehnertz
Department of Epileptology, University of Bonn, Germany
IEEE Eng Med Biol Mag 22:57-63. 2003
Seizure prediction: the long and winding roadFlorian Mormann
Department of Epileptology, University of Bonn, Bonn, Germany
Brain 130:314-33. 2007..We will give an account of the current state of this research field, point towards possible future developments and propose methodological guidelines for future studies on seizure prediction...
Measure profile surrogates: a method to validate the performance of epileptic seizure prediction algorithmsThomas Kreuz
John von Neumann Institute for Computing, Forschungszentrum Julich, 52425 Jülich Germany
Phys Rev E Stat Nonlin Soft Matter Phys 69:061915. 2004..We would like to stress that the proposed method is rather universal and can be applied to many other prediction and detection problems...
Epileptic seizures are preceded by a decrease in synchronizationFlorian Mormann
Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Epilepsy Res 53:173-85. 2003....
Testing the null hypothesis of the nonexistence of a preseizure stateRalph G Andrzejak
John von Neumann Institute for Computing, Forschungszentrum Julich, 52425 Julich, Germany
Phys Rev E Stat Nonlin Soft Matter Phys 67:010901. 2003..In consequence, the evaluation of the reported performance values is problematic. Here, we propose the technique of seizure time surrogates based on a Monte Carlo simulation to remedy this deficit...
