Olav M Andersen

Summary

Country: Germany

Publications

  1. ncbi Differential binding of ligands to the apolipoprotein E receptor 2
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, D 13125 Berlin, Germany
    Biochemistry 42:9355-64. 2003
  2. pmc Ca2+ binding to complement-type repeat domains 5 and 6 from the low-density lipoprotein receptor-related protein
    Olav M Andersen
    Laboratory of Gene Expression, Department of Molecular and Structural Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMC Biochem 4:7. 2003
  3. ncbi Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, Berlin, 13125 Berlin, Germany
    Biochemistry 45:2618-28. 2006
  4. pmc Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 102:13461-6. 2005
  5. doi Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein
    Camilla Gustafsen
    The Lundbeck Foundation Research Centre MIND, Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    J Neurosci 33:64-71. 2013
  6. doi Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis
    Michael Rohe
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    J Biol Chem 283:14826-34. 2008
  7. pmc Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding
    Olga Serup Andersen
    Department of Medical Biochemistry, Membrane Receptors in Neuronal Disease MIND Center, University of Aarhus, OleWorms Allé, Aarhus C, Denmark
    J Biol Chem 285:12210-22. 2010
  8. doi Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease
    Thomas E Willnow
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Sci 126:2751-60. 2013
  9. doi The structure of MESD45-184 brings light into the mechanism of LDLR family folding
    Christian Kohler
    Department of NMR Supported Structural Biology, Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Str 10, 13125 Berlin, Germany
    Structure 19:337-48. 2011
  10. doi Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing
    Anja W Fjorback
    The Lundbeck Foundation Research Centre MIND, Department of Biomedicine, Aarhus University, and MIND Centre, Stereology and Electron Microscopy Laboratory, Centre for Stochastic Geometry and Advanced bioimaging, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Neurosci 32:1467-80. 2012

Collaborators

Detail Information

Publications21

  1. ncbi Differential binding of ligands to the apolipoprotein E receptor 2
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, D 13125 Berlin, Germany
    Biochemistry 42:9355-64. 2003
    ..This finding indicates that aggregation of apoER2 by multivalent ligands such as Reelin may be the structural basis for signal transduction...
  2. pmc Ca2+ binding to complement-type repeat domains 5 and 6 from the low-density lipoprotein receptor-related protein
    Olav M Andersen
    Laboratory of Gene Expression, Department of Molecular and Structural Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMC Biochem 4:7. 2003
    ....
  3. ncbi Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, Berlin, 13125 Berlin, Germany
    Biochemistry 45:2618-28. 2006
    ..These data shed new light on the molecular determinants of neuronal APP trafficking and processing and on possible targets for intervention with senile plaque formation in patients with AD...
  4. pmc Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 102:13461-6. 2005
    ..Consequently, reduced receptor expression in the human brain may increase Abeta production and plaque formation and promote spontaneous AD...
  5. doi Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein
    Camilla Gustafsen
    The Lundbeck Foundation Research Centre MIND, Department of Biomedicine, Aarhus University, DK 8000 Aarhus C, Denmark
    J Neurosci 33:64-71. 2013
    ..Together, our findings establish sortilin, as a novel APP interaction partner that influences both production and cellular uptake of sAPP...
  6. doi Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis
    Michael Rohe
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    J Biol Chem 283:14826-34. 2008
    ..Our data document a role for SORLA not only in control of plaque burden but also in APP-dependent neuronal signaling and suggest a molecular explanation for increased neurogenesis observed in some AD patients...
  7. pmc Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding
    Olga Serup Andersen
    Department of Medical Biochemistry, Membrane Receptors in Neuronal Disease MIND Center, University of Aarhus, OleWorms Allé, Aarhus C, Denmark
    J Biol Chem 285:12210-22. 2010
    ..We furthermore demonstrate that a peptide comprising the ligand-binding epitope can prevent pro-NT-induced apoptosis in RN22 schwannoma cells...
  8. doi Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease
    Thomas E Willnow
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Sci 126:2751-60. 2013
    ..As discussed here, these findings uncovered a unique regulatory pathway for the control of neuronal protein transport, and provide clues as to why defects in this pathway cause neurodegenerative disease. ..
  9. doi The structure of MESD45-184 brings light into the mechanism of LDLR family folding
    Christian Kohler
    Department of NMR Supported Structural Biology, Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Str 10, 13125 Berlin, Germany
    Structure 19:337-48. 2011
    ..The receptor motif recognized by MESD was identified by in vitro-binding studies. Furthermore, in vivo functional evidence for the relevance of the identified contact sites in MESD is provided...
  10. doi Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing
    Anja W Fjorback
    The Lundbeck Foundation Research Centre MIND, Department of Biomedicine, Aarhus University, and MIND Centre, Stereology and Electron Microscopy Laboratory, Centre for Stochastic Geometry and Advanced bioimaging, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Neurosci 32:1467-80. 2012
    ..In conclusion, our data provide a molecular link between reduced retromer expression and increased amyloidogenesis as seen in patients with sporadic AD...
  11. ncbi SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1
    Vanessa Schmidt
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, Berlin, Germany
    J Biol Chem 282:32956-64. 2007
    ..Thus, our findings identified altered routing of sorLA as a major cellular mechanism contributing to abnormal APP processing and enhanced amyloid beta-peptide formation...
  12. ncbi Lipoprotein receptors in Alzheimer's disease
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    Trends Neurosci 29:687-94. 2006
    ....
  13. ncbi Pin-pointing APP processing
    Thomas E Willnow
    Max Delbrueck Center for Molecular Medicine, D 13125, Berlin, Germany
    Mol Interv 6:137-9. 2006
  14. ncbi New light on a long-known protein family
    Olav M Andersen
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Chembiochem 4:1137-46. 2003
  15. ncbi LRP2/megalin is required for patterning of the ventral telencephalon
    Robert Spoelgen
    Max Delbrueck Center for Molecular Medicine, Berlin, 13092, Germany
    Development 132:405-14. 2005
    ..Because megalin mediates endocytic uptake and degradation of BMP4, these findings indicate a role for megalin in neural tube specification, possibly by acting as BMP4 clearance receptor in the neuroepithelium...
  16. ncbi Essential role of the apolipoprotein E receptor-2 in sperm development
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine and Medical Faculty of the Free University, D 13125 Berlin, Germany
    J Biol Chem 278:23989-95. 2003
    ....
  17. ncbi The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family
    Christian Kohler
    Department of NMR Supported Structural Biology, Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Str 10, 13125 Berlin, Germany
    J Struct Funct Genomics 7:131-8. 2006
    ..A structural comparison to entries of the PDB reveals a frequent domain with low sequence homology annotated as HMA and P-II domains in Pfam...
  18. ncbi Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif
    Gitte A Jensen
    SBiN Lab, Institute of Molecular Biology and Physiology, University of Copenhagen, Øster Farimagsgade 2A, DK 1353 Copenhagen K, Denmark
    J Mol Biol 362:700-16. 2006
    ..The present result may be beneficial in the design of antagonists of ligand binding to the LDL receptor family, and especially of drugs for treatment of Alzheimer's disease...
  19. ncbi Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
    Robert Spoelgen
    Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:418-28. 2006
    ..We discovered that sorLA significantly reduced BACE-APP interactions in Golgi. We postulate that sorLA acts as a trafficking receptor that prevents BACE-APP interactions and hence BACE cleavage of APP...
  20. ncbi Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII
    Andrey G Sarafanov
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Thromb Haemost 98:1170-81. 2007
    ..We conclude that A2 interacts with LRP via multiple binding sites spanning CR 3-8 in cluster II and CR 23-29 in cluster IV, and the minimal A2-binding unit of LRP is formed by two adjacent CR...
  21. pmc The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 39:168-77. 2007
    ..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease...