Research Topics
| Hermann P T AmmonSummaryCountry: Germany Publications
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Detail Information
Publications
The phosphatase inhibitor okadaic acid blocks KCl-depolarization-induced rise of cytosolic calcium of rat insulinoma cells (RINm5F)H P Ammon
Department of Pharmacology, University of Tubingen, Germany
Naunyn Schmiedebergs Arch Pharmacol 354:95-101. 1996..The data also suggest that in RINm5F cells protein phosphatases PP-1/PP-2A are related to the function of voltage-dependent calcium channels...
K-ATP channel independent effects of pinacidil on ATP production in isolated cardiomyocyte or pancreatic beta-cell mitochondriaNicolas Lembert
Department of Pharmacology, University of Tubingen, Tubingen, Germany
Biochem Pharmacol 65:1835-41. 2003..In beta-cells without a metabolically inhibited succinate dehydrogenase, there is no stimulation by PIN and tissue protection by PIN is not to be expected...
Modulation of the immune system by Boswellia serrata extracts and boswellic acidsH P T Ammon
Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Tuebingen, Tuebingen, Germany
Phytomedicine 17:862-7. 2010....
[Cinnamon in type 2 diabetics]Hermann P T Ammon
Pharmakologie für Naturwissenschaftler, Pharmazeutisches Institut, Universitat Tubingen, Tubingen
Med Monatsschr Pharm 31:179-83. 2008..In contrary the medical site in this case claims cinnamon as a drug because of its pharmacological effects on glucose tolerance, insulin resistance, insulin release and blood-sugar. In the meantime this is a case of jurisdiction...
Boswellic acids in chronic inflammatory diseasesH P T Ammon
Dept of Pharmacology, Institute of Pharmaceutical Sciences, University of Tuebingen, Tuebingen, Germany
Planta Med 72:1100-16. 2006..Side effects are not severe when compared to modern drugs used for the treatment of these diseases...
[Boswellic acids (the active agent in incense) for the treatment of chronic inflammatory diseases]Hermann P Ammon
, Auf der Morgenstelle 8,
Med Monatsschr Pharm 26:309-15. 2003
[Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases]H P T Ammon
Lehrstuhl Pharmakologie für Naturwissenschaftler, Pharmazeutisches Institut der Universität Tübingen, Deutschland
Wien Med Wochenschr 152:373-8. 2002..In clinical trials promising results were observed in patients with rheumatoid arthritis, chronic colitis, ulcerative colitis, Crohn's disease, bronchial asthma und peritumoral brains edemas...
In vitro test of new biomaterials for the development of a bioartificial pancreasN Lembert
Institute of Pharmaceutical Sciences, University of Tubingen, Germany
Ann N Y Acad Sci 944:271-6. 2001..In conclusion, in vitro membrane screening identified highly substituted hydroxy-methylated PSU as the material of choice for islet encapsulation in a bioartificial pancreas...
Macroencapsulation of rat islets without alteration of insulin secretion kineticsN Lembert
Department of Pharmacology, University of Tubingen, Germany
Exp Clin Endocrinol Diabetes 109:116-9. 2001..In conclusion, highly substituted hydroxy methylated polysulphone allows a rapid and efficient insulin release after macroencapsulation and is suited for the further development of a bioartificial pancreas...
Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATPN Lembert
Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Tubingen, Auf der Morgenstelle 8, D 72076 Tubingen, Germany
Biochem J 354:345-50. 2001..Instead MP may exert a direct extramitochondrial effect, or it may stimulate beta-cell mitochondria to produce coupling factors different from ATP to initiate insulin release...
Concentration-dependent potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase product formation in stimulated PMNLH Safayhi
Department of Pharmacology, University of Tuebingen, Germany
Planta Med 66:110-3. 2000..The in vitro data underline the major importance of drug standardization when Boswellia resin containing preparations are used for the treatment of diseases...
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase IR F Hoernlein
Institute of Pharmaceutical Sciences, Department of Pharmacology, Tuebingen
J Pharmacol Exp Ther 288:613-9. 1999..The data suggest that induction of apoptosis in HL-60 and CCRF-CEM by AKBA may be due to inhibition of topoisomerase I in these cells...
Distribution and stimulation by gastrin-releasing peptide of protein kinase C subfamilies in insulin-secreting cellsA Bihlmayer
Department of Pharmacology, Institute of Pharmaceutical Sciences, Eberhard-Karls University, , Germany
Neuroendocrinology 73:352-7. 2001..It is suggested that PKC alpha, beta and/or zeta may play a role in the modulation of insulin secretion by GRP...
[Ca(2+)](i)- and insulin-stimulating effect of the non-membranepermeable phosphatase-inhibitor microcystin-LR in intact insulin-secreting cells (RINm5F)T Leiers
Department of Pharmacology, Institute of Pharmaceutical Sciences, Eberhard Karls University Tubingen, Germany
Br J Pharmacol 130:1406-10. 2000..5. From these data we conclude that microcystin-LR could affect Ca(2+)-channels and insulin release by inhibiting an extracellular phosphatase-like activity...
Distribution of protein phosphatases type 1 and 2A in RINm5F cellsT Cartus
Institute of Pharmaceutical Sciences, Department of Pharmacology, University of Tubingen, Germany
Regul Pept 77:77-81. 1998..The data suggest that in membrane and nuclear fractions of RINmSF cells predominantly PP1 is present, whereas in the cytosol PP1 as well as PP2A can be detected...
Optimized biosensor for whole blood measurements using a new cellulose based membraneS Eisele
Department of Pharmacology, , Germany
Biosens Bioelectron 9:119-24. 1994..In addition, the measuring range of the glucose sensor could be extended up to 170 mM glucose by treating the bacterial cellulose membrane with a polyamide...
Potentiation of forskolin-induced increase of cAMP by diamide and N-ethylmaleimide in rat pancreatic isletsM I Anazodo
Pharmazeutisches Institut, Abteilung Pharmakologie, , Germany
Horm Metab Res 22:61-4. 1990..The potentiation of forskolin-induced cAMP production in intact islet cells by diamide and NEM may be due to inactivation of the thiols related to the Ni-protein...
