B Allolio

Summary

Country: Germany

Publications

  1. ncbi request reprint Management of adrenocortical carcinoma
    Bruno Allolio
    Endocrinology and Diabetes Unit, Department of Medicine, University of Wurzburg, Germany
    Clin Endocrinol (Oxf) 60:273-87. 2004
  2. ncbi request reprint Clinical review: Adrenocortical carcinoma: clinical update
    Bruno Allolio
    Endocrinology and Diabetes Unit, Department of Medicine I, University Hospital Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 91:2027-37. 2006
  3. ncbi request reprint Functional characterization of adrenal lesions using [123I]IMTO-SPECT/CT
    Stefanie Hahner
    Endocrinology and Diabetes Unit, University Hospital Wurzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 98:1508-18. 2013
  4. doi request reprint [131I]iodometomidate for targeted radionuclide therapy of advanced adrenocortical carcinoma
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Oberduerrbacher Strasse 6, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 97:914-22. 2012
  5. ncbi request reprint DHEA: why, when, and how much--DHEA replacement in adrenal insufficiency
    B Allolio
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Ann Endocrinol (Paris) 68:268-73. 2007
  6. ncbi request reprint New mechanisms of adrenostatic compounds in a human adrenocortical cancer cell line
    M Fassnacht
    Department of Medicine, University of Wuerzburg, Germany
    Eur J Clin Invest 30:76-82. 2000
  7. doi request reprint Improved survival in patients with stage II adrenocortical carcinoma followed up prospectively by specialized centers
    Martin Fassnacht
    Department of Internal Medicine I, University Hospital, University of Wurzburg, Wurzburg, Germany
    J Clin Endocrinol Metab 95:4925-32. 2010
  8. ncbi request reprint Management of adrenal insufficiency in different clinical settings
    Stefanie Hahner
    Department of Endocrinology, University of Wuerzburg, Josef Schneider Str 2, D 97080 Wuerzburg, Germany
    Expert Opin Pharmacother 6:2407-17. 2005
  9. ncbi request reprint Etomidate unmasks intraadrenal regulation of steroidogenesis and proliferation in adrenal cortical cell lines
    S Hahner
    Department of Medicine I, University of Wurzburg, Germany
    Horm Metab Res 42:528-34. 2010
  10. ncbi request reprint Intraoperative haemodynamic stability in patients with phaeochromocytoma--minimally invasive vs conventional open surgery
    Dirk Weismann
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital, Wuerzburg, Germany
    Clin Endocrinol (Oxf) 65:352-8. 2006

Detail Information

Publications89

  1. ncbi request reprint Management of adrenocortical carcinoma
    Bruno Allolio
    Endocrinology and Diabetes Unit, Department of Medicine, University of Wurzburg, Germany
    Clin Endocrinol (Oxf) 60:273-87. 2004
    ..Only large prospective multicentre trials comparing different treatment options will allow to make systematic progress in the management of ACC...
  2. ncbi request reprint Clinical review: Adrenocortical carcinoma: clinical update
    Bruno Allolio
    Endocrinology and Diabetes Unit, Department of Medicine I, University Hospital Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 91:2027-37. 2006
    ..Patients present with hormone excess (e.g. virilization, Cushing's syndrome) or a local mass effect (median tumor size at diagnosis > 10 cm). This paper reviews current diagnostic and therapeutic strategies in ACC...
  3. ncbi request reprint Functional characterization of adrenal lesions using [123I]IMTO-SPECT/CT
    Stefanie Hahner
    Endocrinology and Diabetes Unit, University Hospital Wurzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 98:1508-18. 2013
    ..Conventional imaging often provides only limited information on the origin of these lesions. Novel specific imaging methods are, therefore, of great clinical interest...
  4. doi request reprint [131I]iodometomidate for targeted radionuclide therapy of advanced adrenocortical carcinoma
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Oberduerrbacher Strasse 6, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 97:914-22. 2012
    ..We have shown high and specific retention of [123I]metomidate ([123I]IMTO) in ACC lesions, suggesting that labeling of metomidate with 131I offers targeted radionuclide therapy for advanced ACC...
  5. ncbi request reprint DHEA: why, when, and how much--DHEA replacement in adrenal insufficiency
    B Allolio
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Ann Endocrinol (Paris) 68:268-73. 2007
    ..Until the results of such trials are available DHEA cannot be considered part of standard replacement in AI, but compassionate use of DHEA in individual patients with AI and impaired well-being may be justified...
  6. ncbi request reprint New mechanisms of adrenostatic compounds in a human adrenocortical cancer cell line
    M Fassnacht
    Department of Medicine, University of Wuerzburg, Germany
    Eur J Clin Invest 30:76-82. 2000
    ..We therefore investigated the effects of aminoglutethimide (AG), metyrapone (MTP) and etomidate (ETO) in the human NCI-h295 adrenocortical carcinoma cell line...
  7. doi request reprint Improved survival in patients with stage II adrenocortical carcinoma followed up prospectively by specialized centers
    Martin Fassnacht
    Department of Internal Medicine I, University Hospital, University of Wurzburg, Wurzburg, Germany
    J Clin Endocrinol Metab 95:4925-32. 2010
    ..We hypothesized that these results may have been affected by a referral bias because many patients may contact specialized centers only after recurrence...
  8. ncbi request reprint Management of adrenal insufficiency in different clinical settings
    Stefanie Hahner
    Department of Endocrinology, University of Wuerzburg, Josef Schneider Str 2, D 97080 Wuerzburg, Germany
    Expert Opin Pharmacother 6:2407-17. 2005
    ..However, the pathophysiology and diagnosis criteria of relative adrenal insufficiency and its treatment remain unsettled issues...
  9. ncbi request reprint Etomidate unmasks intraadrenal regulation of steroidogenesis and proliferation in adrenal cortical cell lines
    S Hahner
    Department of Medicine I, University of Wurzburg, Germany
    Horm Metab Res 42:528-34. 2010
    ..Inhibition of steroidogenesis is followed by increased levels of steroidogenic key proteins and reduced proliferation. These changes reflect adaptations to maintain steroidogenesis at the cost of adrenal proliferation...
  10. ncbi request reprint Intraoperative haemodynamic stability in patients with phaeochromocytoma--minimally invasive vs conventional open surgery
    Dirk Weismann
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital, Wuerzburg, Germany
    Clin Endocrinol (Oxf) 65:352-8. 2006
    ..There is conflicting evidence, whether or not minimally invasive adrenalectomy (MA) is associated with an increased perioperative cardiovascular instability in phaeochromocytomas compared to conventional open adrenalectomy (CA)...
  11. ncbi request reprint Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females
    F Callies
    Department of Endocrinology, University of Wuerzburg, Germany
    Steroids 65:98-102. 2000
    ..In conclusion, an oral dose of 30 to 50 mg DHEA restores a physiological urinary steroid profile in subjects with DHEA deficiency without evidence for a relevant hepatic first-pass effect on urinary metabolites...
  12. ncbi request reprint [Replacement therapy with adrenal steroids]
    S Hahner
    Schwerpunkt Endokrinologie und Diabetologie, Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Deutschland
    Internist (Berl) 49:545-6, 548-50, 552. 2008
    ..However, in patients with an age related decline of DHEA levels, the available evidence does not support the use of DHEA replacement as an anti aging treatment...
  13. ncbi request reprint Testosterone undecanoate: a useful tool for testosterone administration in rats
    F Callies
    Department of Endocrinology, Medical University Hospital Wuerzburg, Wuerzburg, Germany
    Exp Clin Endocrinol Diabetes 111:203-8. 2003
    ..TUD was superior to other T release preparations and represents a convenient and effective tool for T administration in experimental animals...
  14. ncbi request reprint [Adrenal crisis. Diagnostic and therapeutic management of acute adrenal cortex insufficiency]
    S Hahner
    Abteilung für Endokrinologie und Diabetologie, Medizinische Universitätsklinik Würzburg
    Internist (Berl) 44:1243-52. 2003
    ..Outcome of adrenal crisis is crucially determined by the physician's clinical competence and immediate initiation of specific treatment...
  15. doi request reprint [Obesity and heart failure]
    S Frantz
    Herzkreislauf Zentrum, Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Internist (Berl) 49:389-90, 392-3. 2008
    ..Therapeutic approaches include weight control by dietary intervention and exercise, as well as bariatric surgery for the morbidly obese. Heart failure treatment should otherwise follow the general heart failure guidelines...
  16. ncbi request reprint Detrimental effects of testosterone on post-myocardial infarction remodelling in female rats
    S Frantz
    Universitat Wurzburg, Medizinische Klinik und Poliklinik I, Germany
    J Physiol Pharmacol 58:717-27. 2007
    ..In conclusion, chronic anabolic T treatment causes myocardial hypertrophy under basal conditions and adversely affects left ventricular remodeling following myocardial infarction in female rats...
  17. ncbi request reprint Failure of recombinant human growth hormone treatment to improve congestive heart failure in hypopituitarism
    M Spindler
    Department of Medicine, University of Wurzburg, Germany
    Exp Clin Endocrinol Diabetes 112:538-41. 2004
    ....
  18. ncbi request reprint [Adrenocortical carcinoma. Diagnostic work-up and treatment]
    S Johanssen
    Schwerpunkt Endokrinologie und Diabetologie, Medizinische Klinik und Poliklinik I, Universitatsklinik, 97080, Wurzburg
    Urologe A 47:172-81. 2008
    ..In advanced ACC, the treatment of choice is mitotane with or without cytotoxic chemotherapy (preferably after inclusion into the FIRM-ACT trial)...
  19. ncbi request reprint Dehydroepiandrosterone replacement in women with adrenal insufficiency
    W Arlt
    Department of Endocrinology, Medical University Hospital, Wuerzburg, Germany
    N Engl J Med 341:1013-20. 1999
    ..Adrenal insufficiency leads to a deficiency of dehydroepiandrosterone; we therefore, investigated the effects of dehydroepiandrosterone replacement, in patients with adrenal insufficiency...
  20. ncbi request reprint Dehydroepiandrosterone replacement in women with adrenal insufficiency: effects on body composition, serum leptin, bone turnover, and exercise capacity
    F Callies
    Department of Endocrinology, Medical University Hospital Wuerzburg, Germany
    J Clin Endocrinol Metab 86:1968-72. 2001
    ..The biological relevance of the changes in leptin and osteocalcin levels remains to be determined...
  21. ncbi request reprint [Osteoporosis in the male]
    B Allolio
    Medizinische Universitätsklinik Würzburg
    Med Klin (Munich) 95:327-38. 2000
    ..Epidemiologic data from Germany indicate that more than 900,000 men are affected by osteoporotic fractures. Diagnosis and therapy of male osteoporosis are hampered by a lack of clinical studies...
  22. doi request reprint [Current TNM classification systems for adrenocortical carcinoma]
    M Fassnacht
    Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie, Universitatsklinikum Wurzburg, Oberdürrbacher Str 6, 97080, Wurzburg, Deutschland
    Pathologe 31:374-8. 2010
    ..Furthermore, exact documentation of the resection status is essential for optimal decisions on treatment...
  23. ncbi request reprint [Malignant tumors of the adrenal cortex]
    B Allolio
    Medizinische Universitätsklinik Würzburg, Schwerpunkt Endokrinologie und Diabetologie, Josef Schneider Strasse 2, 97080 Wurzburg
    Internist (Berl) 43:186-95. 2002
  24. ncbi request reprint Workshop B: androgens for men and women - new insights
    B Allolio
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Wurzburg, Germany
    Growth Horm IGF Res 13:S62. 2003
  25. ncbi request reprint Clodronate inhibits adrenocortical cell proliferation and P450c21 activity
    M Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, 9700 Wuerzburg, Germany
    J Endocrinol 174:509-16. 2002
    ..In addition, for the first time, we describe a suppressive effect of CLO on steroidogenesis via inhibition of adrenal 21-hydroxylase (P450c21) activity...
  26. doi request reprint Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
    K P Lesch
    ADHD Clinical Research Network, Unit for Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 16:491-503. 2011
    ..These findings implicate CNVs of behaviour-related genes in the pathogenesis of ADHD and are consistent with the notion that both frequent and rare variants influence the development of this common multifactorial syndrome...
  27. ncbi request reprint Low circulating androgens and mortality risk in heart failure
    G Güder
    Medizinische Klinik und Poliklinik I Herz Kreislaufzentrum, Klinikum der Universität Würzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    Heart 96:504-9. 2010
    ..The pathophysiological implications of this phenomenon, however, have not been fully elucidated. This clinical study investigated the significance of low serum androgen levels in HF...
  28. ncbi request reprint Evidence against a role of physiological concentrations of estrogen in post-myocardial infarction remodeling
    S Hugel
    Medizinische Universitatsklinik, Universitat Wurzburg, Germany
    J Am Coll Cardiol 34:1427-34. 1999
    ..The purpose of this study was to examine whether endogenous estrogen deficiency induced by ovariectomy affects chronic left ventricular dysfunction post-myocardial infarction (MI)...
  29. ncbi request reprint High-dose 17beta-estradiol treatment prevents development of heart failure post-myocardial infarction in the rat
    Stephanie Beer
    Medizinische Universitatsklinik, Josef Schneider Str 2, 97080, Wurzburg, Germany
    Basic Res Cardiol 102:9-18. 2007
    ....
  30. doi request reprint Dehydroepiandrosterone to enhance physical performance: myth and reality
    Stefanie Hahner
    Department of Medicine I, University of Wurzburg, Wurzburg, Germany
    Endocrinol Metab Clin North Am 39:127-39, x. 2010
    ..However, because studies in female athletes are still lacking, an ergogenic activity of high-dose DHEA in this population cannot be excluded but is expected to be associated with adverse events like hirsutism, acne, and alopecia...
  31. ncbi request reprint Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma
    Martin Fassnacht
    University of Wuerzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit, Wuerzburg, Germany
    J Clin Endocrinol Metab 91:4501-4. 2006
    ..Although radiotherapy is often considered ineffective in the treatment of ACC, the limited number of available studies does not support this statement...
  32. doi request reprint Therapeutic management of adrenal insufficiency
    Stefanie Hahner
    Department of Medicine I, Endocrinology and Diabetes Unit, University of Wuerzburg, Wuerzburg, Germany
    Best Pract Res Clin Endocrinol Metab 23:167-79. 2009
    ..In our experience the well-educated patient often guides the physician not familiar with this disease...
  33. ncbi request reprint Complementary and incremental mortality risk prediction by cortisol and aldosterone in chronic heart failure
    Gülmisal Güder
    University of Wurzburg, Department of Internal Medicine I, Center for Cardiovascular Medicine, Klinikstrasse 6 8, D 97070 Wurzburg, Germany
    Circulation 115:1754-61. 2007
    ..The prognostic significance of cortisol that may also bind and activate the mineralocorticoid receptor in chronic heart failure is unknown...
  34. doi request reprint Osteopontin stimulates invasion of NCI-h295 cells but is not associated with survival in adrenocortical carcinoma
    Dirk Weismann
    University Hospital of Wurzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit, Wurzburg, Germany
    J Pathol 218:232-40. 2009
    ..This relationship remains of relevance to our understanding of carcinogenesis, but further studies are needed to address the physiological and pathological function of OPN in adrenal tissue...
  35. doi request reprint What is the best approach to an apparently nonmetastatic adrenocortical carcinoma?
    Martin Fassnacht
    Department of Internal Medicine I, Endocrine Unit, University Hospital, University of Wurzburg, Germany
    Clin Endocrinol (Oxf) 73:561-5. 2010
    ..In all patients a structured follow-up for 10 years is strongly recommended...
  36. doi request reprint Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: proposal for a Revised TNM Classification
    Martin Fassnacht
    Department of Medicine I, Endocrine and Diabetes Unit, University Hospital, University of Wurzburg, Wurzburg Germany
    Cancer 115:243-50. 2009
    ..However, to date, the prognostic value of the proposed classification has not been evaluated...
  37. doi request reprint Clinical management of adrenocortical carcinoma
    Martin Fassnacht
    Dept of Internal Medicine I, Endocrinology and Diabetes Unit, University Hospital, University of Wurzburg, Wurzburg, Germany
    Best Pract Res Clin Endocrinol Metab 23:273-89. 2009
    ..Several targeted therapies are under investigation (e.g. IGF-1 inhibitors, sunitinib, sorafenib) and may lead to new treatment options...
  38. doi request reprint New targets and therapeutic approaches for endocrine malignancies
    Martin Fassnacht
    Endocrine and Diabetic Unit, Department of Internal Medicine I, University Hospital, University of Wurzburg, Germany
    Pharmacol Ther 123:117-41. 2009
    ..This review covers these recent molecular and clinical advances which most likely will dramatically alter the treatment of endocrine malignancies within the coming decade...
  39. ncbi request reprint Radiotherapy in adrenocortical carcinoma
    Buelent Polat
    Department of Radiation Oncology, University Hospital, University of Wurzburg, Wurzburg, Germany
    Cancer 115:2816-23. 2009
    ..However, the authors concluded that prospective investigations would be required to fully define the therapeutic potential of this important treatment option...
  40. ncbi request reprint Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Endocrinol Metab 290:E423-33. 2006
    ..Our results suggest that ZG cells, in addition to PKA and Epac/Rap proteins, contain other as yet unidentified cAMP mediator(s) involved in regulating CaMK activity and aldosterone secretion...
  41. ncbi request reprint Administration of testosterone is associated with a reduced susceptibility to myocardial ischemia
    Frank Callies
    Department of Endocrinology, Medical University Hospital Wuerzburg, 97080 Wuerzburg, Germany
    Endocrinology 144:4478-83. 2003
    ..In conclusion, administration of testosterone significantly improves recovery from global ischemia. These beneficial effects are associated with an attenuation of reperfusion induced [Ca2+]i overload...
  42. ncbi request reprint DHEA treatment: myth or reality?
    Bruno Allolio
    Dept Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Trends Endocrinol Metab 13:288-94. 2002
    ..Future research should focus on DHEA treatment for adrenal insufficiency, and DHEA administration in both patients receiving chronic glucocorticoid treatment and women with androgen deficiency...
  43. ncbi request reprint Susceptibility to cardiac ischemia/reperfusion injury is modulated by chronic estrogen status
    Stephanie Beer
    Medizinische Universitatsklinik, Wurzburg, Germany
    J Cardiovasc Pharmacol 40:420-8. 2002
    ..This improvement, however, did not include preservation of high-energy phosphate metabolism. Other potential mechanisms include an anti-oxidant activity of 17beta-estradiol-and estrogen-induced alterations in glucose metabolism...
  44. ncbi request reprint N-terminal proopiomelanocortin acts as a mitogen in adrenocortical tumor cells and decreases adrenal steroidogenesis
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Wurzburg 97080, Germany
    J Clin Endocrinol Metab 88:2171-9. 2003
    ..The distinct roles of 1-28-POMC and ACTH in the regulation of adrenal growth and steroidogenesis suggest that the adrenal cortex is under the dual opposing control of fragments from the same mother peptide POMC...
  45. ncbi request reprint Evidence against a role of human airway trypsin-like protease--the human analogue of the growth-promoting rat adrenal secretory protease--in adrenal tumourigenesis
    Stefanie Hahner
    Department of Medicine, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    Eur J Endocrinol 152:143-53. 2005
    ..AsP may therefore play a crucial role in adrenal growth and tumourigenesis. The aim of this study was to further characterize the human homologue of AsP and its possible role in adrenal tumourigenesis...
  46. ncbi request reprint AKT is highly phosphorylated in pheochromocytomas but not in benign adrenocortical tumors
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:4366-70. 2005
    ..Activation of AKT plays a major role in a variety of human neoplasias. In mice, a heterozygous deletion of the Pten gene is associated with increased activation of AKT and with development of pheochromocytomas...
  47. ncbi request reprint Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:6283-9. 2005
    ..In vitro DHEA has been shown to enhance IL-2 release from T lymphocytes, whereas it inhibits IL-6 secretion. Conversely, aging is associated with a decline in both DHEA and IL-2, whereas IL-6 increases...
  48. ncbi request reprint Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion
    W Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University Hospital Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 86:4686-92. 2001
    ..Thus, in contrast to previous findings in adrenal insufficiency, we found no obvious benefit of 4 months of dehydroepiandrosterone supplementation in healthy men with a physiological decline of dehydroepiandrosterone production...
  49. ncbi request reprint Octreotide LAR treatment throughout pregnancy in an acromegalic woman
    M Fassnacht
    Department of Endocrinology, University of Wuerzburg, Germany
    Clin Endocrinol (Oxf) 55:411-5. 2001
    ..Octreotide treatment in pregnancy seems to be feasible and safe. Due to the still-limited number of reported cases, the potential benefits of octreotide treatment should be weighed carefully against its possible risks...
  50. doi request reprint High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors
    Silviu Sbiera
    Department of Internal Medicine I, University Hospital of Wuerzburg, Wurzburg, Germany
    J Clin Endocrinol Metab 95:E161-71. 2010
    ....
  51. ncbi request reprint Effect of testosterone on post-myocardial infarction remodeling and function
    Matthias Nahrendorf
    Medical University Hospital Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Cardiovasc Res 57:370-8. 2003
    ..Moreover, testosterone (T) treatment is increasingly used in elderly males. Therefore, we examined effects of chronic anabolic T administration on left ventricular (LV) remodeling after myocardial infarction (MI)...
  52. ncbi request reprint Adrenocortical carcinoma -- improving patient care by establishing new structures
    A C Koschker
    Endocrinology and Diabetes Unit, Department of Medicine I, University Hospital Wurzburg, Germany
    Exp Clin Endocrinol Diabetes 114:45-51. 2006
    ..For the first time, patients with metastatic/unresectable ACC can participate in a prospective controlled randomized trial comparing two different cytotoxic chemotherapy regimes (FIRM-ACT)...
  53. doi request reprint Prevention of hypertensive crises in rats induced by acute and chronic norepinephrine excess
    D Weismann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    Horm Metab Res 42:803-8. 2010
    ..POB was the most effective drug used in monotherapy, but BP stabilization was superior using a combination of POB pretreatment with a continuous nifedipine infusion in this model...
  54. ncbi request reprint Survivin in adrenocortical tumors - pathophysiological implications and therapeutic potential
    S Sbiera
    Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Wurzburg, University of Wurzburg, Wurzburg, Germany
    Horm Metab Res 45:137-46. 2013
    ..In conclusion, our data suggest that survivin could play an important role in the anti-apoptotic mechanisms in ACC and provide first hints that targeting survivin might be an interesting new therapeutic approach in this rare disease...
  55. ncbi request reprint Angiotensin II type 1 receptor and ACTH receptor expression in human adrenocortical neoplasms
    B Schubert
    Schwerpunkt Endokrinologie, Department of Medicine, , Germany
    Clin Endocrinol (Oxf) 54:627-32. 2001
    ..The predominant receptor expressed in adrenocortical tumours is the Angiotensin II type 1 receptor whereas type 2 receptor expression is minimal...
  56. doi request reprint Epidemiology of adrenal crisis in chronic adrenal insufficiency: the need for new prevention strategies
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wurzburg, Oberdürrbacher Str 6, D 97080 Wurzburg, Germany
    Eur J Endocrinol 162:597-602. 2010
    ..Adrenal crisis (AC) is a life-threatening complication of adrenal insufficiency (AI). Here, we evaluated frequency, causes and risk factors of AC in patients with chronic AI...
  57. ncbi request reprint The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease
    Immo A Hansen
    Endocrinology and Diabetes Unit, Department of Medicine, University of Wuerzburg, Germany
    Endocrinology 145:1898-905. 2004
    ..These findings indicate a multifunctional role of these proteases beyond adrenal proliferation...
  58. ncbi request reprint Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma
    Sebastian Wortmann
    Endocrine and Diabetes Unit, Department of Internal Medicine I, University Hospital of Wurzburg, University of Wurzburg, Oberdurrbacher Strasse 6, 97080 Wurzburg, Germany
    Eur J Endocrinol 162:349-56. 2010
    ..However, there is no evidence for any therapy beneficial in patients failing these therapies. Therefore, we evaluated the effects of the anti-VEGF antibody bevacizumab plus capecitabine as salvage therapy in ACC...
  59. ncbi request reprint [123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine, University of Wuerzburg, Josef Schneider Strasse 2, Wuerzburg, Germany
    J Clin Endocrinol Metab 93:2358-65. 2008
    ..New specific imaging methods would therefore be of great clinical value. We, therefore, studied the potential of iodometomidate (IMTO) as tracer for molecular imaging of cytochrome P450 family 11B (Cyp11B) enzymes...
  60. ncbi request reprint Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 92:3912-22. 2007
    ..Here we evaluated the subjective health status in primary and secondary AI and the effect of concomitant disease...
  61. doi request reprint Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma
    Wiebke Fenske
    Endocrine and Diabetic Unit, Department of Internal Medicine I, University Hospital of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Endocr Relat Cancer 16:919-28. 2009
    ..31 (1.80-15.62) in patients with metastatic ACC and in patients after radical resection the HR for disease-free survival was 6.10 (2.16-16.94). In conclusion, GLUT1 is a highly promising stage-independent, prognostic marker in ACC...
  62. ncbi request reprint Lack of hepatic conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA
    F Hammer
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Endocr Res 30:759-60. 2004
  63. ncbi request reprint Adrenal tumors: how to establish malignancy ?
    M Fassnacht
    Endocrinology and Diabetes Unit, University of Wuerzburg, Germany
    J Endocrinol Invest 27:387-99. 2004
    ..In conclusion, an interdisciplinary approach with a structured use of available diagnostic tools is needed to classify adrenal tumors correctly...
  64. ncbi request reprint Improved metabolic control after 12-week dietary intervention with low glycaemic isomalt in patients with type 2 diabetes mellitus
    I Holub
    University of Wurzburg, Department of Medicine II, Division of Gastroenterology, 97080 Wurzburg, Germany
    Horm Metab Res 41:886-92. 2009
    ..The present study is in agreement with findings of previous reported studies in human subjects demonstrating beneficial effects of low glycaemic diets on glucose metabolism in patients with diabetes mellitus type 2...
  65. ncbi request reprint A dangerous liaison--pheochromocytoma in patients with malignant disease
    Dirk Weismann
    Endocrine and Diabetes Unit, Department of Medicine, University of Wuerzburg, Josef Schneider Str 2, Wuerzburg, D 97080, Germany
    Ann Surg Oncol 13:1696-701. 2006
    ..Despite improved imaging techniques, it remains difficult to distinguish an adrenal metastasis from a pheochromocytoma or a lipid-poor adrenocortical adenoma...
  66. doi request reprint Expression of excision repair cross complementing group 1 and prognosis in adrenocortical carcinoma patients treated with platinum-based chemotherapy
    Cristina L Ronchi
    Endocrine and Diabetes Unit, Department of Medicine I, University Hospital, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Endocr Relat Cancer 16:907-18. 2009
    ..2, 95% CI 1.0-4.5, P=0.038). Our findings suggest that ERCC1 expression is the first factor for predicting survival in ACC patients treated with platinum-based chemotherapy...
  67. ncbi request reprint The pro-opiomelanocortin gene of the zebrafish (Danio rerio)
    Immo A Hansen
    Endocrinology and Diabetes Unit, University of Wuerzburg, Josef Schneider Strasse 2, Germany
    Biochem Biophys Res Commun 303:1121-8. 2003
    ..These findings will facilitate the use of the zebrafish as a model organism in the study of the physiological role of POMC-derived peptides...
  68. ncbi request reprint Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D
    Wiebke Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, Germany
    Eur J Endocrinol 146:215-22. 2002
    ..Only few studies have evaluated the efficacy of calcium/vitamin D treatment in hypoparathyroidism; the impact of chronic hypoparathyroid disease on well-being has not been investigated previously...
  69. ncbi request reprint No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:3600-5. 2005
    ..DHEAS does not seem to represent a circulating storage pool for DHEA regeneration, and therefore serum DHEAS is unlikely to reflect bioavailable DHEA...
  70. ncbi request reprint Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 88:2760-6. 2003
    ..05). Taken together, these data indicate enhanced peripheral 5 alpha-reductase activity in PCOS. Thus, not only ovary and adrenal, but also liver and peripheral target tissues, significantly contribute to steroid alterations in PCOS...
  71. doi request reprint Altered insulin requirement in patients with type 1 diabetes and primary adrenal insufficiency receiving standard glucocorticoid replacement therapy
    Ulf Elbelt
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Eur J Endocrinol 160:919-24. 2009
    ..This may lead to changes in insulin requirement in patients with primary adrenal insufficiency and type 1 diabetes. Therefore, we assessed insulin requirement in patients with autoimmune polyendocrine syndrome type 2 (APS-2)...
  72. doi request reprint Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factors
    Gülmisal Güder
    Medizinische Klinik und Poliklinik I, University Hospital Wurzburg, Wurzburg, Germany
    Circ Heart Fail 2:563-71. 2009
    ..We estimated the prognostic role of these risk factors in unselected patients with heart failure...
  73. ncbi request reprint [Recurrent hypertensive crises associated with severe orthostatic hypotension due to baroreflex failure syndrome]
    S Frantz
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Z Kardiol 91:946-50. 2002
    ..Both high blood pressure and orthostatically induced syncope improved substantially after treatment with clonidine...
  74. doi request reprint Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests
    Wiebke Fenske
    Department of Internal Medicine I Endocrine Unit, University Hospital Wurzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 96:1506-15. 2011
    ..In theory, direct measurement of AVP is highly attractive but is hampered by technical difficulties...
  75. ncbi request reprint Silencing of the mineralocorticoid receptor by ribonucleic acid interference in transgenic rats disrupts endocrine homeostasis
    Hee Young Lim
    University of Wurzburg, Wurzburg, Germany
    Mol Endocrinol 22:1304-11. 2008
    ..In conclusion, this is the first example of a human disease model based on RNA interference in rats...
  76. ncbi request reprint Gorham-Stout disease--stabilization during bisphosphonate treatment
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Wurzburg, Germany
    J Bone Miner Res 20:350-3. 2005
    ..v. every 3 months) was initiated, leading to rapid disappearance of local pain. Follow-up over 24 months documented a stable clinical and radiological picture without evidence of progressive bone destruction...
  77. doi request reprint Copeptin in the differential diagnosis of hyponatremia
    Wiebke Fenske
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 94:123-9. 2009
    ..This study was designed to evaluate the diagnostic potential of copeptin, the C-terminal part of provasopressin, as a new marker in the differential diagnosis of hyponatremia...
  78. ncbi request reprint Pituitary-interrenal interaction in zebrafish interrenal organ development
    Thuy Thanh To
    Endocrinology and Diabetes Unit, Department of Medicine, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Mol Endocrinol 21:472-85. 2007
    ..These data demonstrate a gradual transition from early pituitary-independent interrenal organogenesis to developmental control by the anterior domain of pituitary corticotrophs acting via Mc2 receptors...
  79. ncbi request reprint Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock
    Wiebke Arlt
    Medical Research Council Senior Clinical Fellow, Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Room 233, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:2548-54. 2006
    ..However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels...
  80. ncbi request reprint Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs. timed serum cortisol measurements
    Wiebke Arlt
    Division of Medical Sciences Institute of Biomedical Research IBR Endocrinology and Metabolism, The Medical School, University of Birmingham, Edgbaston, UK
    Clin Endocrinol (Oxf) 64:384-9. 2006
    ..Here we compared the results of a structured clinical assessment to the outcome of repeated, timed serum cortisol measurements...
  81. ncbi request reprint Adjuvant mitotane treatment for adrenocortical carcinoma
    Massimo Terzolo
    Universita di Torino, Turin, Italy
    N Engl J Med 356:2372-80. 2007
    ..Whether the use of mitotane is beneficial as an adjuvant treatment has been controversial. Our aim was to evaluate the efficacy of adjuvant mitotane in prolonging recurrence-free survival...
  82. ncbi request reprint [New diabetes therapy in clinical trial: will need adapted insulin supply be available soon? (interview by Dr. Judith Neumaier)]
    Bruno Allolio
    MMW Fortschr Med 146:10. 2004
  83. pmc Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production
    Anthony P Coll
    Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, UK
    J Endocrinol 190:515-25. 2006
    ..In a mouse model which lacks all endogenous POMC peptides, s.c. treatment with synthetic 1-28 POMC alone can reduce food intake and body weight, but has no impact upon adrenal growth or steroidogenesis...
  84. ncbi request reprint Treatment of advanced adrenocortical carcinoma with erlotinib plus gemcitabine
    Marcus Quinkler
    Clinical Endocrinology, Charite Campus Mitte, Charite University Medicine Berlin, Germany
    J Clin Endocrinol Metab 93:2057-62. 2008
    ..However, many patients have progressive disease despite treatment with these regimens...
  85. ncbi request reprint DHEA replacement in adrenal insufficiency
    Wiebke Arlt
    J Clin Endocrinol Metab 88:4001; author reply 4001-2. 2003
  86. ncbi request reprint Adrenal insufficiency
    Wiebke Arlt
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Lancet 361:1881-93. 2003
    ..Thus, long-term management of patients with adrenal insufficiency remains a challenge, requiring an experienced specialist. However, all doctors should know how to diagnose and manage suspected acute adrenal failure...
  87. ncbi request reprint Dehydroepiandrosterone supplementation in elderly men: the role of estrogens versus androgens on the male skeleton
    Lorenz C Hofbauer
    J Clin Endocrinol Metab 87:4009; author reply 4009. 2002
  88. ncbi request reprint Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney
    Marcus Quinkler
    Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    Hypertension 46:787-98. 2005
    ..These data show that alphaENaC expression is directly regulated by androgens in vitro and in vivo and highlight a potential mechanism explaining the reported gender differences in blood pressure...
  89. ncbi request reprint Comprehensive mutation scanning of NF1 in apparently sporadic cases of pheochromocytoma
    Birke Bausch
    Medizinische Universitatsklinik, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Clin Endocrinol Metab 91:3478-81. 2006
    ..The 57-exon susceptibility gene NF1 has so far not been systematically scanned for unexpected germline mutations in individuals with sporadic pheochromocytoma...