Sebastian Alers

Summary

Country: Germany

Publications

  1. pmc The incredible ULKs
    Sebastian Alers
    Department of Internal Medicine I, University Hospital of Tubingen, Otfried M and 252ller Str, 10, 72076 Tubingen, Germany
    Cell Commun Signal 10:7. 2012
  2. doi request reprint AMPK-independent induction of autophagy by cytosolic Ca2+ increase
    Antje Grotemeier
    Department of Internal Medicine I, University Clinic of Tubingen, Germany
    Cell Signal 22:914-25. 2010
  3. ncbi request reprint Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
    Antje S Löffler
    Department of Internal Medicine I, University of Tubingen, Tubingen, Germany
    Autophagy 7:696-706. 2011
  4. doi request reprint Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1
    Joachim Manns
    Department of Internal Medicine I, Institute for Medical Virology and Epidemiology of Viral Diseases, University of Tubingen, Tubingen, Germany
    FASEB J 25:3250-61. 2011
  5. pmc Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
    Sebastian Alers
    Department of Internal Medicine I, University Clinic of Tubingen, Tubingen, Germany
    Mol Cell Biol 32:2-11. 2012
  6. doi request reprint The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis
    Alexandra Dieterle
    Department of Internal Medicine I, University of Tubingen, Tubingen, Germany
    Int J Cancer 125:932-41. 2009

Collaborators

  • Susanne Ullrich
  • Tassula Proikas-Cezanne
  • Thomas Iftner
  • Benoit Viollet
  • Mondira Kundu
  • Sebastian Wesselborg
  • Björn Stork
  • Alexandra Dieterle
  • Merle Daubrawa
  • Antje Grotemeier
  • Antje S Löffler
  • Joachim Manns
  • Florian Paasch
  • Hildegard Keppeler
  • Alexandra M Dieterle
  • Klaus Schulze-Osthoff
  • Antje Löffler
  • Stefan Driessen
  • Mirita Franz-Wachtel
  • David G Campbell
  • Nadine Hoffmann
  • Dario R Alessi
  • Kirsten Lauber
  • Simon G Pfisterer
  • Reiner Lammers
  • Ronald Orth

Detail Information

Publications6

  1. pmc The incredible ULKs
    Sebastian Alers
    Department of Internal Medicine I, University Hospital of Tubingen, Otfried M and 252ller Str, 10, 72076 Tubingen, Germany
    Cell Commun Signal 10:7. 2012
    ....
  2. doi request reprint AMPK-independent induction of autophagy by cytosolic Ca2+ increase
    Antje Grotemeier
    Department of Internal Medicine I, University Clinic of Tubingen, Germany
    Cell Signal 22:914-25. 2010
    ..We suggest that apart from reported AMPK-dependent regulation of autophagic degradation, an AMPK-independent pathway triggers Ca(2+)-mediated autophagy, involving the PI(3)P-effector protein WIPI-1 and LC3...
  3. ncbi request reprint Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
    Antje S Löffler
    Department of Internal Medicine I, University of Tubingen, Tubingen, Germany
    Autophagy 7:696-706. 2011
    ..Thus, we propose that Ulk1 is not only involved in the induction of autophagy, but also in terminating signaling events that trigger autophagy. In our model, phosphorylation of AMPK by Ulk1 represents a negative feedback circuit...
  4. doi request reprint Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1
    Joachim Manns
    Department of Internal Medicine I, Institute for Medical Virology and Epidemiology of Viral Diseases, University of Tubingen, Tubingen, Germany
    FASEB J 25:3250-61. 2011
    ..Since staurosporine derivatives have proven efficacy in clinical trials, activation of this novel pathway might represent a powerful target to induce apoptosis in multidrug-resistant tumor cells...
  5. pmc Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
    Sebastian Alers
    Department of Internal Medicine I, University Clinic of Tubingen, Tubingen, Germany
    Mol Cell Biol 32:2-11. 2012
    ....
  6. doi request reprint The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis
    Alexandra Dieterle
    Department of Internal Medicine I, University of Tubingen, Tubingen, Germany
    Int J Cancer 125:932-41. 2009
    ..Therefore, this combinatorial treatment might open a promising therapeutic approach for the elimination of hormone-refractory prostate cancers, which are largely resistant to conventional DNA damaging anticancer drugs or irradiation...