Thomas Aigner

Summary

Country: Germany

Publications

  1. ncbi EBV-associated post-transplantation B-cell lymphoproliferative disorder following allogenic stem cell transplantation for acute lymphoblastic leukaemia: tumor regression after reduction of immunosuppression--a case report
    Alexander Krenauer
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, Germany
    Diagn Pathol 5:21. 2010
  2. ncbi Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year
    Bastian Marquass
    Department of Trauma and Reconstructive Surgery, University of Leipzig, Leipzig, Germany
    Am J Sports Med 39:1401-12. 2011
  3. ncbi FOXO3a: a novel player in thyroid carcinogenesis?
    Stefan Karger
    Department of Internal Medicine, University of Leipzig, Ph Rosenthal Street 27, 04103 Leipzig, Germany
    Endocr Relat Cancer 16:189-99. 2009
  4. ncbi SOX gene expression in human osteoarthritic cartilage
    Jochen Haag
    Institute of Pathology, University Hospital Leipzig, Leipzig, Germany
    Pathobiology 75:195-9. 2008
  5. ncbi Identification of calponin 3 as a novel Smad-binding modulator of BMP signaling expressed in cartilage
    Jochen Haag
    Cartilage Research, Department of Pathology, University of Leipzig, Liebigstrasse 26, 04103, Leipzig, Germany
    Exp Cell Res 313:3386-94. 2007
  6. ncbi Functional genomics, evo-devo and systems biology: a chance to overcome complexity?
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Curr Opin Rheumatol 19:463-70. 2007
  7. ncbi Soft tissue metastasis of thyroid carcinoma in the knee region mimicking a paraarticular inflammatory lesion
    Torsten Prietzel
    Orthopedic Hospital, University of Leipzig, Leipzig, Germany
    Arch Orthop Trauma Surg 130:1425-8. 2010
  8. ncbi Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model
    Matthias Zscharnack
    Department of Cell Techniques and Applied Stem Cell Biology, Center of Biotechnology and Biomedicine, University of Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    Am J Sports Med 38:1857-69. 2010
  9. ncbi Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Germany
    Nat Clin Pract Rheumatol 3:391-9. 2007
  10. ncbi Matrix biochemistry and cell biology of dedifferentiated chondrosarcomas
    Kerstin Dornauer
    Institute of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Pathol Int 60:365-72. 2010

Collaborators

Detail Information

Publications13

  1. ncbi EBV-associated post-transplantation B-cell lymphoproliferative disorder following allogenic stem cell transplantation for acute lymphoblastic leukaemia: tumor regression after reduction of immunosuppression--a case report
    Alexander Krenauer
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, Germany
    Diagn Pathol 5:21. 2010
    ..This observation supports the idea that regression of PTLD is mediated by cytotoxic T-cells and is in keeping with the observation that T-cell depletion, represents a major risk factor for the development of PTLD...
  2. ncbi Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year
    Bastian Marquass
    Department of Trauma and Reconstructive Surgery, University of Leipzig, Leipzig, Germany
    Am J Sports Med 39:1401-12. 2011
    ..This raises the need for a longer term follow-up study and comparison with a clinically established method...
  3. ncbi FOXO3a: a novel player in thyroid carcinogenesis?
    Stefan Karger
    Department of Internal Medicine, University of Leipzig, Ph Rosenthal Street 27, 04103 Leipzig, Germany
    Endocr Relat Cancer 16:189-99. 2009
    ..Furthermore, PI3K-dependent FOXO3a inactivation may be a novel pathomechanism for the escape from apoptosis in thyroid cancer cells, in particular in follicular thyroid carcinoma...
  4. ncbi SOX gene expression in human osteoarthritic cartilage
    Jochen Haag
    Institute of Pathology, University Hospital Leipzig, Leipzig, Germany
    Pathobiology 75:195-9. 2008
    ..Therefore, the aim of the present study was to present a thorough analysis of SOX gene expression in normal and osteoarthritic human adult cartilage...
  5. ncbi Identification of calponin 3 as a novel Smad-binding modulator of BMP signaling expressed in cartilage
    Jochen Haag
    Cartilage Research, Department of Pathology, University of Leipzig, Liebigstrasse 26, 04103, Leipzig, Germany
    Exp Cell Res 313:3386-94. 2007
    ..Furthermore, our data provide a possible explanation for the effect of the related protein calponin 1 on bone and cartilage development...
  6. ncbi Functional genomics, evo-devo and systems biology: a chance to overcome complexity?
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Curr Opin Rheumatol 19:463-70. 2007
    ..This review addresses the key question of how to integrate a high complexity of processes and data to a unifying picture of disease processes and progression relevant for osteoarthritis...
  7. ncbi Soft tissue metastasis of thyroid carcinoma in the knee region mimicking a paraarticular inflammatory lesion
    Torsten Prietzel
    Orthopedic Hospital, University of Leipzig, Leipzig, Germany
    Arch Orthop Trauma Surg 130:1425-8. 2010
    ..Thus, in such patients, a metastatic lesion even in unusual places such as the periarticular soft tissue should be included in the differential diagnosis...
  8. ncbi Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model
    Matthias Zscharnack
    Department of Cell Techniques and Applied Stem Cell Biology, Center of Biotechnology and Biomedicine, University of Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    Am J Sports Med 38:1857-69. 2010
    ..However, there is a lack of studies in large-animal models examining the benefits of chondrogenic predifferentiation in vitro for repair of chronic osteochondral defects...
  9. ncbi Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Germany
    Nat Clin Pract Rheumatol 3:391-9. 2007
    ..Thus, anti-aging strategies might complement existing therapeutic targets related to anabolism, catabolism, inflammation, and apoptosis-processes that are integral to the pathogenesis of osteoarthritis...
  10. ncbi Matrix biochemistry and cell biology of dedifferentiated chondrosarcomas
    Kerstin Dornauer
    Institute of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Pathol Int 60:365-72. 2010
    ..There was no difference in the clinical outcome of patients with differing high-grade tumor types, emphasizing that grade is a more important predictor of biological behavior than the direction of tumor differentiation...
  11. ncbi Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis
    Kerstin Krause
    Division of Endocrinology, Department of Internal Medicine, University of Leipzig, Ph Rosenthal Str 27, D 04103 Leipzig, Germany
    J Endocrinol 198:291-9. 2008
    ..Thyroid cancers are characterized by APP upregulation, increased membrane targeting of the APP ectodomain and significantly increased mRNA levels of the APP scaffold proteins JIP1, ShcA and Fe65...
  12. ncbi Achondrogenesis Type IA (Houston-Harris): a still-unresolved molecular phenotype
    Thomas Aigner
    Institute of Pathology, Liebigstrasse 26, Leipzig, Germany
    Pediatr Dev Pathol 10:328-34. 2007
    ..Presumably, as a consequence of this event, processes of chondrocyte maturation and differentiation and endochondral bone formation are severely affected in this case of achondrogenesis type IA...
  13. ncbi Senile EBV-associated B-cell lymphoproliferative disorder of prepatellar bursa in an elderly patient with multifocal urate arthropathy
    Susanna Mueller
    Institute for Pathology, University of Leipzig, Leipzig, Germany
    Hematol Oncol 25:140-2. 2007
    ..We suggest that an impaired EBV-specific T-cell immunity, local or systemic, may play a role in the development of this disorder and that chronic diseases such as gout may be contributing factors...