Research Topics
| Daigeler AdrienSummaryCountry: Germany Publications
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Publications
Intravascular leiomyosarcoma of the brachiocephalic region -- report of an unusual tumour localisation: case report and review of the literatureDaniel Johannes Tilkorn
Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
World J Surg Oncol 6:113. 2008..Intravascular leiomyosarcoma is a rare tumour entity originating from venous vessel structures and most frequently affecting the inferior vena cava...- Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissuesAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
BMC Surg 6:10. 2006..Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results... 
The pedicled gastrocnemius muscle flap: a review of 218 casesAdrien Daigeler
Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Plast Reconstr Surg 123:250-7. 2009..Data regarding donor-site morbidity, postoperative clinical course, and functional and aesthetic outcome after gastrocnemius muscle flaps are rare...- Sternal osteomyelitis: long-term results after pectoralis muscle flap reconstructionAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Plast Reconstr Surg 123:910-7. 2009..Reports regarding long-term follow-up including quality-of-life assessment, pulmonary function, and donor-site morbidity after operative treatment for sternal osteomyelitis are rare... 
Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagusAdrien Daigeler
Department of General and Visceral Surgery, St Josef Hospital Ruhr University, Bochum, Germany
Int J Oncol 32:1205-20. 2008..Taking into consideration that the non-toxic TRD was able to reduce rhTRAIL toxicity and dose, combined therapy with TRD and rhTRAIL may offer new options for treatment in esophageal cancer...- Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma culturesAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
BMC Cancer 8:313. 2008..This study was performed to identify gene expression changes in liposarcoma after doxorubicin treatment... - Alveolar soft part sarcoma: clinicopathological findings in a series of 11 casesAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
World J Surg Oncol 6:71. 2008..The aim of this study was a clinicopathological analysis with special reference to treatment and outcome... - Lymph node metastases in soft tissue sarcomas: a single center analysis of 1,597 patientsA Daigeler
Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Langenbecks Arch Surg 394:321-9. 2009..The aim of this study was to examine the clinical course of patients with the rare finding of regional lymph node metastasis (RLNM) from soft tissue sarcoma... - Reconstruction of the thoracic wall-long-term follow-up including pulmonary function testsAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789, Bochum, Germany
Langenbecks Arch Surg 394:705-15. 2009.... - Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot studyAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
Langenbecks Arch Surg 395:261-75. 2010..This study focused on these tumors and analyzed the association of gene expression profiles to clinical outcome... - TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcomaAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
J Exp Clin Cancer Res 27:82. 2008..Disseminated soft tissue sarcoma still represents a therapeutic dilemma because effective cytostatics are missing. Therefore we tested TRAIL and Tarolidine (TRD), two substances with apoptogenic properties on human fibrosarcoma (HT1080)... - [Manifestations of scleroderma at the hand--options for hand surgery in an interdisciplinary concept]A Daigeler
Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, Berufsgenossenschaftliche Kliniken Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum
Handchir Mikrochir Plast Chir 39:128-34. 2007..With reference to several cases seen at our institution, we propose an interdisciplinary treatment concept for acral manifestations of scleroderma... - Metachronous bilateral soft tissue sarcoma of the extremitiesA Daigeler
Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University, Buerkle de la Camp Platz 1, 44789, Bochum, Germany
Langenbecks Arch Surg 393:207-12. 2008..Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas... - Elastofibroma dorsi--differential diagnosis in chest wall tumoursAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
World J Surg Oncol 5:15. 2007..The pathogenesis of the lesion is still unclear, but repetitive microtrauma by friction between the scapula and the thoracic wall may cause the reactive hyperproliferation of fibroelastic tissue... - [Differential diagnosis of "sterile" phlegmonous hand infections]A Daigeler
Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Kliniken Bergmannsheil Bochum, Ruhr Universitat Bochum
Chirurg 77:1040-5. 2006..In these cases, operative treatment would be harmful. Therefore two cases-pyoderma gangrenosum and tuberculosis-are presented here in relation to common bacterial hand infection... - Gene expression analysis of cell death induction by taurolidine in different malignant cell linesAnsgar M Chromik
Department of Visceral and General Surgery, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
BMC Cancer 10:595. 2010..The aim of this study was to identify potential common target genes modulated at the transcriptional level following TRD treatment in tumour cell lines originating from different cancer types... - Proximal major limb amputations--a retrospective analysis of 45 oncological casesAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
World J Surg Oncol 7:15. 2009..The aim of this retrospective study was to analyse outcome in those patients, including the postoperative course, survival, pain, quality of life, and prosthesis usage... - MFH revisited: outcome after surgical treatment of undifferentiated pleomorphic or not otherwise specified (NOS) sarcomas of the extremities -- an analysis of 140 patientsMarcus Lehnhardt
Department of Plastic Surgery, Burn Center, Handsurgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Langenbecks Arch Surg 394:313-20. 2009..The objective of this study is to determine prognostic factors for the outcome after surgical treatment with respect to the recent developments in classification... - Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathwaysMarcus Lehnhardt
Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
BMC Cancer 5:74. 2005..In this study we elucidated the response of a fibrosarcoma cell line to clinically used cytostatic agents on the level of gene expression... - Laser-mediated fixation of collagen-based scaffolds to dermal woundsLars Steinstraesser
Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, 44789 Bochum, Germany
Lasers Surg Med 42:141-9. 2010..Laser-mediated tissue welding in a wet environment is a potential alternative for collagen scaffold fixation and may be advantageous to suture, staple, and tissue glue fixation... - Synergistic effects of sonoporation and taurolidin/TRAIL on apoptosis in human fibrosarcomaAdrien Daigeler
Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Unfallkrankenhaus, Ludwigshafen, Germany
Ultrasound Med Biol 36:1893-906. 2010..Further studies are needed to explore the options of sonodynamic therapy on soft tissue sarcoma and its molecular mechanisms... - Intravital pathophysiologic comparison of frostbite and burn injury in a murine modelOle Goertz
Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
J Surg Res 167:e395-401. 2011..To determine pathophysiologic similarities and differences, two comparable in vivo frostbite and burn models were used to assess microcirculatory and angiogenetic changes in burn and frostbite injuries... - Determination of microcirculatory changes and angiogenesis in a model of frostbite injury in vivoOle Goertz
Department of Plastic and Hand Surgery, Burn Center, Ruhr University Bochum, Germany
J Surg Res 168:155-61. 2011..However, little is known as yet. The aim was to develop an in vivo frostbite model to monitor microcirculatory changes and angiogenesis after frostbite injury... - Tendon transfers for drop foot correction: long-term results including quality of life assessment, and dynamometric and pedobarographic measurementsHans Ulrich Steinau
Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
Arch Orthop Trauma Surg 131:903-10. 2011.... - Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell linesAnsgar M Chromik
Department of Visceral and General Surgery, St Josef Hospital, Ruhr University Bochum, Germany
J Exp Clin Cancer Res 29:21. 2010..The aim of this study was therefore, to perform a comparative analysis of cell death induction by TRD simultaneously in different malignant cell lines... - Identification of patients at risk for development of tertiary peritonitis on a surgical intensive care unitAnsgar M Chromik
Department of General and Visceral Surgery, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
J Gastrointest Surg 13:1358-67. 2009..The aim of this study was to analyze the characteristics of patients with SP who will further develop TP in order to define early diagnostic markers for TP... - Major and lethal complications of liposuction: a review of 72 cases in Germany between 1998 and 2002Marcus Lehnhardt
Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Plast Reconstr Surg 121:396e-403e. 2008..The public perception of liposuction as minor surgery fails to consider the potential of major complications or a possibly fatal outcome... - [Therapeutic management of acral manifestations of systemic sclerosis]Martin F Meyer
Medizinische Klinik I, Zentrum fur Innere Medizin, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr Universitat Bochum, Bochum, Deutschland
Med Klin (Munich) 102:209-18. 2007.... - Influence of topically applied antimicrobial agents on muscular microcirculationOle Goertz
Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Ann Plast Surg 67:407-12. 2011..If the antimicrobial efficacy is comparable, the antiseptic with less toxic effects should be chosen, especially in critically perfused wounds... - The versatility of the pedicled vertical rectus abdominis myocutaneous flap in oncologic patientsAdrien Daigeler
Department of Plastic Surgery, Burn Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Buerkle de la Camp Place 1, 44789, Bochum, Germany
Langenbecks Arch Surg 396:1271-9. 2011..Detailed long-time follow-up studies in oncologic patients including complications and donor site morbidity are rare. In this study, complications and donor site morbidity were analysed... - Establishing efficient xenograft models with intrinsic vascularisation for growing primary human low-grade sarcomasDaniel Tilkorn
Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, 44789 Bochum, North Rhine Westphalia, Germany
Anticancer Res 31:4061-6. 2011..Models with an intrinsic tissue - engineered vascular supply may overcome this obstacle. The aim of this study was to establish a novel xenograft model of primary human low grade soft tissue sarcoma... - Extramedullary multiple myeloma associated with amyloidomas of the lower limbsAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University, Bochum, Germany
Plast Reconstr Surg 118:298-301. 2006 - Limb salvage in malignant tumorsHans Ulrich Steinau
Department of Plastic Surgery and Burns, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University, Bochum, Germany
Semin Plast Surg 24:18-33. 2010..Long-term survivors after microsurgical reconstructions and possible secondary malignancies will be addressed... - Host defence peptides in human burnsAljoscha Kaus
Department of Plastic Surgery, Burn Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
Burns 34:32-40. 2008..However, the finding of higher host defence peptide gene expression rates does not correlate with the incidence of wound infection in burns. We hypothesise that the epithelial innate immune response in burns is complex... - Orthogonal polarization spectral imaging: a tool for assessing burn depths?Ole Goertz
Department of Plastic and Hand Surgery, Burn Center, Ruhr University Bochum, Buerkle de la Camp Platz 1, Bochum, Germany
Ann Plast Surg 64:217-21. 2010..It is not an alternative to an experienced burn surgeon but provides important additional information... - The value of expert second opinion in diagnosis of soft tissue sarcomasMarcus Lehnhardt
Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
J Surg Oncol 97:40-3. 2008..The value of consultative second opinions has been proven for general surgical pathology; some studies suggest an even higher value for the soft tissue tumour specimens in particular... - Host defense peptides in wound healingLars Steinstraesser
Plastic Surgery, Ruhr University Bochum, Germany
Mol Med 14:528-37. 2008..This review focuses on the current knowledge of host defense peptides affecting wound healing and infection. We discuss the current data and highlight the potential future developments in this field of research... - A follow-up study of adults with suicidal burns: psychosocial adjustment and quality of lifeAdrien Daigeler
Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, 44789 Bochum, Germany
J Burn Care Res 30:844-51. 2009..Patients who survive the suicide attempt can become integrated in social life again. More data are needed to reliably identify patients at risk in advance... - Burn model for in vivo investigations of microcirculatory changesOle Goertz
Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, Bochum 44789, Germany
Eplasty 9:e13. 2009..The aim of the study was to develop a reliable burn model that allows for reproducible quantitative in vivo analysis of the microcirculation, angiogenesis, and leukocyte endothelium interaction after burn injury... - Burn wounds infected with Pseudomonas aeruginosa triggers weight loss in ratsLars Steinstraesser
Dept of Surgery, University of Michigan, Ann Arbor, MI 48109 0666, USA
BMC Surg 5:19. 2005..The aim of this study was to shed light on the impact of acute burn injury with or without infection on cytokine profiles... - Clinical safety and efficacy of a novel thermoreversible polyhexanide-preserved wound covering gelO Goertz
Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, Bochum, Germany
Eur Surg Res 44:96-101. 2010..An ideal topical formulation for wound therapy does not exist. The aim of this study was to develop a novel improved therapeutic option for the treatment of acute and chronic wounds... - [Anterolateral thigh flaps for reconstruction of traumatological and oncological defects]S Langer
Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Extremitätentumore, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum, Germany
Unfallchirurg 111:323-30. 2008..The article presents the authors' experience using the ALT flap for various indications in the upper and lower extremities... - [Plastic surgery reconstruction of radiation-induced trunk and body cavity defects]D Druecke
, Handchirurgiezentrum, , BG-Kliniken Bergmannsheil,
Dtsch Med Wochenschr 132:945-9. 2007 - [Plastic surgery reconstruction of radiation injuries to the extremities]M Lehnhardt
, Handchirurgiezentrum, , BG--Kliniken Bergmannsheil,
Dtsch Med Wochenschr 132:939-44. 2007 - [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases]M Lehnhardt
Klinik für Plastische Chirurgie u Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Universitatsklinikum Bergmannsheil, Burkle de la Camp Platz 1, Bochum, Germany
Chirurg 80:341-7. 2009..For optimal treatment of soft tissue sarcomas, we suggest obtaining expert second opinion to ensure adequate surgical therapy and precise indications for radiation and chemotherapy... - Effects of maleimide-polyethylene glycol-modified human hemoglobin (MP4) on tissue necrosis in SKH1-hr hairless miceOle Goertz
Department of Plastic and Hand Surgery, Burn Center, Ruhr University Bochum, Bochum, Germany
Eur J Med Res 14:123-9. 2009..The aim of this study was to investigate the potential of the chemically modified hemoglobin, MP4, to reduce skin flap necrosis and its effect on selected blood markers and kidneys... - Photoplanimetric evaluation and impedance measurement of split-thickness skin grafts: a new model for objective wound-healing assessment in clinical trialsJ Hauser
Department of Plastic and Hand Surgery, Burn Center, University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Skin Res Technol 15:168-71. 2009..Here, we present a wound model and non-invasive analysis techniques to evaluate human wound healing. The model described was used in a clinical trial on 167 patients treated with a new wound therapeutic agent... - Evaluation of a novel polihexanide-preserved wound covering gel on dermal wound healingO Goertz
Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Eur Surg Res 44:23-9. 2010..The aim of the study was to investigate the effect of a wound covering gel on wound healing and the skin's microcirculation... - A qualitative and quantitative analysis of protein substitution in human burn woundsHamid Joneidi-Jafari
Department of Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
Eplasty 9:e42. 2009..We quantified and qualified the systemic and local protein loss in burn patients during protein substitution, comparing fresh frozen plasma and the human serum protein solution Biseko... - [Future treatment options for chronic wounds]L Steinsträsser
Klinik für Plastische Chirurgie und Schwerbrandverletzte, BG Universitatsklinikum Bergmannsheil, Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Deutschland
Chirurg 79:555-9. 2008..This article discusses current and future treatment options in wound conditioning, therapy, and regeneration... - Extramedullary multiple myeloma associated with amyloidomas of the lower limbsAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG-University-Hospital Bergmannsheil, Ruhr University, Bochum, Germany
Plast Reconstr Surg 117:2530-2. 2006 - Antimicrobial activity of the recombinant designer host defence peptide P-novispirin G10 in infected full-thickness wounds of porcine skinF Jacobsen
Department of Plastic Surgery, Burn Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
J Antimicrob Chemother 59:493-8. 2007..Therefore, the aim of this study was to investigate the antimicrobial activity of proline-novispirin G10 (P-novispirin G10) in vitro and in the infected porcine titanium wound chamber model... - A novel human skin chamber model to study wound infection ex vivoLars Steinstraesser
Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
Arch Dermatol Res 302:357-65. 2010..For investigation of wound infection, treatment and healing, the BO-drum presents a convenient model and may help to standardize wound research... - Donor-site morbidity of the pedicled rectus femoris muscle flapAdrien Daigeler
Division of Plastic, Reconstructive, and Hand Surgery, Medical Faculty of the Otto von Guericke University, Magdeburg, Germany
Plast Reconstr Surg 115:786-92. 2005..There is no decrease in active range of motion in the knee and hip. Patient satisfaction with the functional and aesthetic outcome was high...