Burkhard Helpap

Summary

Affiliation: Academic Teaching Hospital
Country: Germany

Publications

  1. pmc Impact of hormonal therapy on the detection of promoter hypermethylation of the detoxifying glutathione-S-transferase P1 gene (GSTP1) in prostate cancer
    Jens Kollermann
    Urologische Klinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    BMC Urol 6:15. 2006
  2. ncbi [Therapy induced regressive changes of prostate cancer]
    B Helpap
    Institut fur Pathologie, Hegau Klinikum, Akademisches Lehrkrankenhaus der Universität Freiburg, Singen
    Pathologe 25:461-8. 2004
  3. ncbi Molecular pathology of non-invasive urothelial carcinomas (part I)
    Burkhard Helpap
    Institute of Pathology, Hegau Klinikum, 78207 Singen, Germany
    Virchows Arch 442:309-16. 2003
  4. ncbi Nonepithelial tumor-like lesions of the prostate: a never-ending diagnostic problem
    Burkhard Helpap
    Department of Pathology, Hegau Klinikum Singen, Academic Teaching Hospital, University of Freiburg, Postfach 720, 78207 Singen, Germany
    Virchows Arch 441:231-7. 2002
  5. ncbi Morphology and therapeutic strategies for neuroendocrine tumors of the genitourinary tract
    Burkhard Helpap
    Department of Pathology, Singen, Academic Teaching Hospital of the University of Freiburg, Singen, Germany
    Cancer 95:1415-20. 2002
  6. ncbi Fundamentals on the pathology of prostatic carcinoma after brachytherapy
    Burkhard Helpap
    Department of Pathology, Hegau Klinikum Singen, Germany
    World J Urol 20:207-12. 2002
  7. ncbi Neuroendocrine carcinomas of the prostate and urinary bladder: a diagnostic and therapeutic challenge
    Burkhard Helpap
    Department of Pathology, Academic Hospital of the University of Freiburg, Postfach 720, 78207 Singen, Germany
    Virchows Arch 440:241-8. 2002
  8. ncbi Nonepithelial neoplasms of the urinary bladder
    B Helpap
    Department of Pathology, Hegau Klinikum Singen, University of Freiburg, Germany
    Virchows Arch 439:497-503. 2001
  9. ncbi [Revisions in the WHO histological classification of urothelial bladder tumors and flat urothelial lesions]
    B Helpap
    Institut fur Pathologie, Hegau Klinikum GmbH Singen, Akademisches Lehrkrankenhaus, Universitat Freiburg
    Pathologe 21:211-7. 2000
  10. ncbi Immunohistochemical analysis of the proliferative activity of neuroendocrine tumors from various organs. Are there indications for a neuroendocrine tumor-carcinoma sequence?
    B Helpap
    Department of Pathology, Hegau Klinikum GmbH, Academic Teaching Hospital of the University of Freiburg, Singen, Germany
    Virchows Arch 438:86-91. 2001

Detail Information

Publications31

  1. pmc Impact of hormonal therapy on the detection of promoter hypermethylation of the detoxifying glutathione-S-transferase P1 gene (GSTP1) in prostate cancer
    Jens Kollermann
    Urologische Klinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    BMC Urol 6:15. 2006
    ..The purpose of our study was to assess the impact of endocrine therapy on the detection of GSTP1-HM by methylation-specific PCR (MSP) in prostate cancer...
  2. ncbi [Therapy induced regressive changes of prostate cancer]
    B Helpap
    Institut fur Pathologie, Hegau Klinikum, Akademisches Lehrkrankenhaus der Universität Freiburg, Singen
    Pathologe 25:461-8. 2004
    ..Knowledge about these changes, the selective use of immunohistochemistry as well as a very thorough histological workup is essential for the correct assessment of these specimens...
  3. ncbi Molecular pathology of non-invasive urothelial carcinomas (part I)
    Burkhard Helpap
    Institute of Pathology, Hegau Klinikum, 78207 Singen, Germany
    Virchows Arch 442:309-16. 2003
    ..These molecular markers were analyzed in diagnosis of urothelial carcinomas, recurrences, progression and response to treatment...
  4. ncbi Nonepithelial tumor-like lesions of the prostate: a never-ending diagnostic problem
    Burkhard Helpap
    Department of Pathology, Hegau Klinikum Singen, Academic Teaching Hospital, University of Freiburg, Postfach 720, 78207 Singen, Germany
    Virchows Arch 441:231-7. 2002
    ..This review focuses on the differential diagnosis between the various benign and malignant entities and compares the new WHO classification with a recently published typing of prostatic stromal lesions of unknown malignant potential...
  5. ncbi Morphology and therapeutic strategies for neuroendocrine tumors of the genitourinary tract
    Burkhard Helpap
    Department of Pathology, Singen, Academic Teaching Hospital of the University of Freiburg, Singen, Germany
    Cancer 95:1415-20. 2002
    ..In the current study the author discusses the significant differences between NET and NEC of the urinary bladder and the prostate, including therapeutic consequences...
  6. ncbi Fundamentals on the pathology of prostatic carcinoma after brachytherapy
    Burkhard Helpap
    Department of Pathology, Hegau Klinikum Singen, Germany
    World J Urol 20:207-12. 2002
    ..The sequels of brachytherapy are compared with the reactions of prostatic carcinomas to various modes of therapy. It is demonstrated what the clinician can expect and which modes of control exist at present...
  7. ncbi Neuroendocrine carcinomas of the prostate and urinary bladder: a diagnostic and therapeutic challenge
    Burkhard Helpap
    Department of Pathology, Academic Hospital of the University of Freiburg, Postfach 720, 78207 Singen, Germany
    Virchows Arch 440:241-8. 2002
    ..In the case of high-grade neuroendocrine carcinomas, early diagnosis and initiation of appropriate chemotherapy may increase survival and potentially induce complete remission in individual cases...
  8. ncbi Nonepithelial neoplasms of the urinary bladder
    B Helpap
    Department of Pathology, Hegau Klinikum Singen, University of Freiburg, Germany
    Virchows Arch 439:497-503. 2001
    ..In the following we will describe the histology, immunohistology, and cytogenetics of nonepithelial tumors and lesions...
  9. ncbi [Revisions in the WHO histological classification of urothelial bladder tumors and flat urothelial lesions]
    B Helpap
    Institut fur Pathologie, Hegau Klinikum GmbH Singen, Akademisches Lehrkrankenhaus, Universitat Freiburg
    Pathologe 21:211-7. 2000
    ..papillary carcinoma. Long-term follow-up studies are needed to determine the clinical significance of this differentiation...
  10. ncbi Immunohistochemical analysis of the proliferative activity of neuroendocrine tumors from various organs. Are there indications for a neuroendocrine tumor-carcinoma sequence?
    B Helpap
    Department of Pathology, Hegau Klinikum GmbH, Academic Teaching Hospital of the University of Freiburg, Singen, Germany
    Virchows Arch 438:86-91. 2001
    ..Transitions from NET to NEC could not be observed. NETs and low-grade NECs differ in their proliferative activity from high-grade NECs, suggesting that they may arise from different precursor cell populations...
  11. doi The heterogeneous Gleason 7 carcinoma of the prostate: analyses of low and high grade (risk) carcinomas with criteria of the International Society of Urological Pathology (ISUP)
    Burkhard Helpap
    Department of Pathology, HBH Hospital, Singen, Germany
    Pathol Res Pract 209:190-4. 2013
    ....
  12. ncbi Modified Gleason grading. An updated review
    Burkhard Helpap
    Department of Pathology, Center of Uropathology, General Hospital Hegau Bodensee Klinikum Singen, Academic Hospital of the University of Freiburg, Germany
    Histol Histopathol 24:661-6. 2009
    ..Conclusion: With the modified Gleason system, grade, stage, tumour extent and serum PSA show good correlations and characterize the difference between low and high grade malignancy of prostate carcinoma...
  13. ncbi Correlation of modified Gleason grading of prostate carcinoma with age, serum prostate specific antigen and tumor extent in needle biopsy specimens
    Burkhard Helpap
    Department of Pathology, General Hospital HBH Kliniken Singen, Academic Hospital, University of Freiburg, Singen, Germany
    Anal Quant Cytol Histol 30:133-8. 2008
    ..To investigate the correlation of biopsy grade with age, serum prostate specific antigen (PSA) and biopsy tumor extent using the conventional and modified Gleason grading systems...
  14. ncbi Limiting the diagnosis of atypical small glandular proliferations in needle biopsies of the prostate by the use of immunohistochemistry
    B Helpap
    Institute of Pathology, Hegau-Klinikum GmbH, Singen, Academic Instructional Hospital of the University of Freiburg, Germany
    J Pathol 193:350-3. 2001
    ..In these cases, therefore, at least clinical follow-up is strongly recommended and repeat biopsies are encouraged...
  15. doi Significance of Gleason grading of low-grade carcinoma of the prostate with therapeutic option of active surveillance
    Burkhard Helpap
    Institute of Pathology, HB Hospital Singen, Singen, Germany burkhard helpap hbh kliniken de
    Urol Int 90:17-23. 2013
    ..However, how accurate is the gold standard of GS 6 in predicting a small pT2 carcinoma? To answer this question, we have analyzed grading systems in this study...
  16. ncbi Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract
    Matthias Eiber
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Am J Surg Pathol 31:938-46. 2007
    ..Ancillary markers may help to resolve such cases and clarify the reported malignant potential of some IPs...
  17. ncbi Correlation of modified Gleason grading with pT stage of prostatic carcinoma after radical prostatectomy
    Burkhard Helpap
    Department of Pathology, General Hospital HBH Kliniken Singen, Academic Hospital of the University of Freiburg, Singen, Germany
    Anal Quant Cytol Histol 30:1-7. 2008
    ..To study the correlation between modified Gleason score (GS) and pT stage of radical prostatectomy (RP) specimens...
  18. ncbi [Small suggestive lesions of the prostate. Histological and immunohistochemical analyses -- report of the uropathology consultation service]
    B Helpap
    Institut fur Pathologie, Singen
    Pathologe 26:398-404. 2005
    ..9% of cases of prostate carcinoma in the grey area of diagnoses endorsed "suggestive" or "suspected". The patients concerned were thus spared multiple screening biopsies and were assigned for definitive treatment...
  19. doi Combined histoarchitectural and cytological biopsy grading improves grading accuracy in low-grade prostate cancer
    Burkhard Helpap
    Institute of Pathology, Center of Uropathology, General Hospital Hegau Bodensee Klinikum Singen, Academic Hospital of University of Freiburg, Singen, Germany
    Int J Urol 19:126-33. 2012
    ..We questioned whether Gleason grading combined with an established alternative grading system incorporating cytological parameters improves grading accuracy...
  20. ncbi The significance of modified Gleason grading of prostatic carcinoma in biopsy and radical prostatectomy specimens
    Burkhard Helpap
    Department of Pathology, Center of Uropathology, General Hospital Hegau Bodensee Klinikum Singen, Academic Hospital of the University of Freiburg, P O Box 720, 78207 Singen, Germany
    Virchows Arch 449:622-7. 2006
    ..The overall agreement improved from 58 to 72% (p < 0.001) compared to conventional GS. The higher agreement with modified Gleason grading may facilitate therapeutic decisions...
  21. ncbi The significance of the P504S expression pattern of high-grade prostatic intraepithelial neoplasia (HGPIN) with and without adenocarcinoma of the prostate in biopsy and radical prostatectomy specimens
    Burkhard Helpap
    Department of Pathology, Hegau Bodensee Hochrhein General Hospital Singen, Singen, Germany
    Virchows Arch 448:480-4. 2006
    ..These results suggest that moderate to strong P504S expression in HGPIN of biopsy specimens is indicative of an associated adenocarcinoma and may be helpful in the choice of therapy...
  22. ncbi Comparative immunocytochemical assessment of isolated carcinoma cells in lymph nodes and bone marrow of patients with clinically localized prostate cancer
    J Kollermann
    Institute of Pathology, Hegau Klinikum, Singen, Germany
    Int J Cancer 84:145-9. 1999
    ..Although the overall incidence of occult tumor cell spread corresponds to similar incidence of relapses after radical prostatectomy as reported by others, the fate of these cells needs to be evaluated in longer follow-up studies...
  23. ncbi Nondetected tumor (pT0) after prolonged, neoadjuvant treatment of localized prostatic carcinoma
    J Kollermann
    Institute of Pathology, Hegau Clinic, Singen, Germany
    Eur Urol 38:714-20. 2000
    ..The present work was done to elucidate the initial characteristics of these tumors, to see if additional workup of these prostatectomy specimens is able to detect tumor vestiges and, if so, to describe their morphology...
  24. ncbi [New WHO classification of urothelial carcinoma of the urinary bladder]
    B Helpap
    Institut fur Pathologie, Hegau Klinikum Singen, Akademisches Lehrkrankenhaus, Universitat Freiburg
    Verh Dtsch Ges Pathol 86:57-66. 2002
    ..The recurrence rate increases from stage pT1b. This substaging may be of therapeutical relevance...
  25. doi [Clinical insignificance of prostate cancer: are there morphological findings?]
    B Helpap
    Schwerpunkt Uropathologie, Institut fur Pathologie, Singen, Deutschland
    Urologe A 48:170-4. 2009
    ..Overdiagnosis and overtreatment of microfocal nonpalpable and early-stage prostatic adenocarcinoma are currently a topic of strong discussion. We tried to find morphological findings of such insignificant carcinomas of the prostate...
  26. ncbi [The value of the modified Gleason grading system of prostate adenocarcinoma in routine urological diagnostics]
    B Helpap
    Konsultationsdienst für Uropathologie, Institut fur Pathologie, Singen
    Urologe A 46:59-62. 2007
    ..The border between low- and high-grade prostatic carcinoma may be probably Gleason score 7a and 7b. The prognostic value of score 6 should be changed to score 7a in the different therapeutic options for prostatic carcinomas...
  27. ncbi Expression of vascular endothelial growth factor (VEGF) and VEGF receptor Flk-1 in benign, premalignant, and malignant prostate tissue
    J Kollermann
    Institute of Pathology, Hegau Klinikum, Singen, Germany
    Am J Clin Pathol 116:115-21. 2001
    ..The VEGF-Flk-1 system may have an important role in the process of malignant transformation and tumor progression...
  28. ncbi Neuroendocrine differentiation and short-term neoadjuvant hormonal treatment of prostatic carcinoma with special regard to tumor regression
    J Kollermann
    Institute of Pathology, Hegau Klinikum, Singen, Germany
    Eur Urol 40:313-7. 2001
    ..However, there is little knowledge about the impact of short-term neoadjuvant hormonal therapy on NE differentiation and on whether the degree of tumor regression is linked with the extent of NE differentiation...
  29. ncbi Prognosis of stage pT0 after prolonged neoadjuvant endocrine therapy of prostate cancer: a matched-pair analysis
    Jens Kollermann
    Department of Urology, University Hospital Benjamin Franklin, Free University, Hindenburgdamm 30, 12200, Berlin, Germany
    Eur Urol 45:42-5. 2004
    ..The purpose of this study was to assess whether the PSA progression rate of pT0 patients after PPNET is lower than that of non-pT0 patients after PPNET...
  30. ncbi Follow-up of nondetectable prostate carcinoma (pT0) after prolonged PSA-monitored neoadjuvant hormonal therapy followed by radical prostatectomy
    Jens Kollermann
    Department of Urology, University Hospital Benjamin Franklin, Free University, Berlin, Germany
    Urology 62:476-80. 2003
    ..To test the hypothesis that in patients with Stage pT0 after prolonged prostate-specific antigen (PSA)-monitored neoadjuvant endocrine therapy, biochemical relapse is extremely rare and derives from systemic tumor recurrence...
  31. ncbi Methylation-specific PCR for DNA-based detection of occult tumor cells in lymph nodes of prostate cancer patients
    Jens Kollermann
    Department of Urology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur Urol 44:533-8. 2003
    ..To assess the feasibility of methylation-specific PCR (MSP) for the detection of promoter hypermethylation of the detoxifying glutathione-S-transferase P1 gene (GSTP1) to detect occult prostate cancer cells in lymph nodes (LNs)...