P H Seeburg

Summary

Affiliation: Abteilung Zellphysiologie
Country: Germany

Publications

  1. pmc Impaired synaptic scaling in mouse hippocampal neurones expressing NMDA receptors with reduced calcium permeability
    Verena Pawlak
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Physiol 562:771-83. 2005
  2. pmc GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice
    Andrei Rozov
    Division of Neuroscience, Medical Research Institute Ninewells Hospital and Medical School, Dundee University Dundee, UK
    Front Mol Neurosci 5:22. 2012
  3. pmc Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
    Mol Pain 5:46. 2009
  4. ncbi request reprint Regulation of ion channel/neurotransmitter receptor function by RNA editing
    Peter H Seeburg
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Curr Opin Neurobiol 13:279-83. 2003
  5. ncbi request reprint Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse
    P H Seeburg
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstr 29, 69120, Heidelberg, Germany
    Brain Res 907:233-43. 2001
  6. ncbi request reprint A-to-I editing: new and old sites, functions and speculations
    Peter H Seeburg
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Neuron 35:17-20. 2002
  7. ncbi request reprint Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice
    V Mack
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Science 292:2501-4. 2001
  8. ncbi request reprint Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
    D Zamanillo
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Science 284:1805-11. 1999
  9. ncbi request reprint Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
    M Higuchi
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    Nature 406:78-81. 2000
  10. ncbi request reprint Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
    D Feldmeyer
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 2:57-64. 1999

Collaborators

Detail Information

Publications59

  1. pmc Impaired synaptic scaling in mouse hippocampal neurones expressing NMDA receptors with reduced calcium permeability
    Verena Pawlak
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Physiol 562:771-83. 2005
    ..Our results indicate that NMDAR-mediated Ca(2+) signalling is important for synaptic scaling of AMPA currents in the hippocampus in vivo...
  2. pmc GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice
    Andrei Rozov
    Division of Neuroscience, Medical Research Institute Ninewells Hospital and Medical School, Dundee University Dundee, UK
    Front Mol Neurosci 5:22. 2012
    ..This article is part of a Special Issue entitled "Calcium permeable AMPARs in synaptic plasticity and disease."..
  3. pmc Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
    Mol Pain 5:46. 2009
    ..Our results demonstrate that AMPA receptor subunit GluA1 is a key mechanism for the expression of ACC LTP and inflammation-induced long-term plastic changes in the ACC...
  4. ncbi request reprint Regulation of ion channel/neurotransmitter receptor function by RNA editing
    Peter H Seeburg
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Curr Opin Neurobiol 13:279-83. 2003
    ....
  5. ncbi request reprint Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse
    P H Seeburg
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstr 29, 69120, Heidelberg, Germany
    Brain Res 907:233-43. 2001
    ..Therefore, the impact on adult synaptic function and plasticity by glutamate receptor channels with changed ion selectivity and conductance needs to be addressed by conditional expression of the mutant receptors...
  6. ncbi request reprint A-to-I editing: new and old sites, functions and speculations
    Peter H Seeburg
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Neuron 35:17-20. 2002
    ....
  7. ncbi request reprint Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice
    V Mack
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Science 292:2501-4. 2001
    ..This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP...
  8. ncbi request reprint Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
    D Zamanillo
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Science 284:1805-11. 1999
    ..The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory...
  9. ncbi request reprint Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
    M Higuchi
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    Nature 406:78-81. 2000
    ..We conclude that this transcript is the physiologically most important substrate of ADAR2...
  10. ncbi request reprint Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
    D Feldmeyer
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 2:57-64. 1999
    ..Thus, changes in GluR-B gene expression and Q/R site editing can affect critical architectural and functional aspects of excitatory principal neurons...
  11. ncbi request reprint Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression
    J Jerecic
    Department of Molecular Neurobiology, Max-Planck Institute for Medical Research, Jahnstrasse 29, 69120, Heidelberg, Germany
    Brain Res Mol Brain Res 94:96-104. 2001
    ..Thus, glutamate receptor function can be altered in the mouse by regulated NR1(R) transgene expression...
  12. pmc A GFP-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouse
    H E Krestel
    Department of Molecular Neurobiology, Max-Planck-Institute for Medical Research, Jahnstrasse. 29, D-69120 Heidelberg, Germany
    Nucleic Acids Res 29:E39. 2001
    ..We conclude that the tTA-sensitive bidirectional expression module is well suited to express genes of interest in a regulated manner and that GFP can be used to track transcriptional activity of the module in the living mouse...
  13. ncbi request reprint Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R)
    F N Single
    Max Planck Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstrabetae 29, D 69120 Heidelberg, Germany
    J Neurosci 20:2558-66. 2000
    ..We conclude that disturbed NMDA receptor signaling mediates a variety of neurological phenotypes...
  14. ncbi request reprint Channel-lining residues of the AMPA receptor M2 segment: structural environment of the Q/R site and identification of the selectivity filter
    T Kuner
    Abteilung Molekulare Neurobiologie, Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, 69120 Heidelberg, Germany
    J Neurosci 21:4162-72. 2001
    ....
  15. ncbi request reprint RNA editing of brain glutamate receptor channels: mechanism and physiology
    P H Seeburg
    Max Planck Institute for Medical Research, Department of Molecular Neuroscience, Jahnstr 29, 69120 Heidelberg, Germany
    Brain Res Brain Res Rev 26:217-29. 1998
    ..If so, RNA editing by adenosine deamination may significantly enlarge the functional repertoire of the mammalian genome...
  16. ncbi request reprint Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum
    G Kohr
    Max Planck Institute for Medical Research, Molecular Neurobiology, Heidelberg, Germany
    Neuropharmacology 37:1411-7. 1998
    ..The differential ADAR expression revealed by our study might underlie the distinct editing efficiencies and selectivities in different GluR subunit transcripts...
  17. ncbi request reprint The role of NMDAR subtypes and charge transfer during hippocampal LTP induction
    Sven Berberich
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuropharmacology 52:77-86. 2007
    ..Thus, at least for LFS pairing, the amount of charge transfer, and thus Ca2+ influx, during LTP induction is a factor more critical than the participation of a particular NMDAR subtype...
  18. pmc The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function
    K Kask
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 95:13777-82. 1998
    ..This constitutes proof in vivo that elevated calcium influx through AMPARs need not generate pathophysiological consequences...
  19. ncbi request reprint Using reporter genes to label selected neuronal populations in transgenic mice for gene promoter, anatomical, and physiological studies
    D J Spergel
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120, Heidelberg, Germany
    Prog Neurobiol 63:673-86. 2001
    ....
  20. ncbi request reprint Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation
    Sven Berberich
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 25:6907-10. 2005
    ....
  21. pmc Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences
    A Herb
    Laboratory for Molecular Neuroendocrinololgy, Zentrum fur Molekulare Biologie, Heidelberg, Germany
    Proc Natl Acad Sci U S A 93:1875-80. 1996
    ..This enzyme when coexpressed in HEK 293 cells preferentially targets the adenosine of the Q/R site and of an unpaired position in the ECS which is highly edited in brain...
  22. ncbi request reprint RED2, a brain-specific member of the RNA-specific adenosine deaminase family
    T Melcher
    Laboratory for Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 12, 69120 Heidelberg, Germany
    J Biol Chem 271:31795-8. 1996
    ..However, a chimera of RED1 and RED2 edited the GluR-B Q/R and R/G sites with moderate efficiency. Our data suggest that RED2 may edit brain-specific transcripts with distinct structural features...
  23. ncbi request reprint Frequency-dependent impairment of hippocampal LTP from NMDA receptors with reduced calcium permeability
    Verena Pawlak
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    Eur J Neurosci 22:476-84. 2005
    ..Moreover, LTP induced by the first HFS stimulus train required lower Ca2+ levels than the additional LTP obtained by repeated trains...
  24. ncbi request reprint Codon-improved Cre recombinase (iCre) expression in the mouse
    D R Shimshek
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Heidelberg, Germany
    Genesis 32:19-26. 2002
    ..Thus, whereas efficient activation of Cre fusion proteins in the brain needs further improvements, our studies indicate that iCre should facilitate genetic experiments in the mouse...
  25. ncbi request reprint EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains
    K Brückner
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Neuron 22:511-24. 1999
    ..Our findings suggest that GRIP proteins provide a scaffold for the assembly of a multiprotein signaling complex downstream of ephrinB ligands...
  26. pmc Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice
    Yair Pilpel
    Max Planck Institute for Medical Research, Department of Molecular Neurobiology, Heidelberg, Germany
    J Physiol 587:787-804. 2009
    ..Associated learning and memory deficits would contribute to the fragile X mental retardation phenotype...
  27. ncbi request reprint Forebrain-specific glutamate receptor B deletion impairs spatial memory but not hippocampal field long-term potentiation
    Derya R Shimshek
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 26:8428-40. 2006
    ....
  28. doi request reprint Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice
    Nixon M Abraham
    Institute of Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120 Heidelberg, Germany WIN Olfactory Dynamics Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Neuron 65:399-411. 2010
    ..Thus, spatiotemporally defined molecular perturbations of olfactory bulb granule cells directly link stimulus similarity, neuronal processing time, and discrimination behavior to synaptic inhibition...
  29. pmc Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors
    Derya R Shimshek
    Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    PLoS Biol 3:e354. 2005
    ..Thus, correlated differences in behavior and levels of GluR-B expression allowed a mechanistic and spatial dissection of olfactory learning, discrimination, and memory capabilities...
  30. ncbi request reprint Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors
    Alexander Kolleker
    Max Planck Institute for Medical Research, Department of Molecular Neurobiology, Jahnstrasse 29, 69120, Heidelberg, Germany
    Neuron 40:1199-212. 2003
    ..Trafficking of GluR-B(long)-containing receptors thus mediates a GluR-A-independent form of glutamatergic synaptic plasticity in the juvenile hippocampus...
  31. ncbi request reprint A common architecture for K+ channels and ionotropic glutamate receptors?
    Thomas Kuner
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Trends Neurosci 26:27-32. 2003
  32. ncbi request reprint Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction
    Georg Köhr
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 23:10791-9. 2003
    ..Thus, besides NMDA receptor-mediated Ca2+ influx, subtype-specific signaling is critical for LTP induction, with the intracellular C-terminal domain of the NR2 subunits directing signaling pathways with an age-dependent preference...
  33. ncbi request reprint Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin
    A Herb
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research and Laboratory for Molecular Neuroendocrinology, Heidelberg, Germany
    Mol Cell Neurosci 8:367-74. 1997
    ..The restricted expression and dendritic location are compatible with a role for DEN in synaptic plasticity of central neocortical forebrain neurons...
  34. ncbi request reprint Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo
    R Sprengel
    Max Planck Institute for Medical Research, Department of Molecular Neuroscience, Heidelberg, Germany
    Cell 92:279-89. 1998
    ..C-terminal truncation of NR2 subunits does not interfere with the formation of gateable receptor channels that can be synaptically activated. Thus, the phenotypes of our mutants appear to reflect defective intracellular signaling...
  35. doi request reprint Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice
    V Grinevich
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany
    Horm Metab Res 43:551-6. 2011
    ..These results, together with the detection of Homer 1 mRNA and protein in the adrenal cortex of WT mice, indicate that Homer 1 directly affects the steroidogenic function of the adrenal glands...
  36. ncbi request reprint The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain
    Bettina Hartmann
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Neuron 44:637-50. 2004
    ..Thus, AMPA receptors are not mere determinants of fast synaptic transmission underlying basal pain sensitivity as previously thought, but are critically involved in activity-dependent changes in synaptic processing of nociceptive inputs...
  37. ncbi request reprint Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors
    Jakob von Engelhardt
    IZN and Department of Clinical Neurobiology, University Hospital of Neurology, INF 364, 69120 Heidelberg, Germany
    Neuropharmacology 53:10-7. 2007
    ..Our findings predict that successful therapeutic intervention in stroke based on currently available NMDA receptor subtype-selective blockers is unlikely...
  38. doi request reprint Rapid, reproducible transduction of select forebrain regions by targeted recombinant virus injection into the neonatal mouse brain
    Noam Pilpel
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg 69120, Germany
    J Neurosci Methods 182:55-63. 2009
    ....
  39. ncbi request reprint Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1
    Jochen C Hartner
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Biol Chem 279:4894-902. 2004
    ..Thus, ADAR1 subserves critical steps in developing non-nervous tissue, which are likely to include transcript editing...
  40. ncbi request reprint Neuronal toxicity in Caenorhabditis elegans from an editing site mutant in glutamate receptor channels
    Rachel Aronoff
    Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    J Neurosci 24:8135-40. 2004
    ..Thus, synaptically activated GLR-2(R)-containing iGluR channels appear to trigger inappropriate, neurotoxic Ca2+ release from intracellular stores...
  41. ncbi request reprint Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL
    Torsten W Schulz
    Max Planck Institute for Medical Research, Department of Molecular Neurobiology, 69120 Heidelberg, Germany
    J Neurosci 24:8584-94. 2004
    ....
  42. ncbi request reprint A genetic switch for epilepsy in adult mice
    Heinz E Krestel
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    J Neurosci 24:10568-78. 2004
    ....
  43. ncbi request reprint Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons
    Derya R Shimshek
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Heidelberg, Germany
    Mol Endocrinol 20:219-31. 2006
    ....
  44. pmc Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit
    Rohini Kuner
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 102:5826-31. 2005
    ....
  45. pmc Combinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processing
    Stefan Bonn
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Mol Cell Biol 27:4121-32. 2007
    ....
  46. ncbi request reprint Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit
    W Wisden
    Laboratory Molecular Neuroendocrinology, Center for Molecular Biology, Heidelberg, Germany
    FEBS Lett 289:227-30. 1991
    ..The alpha 4 mRNA is found at lower levels in cortex and caudate putamen, and is rare in cerebellum...
  47. pmc The third gamma subunit of the gamma-aminobutyric acid type A receptor family
    A Herb
    Laboratory for Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, ZMBH, Heidelberg, Germany
    Proc Natl Acad Sci U S A 89:1433-7. 1992
    ..Furthermore, the presence of gamma 3 in place of gamma 2 in alpha 1 beta 2 gamma x receptors generates a marked decrease in the affinity of agonists while leaving the affinity of antagonists or negative modulators largely unaffected...
  48. ncbi request reprint Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression
    Daniele Bottai
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    J Neurosci 22:167-75. 2002
    ..These coordinate transcriptional events rapidly convert a constitutive gene to an IEG and regulate the expression of functionally different Homer 1 proteins...
  49. ncbi request reprint {gamma}-Protocadherins, presenilin-mediated release of C-terminal fragment promotes locus expression
    Boris Hambsch
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    J Biol Chem 280:15888-97. 2005
    ..These results reveal an intracellular signaling mechanism for gamma-pcdhs and identify a novel vital target for the gamma-secretase complex...
  50. ncbi request reprint Sindbis vector SINrep(nsP2S726): a tool for rapid heterologous expression with attenuated cytotoxicity in neurons
    Jinhyun Kim
    Max Planck Institute for Medical Research, Department of Molecular Neurobiology, Jahnstrasse 29, 69120 Heidelberg, Germany
    J Neurosci Methods 133:81-90. 2004
    ..As an experimental example, we demonstrate the applicability of this system for high-resolution two-photon imaging of dendritic spines in vivo...
  51. ncbi request reprint Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors
    Joseph P Yuan
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 114:777-89. 2003
    ..Since H1a is transcriptionally regulated by cellular activity, this mechanism can affect both short and long-term regulation of TRPC1 function...
  52. pmc A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A
    Vidar Jensen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103 Blindern, N0317 Oslo, Norway
    J Physiol 553:843-56. 2003
    ..Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit...
  53. ncbi request reprint NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory
    David M Bannerman
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 28:3623-30. 2008
    ..In contrast, the ability to associate a particular spatial location with the water maze escape platform or food reward is NR2A independent, as well as GluR-A independent...
  54. pmc Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy
    Heneu O Tan
    Howard Florey Institute, University of Melbourne, Parkville 3010, Australia
    Proc Natl Acad Sci U S A 104:17536-41. 2007
    ..We hypothesize that a subtle reduction in cortical inhibition underlies childhood absence epilepsy seen in humans harboring the R43Q mutation...
  55. ncbi request reprint Signalling mechanisms
    Erin M Schuman
    Curr Opin Neurobiol 16:247-50. 2006
  56. ncbi request reprint Neurobiology: a thorny issue
    Peter H Seeburg
    Nature 424:627-8. 2003
  57. ncbi request reprint The role of hippocampal glutamate receptor-A-dependent synaptic plasticity in conditional learning: the importance of spatiotemporal discontiguity
    Wolfram B Schmitt
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 24:7277-82. 2004
    ..We suggest that hippocampal GluR-A-dependent synaptic plasticity contributes to a memory system in rodents for encoding both the spatial and temporal contexts (the where and the when) associated with a particular event...
  58. pmc Modulation of microRNA processing and expression through RNA editing by ADAR deaminases
    Weidong Yang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Struct Mol Biol 13:13-21. 2006
    ..Consequently, mature miRNA-142 expression levels increased substantially in ADAR1 null or ADAR2 null mice. Our results demonstrate a new function of RNA editing in the control of miRNA biogenesis...