Research Topics
Genomes and Genes
| P H SeeburgSummaryAffiliation: Abteilung Zellphysiologie Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Impaired synaptic scaling in mouse hippocampal neurones expressing NMDA receptors with reduced calcium permeabilityVerena Pawlak
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
J Physiol 562:771-83. 2005..Our results indicate that NMDAR-mediated Ca(2+) signalling is important for synaptic scaling of AMPA currents in the hippocampus in vivo...- Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortexHiroki Toyoda
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
Mol Pain 5:46. 2009..Our results demonstrate that AMPA receptor subunit GluA1 is a key mechanism for the expression of ACC LTP and inflammation-induced long-term plastic changes in the ACC... 
Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouseP H Seeburg
Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstr 29, 69120, Heidelberg, Germany
Brain Res 907:233-43. 2001..Therefore, the impact on adult synaptic function and plasticity by glutamate receptor channels with changed ion selectivity and conductance needs to be addressed by conditional expression of the mutant receptors...- Regulation of ion channel/neurotransmitter receptor function by RNA editingPeter H Seeburg
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Curr Opin Neurobiol 13:279-83. 2003.... - A-to-I editing: new and old sites, functions and speculationsPeter H Seeburg
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Neuron 35:17-20. 2002.... - Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learningD Zamanillo
Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Science 284:1805-11. 1999..The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory... - Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient miceV Mack
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
Science 292:2501-4. 2001..This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP... - Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2M Higuchi
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
Nature 406:78-81. 2000..We conclude that this transcript is the physiologically most important substrate of ADAR2... - Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-BD Feldmeyer
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
Nat Neurosci 2:57-64. 1999..Thus, changes in GluR-B gene expression and Q/R site editing can affect critical architectural and functional aspects of excitatory principal neurons... - Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expressionJ Jerecic
Department of Molecular Neurobiology, Max-Planck Institute for Medical Research, Jahnstrasse 29, 69120, Heidelberg, Germany
Brain Res Mol Brain Res 94:96-104. 2001..Thus, glutamate receptor function can be altered in the mouse by regulated NR1(R) transgene expression... - Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R)F N Single
Max Planck Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstrabetae 29, D 69120 Heidelberg, Germany
J Neurosci 20:2558-66. 2000..We conclude that disturbed NMDA receptor signaling mediates a variety of neurological phenotypes... - Channel-lining residues of the AMPA receptor M2 segment: structural environment of the Q/R site and identification of the selectivity filterT Kuner
Abteilung Molekulare Neurobiologie, Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, 69120 Heidelberg, Germany
J Neurosci 21:4162-72. 2001.... - A GFP-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouseH E Krestel
Department of Molecular Neurobiology, Max-Planck-Institute for Medical Research, Jahnstrasse. 29, D-69120 Heidelberg, Germany
Nucleic Acids Res 29:E39. 2001..We conclude that the tTA-sensitive bidirectional expression module is well suited to express genes of interest in a regulated manner and that GFP can be used to track transcriptional activity of the module in the living mouse... - RNA editing of brain glutamate receptor channels: mechanism and physiologyP H Seeburg
Max Planck Institute for Medical Research, Department of Molecular Neuroscience, Jahnstr 29, 69120 Heidelberg, Germany
Brain Res Brain Res Rev 26:217-29. 1998..If so, RNA editing by adenosine deamination may significantly enlarge the functional repertoire of the mammalian genome... - Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellumG Kohr
Max Planck Institute for Medical Research, Molecular Neurobiology, Heidelberg, Germany
Neuropharmacology 37:1411-7. 1998..The differential ADAR expression revealed by our study might underlie the distinct editing efficiencies and selectivities in different GluR subunit transcripts... - The role of NMDAR subtypes and charge transfer during hippocampal LTP inductionSven Berberich
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
Neuropharmacology 52:77-86. 2007..Thus, at least for LFS pairing, the amount of charge transfer, and thus Ca2+ influx, during LTP induction is a factor more critical than the participation of a particular NMDAR subtype... - The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and functionK Kask
Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 95:13777-82. 1998..This constitutes proof in vivo that elevated calcium influx through AMPARs need not generate pathophysiological consequences... - Using reporter genes to label selected neuronal populations in transgenic mice for gene promoter, anatomical, and physiological studiesD J Spergel
Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120, Heidelberg, Germany
Prog Neurobiol 63:673-86. 2001.... - Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiationSven Berberich
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
J Neurosci 25:6907-10. 2005.... - RED2, a brain-specific member of the RNA-specific adenosine deaminase familyT Melcher
Laboratory for Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 12, 69120 Heidelberg, Germany
J Biol Chem 271:31795-8. 1996..However, a chimera of RED1 and RED2 edited the GluR-B Q/R and R/G sites with moderate efficiency. Our data suggest that RED2 may edit brain-specific transcripts with distinct structural features... - Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequencesA Herb
Laboratory for Molecular Neuroendocrinololgy, Zentrum fur Molekulare Biologie, Heidelberg, Germany
Proc Natl Acad Sci U S A 93:1875-80. 1996..This enzyme when coexpressed in HEK 293 cells preferentially targets the adenosine of the Q/R site and of an unpaired position in the ECS which is highly edited in brain... - Frequency-dependent impairment of hippocampal LTP from NMDA receptors with reduced calcium permeabilityVerena Pawlak
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
Eur J Neurosci 22:476-84. 2005..Moreover, LTP induced by the first HFS stimulus train required lower Ca2+ levels than the additional LTP obtained by repeated trains... - Codon-improved Cre recombinase (iCre) expression in the mouseD R Shimshek
Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Heidelberg, Germany
Genesis 32:19-26. 2002..Thus, whereas efficient activation of Cre fusion proteins in the brain needs further improvements, our studies indicate that iCre should facilitate genetic experiments in the mouse... - EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomainsK Brückner
Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Neuron 22:511-24. 1999..Our findings suggest that GRIP proteins provide a scaffold for the assembly of a multiprotein signaling complex downstream of ephrinB ligands... - Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptorsDerya R Shimshek
Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
PLoS Biol 3:e354. 2005..Thus, correlated differences in behavior and levels of GluR-B expression allowed a mechanistic and spatial dissection of olfactory learning, discrimination, and memory capabilities... - Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptorsAlexander Kolleker
Max Planck Institute for Medical Research, Department of Molecular Neurobiology, Jahnstrasse 29, 69120, Heidelberg, Germany
Neuron 40:1199-212. 2003..Trafficking of GluR-B(long)-containing receptors thus mediates a GluR-A-independent form of glutamatergic synaptic plasticity in the juvenile hippocampus... - Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation inductionGeorg Köhr
Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
J Neurosci 23:10791-9. 2003..Thus, besides NMDA receptor-mediated Ca2+ influx, subtype-specific signaling is critical for LTP induction, with the intracellular C-terminal domain of the NR2 subunits directing signaling pathways with an age-dependent preference... - Forebrain-specific glutamate receptor B deletion impairs spatial memory but not hippocampal field long-term potentiationDerya R Shimshek
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
J Neurosci 26:8428-40. 2006.... - Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout miceYair Pilpel
Max Planck Institute for Medical Research, Department of Molecular Neurobiology, Heidelberg, Germany
J Physiol 587:787-804. 2009..Associated learning and memory deficits would contribute to the fragile X mental retardation phenotype... - A common architecture for K+ channels and ionotropic glutamate receptors?Thomas Kuner
Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Trends Neurosci 26:27-32. 2003 
Synaptic inhibition in the olfactory bulb accelerates odor discrimination in miceNixon M Abraham
Institute of Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120 Heidelberg, Germany WIN Olfactory Dynamics Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Neuron 65:399-411. 2010..Thus, spatiotemporally defined molecular perturbations of olfactory bulb granule cells directly link stimulus similarity, neuronal processing time, and discrimination behavior to synaptic inhibition...- Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrinA Herb
Department of Molecular Neurobiology, Max Planck Institute for Medical Research and Laboratory for Molecular Neuroendocrinology, Heidelberg, Germany
Mol Cell Neurosci 8:367-74. 1997..The restricted expression and dendritic location are compatible with a role for DEN in synaptic plasticity of central neocortical forebrain neurons... - Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivoR Sprengel
Max Planck Institute for Medical Research, Department of Molecular Neuroscience, Heidelberg, Germany
Cell 92:279-89. 1998..C-terminal truncation of NR2 subunits does not interfere with the formation of gateable receptor channels that can be synaptically activated. Thus, the phenotypes of our mutants appear to reflect defective intracellular signaling... - Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout miceV Grinevich
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany
Horm Metab Res 43:551-6. 2011..These results, together with the detection of Homer 1 mRNA and protein in the adrenal cortex of WT mice, indicate that Homer 1 directly affects the steroidogenic function of the adrenal glands... - Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptorsJakob von Engelhardt
IZN and Department of Clinical Neurobiology, University Hospital of Neurology, INF 364, 69120 Heidelberg, Germany
Neuropharmacology 53:10-7. 2007..Our findings predict that successful therapeutic intervention in stroke based on currently available NMDA receptor subtype-selective blockers is unlikely... - Rapid, reproducible transduction of select forebrain regions by targeted recombinant virus injection into the neonatal mouse brainNoam Pilpel
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg 69120, Germany
J Neurosci Methods 182:55-63. 2009.... - Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neuronsDerya R Shimshek
Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Heidelberg, Germany
Mol Endocrinol 20:219-31. 2006.... - A genetic switch for epilepsy in adult miceHeinz E Krestel
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
J Neurosci 24:10568-78. 2004.... - Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1Jochen C Hartner
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
J Biol Chem 279:4894-902. 2004..Thus, ADAR1 subserves critical steps in developing non-nervous tissue, which are likely to include transcript editing... - Neuronal toxicity in Caenorhabditis elegans from an editing site mutant in glutamate receptor channelsRachel Aronoff
Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
J Neurosci 24:8135-40. 2004..Thus, synaptically activated GLR-2(R)-containing iGluR channels appear to trigger inappropriate, neurotoxic Ca2+ release from intracellular stores... - Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RILTorsten W Schulz
Max Planck Institute for Medical Research, Department of Molecular Neurobiology, 69120 Heidelberg, Germany
J Neurosci 24:8584-94. 2004.... - The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory painBettina Hartmann
Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Neuron 44:637-50. 2004..Thus, AMPA receptors are not mere determinants of fast synaptic transmission underlying basal pain sensitivity as previously thought, but are critically involved in activity-dependent changes in synaptic processing of nociceptive inputs... - Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunitRohini Kuner
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 102:5826-31. 2005.... - Combinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processingStefan Bonn
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Mol Cell Biol 27:4121-32. 2007.... - The third gamma subunit of the gamma-aminobutyric acid type A receptor familyA Herb
Laboratory for Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, ZMBH, Heidelberg, Germany
Proc Natl Acad Sci U S A 89:1433-7. 1992..Furthermore, the presence of gamma 3 in place of gamma 2 in alpha 1 beta 2 gamma x receptors generates a marked decrease in the affinity of agonists while leaving the affinity of antagonists or negative modulators largely unaffected... - Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunitW Wisden
Laboratory Molecular Neuroendocrinology, Center for Molecular Biology, Heidelberg, Germany
FEBS Lett 289:227-30. 1991..The alpha 4 mRNA is found at lower levels in cortex and caudate putamen, and is rare in cerebellum... - Sindbis vector SINrep(nsP2S726): a tool for rapid heterologous expression with attenuated cytotoxicity in neuronsJinhyun Kim
Max-Planck Institute for Medical Research, Department of Molecular Neurobiology, Jahnstrasse 29, 69120 Heidelberg, Germany
J Neurosci Methods 133:81-90. 2004..As an experimental example, we demonstrate the applicability of this system for high-resolution two-photon imaging of dendritic spines in vivo... - {gamma}-Protocadherins, presenilin-mediated release of C-terminal fragment promotes locus expressionBoris Hambsch
Department of Molecular Neurobiology, Max-Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
J Biol Chem 280:15888-97. 2005..These results reveal an intracellular signaling mechanism for gamma-pcdhs and identify a novel vital target for the gamma-secretase complex... - Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expressionDaniele Bottai
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
J Neurosci 22:167-75. 2002..These coordinate transcriptional events rapidly convert a constitutive gene to an IEG and regulate the expression of functionally different Homer 1 proteins... - Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptorsJoseph P Yuan
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 114:777-89. 2003..Since H1a is transcriptionally regulated by cellular activity, this mechanism can affect both short and long-term regulation of TRPC1 function... - A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-AVidar Jensen
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103 Blindern, N0317 Oslo, Norway
J Physiol 553:843-56. 2003..Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit... - Reduced cortical inhibition in a mouse model of familial childhood absence epilepsyHeneu O Tan
Howard Florey Institute, University of Melbourne, Parkville 3010, Australia
Proc Natl Acad Sci U S A 104:17536-41. 2007..We hypothesize that a subtle reduction in cortical inhibition underlies childhood absence epilepsy seen in humans harboring the R43Q mutation... - Modulation of microRNA processing and expression through RNA editing by ADAR deaminasesWeidong Yang
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Nat Struct Mol Biol 13:13-21. 2006..Consequently, mature miRNA-142 expression levels increased substantially in ADAR1 null or ADAR2 null mice. Our results demonstrate a new function of RNA editing in the control of miRNA biogenesis... - Neurobiology: a thorny issuePeter H Seeburg
Nature 424:627-8. 2003 - Signalling mechanismsErin M Schuman
Curr Opin Neurobiol 16:247-50. 2006 - The role of hippocampal glutamate receptor-A-dependent synaptic plasticity in conditional learning: the importance of spatiotemporal discontiguityWolfram B Schmitt
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
J Neurosci 24:7277-82. 2004..We suggest that hippocampal GluR-A-dependent synaptic plasticity contributes to a memory system in rodents for encoding both the spatial and temporal contexts (the where and the when) associated with a particular event... - NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memoryDavid M Bannerman
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
J Neurosci 28:3623-30. 2008..In contrast, the ability to associate a particular spatial location with the water maze escape platform or food reward is NR2A independent, as well as GluR-A independent...