Research Topics
| Moritz HelmstaedterSummaryAffiliation: Abteilung Zellphysiologie Country: Germany Publications
| Collaborators
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Detail Information
Publications
Neuronal correlates of local, lateral, and translaminar inhibition with reference to cortical columnsMoritz Helmstaedter
Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
Cereb Cortex 19:926-37. 2009....- 3D structural imaging of the brain with photons and electronsMoritz Helmstaedter
Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg, Germany
Curr Opin Neurobiol 18:633-41. 2008..Both photon-based and electron-based imaging methods will ultimately need highly automated data analysis, because the manual tracing of most networks of interest would require hundreds to tens of thousands of years in human labor... - L2/3 interneuron groups defined by multiparameter analysis of axonal projection, dendritic geometry, and electrical excitabilityMoritz Helmstaedter
Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
Cereb Cortex 19:951-62. 2009..This scheme of identifying L2/3 INs may help to quantitatively describe inhibitory effects on sensory stimulus representations in L2/3 of cortical columns... - The relation between dendritic geometry, electrical excitability, and axonal projections of L2/3 interneurons in rat barrel cortexMoritz Helmstaedter
Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
Cereb Cortex 19:938-50. 2009..We conclude that 1) dendritic polarity is correlated to intrinsic electrical excitability, and 2) the axonal projection pattern represents an independent classifier of interneurons... - Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortexMoritz Helmstaedter
Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
J Neurosci 28:8273-84. 2008..Our results suggest that L4 spiny neurons may more efficiently recruit L2/3 interneurons than L2/3 pyramidal neurons, and that glutamate release from translaminar boutons of L4 spiny neuron axons is target cell specific... - High-accuracy neurite reconstruction for high-throughput neuroanatomyMoritz Helmstaedter
Max Planck Institute for Medical Research, Heidelberg, Germany
Nat Neurosci 14:1081-8. 2011..Focused reannotation of difficult locations promises a rather steep increase of reliability as a function of the average skeleton redundancy and thus the nearly error-free analysis of large neuroanatomical datasets... 
Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortexHanno S Meyer
Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
Cereb Cortex 20:2277-86. 2010..The number of APs evoked in a column by a sensory stimulus (principal whisker deflection) was estimated as 4441 within 100 ms post-stimulus...- Cell type-specific thalamic innervation in a column of rat vibrissal cortexHanno S Meyer
Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
Cereb Cortex 20:2287-303. 2010.... - Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5AHanno S Meyer
Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 108:16807-12. 2011.... - Wiring specificity in the direction-selectivity circuit of the retinaKevin L Briggman
Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg 69120, Germany
Nature 471:183-8. 2011..Our study demonstrates how otherwise intractable neurobiological questions can be addressed by combining functional imaging with the analysis of neuronal connectivity using large-scale electron microscopy... 
Monosynaptic connections between pairs of L5A pyramidal neurons in columns of juvenile rat somatosensory cortexAndreas Frick
Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, D 69120 Heidelberg, Germany
Cereb Cortex 18:397-406. 2008....- Structural neurobiology: missing link to a mechanistic understanding of neural computationWinfried Denk
Max Planck Institute for Medical Research, Heidelberg 69120, Germany
Nat Rev Neurosci 13:351-8. 2012..Given that the brain's algorithms are ultimately encoded by this network, knowing where all of these connections are should, at the very least, provide the data needed to distinguish between models of neural computation... - Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortexGiorgio A Ascoli
Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
Nat Rev Neurosci 9:557-68. 2008..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project... - Dendritic voltage-gated K+ conductance gradient in pyramidal neurones of neocortical layer 5B from ratsAndreas T Schaefer
Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
J Physiol 579:737-52. 2007..The steep negative K+ conductance density gradient along the apical dendrite may help to define a distal, low-threshold region for amplification of distal synaptic input in L5B pyramidal neurones... - Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channelsAndreas T Schaefer
Abteilung Zellphysiologie, , D-69120 Heidelberg, Germany
Biophys J 84:3508-28. 2003..The generality and robustness of the algorithm make it a useful tool for voltage-clamp analysis of voltage-gated currents in structures of any morphology that is amenable to the voltage-clamp technique...