Moritz Helmstaedter

Summary

Affiliation: Abteilung Zellphysiologie
Country: Germany

Publications

  1. doi request reprint 3D structural imaging of the brain with photons and electrons
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg, Germany
    Curr Opin Neurobiol 18:633-41. 2008
  2. doi request reprint Neuronal correlates of local, lateral, and translaminar inhibition with reference to cortical columns
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:926-37. 2009
  3. doi request reprint L2/3 interneuron groups defined by multiparameter analysis of axonal projection, dendritic geometry, and electrical excitability
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:951-62. 2009
  4. doi request reprint The relation between dendritic geometry, electrical excitability, and axonal projections of L2/3 interneurons in rat barrel cortex
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:938-50. 2009
  5. doi request reprint Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortex
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 28:8273-84. 2008
  6. doi request reprint High-accuracy neurite reconstruction for high-throughput neuroanatomy
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 14:1081-8. 2011
  7. pmc Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2277-86. 2010
  8. pmc Cell type-specific thalamic innervation in a column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2287-303. 2010
  9. pmc Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A
    Hanno S Meyer
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 108:16807-12. 2011
  10. doi request reprint Wiring specificity in the direction-selectivity circuit of the retina
    Kevin L Briggman
    Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg 69120, Germany
    Nature 471:183-8. 2011

Detail Information

Publications16

  1. doi request reprint 3D structural imaging of the brain with photons and electrons
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg, Germany
    Curr Opin Neurobiol 18:633-41. 2008
    ..Both photon-based and electron-based imaging methods will ultimately need highly automated data analysis, because the manual tracing of most networks of interest would require hundreds to tens of thousands of years in human labor...
  2. doi request reprint Neuronal correlates of local, lateral, and translaminar inhibition with reference to cortical columns
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:926-37. 2009
    ....
  3. doi request reprint L2/3 interneuron groups defined by multiparameter analysis of axonal projection, dendritic geometry, and electrical excitability
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:951-62. 2009
    ..This scheme of identifying L2/3 INs may help to quantitatively describe inhibitory effects on sensory stimulus representations in L2/3 of cortical columns...
  4. doi request reprint The relation between dendritic geometry, electrical excitability, and axonal projections of L2/3 interneurons in rat barrel cortex
    Moritz Helmstaedter
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
    Cereb Cortex 19:938-50. 2009
    ..We conclude that 1) dendritic polarity is correlated to intrinsic electrical excitability, and 2) the axonal projection pattern represents an independent classifier of interneurons...
  5. doi request reprint Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortex
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Neurosci 28:8273-84. 2008
    ..Our results suggest that L4 spiny neurons may more efficiently recruit L2/3 interneurons than L2/3 pyramidal neurons, and that glutamate release from translaminar boutons of L4 spiny neuron axons is target cell specific...
  6. doi request reprint High-accuracy neurite reconstruction for high-throughput neuroanatomy
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 14:1081-8. 2011
    ..Focused reannotation of difficult locations promises a rather steep increase of reliability as a function of the average skeleton redundancy and thus the nearly error-free analysis of large neuroanatomical datasets...
  7. pmc Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2277-86. 2010
    ..The number of APs evoked in a column by a sensory stimulus (principal whisker deflection) was estimated as 4441 within 100 ms post-stimulus...
  8. pmc Cell type-specific thalamic innervation in a column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2287-303. 2010
    ....
  9. pmc Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A
    Hanno S Meyer
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 108:16807-12. 2011
    ..The "hot zones" of inhibition in L2 and L5A match the reported low stimulus-evoked spiking rates of excitatory neurons in these layers, suggesting that these inhibitory hot zones substantially suppress activity in the neocortex...
  10. doi request reprint Wiring specificity in the direction-selectivity circuit of the retina
    Kevin L Briggman
    Max Planck Institute for Medical Research, Department of Biomedical Optics, Heidelberg 69120, Germany
    Nature 471:183-8. 2011
    ..Our study demonstrates how otherwise intractable neurobiological questions can be addressed by combining functional imaging with the analysis of neuronal connectivity using large-scale electron microscopy...
  11. doi request reprint Connectomic reconstruction of the inner plexiform layer in the mouse retina
    Moritz Helmstaedter
    Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Nature 500:168-74. 2013
    ..Circuit motifs that emerge from our data indicate a functional mechanism for a known cellular response in a ganglion cell that detects localized motion, and predict that another ganglion cell is motion sensitive...
  12. ncbi request reprint Monosynaptic connections between pairs of L5A pyramidal neurons in columns of juvenile rat somatosensory cortex
    Andreas Frick
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, D 69120 Heidelberg, Germany
    Cereb Cortex 18:397-406. 2008
    ....
  13. doi request reprint Structural neurobiology: missing link to a mechanistic understanding of neural computation
    Winfried Denk
    Max Planck Institute for Medical Research, Heidelberg 69120, Germany
    Nat Rev Neurosci 13:351-8. 2012
    ..Given that the brain's algorithms are ultimately encoded by this network, knowing where all of these connections are should, at the very least, provide the data needed to distinguish between models of neural computation...
  14. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
    ..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project...
  15. pmc Dendritic voltage-gated K+ conductance gradient in pyramidal neurones of neocortical layer 5B from rats
    Andreas T Schaefer
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    J Physiol 579:737-52. 2007
    ..The steep negative K+ conductance density gradient along the apical dendrite may help to define a distal, low-threshold region for amplification of distal synaptic input in L5B pyramidal neurones...
  16. pmc Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels
    Andreas T Schaefer
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, D 69120 Heidelberg, Germany
    Biophys J 84:3508-28. 2003
    ..The generality and robustness of the algorithm make it a useful tool for voltage-clamp analysis of voltage-gated currents in structures of any morphology that is amenable to the voltage-clamp technique...