Ulrich Costabel

Summary

Affiliation: Abteilung Pneumologie
Country: Germany

Publications

  1. ncbi request reprint Bronchoalveolar lavage in drug-induced lung disease
    Ulrich Costabel
    Ruhrlandklinik, Department Pneumology Allergy, Tueschener Weg 40, D 45239 Essen, Germany
    Clin Chest Med 25:25-35. 2004
  2. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
    Respir Res 10:101. 2009
  3. doi request reprint Diagnosis of sarcoidosis
    Ulrich Costabel
    Department of Pneumology Allergy, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Curr Opin Pulm Med 14:455-61. 2008
  4. doi request reprint Wash-out kinetics and efficacy of a modified lavage technique for alveolar proteinosis
    Francesco Bonella
    Ruhrlandklinik and Medical Faculty, University of Duisburg Essen, Essen, Germany
    Eur Respir J 40:1468-74. 2012
  5. doi request reprint Interleukin 12, interleukin 18, and tumor necrosis factor alpha release by alveolar macrophages: acute and chronic hypersensitivity pneumonitis
    Qiao Ye
    Department of Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Germany
    Ann Allergy Asthma Immunol 102:149-54. 2009
  6. ncbi request reprint Extrinsic allergic alveolitis: inhibitory effects of pentoxifylline on cytokine production by alveolar macrophages
    Zhaohui Tong
    Department of Pneumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
    Ann Allergy Asthma Immunol 92:234-9. 2004
  7. pmc Serum KL-6 is a predictor of outcome in pulmonary alveolar proteinosis
    Francesco Bonella
    Department of Pneumology Allergy, Ruhrlandklinik, University Hospital, University of Duisburg Essen, Essen, Germany
    Orphanet J Rare Dis 8:53. 2013
  8. doi request reprint Comparison of serum KL-6 versus bronchoalveolar lavage neutrophilia for the diagnosis of bronchiolitis obliterans in lung transplantation
    Shinichiro Ohshimo
    Department of Pneumology Allergy, Ruhrlandklinik, University Hospital, Essen, Germany
    J Heart Lung Transplant 30:1374-80. 2011
  9. doi request reprint Pulmonary alveolar proteinosis: new insights from a single-center cohort of 70 patients
    Francesco Bonella
    Department of Pneumology Allergy, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Tueschener Weg 40, 45239 Essen, Germany
    Respir Med 105:1908-16. 2011
  10. ncbi request reprint Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis
    Huaping Dai
    Department of Penumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
    Chest 127:251-6. 2005

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Bronchoalveolar lavage in drug-induced lung disease
    Ulrich Costabel
    Ruhrlandklinik, Department Pneumology Allergy, Tueschener Weg 40, D 45239 Essen, Germany
    Clin Chest Med 25:25-35. 2004
    ..BAL also is helpful in the differential diagnosis, primarily in the exclusion of an infective cause and of involvement of the lungs by the underlying disease (eg, metastatic cancer or malignant lymphoma)...
  2. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
    Respir Res 10:101. 2009
    ..To better understand the clinical implications of these findings we performed additional, explorative analyses of the IFGENIA data set...
  3. doi request reprint Diagnosis of sarcoidosis
    Ulrich Costabel
    Department of Pneumology Allergy, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Curr Opin Pulm Med 14:455-61. 2008
    ..To describe the recent advances in the diagnostic procedures for sarcoidosis and explore future directions...
  4. doi request reprint Wash-out kinetics and efficacy of a modified lavage technique for alveolar proteinosis
    Francesco Bonella
    Ruhrlandklinik and Medical Faculty, University of Duisburg Essen, Essen, Germany
    Eur Respir J 40:1468-74. 2012
    ..011). Exposure to dust seems to influence the kinetics of the protein wash-out. Applying manual ventilation during the procedure can enhance the efficacy of WLL...
  5. doi request reprint Interleukin 12, interleukin 18, and tumor necrosis factor alpha release by alveolar macrophages: acute and chronic hypersensitivity pneumonitis
    Qiao Ye
    Department of Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Germany
    Ann Allergy Asthma Immunol 102:149-54. 2009
    ..The TH1-associated cytokines interleukin (IL) 12 and IL-18 and tumor necrosis factor alpha (TNF-alpha) may be involved in the pathogenesis of both the acute and chronic forms of HP...
  6. ncbi request reprint Extrinsic allergic alveolitis: inhibitory effects of pentoxifylline on cytokine production by alveolar macrophages
    Zhaohui Tong
    Department of Pneumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
    Ann Allergy Asthma Immunol 92:234-9. 2004
    ..Extrinsic allergic alveolitis (EAA) is a granulomatous disease that is driven by T-cell and alveolar macrophage (AM)-derived cytokines...
  7. pmc Serum KL-6 is a predictor of outcome in pulmonary alveolar proteinosis
    Francesco Bonella
    Department of Pneumology Allergy, Ruhrlandklinik, University Hospital, University of Duisburg Essen, Essen, Germany
    Orphanet J Rare Dis 8:53. 2013
    ..The prognostic significance of KL-6 in PAP is still unknown. Aim of the study was to evaluate whether serum KL-6 levels correlate with the outcome of the disease...
  8. doi request reprint Comparison of serum KL-6 versus bronchoalveolar lavage neutrophilia for the diagnosis of bronchiolitis obliterans in lung transplantation
    Shinichiro Ohshimo
    Department of Pneumology Allergy, Ruhrlandklinik, University Hospital, Essen, Germany
    J Heart Lung Transplant 30:1374-80. 2011
    ..Our study compared the clinical utility of serum KL-6 level, a marker for pulmonary fibrosis, with that of neutrophilia in bronchoalveolar lavage fluid (BALF) for detecting BOS...
  9. doi request reprint Pulmonary alveolar proteinosis: new insights from a single-center cohort of 70 patients
    Francesco Bonella
    Department of Pneumology Allergy, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Tueschener Weg 40, 45239 Essen, Germany
    Respir Med 105:1908-16. 2011
    ..The aim of the study is to describe the epidemiologic, clinical, physiologic, and laboratory features of PAP in a large single-center cohort of patients with PAP...
  10. ncbi request reprint Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis
    Huaping Dai
    Department of Penumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
    Chest 127:251-6. 2005
    ..The effects of TNF-alpha are mediated by membrane TNF receptor (mTNFR)-1 and mTNFR-2, and can be blocked by soluble TNF receptor (sTNFR)-1 and sTNFR-2...
  11. pmc Diagnostic approach to interstitial pneumonias in a single centre: report on 88 cases
    Dirk Theegarten
    Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Hufelandstrasse 55, Essen 45147, Germany
    Diagn Pathol 7:160. 2012
    ..The aim of this study was to compare the results of histological evaluations with the final diagnosis after interdisciplinary case evaluation...
  12. ncbi request reprint Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis
    Esra Uzaslan
    Department of Pneumology and Allergy, Ruhrlandklinik, Essen, Germany
    Respiration 72:46-51. 2005
    ..We also investigated the expression of the transferrin receptor CD71 on cockade+ alveolar macrophages...
  13. doi request reprint Angiogenic and angiostatic chemokines in idiopathic pulmonary fibrosis and granulomatous lung disease
    Ai Cui
    Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Tueschener Weg 40, Essen, Germany
    Respiration 80:372-8. 2010
    ..Angiogenesis-angiostasis balance and leukocyte recruitment are influenced by different concentrations of distinct chemokines...
  14. doi request reprint Diagnostic modalities in sarcoidosis: BAL, EBUS, and PET
    Ulrich Costabel
    Medical Faculty, University of Duisburg Essen, Department of Pneumology Allergy, Ruhrlandklinik, Essen, Germany
    Semin Respir Crit Care Med 31:404-8. 2010
    ..These recent developments including novel biopsy procedures and novel imaging techniques could be of value to diagnosing sarcoidosis...
  15. doi request reprint Chronic hypersensitivity pneumonitis
    Ulrich Costabel
    Department of Pneumology Allergy, Ruhrlandklinik, University Hospital, Essen, Germany
    Clin Chest Med 33:151-63. 2012
    ..Additional research is needed to understand why the disease develops only in a minority of exposed individuals and why cases of chronic HP may progress without further antigen exposure...
  16. ncbi request reprint Bronchoalveolar lavage in other interstitial lung diseases
    Ulrich Costabel
    Department of Pneumology Allergy, Ruhrlandklinik, and University of Duisburg Essen, Essen, Germany
    Semin Respir Crit Care Med 28:514-24. 2007
    ..The same is true for radiation-induced lung injury...
  17. doi request reprint Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumonia
    Qiao Ye
    Department of Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Duisburg Essen, Germany
    Respir Med 105:292-7. 2011
    ..Patients with cryptogenic organizing pneumonia (COP) usually respond well to corticosteroids, in contrast to those with idiopathic pulmonary fibrosis (IPF). This may be due to the different pathogenesis...
  18. ncbi request reprint Production of IL-12, IL-18 and TNF-alpha by alveolar macrophages in hypersensitivity pneumonitis
    Baomin Chen
    Department of Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, University of Essen, Germany
    Sarcoidosis Vasc Diffuse Lung Dis 21:199-203. 2004
    ....
  19. doi request reprint Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis
    Shinichiro Ohshimo
    University of Duisburg Essen, Department of Pneumology Allergy, Ruhrlandklinik Tueschener Weg 40, 45239 Essen, Germany
    Am J Respir Crit Care Med 179:1043-7. 2009
    ..Bronchoalveolar lavage (BAL) and/or transbronchial biopsy, one of four major criteria in the 2000 ATS/ERS IPF Statement, was no more essential in the diagnostic algorithm of 2002 ATS/ERS Consensus Classification...
  20. doi request reprint Macrolides inhibit cytokine production by alveolar macrophages in bronchiolitis obliterans organizing pneumonia
    Miaotian Cai
    Department of Pneumology and Allergology, Ruhrlandklinik, University Hospital, Essen, Germany Beijng Institute of Respiratory Medicine, Beijing Chao Yang Hospital, Capital Medical University, Beijing, China
    Immunobiology 218:930-7. 2013
    ..This study aimed to investigate whether alveolar macrophages (AMs) produce aberrant proinflammatory cytokines in BOOP and whether this can be inhibited by clarithromycin (CAM) or azithromycin (AZM)...
  21. ncbi request reprint Systemic evaluation of a potential cutaneous sarcoidosis patient
    Ulrich Costabel
    Department of Pneumology Allergy, Ruhrlandklinik Essen, D 45239 Essen, Germany
    Clin Dermatol 25:303-11. 2007
    ..The evaluation leads to a wide number of organs being assessed by either history, physical examination or routine laboratory investigations. The major organs routinely assessed are the lungs, the eyes, the liver and the heart...
  22. doi request reprint Alveolar extracellular 20S proteasome in patients with acute respiratory distress syndrome
    Stephan Urs Sixt
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Germany
    Am J Respir Crit Care Med 179:1098-106. 2009
    ..Repair mechanisms resulting in alveolar protein degradation in acute respiratory distress syndrome (ARDS) are largely unknown...
  23. doi request reprint CD4+CD25+ T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosis
    Benjamin Wilde
    Department of Nephrology, University Duisburg Essen, Essen, Germany
    Nephrol Dial Transplant 24:161-71. 2009
    ..An increased CD4(+) CD25(+) T-cell population is observed in Wegener's granulomatosis (WG). This T-cell population is not well characterized yet and their contribution to the disease pathogenesis remains obscure...
  24. ncbi request reprint Inhibition of cytokine release from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline: comparison with dexamethasone
    Zhaohui Tong
    Department of Pneumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
    Chest 124:1526-32. 2003
    ....
  25. ncbi request reprint Pulmonary alveolar proteinosis: a new autoimmune disease
    Ulrich Costabel
    Medical Faculty, University of Duisburg Essen, and Department of Pneumology Allergy, Ruhrlandklinik, Essen, Germany
    Sarcoidosis Vasc Diffuse Lung Dis 22:S67-73. 2005
    ..We report the studies that developed the concept that this disorder is an autoimmune disease caused by auto-antibodies against GM-CSF. The clinical management of the patients is also described...
  26. ncbi request reprint Rare infiltrative lung diseases: a challenge for clinicians
    Venerino Poletti
    Dipartimento di Malattie dell Apparato Respiratorio e del Torace, Ospedale GB Morgagni, IT 47100 Forlì, Italy
    Respiration 71:431-43. 2004
    ..The intent is, however, to emphasize that in this difficult field multidisciplinary expertise and the knowledge of the most recent pathogenetic mechanisms have the main role in diagnosis and treatment...
  27. ncbi request reprint Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement
    Robert P Baughman
    University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Am J Respir Crit Care Med 174:795-802. 2006
    ..Evidence suggests that tumor necrosis factor (TNF)-alpha plays an important role in the pathophysiology of sarcoidosis...
  28. ncbi request reprint [Current trends in pneumology 2002 -- Part 1]
    Claus Kroegel
    Pneumologie and Allerologie Immunologie, Medizinische Klinik IV, Friedrich Schillier Universität, Jena
    Med Klin (Munich) 98:30-56. 2003
  29. ncbi request reprint Colpoplasty and acute pneumonitis
    Ulrich Costabel
    Respiration 70:31. 2003
  30. ncbi request reprint Idiopathic bronchiolitis mimicking diffuse panbronchiolitis
    Venerino Poletti
    Dipartimento di Malattie dell Apparato Respiratorio e del Torace, Ospedale G B Morgagni, Forli, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 20:62-8. 2003
    ..We suggest that diseases classified as IB in this study might be homogeneous entities which are clinically and radiologically similar to DPB...
  31. ncbi request reprint Clinical features of recurrent and insidious chronic bird fancier's lung
    Yoshio Ohtani
    Pulmonary Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Ann Allergy Asthma Immunol 90:604-10. 2003
    ....
  32. ncbi request reprint Clinical diagnosis of hypersensitivity pneumonitis
    Yves Lacasse
    Centre de Pneumologie, Hopital Laval, Universite Laval, Ste Foy, Quebec, Canada
    Am J Respir Crit Care Med 168:952-8. 2003
    ..The rule retained its accuracy when validated in a separate cohort of 261 patients. The diagnosis of HP can often be made or rejected with confidence, especially in areas of high or low prevalence, respectively, without BAL or biopsy...
  33. ncbi request reprint [Inhibition of cytokine release from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline]
    Zhao Hui Tong
    Beijing Chaoyang Hospital Beijing Institute of Respiratory Medicine, Beijing 100020, China
    Zhonghua Jie He He Hu Xi Za Zhi 26:415-8. 2003
    ..It was investigated that the effects of POF on the production of TNF-alpha, interleukin (IL)-1beta, IL-6, IL-8, IL-10 and the soluble TNF-alpha receptors (sTNFR-1 and sTNFR-2) from AM in sarcoidosis, as comparison to dexamethasone (DEX)...
  34. ncbi request reprint [Preliminary study on effect of pentoxifylline in treatment of extrinsic allergic alveolitis]
    Zhao Hui Tong
    Beijing Chao Yang Hospital Beijing Institute of Respiratory Medicine, Beijing 100020, China
    Zhonghua Yi Xue Za Zhi 84:482-5. 2004
    ....
  35. ncbi request reprint Reactive alveolar epithelium in chondroid hamartoma of the lung
    Esra Uzaslan
    General and Experimental Pathology, University of Bochum, Bochum, Germany
    Acta Cytol 49:154-6. 2005
    ..To determine the morphologic characteristics of the nonciliated epithelium found in chondroid hamartoma of the lung...
  36. ncbi request reprint High-dose acetylcysteine in idiopathic pulmonary fibrosis
    Maurits Demedts
    University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    N Engl J Med 353:2229-42. 2005
    ..Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor prognosis...
  37. ncbi request reprint Immune cells in bronchoalveolar lavage in peripheral lung cancer--analysis of 140 cases
    Joanna Domagała-Kulawik
    Department of Pneumonology and Allergology, Medical Academy, Warsaw, Poland
    Respiration 70:43-8. 2003
    ..Changes in the bronchoalveolar lavage fluid (BALF) cell profile may reflect immunologic reactions of the lung in pulmonary malignancies...