Klaus Abraham

Summary

Country: Germany

Publications

  1. doi request reprint Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers
    Klaus Abraham
    Federal Institute for Risk Assessment, Department of Food Safety, Berlin, Germany
    Mol Nutr Food Res 55:644-53. 2011
  2. doi request reprint Toxicology and risk assessment of coumarin: focus on human data
    Klaus Abraham
    Federal Institute for Risk Assessment BfR, 14195 Berlin, Germany
    Mol Nutr Food Res 54:228-39. 2010
  3. doi request reprint Relative oral bioavailability of glycidol from glycidyl fatty acid esters in rats
    Klaus E Appel
    Department of Food Safety, Federal Institute for Risk Assessment BfR, Max Dohrn Str 8 10, 10589 Berlin, Germany
    Arch Toxicol 87:1649-59. 2013
  4. doi request reprint Toxicology and risk assessment of acrolein in food
    Klaus Abraham
    Federal Institute for Risk Assessment BfR, Berlin, Germany
    Mol Nutr Food Res 55:1277-90. 2011
  5. doi request reprint Relative oral bioavailability of 3-MCPD from 3-MCPD fatty acid esters in rats
    Klaus Abraham
    Department of Food Safety, Federal Institute for Risk Assessment, Max Dohrn Strasse 8 10, 10589 Berlin, Germany
    Arch Toxicol 87:649-59. 2013
  6. doi request reprint Toxicology and risk assessment of 5-Hydroxymethylfurfural in food
    Klaus Abraham
    Department of Food Safety, Federal Institute for Risk Assessment, Germany
    Mol Nutr Food Res 55:667-78. 2011
  7. doi request reprint A probabilistic model for the carry-over of PCDD/Fs from feed to growing pigs
    Julian Adolphs
    Federal Institute for Risk Assessment BfR, Max Dohrn Str 8 10, 10589 Berlin, Germany
    Chemosphere 93:474-9. 2013
  8. doi request reprint Risks and benefits of dietary isoflavones for cancer
    Susanne Andres
    Department of Food Safety, Federal Institute for Risk Assessment, Berlin, Germany
    Crit Rev Toxicol 41:463-506. 2011
  9. doi request reprint Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food
    Nadiya Bakhiya
    Federal Institute for Risk Assessment BfR, Department Food Safety, Berlin, Germany
    Mol Nutr Food Res 55:509-21. 2011
  10. ncbi request reprint Acute inhalative exposure assessment: derivation of guideline levels with special regard to sensitive subpopulations and time scaling
    Hans Mielke
    Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
    Toxicology 214:256-67. 2005

Collaborators

Detail Information

Publications15

  1. doi request reprint Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers
    Klaus Abraham
    Federal Institute for Risk Assessment, Department of Food Safety, Berlin, Germany
    Mol Nutr Food Res 55:644-53. 2011
    ..Heavy consumption of this spice may result in a dose exceeding the tolerable daily intake (TDI). In this context, the question was raised whether coumarin in the plant matrix of cinnamon has the same bioavailability as isolated coumarin...
  2. doi request reprint Toxicology and risk assessment of coumarin: focus on human data
    Klaus Abraham
    Federal Institute for Risk Assessment BfR, 14195 Berlin, Germany
    Mol Nutr Food Res 54:228-39. 2010
    ..Heavy consumers of cassia cinnamon may reach a daily coumarin intake corresponding to the TDI...
  3. doi request reprint Relative oral bioavailability of glycidol from glycidyl fatty acid esters in rats
    Klaus E Appel
    Department of Food Safety, Federal Institute for Risk Assessment BfR, Max Dohrn Str 8 10, 10589 Berlin, Germany
    Arch Toxicol 87:1649-59. 2013
    ..Therefore, assessment of human exposure to glycidyl fatty acid ester should be regarded as an exposure to the same molar quantity of glycidol...
  4. doi request reprint Toxicology and risk assessment of acrolein in food
    Klaus Abraham
    Federal Institute for Risk Assessment BfR, Berlin, Germany
    Mol Nutr Food Res 55:1277-90. 2011
    ..High exposure could be ten times higher after the consumption of certain foods. Although the estimation of the dietary acrolein exposure is associated with uncertainties, it is concluded that a health risk seems to be unlikely...
  5. doi request reprint Relative oral bioavailability of 3-MCPD from 3-MCPD fatty acid esters in rats
    Klaus Abraham
    Department of Food Safety, Federal Institute for Risk Assessment, Max Dohrn Strasse 8 10, 10589 Berlin, Germany
    Arch Toxicol 87:649-59. 2013
    ..Therefore, assessment of the extent of exposure to 3-MCPD released from its fatty acid esters should be performed in the same way as exposure to the same molar quantity of 3-MCPD...
  6. doi request reprint Toxicology and risk assessment of 5-Hydroxymethylfurfural in food
    Klaus Abraham
    Department of Food Safety, Federal Institute for Risk Assessment, Germany
    Mol Nutr Food Res 55:667-78. 2011
    ..Safety margins are generally sufficient. However, 5-HMF exposure resulting from caramel colours used as food additives should be further evaluated...
  7. doi request reprint A probabilistic model for the carry-over of PCDD/Fs from feed to growing pigs
    Julian Adolphs
    Federal Institute for Risk Assessment BfR, Max Dohrn Str 8 10, 10589 Berlin, Germany
    Chemosphere 93:474-9. 2013
    ..The approach demonstrated here is a showcase how a risk assessment in the case of contaminated feeding can be performed...
  8. doi request reprint Risks and benefits of dietary isoflavones for cancer
    Susanne Andres
    Department of Food Safety, Federal Institute for Risk Assessment, Berlin, Germany
    Crit Rev Toxicol 41:463-506. 2011
    ..Therefore, this review examines the risks but also the benefits of isoflavones with regard to various kinds of cancer, which can be derived from animal and human studies as well as from in vitro experiments...
  9. doi request reprint Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food
    Nadiya Bakhiya
    Federal Institute for Risk Assessment BfR, Department Food Safety, Berlin, Germany
    Mol Nutr Food Res 55:509-21. 2011
    ..As this gives rise for toxicological concern, the currently available toxicological data of 3-MCPD and glycidol and their esters are summarized in this review and discussed with regard to data gaps and further research needs...
  10. ncbi request reprint Acute inhalative exposure assessment: derivation of guideline levels with special regard to sensitive subpopulations and time scaling
    Hans Mielke
    Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
    Toxicology 214:256-67. 2005
    ..In comparison to the conventional procedure, the alternative approaches are based on mechanistic models of the toxicodynamic effect. Use of these models results in AEGL values which are biologically justified...
  11. ncbi request reprint Internal exposure of children by simulated acute inhalation of volatile organic compounds: the influence of chemical properties on the child/adult concentration ratio
    Klaus Abraham
    Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
    Basic Clin Pharmacol Toxicol 96:242-3. 2005
  12. ncbi request reprint Elevated internal exposure of children in simulated acute inhalation of volatile organic compounds: effects of concentration and duration
    Klaus Abraham
    Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
    Arch Toxicol 79:63-73. 2005
    ..For shorter exposures, the dose dependency of the concentration ratios (newborn/adult) is less pronounced. This is the first article to show that the intraspecies assessment factor may vary with concentration and duration of exposure...
  13. doi request reprint Physiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation--the case of coumarin
    Hans Mielke
    Federal Institute for Risk Assessment BfR, Thielallee 88 92, 14195 Berlin, Germany
    Toxicol Lett 202:100-10. 2011
    ..If these findings can be transferred to the situation in humans, the result demonstrates that route specific differences in organ peak concentrations have to be considered when performing route-to-route extrapolation...
  14. doi request reprint Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from indonesia
    Friederike Woehrlin
    Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
    J Agric Food Chem 58:10568-75. 2010
    ..Interestingly, a high variation was observed in one of the trees, whereas no coumarin was detected in the samples of two other trees. In conclusion, coumarin levels in cassia cinnamon can vary widely even within a single tree...
  15. ncbi request reprint Zero tolerances in food and animal feed -- are there any scientific alternatives? A European point of view on an international controversy
    Thomas Heberer
    Federal Institute for Risk Assessment, Section 55, Residues of Medicinal Products, Diedersdorfer Weg 1, 12277 Berlin, Germany
    Toxicol Lett 175:118-35. 2007
    ..In microbiology, there is no legal room for manoeuvre with regard to food safety criteria established for reasons of consumer health protection on the basis of scientific assessments...