Research Topics
| Klaus AbrahamSummaryCountry: Germany Publications
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Detail Information
Publications
Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteersKlaus Abraham
Federal Institute for Risk Assessment, Department of Food Safety, Berlin, Germany
Mol Nutr Food Res 55:644-53. 2011..Heavy consumption of this spice may result in a dose exceeding the tolerable daily intake (TDI). In this context, the question was raised whether coumarin in the plant matrix of cinnamon has the same bioavailability as isolated coumarin...- Toxicology and risk assessment of coumarin: focus on human dataKlaus Abraham
Federal Institute for Risk Assessment BfR, 14195 Berlin, Germany
Mol Nutr Food Res 54:228-39. 2010..Heavy consumers of cassia cinnamon may reach a daily coumarin intake corresponding to the TDI... - Toxicology and risk assessment of acrolein in foodKlaus Abraham
Federal Institute for Risk Assessment BfR, Berlin, Germany
Mol Nutr Food Res 55:1277-90. 2011..High exposure could be ten times higher after the consumption of certain foods. Although the estimation of the dietary acrolein exposure is associated with uncertainties, it is concluded that a health risk seems to be unlikely... - Toxicology and risk assessment of 5-Hydroxymethylfurfural in foodKlaus Abraham
Department of Food Safety, Federal Institute for Risk Assessment, Germany
Mol Nutr Food Res 55:667-78. 2011..Safety margins are generally sufficient. However, 5-HMF exposure resulting from caramel colours used as food additives should be further evaluated... - Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in foodNadiya Bakhiya
Federal Institute for Risk Assessment BfR, Department Food Safety, Berlin, Germany
Mol Nutr Food Res 55:509-21. 2011..As this gives rise for toxicological concern, the currently available toxicological data of 3-MCPD and glycidol and their esters are summarized in this review and discussed with regard to data gaps and further research needs... - Risks and benefits of dietary isoflavones for cancerSusanne Andres
Department of Food Safety, Federal Institute for Risk Assessment, Berlin, Germany
Crit Rev Toxicol 41:463-506. 2011..Therefore, this review examines the risks but also the benefits of isoflavones with regard to various kinds of cancer, which can be derived from animal and human studies as well as from in vitro experiments... 
Elevated internal exposure of children in simulated acute inhalation of volatile organic compounds: effects of concentration and durationKlaus Abraham
Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
Arch Toxicol 79:63-73. 2005..For shorter exposures, the dose dependency of the concentration ratios (newborn/adult) is less pronounced. This is the first article to show that the intraspecies assessment factor may vary with concentration and duration of exposure...- Internal exposure of children by simulated acute inhalation of volatile organic compounds: the influence of chemical properties on the child/adult concentration ratioKlaus Abraham
Federal Institute for Risk Assessment, Thielallee 88-92, 14195 Berlin, Germany
Basic Clin Pharmacol Toxicol 96:242-3. 2005 - Acute inhalative exposure assessment: derivation of guideline levels with special regard to sensitive subpopulations and time scalingHans Mielke
Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
Toxicology 214:256-67. 2005..In comparison to the conventional procedure, the alternative approaches are based on mechanistic models of the toxicodynamic effect. Use of these models results in AEGL values which are biologically justified... - Relative oral bioavailability of 3-MCPD from 3-MCPD fatty acid esters in ratsKlaus Abraham
Department of Food Safety, Federal Institute for Risk Assessment, Max Dohrn Strasse 8 10, 10589 Berlin, Germany
Arch Toxicol 87:649-59. 2013..Therefore, assessment of the extent of exposure to 3-MCPD released from its fatty acid esters should be performed in the same way as exposure to the same molar quantity of 3-MCPD... - Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from indonesiaFriederike Woehrlin
Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
J Agric Food Chem 58:10568-75. 2010..Interestingly, a high variation was observed in one of the trees, whereas no coumarin was detected in the samples of two other trees. In conclusion, coumarin levels in cassia cinnamon can vary widely even within a single tree... - Physiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation--the case of coumarinHans Mielke
Federal Institute for Risk Assessment BfR, Thielallee 88 92, 14195 Berlin, Germany
Toxicol Lett 202:100-10. 2011..If these findings can be transferred to the situation in humans, the result demonstrates that route specific differences in organ peak concentrations have to be considered when performing route-to-route extrapolation... - Zero tolerances in food and animal feed -- are there any scientific alternatives? A European point of view on an international controversyThomas Heberer
Federal Institute for Risk Assessment, Section 55, Residues of Medicinal Products, Diedersdorfer Weg 1, 12277 Berlin, Germany
Toxicol Lett 175:118-35. 2007..In microbiology, there is no legal room for manoeuvre with regard to food safety criteria established for reasons of consumer health protection on the basis of scientific assessments...