Mark S George

Summary

Publications

  1. ncbi request reprint Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS)
    Mark S George
    Brain Stimulation Laboratory and the Department of Psychiatry, Center for Advanced Imaging Research at the Medical University of South Carolina, Charleston, SC, USA
    Semin Clin Neuropsychiatry 7:293-304. 2002
  2. ncbi request reprint Low CSF somatostatin associated with response to nimodipine in patents with affective illness
    Mark A Frye
    UCLA Neuropsychiatric Institute, Los Angeles, California, USA
    Biol Psychiatry 53:180-3. 2003
  3. ncbi request reprint Stimulating the brain
    Mark S George
    Sci Am 289:66-73. 2003
  4. pmc Volitional reduction of anterior cingulate cortex activity produces decreased cue craving in smoking cessation: a preliminary real-time fMRI study
    Xingbao Li
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Addict Biol 18:739-48. 2013
  5. pmc Decreasing procedural pain over time of left prefrontal rTMS for depression: initial results from the open-label phase of a multi-site trial (OPT-TMS)
    Berry S Anderson
    Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, SC 29425, USA
    Brain Stimul 2:88-92. 2009
  6. ncbi request reprint Brain stimulation for the treatment of psychiatric disorders
    Mark S George
    Brain Stimulation Laboratory and Mood Disorders Clinic, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Psychiatry 20:250-4; discussion 247-9. 2007
  7. pmc Focal electrical stimulation as a sham control for repetitive transcranial magnetic stimulation: Does it truly mimic the cutaneous sensation and pain of active prefrontal repetitive transcranial magnetic stimulation?
    Ashley B Arana
    Brain Stimulation Laboratory BSL, Psychiatry Department, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    Brain Stimul 1:44-51. 2008
  8. pmc A pilot study investigating the effects of fast left prefrontal rTMS on chronic neuropathic pain
    Jeffrey J Borckardt
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pain Med 10:840-9. 2009
  9. ncbi request reprint Serial vagus nerve stimulation functional MRI in treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Brain Stimulation Laboratory, Mood Disorders Program, Institute of Psychiatry, Charleston, SC 29403, USA
    Neuropsychopharmacology 32:1649-60. 2007
  10. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005

Detail Information

Publications93

  1. ncbi request reprint Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS)
    Mark S George
    Brain Stimulation Laboratory and the Department of Psychiatry, Center for Advanced Imaging Research at the Medical University of South Carolina, Charleston, SC, USA
    Semin Clin Neuropsychiatry 7:293-304. 2002
    ..These novel treatments are thus the translational tools to bridge from advances in brain imaging, into new treatments for depressed patients...
  2. ncbi request reprint Low CSF somatostatin associated with response to nimodipine in patents with affective illness
    Mark A Frye
    UCLA Neuropsychiatric Institute, Los Angeles, California, USA
    Biol Psychiatry 53:180-3. 2003
    ..This study was conducted to assess whether a low baseline level of CSF SRIF was associated with response to nimodipine treatment...
  3. ncbi request reprint Stimulating the brain
    Mark S George
    Sci Am 289:66-73. 2003
  4. pmc Volitional reduction of anterior cingulate cortex activity produces decreased cue craving in smoking cessation: a preliminary real-time fMRI study
    Xingbao Li
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Addict Biol 18:739-48. 2013
    ..Further research is needed to determine the optimal parameters of neurofeedback rtfMRI, and whether it might eventually become a therapeutic tool for nicotine dependence...
  5. pmc Decreasing procedural pain over time of left prefrontal rTMS for depression: initial results from the open-label phase of a multi-site trial (OPT-TMS)
    Berry S Anderson
    Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, SC 29425, USA
    Brain Stimul 2:88-92. 2009
    ..We analyzed interim results from the open-label phase of a multi-site randomized trial of rTMS as a treatment for depression to investigate whether the procedural pain of left prefrontal rTMS changes over time...
  6. ncbi request reprint Brain stimulation for the treatment of psychiatric disorders
    Mark S George
    Brain Stimulation Laboratory and Mood Disorders Clinic, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Psychiatry 20:250-4; discussion 247-9. 2007
    ..The methods in this class range from non-invasive (transcranial magnetic stimulation) to invasive brain surgery (deep brain stimulation)...
  7. pmc Focal electrical stimulation as a sham control for repetitive transcranial magnetic stimulation: Does it truly mimic the cutaneous sensation and pain of active prefrontal repetitive transcranial magnetic stimulation?
    Ashley B Arana
    Brain Stimulation Laboratory BSL, Psychiatry Department, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    Brain Stimul 1:44-51. 2008
    ....
  8. pmc A pilot study investigating the effects of fast left prefrontal rTMS on chronic neuropathic pain
    Jeffrey J Borckardt
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pain Med 10:840-9. 2009
    ..It is unclear whether the motor cortex is the only effective cortical target for managing neuropathic pain, and no published studies to date have investigated the effects of prefrontal stimulation on neuropathic pain...
  9. ncbi request reprint Serial vagus nerve stimulation functional MRI in treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Brain Stimulation Laboratory, Mood Disorders Program, Institute of Psychiatry, Charleston, SC 29403, USA
    Neuropsychopharmacology 32:1649-60. 2007
    ..Future interleaved VNS/fMRI studies to confirm these findings and further clarify the regional neurobiological effects of VNS...
  10. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005
    ..We examined the effects of adjunctive VNS over 24 months in this cohort...
  11. pmc Significant analgesic effects of one session of postoperative left prefrontal cortex repetitive transcranial magnetic stimulation: a replication study
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    Brain Stimul 1:122-7. 2008
    ..This study sought to test this finding for replication and to more accurately estimate the effect size of this brief intervention on postoperative morphine use and postoperative pain and mood ratings...
  12. pmc Real-time fMRI in the treatment of nicotine dependence: a conceptual review and pilot studies
    Karen J Hartwell
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychol Addict Behav 27:501-9. 2013
    ..While rtfMRI feedback remains an intriguing possibility for the treatment of addictions, much work remains to be done in establishing its efficacy...
  13. ncbi request reprint Acute vagus nerve stimulation using different pulse widths produces varying brain effects
    Qiwen Mu
    Brain Stimulation Laboratory, Medical University of South Carolina, Institute of Psychiatry 502N, 67 President Street, Charleston, SC 29425, USA
    Biol Psychiatry 55:816-25. 2004
    ....
  14. pmc A randomized, controlled investigation of motor cortex transcranial magnetic stimulation (TMS) effects on quantitative sensory measures in healthy adults: evaluation of TMS device parameters
    Jeffrey J Borckardt
    Departments of Psychiatry and Behavioral, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin J Pain 27:486-94. 2011
    ..Further, there is considerable inconsistency between studies with respect to laboratory pain measurement procedures, TMS treatment parameters, sophistication of the sham methods, and sample sizes...
  15. ncbi request reprint A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia
    Qiwen Mu
    Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Schizophr Res 94:332-41. 2007
    ..These data are consistent with the hypothesis formulated from studies of non-human primates that dihydrexidine and other D1 agonists may be able to modulate prefrontal dopaminergic function...
  16. pmc Motor threshold in transcranial magnetic stimulation: the impact of white matter fiber orientation and skull-to-cortex distance
    Tal Herbsman
    Mood Disorders Program and Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hum Brain Mapp 30:2044-55. 2009
    ..82, F = 20.27, P < 0.0001) in measurements of MT. The corticospinal tract's anterior-posterior direction alone contributes 13% of the variance explained...
  17. pmc Reduction of cue-induced craving through realtime neurofeedback in nicotine users: the role of region of interest selection and multiple visits
    Colleen A Hanlon
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychiatry Res 213:79-81. 2013
    ..g. ventral anterior cingulate cortex (vACC)) rather than increasing activity in regions involved in "resisting" (e.g. dorsal medial prefrontal cortex (dmPFC))...
  18. doi request reprint Resisting the urge to smoke and craving during a smoking quit attempt on varenicline: results from a pilot fMRI study
    Karen J Hartwell
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Drug Alcohol Abuse 39:92-8. 2013
    ..Varenicline has been shown to reduce cigarette craving during a quit attempt...
  19. doi request reprint Interleaved transcranial magnetic stimulation and fMRI suggests that lamotrigine and valproic acid have different effects on corticolimbic activity
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 502N, 67 President St, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 209:233-44. 2010
    ..A previous study showed that lamotrigine (LTG) inhibited brain activation induced when TMS was applied over motor cortex, whereas it increased activation induced by TMS applied over prefrontal cortex...
  20. doi request reprint A pilot study of the tolerability and effects of high-definition transcranial direct current stimulation (HD-tDCS) on pain perception
    Jeffrey J Borckardt
    Brain Stimulation Laboratory, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    J Pain 13:112-20. 2012
    ..Future studies are warranted to investigate HD-tDCS in other applications, and to examine further its potential to affect pain perception...
  21. ncbi request reprint Mechanisms and the current state of transcranial magnetic stimulation
    Mark S George
    Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    CNS Spectr 8:496-514. 2003
    ..TMS' ability to non-invasively and focally stimulate the brain of an awake human is proving to be a most important development for neuroscience in general, and neuropsychiatry in particular...
  22. doi request reprint Using interleaved transcranial magnetic stimulation/functional magnetic resonance imaging (fMRI) and dynamic causal modeling to understand the discrete circuit specific changes of medications: lamotrigine and valproic acid changes in motor or prefrontal e
    Xingbao Li
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA
    Psychiatry Res 194:141-8. 2011
    ..These results suggest that interleaved TMS/fMRI can assess region- and circuit-specific effects of medications or interventions...
  23. ncbi request reprint Safety and benefits of distance-adjusted prefrontal transcranial magnetic stimulation in depressed patients 55-75 years of age: a pilot study
    Ziad Nahas
    Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Depress Anxiety 19:249-56. 2004
    ....
  24. pmc Focal electrically administered therapy: device parameter effects on stimulus perception in humans
    Jeffrey J Borckardt
    Psychiatry Department, Medical University of South Carolina, Charleston, SC 29425, USA
    J ECT 25:91-8. 2009
    ..This study used a simpler paradigm and evaluated the effects of different stimulation parameters on subjective perception of the quality and location of scalp pain...
  25. doi request reprint Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, MUSC IOP, 502 N, 67 President Street, Charleston, SC, 29425, USA
    J Neural Transm 116:423-9. 2009
    ..07, P < 0.05) and enhanced by valproic acid (t = 2.39, P < 0.05). Lamotrigine and valproic acid have different effects on cortical neuronal excitability as demonstrated by TMS...
  26. ncbi request reprint Vagus nerve stimulation for the treatment of depression and other neuropsychiatric disorders
    Mark S George
    Institute of Psychiatry MUSC, Brain Stimulation Laboratory, 67 President Street, Room 502 North, Charleston, SC 29425, USA
    Expert Rev Neurother 7:63-74. 2007
    ..Much more research is needed regarding exactly how to refine and deliver the electrical pulses and how this differentially affects brain function in health and disease...
  27. ncbi request reprint Interleaved transcranial magnetic stimulation/functional MRI confirms that lamotrigine inhibits cortical excitability in healthy young men
    Xingbao Li
    Brain Stimulation Laboratory, Center for Advanced Imaging Research CAIR, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    Neuropsychopharmacology 29:1395-407. 2004
    ..Furthermore, the interleaved TMS/fMRI technique may be a useful tool for investigating regional brain effects of psychoactive compounds...
  28. pmc Naloxone-reversible modulation of pain circuitry by left prefrontal rTMS
    Joseph J Taylor
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29414, USA
    Neuropsychopharmacology 38:1189-97. 2013
    ..These preliminary results suggest that left DLPFC rTMS drives top-down opioidergic analgesia...
  29. pmc Sustained reduction of nicotine craving with real-time neurofeedback: exploring the role of severity of dependence
    Melanie Canterberry
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC
    Nicotine Tob Res 15:2120-4. 2013
    ..The current study examined the role of nicotine-dependence severity and the efficacy of multiple visits of neurofeedback from a single region of interest (ROI) in the anterior cingulate cortex (ACC) on craving reduction...
  30. pmc Individual variability in the locus of prefrontal craving for nicotine: implications for brain stimulation studies and treatments
    Colleen A Hanlon
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Alcohol Depend 125:239-43. 2012
    ..This investigation aims to guide these studies by assessing individual variability in the location of peak cortical activity during cue-elicited craving...
  31. pmc Ten sessions of adjunctive left prefrontal rTMS significantly reduces fibromyalgia pain: a randomized, controlled pilot study
    E Baron Short
    Brain Stimulation Laboratory, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President St, PO Box 250861, Charleston, SC 29425, USA
    Pain 152:2477-84. 2011
    ..TMS was well tolerated, with few side effects. Further studies that address study limitations are needed to determine whether daily prefrontal TMS may be an effective, durable, and clinically useful treatment for fibromyalgia symptoms...
  32. doi request reprint Feasibility, safety, and effectiveness of transcranial direct current stimulation for decreasing post-ERCP pain: a randomized, sham-controlled, pilot study
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Gastrointest Endosc 73:1158-64. 2011
    ..No studies have examined the analgesic effects of tDCS immediately after surgical/endoscopic procedures. Endoscopy investigating abdominal pain, especially ERCP, can cause significant postprocedural pain...
  33. doi request reprint Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial
    Mark S George
    Brain Stimulation Division, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Arch Gen Psychiatry 67:507-16. 2010
    ..Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately mask sham conditions...
  34. ncbi request reprint A review of functional neuroimaging studies of vagus nerve stimulation (VNS)
    Jeong Ho Chae
    The Center for Advanced Imaging Research and Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, SC 29425, USA
    J Psychiatr Res 37:443-55. 2003
    ..These include the thalamus, cerebellum, orbitofrontal cortex, limbic system, hypothalamus, and medulla. Functional neuroimaging studies have the potential to provide greater insight into the brain circuitry behind the activity of VNS...
  35. ncbi request reprint Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation
    Qiwen Mu
    Brain Stimulation Laboratory, Medical University of South Carolina IOP, 502 N, 67 President St, Charleston, SC 29425, USA
    Sleep 28:433-46. 2005
    ..To examine whether differences in patterns of brain activation under baseline conditions relate to the differences in sleep-deprivation vulnerability...
  36. pmc Development and evaluation of a portable sham transcranial magnetic stimulation system
    Jeffrey J Borckardt
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Brain Stimul 1:52-9. 2008
    ..Portability will likely become more and more important as TMS applications expand into different clinical areas (eg, TMS in the postanesthesia care unit after surgery)...
  37. ncbi request reprint Can left prefrontal rTMS be used as a maintenance treatment for bipolar depression?
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Room 502 North, PO Box 250861, Charleston, SC 29425, USA
    Depress Anxiety 20:98-100. 2004
    ..9) over the year. These data suggest but do not prove that TMS might eventually be used as an adjunctive maintenance treatment for at least some patients with bipolar depression. Much work remains...
  38. pmc Fifteen minutes of left prefrontal repetitive transcranial magnetic stimulation acutely increases thermal pain thresholds in healthy adults
    Jeffery J Borckardt
    Depart of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Pain Res Manag 12:287-90. 2007
    ..There is, however, emerging brain imaging evidence that the left prefrontal cortex is involved in pain inhibition in humans...
  39. pmc Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia
    Leonardo Bonilha
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    Schizophr Res 101:142-51. 2008
    ..We investigated the relationship between prefrontal cortical atrophy as measured by MRI and the neuropsychological performance of participants diagnosed with DSM-IV-TR schizophrenia...
  40. ncbi request reprint Vagus nerve stimulation (VNS) for depression: what do we know now and what should be done next?
    Ziad Nahas
    Mood Disorders Program, Medical Director of Brain Stimulation Laboratory Institute of Psychiatry, 67 President Street, Room 502 North, Charleston, SC 29403, USA
    Curr Psychiatry Rep 8:445-51. 2006
    ..Further clinical studies, in addition to prospective cost utilization and health economic investigations, are needed to better understand VNS therapy and the impact it holds on TRD care...
  41. pmc Bilateral epidural prefrontal cortical stimulation for treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Mood Disorders Program and Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA
    Biol Psychiatry 67:101-9. 2010
    ..We chose to pilot the safety and therapeutic benefits of chronic and intermittent epidural prefrontal cortical stimulation (EpCS) in patients with treatment-resistant depression...
  42. pmc Cerebral cortex plasticity after 90 days of bed rest: data from TMS and fMRI
    Donna R Roberts
    Department of Radiology and Radiological Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Aviat Space Environ Med 81:30-40. 2010
    ..In this pilot study, we explored corticospinal plasticity in a bed rest model. We hypothesized that the lack of weight bearing would induce cortical reorganization correlating with performance...
  43. ncbi request reprint Reducing pain and unpleasantness during repetitive transcranial magnetic stimulation
    Jeffrey J Borckardt
    Medical University of South Carolina, Charleston, SC, USA
    J ECT 22:259-64. 2006
    ..More systematic research is needed on the effectiveness of different strategies for reducing rTMS-related pain and discomfort...
  44. ncbi request reprint Acute and long-term VNS effects on pain perception in a case of treatment-resistant depression
    Jeffrey J Borckardt
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Neurocase 12:216-20. 2006
    ..If the acutely increased sensitivity sets the stage for the slower chronic anti-pain effects, the increased acute sensitivity does not disappear. Acute and chronic effects of VNS on pain perception merit further research...
  45. ncbi request reprint Mechanisms and state of the art of transcranial magnetic stimulation
    Mark S George
    Psychiatry Departmemt, Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    J ECT 18:170-81. 2002
    ..This article reviews the major recent advances with this interesting noninvasive technique for stimulating the brain, critically reviewing the data on whether TMS has anticonvulsant effects or modulates cortical-limbic loops...
  46. ncbi request reprint Detecting deception using functional magnetic resonance imaging
    F Andrew Kozel
    Center for Advanced Imaging Research CAIR, Medical University of South Carolina, Charleston, SC, USA
    Biol Psychiatry 58:605-13. 2005
    ..e., conduct disorder, antisocial personality disorder, etc.)...
  47. doi request reprint Executive control circuitry differentiates degree of success in weight loss following gastric-bypass surgery
    Rachel L Goldman
    Department of Psychiatry and Behavioral Sciences, Charleston, South Carolina, USA
    Obesity (Silver Spring) 21:2189-96. 2013
    ..The purpose of this study was to determine whether, after gastric-bypass surgery, the degree of weight loss can be differentiated based on the neural response to food cues...
  48. pmc The painfulness of active, but not sham, transcranial magnetic stimulation decreases rapidly over time: results from the double-blind phase of the OPT-TMS Trial
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston, SC, USA Electronic address
    Brain Stimul 6:925-8. 2013
    ..The reduction in pain is hypothesized to be due to prefrontal stimulation and is not solely explained by accommodation to the stimulation...
  49. pmc Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers
    Karen J Hartwell
    Medical University of South Carolina, Charleston, 29425, USA
    Addict Biol 16:654-66. 2011
    ..Different strategies for resisting, such as distraction, activated different regions. Understanding the underlying neurobiology of resisting craving to smoke may identify new foci for treatments...
  50. ncbi request reprint Acute left prefrontal transcranial magnetic stimulation in depressed patients is associated with immediately increased activity in prefrontal cortical as well as subcortical regions
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Charleston, South Carolina 29425, USA
    Biol Psychiatry 55:882-90. 2004
    ....
  51. ncbi request reprint A pilot safety study of repetitive transcranial magnetic stimulation (rTMS) in Tourette's syndrome
    Jeong Ho Chae
    Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina, USA
    Cogn Behav Neurol 17:109-17. 2004
    ..We administered repetitive transcranial magnetic stimulation over prefrontal cortex or motor cortex, with either fast or slow repetitive transcranial magnetic stimulation, to 8 Tourette's syndrome patients...
  52. ncbi request reprint Vagus nerve stimulation acutely alters food craving in adults with depression
    Jamie S Bodenlos
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 165 Cannon Street, 3rd Floor, P O Box 250852, Charleston, SC 29425, USA
    Appetite 48:145-53. 2007
    ..Further studies are warranted addressing how acute or chronic VNS might modify eating behavior and weight...
  53. ncbi request reprint A high resolution assessment of the repeatability of relative location and intensity of transcranial magnetic stimulation-induced and volitionally induced blood oxygen level-dependent response in the motor cortex
    Stewart Denslow
    Center for Advanced Imaging Research and Brain Stimulation Laboratories, Department of Radiology, Medical University of South Carolina, Charleston, South Carolina, USA
    Cogn Behav Neurol 17:163-73. 2004
    ..Using functional magnetic resonance imaging, we assessed variation in location and intensity of blood oxygen level-dependent contrast associated with movements induced by transcranial magnetic stimulation or volition...
  54. pmc Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Pain 152:182-7. 2011
    ..Despite evidence that prefrontal TMS can have analgesic effects, fast left prefrontal TMS appears to acutely suppress analgesia associated with perceived-control. This effect may be limited to the emotional dimension of pain experience...
  55. doi request reprint A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Brain Stimul 1:112-21. 2008
    ....
  56. ncbi request reprint An increased precision comparison of TMS-induced motor cortex BOLD fMRI response for image-guided versus function-guided coil placement
    Stewart Denslow
    Department of Radiology, Center for Advanced Imaging Research and Brain Stimulation Laboratories, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Cogn Behav Neurol 18:119-26. 2005
    ..To examine with high precision the differences between function-guided and image-guided transcranial magnetic stimulation (TMS)...
  57. doi request reprint Prefrontal cortex transcranial direct current stimulation (tDCS) temporarily reduces food cravings and increases the self-reported ability to resist food in adults with frequent food craving
    Rachel L Goldman
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 1 South, 67 President Street, Charleston, SC 29425, USA
    Appetite 56:741-6. 2011
    ..These findings in healthy subjects indicate that tDCS is able to temporarily reduce food cravings and improve the self-reported ability to resist foods...
  58. pmc Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving
    Xingbao Li
    Medical University of South Carolina, Charleston, SC 29425, USA
    Biol Psychiatry 73:714-20. 2013
    ..We hypothesized that a single high-frequency rTMS session over the left dorsolateral prefrontal cortex (DLPFC) would reduce cue craving for cigarettes compared with a sham TMS session...
  59. pmc Endogenous opioids mediate left dorsolateral prefrontal cortex rTMS-induced analgesia
    Joseph J Taylor
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29414, USA
    Pain 153:1219-25. 2012
    ..Further studies with chronic dosing regimens of drugs that block or augment the actions of opiates are needed to determine whether TMS can augment opiates in chronic or postoperative pain management...
  60. pmc Intermittent "real-time" fMRI feedback is superior to continuous presentation for a motor imagery task: a pilot study
    Kevin A Johnson
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA
    J Neuroimaging 22:58-66. 2012
    ..The primary objective of this preliminary study was to compare the methods of continuous and intermittent presentation of neural feedback on targeted brain activity...
  61. doi request reprint Conditioning of transcranial magnetic stimulation: evidence of sensory-induced responding and prepulse inhibition
    Kevin A Johnson
    Department of Neuroscience, Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Brain Stimul 3:78-86. 2010
    ..Our primary objective was to determine whether TMS effects could be conditioned. Prepulse inhibition represents another relationship between two stimuli, and a secondary assessment was performed to explore this relationship...
  62. pmc Food cravings and the effects of left prefrontal repetitive transcranial magnetic stimulation using an improved sham condition
    Kelly S Barth
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina Charleston, SC, USA
    Front Psychiatry 2:9. 2011
    ..A sham condition which matches the painfulness is important to understand the true effects of TMS on behaviors and diseases...
  63. ncbi request reprint Prefrontal cortex transcranial magnetic stimulation does not change local diffusion: a magnetic resonance imaging study in patients with depression
    Xingbao Li
    Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Cogn Behav Neurol 16:128-35. 2003
    ....
  64. doi request reprint More lateral and anterior prefrontal coil location is associated with better repetitive transcranial magnetic stimulation antidepressant response
    Tal Herbsman
    Department of Psychiatry, Brain Stimulation Laboratory, Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 66:509-15. 2009
    ..This study is a post hoc analysis of data from a large repetitive TMS (rTMS) trial in which we examined the variability of coil placement and how it affects antidepressant efficacy...
  65. ncbi request reprint Regional brain activity in women grieving a romantic relationship breakup
    Arif Najib
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Psychiatry 161:2245-56. 2004
    ....
  66. pmc Probing the frontostriatal loops involved in executive and limbic processing via interleaved TMS and functional MRI at two prefrontal locations: a pilot study
    Colleen A Hanlon
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 8:e67917. 2013
    ....
  67. pmc Feature selection for fMRI-based deception detection
    Bo Jin
    Medical University of South Carolina, Charleston, SC, USA
    BMC Bioinformatics 10:S15. 2009
    ..In this paper, we investigated the procedures of feature selection to enhance fMRI-based deception detection...
  68. ncbi request reprint Vagus nerve stimulation (VNS): utility in neuropsychiatric disorders
    Mark S George
    Brain Stimulation Laboratory, Department of Psychiatry, Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Neuropsychopharmacol 6:73-83. 2003
    ..Comments on the clinical utility of VNS in actual clinical practice are provided...
  69. ncbi request reprint New methods of minimally invasive brain modulation as therapies in psychiatry: TMS, MST, VNS and DBS
    Mark S George
    Center for Advanced Imaging Research, Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Zhonghua Yi Xue Za Zhi (Taipei) 65:349-60. 2002
    ..These brain stimulation tools, or their next iterations, will play an ever-larger role in clinical neuropsychiatric practice...
  70. ncbi request reprint A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, 67 President Street 502 N, Charleston, SC 29425, USA
    Biol Psychiatry 58:364-73. 2005
    ..To better understand these effects on long-term outcome, we compared 12-month VNS+TAU outcomes with those of a comparable TRD group...
  71. pmc An efficient and accurate new method for locating the F3 position for prefrontal TMS applications
    William Beam
    Medical University of South Carolina, Charleston, 29425, USA
    Brain Stimul 2:50-4. 2009
    ..This system requires less time and training to find the optimal position for prefrontal coil placement and it saves considerable time compared to the 10-20 EEG system...
  72. doi request reprint Controversy: Repetitive transcranial magnetic stimulation or transcranial direct current stimulation shows efficacy in treating psychiatric diseases (depression, mania, schizophrenia, obsessive-complusive disorder, panic, posttraumatic stress disorder)
    Mark S George
    Psychiatry Department, Medical University of South Carolina, Charleston, 29425, USA
    Brain Stimul 2:14-21. 2009
    ..In general, TMS or tDCS as a treatment for most psychiatric disorders remains exciting but controversial, other than prefrontal TMS for depression...
  73. ncbi request reprint Vagus nerve stimulation (VNS) synchronized BOLD fMRI suggests that VNS in depressed adults has frequency/dose dependent effects
    Mikhail Lomarev
    Department of Radiology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    J Psychiatr Res 36:219-27. 2002
    ..g. hearing a tone)...
  74. ncbi request reprint Tolerability and safety of high daily doses of repetitive transcranial magnetic stimulation in healthy young men
    Berry Anderson
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, 29425, USA
    J ECT 22:49-53. 2006
    ..Despite this intense treatment regimen, we failed to produce significant side effects. Doses of up to 12,960 pulses per day appear safe and tolerable in healthy young men...
  75. ncbi request reprint Prefrontal EEG asymmetry as a potential biomarker of antidepressant treatment response with transcranial magnetic stimulation (TMS): a case series
    Agnes P Funk
    Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina MUSC, Charleston, South Carolina, USA
    Clin EEG Neurosci 39:125-30. 2008
    ..EEG shows potential as a biomarker of response for depression treatments, particularly the brain stimulation devices, which, unlike medications, can focally interact with neural tissue in specific frequency patterns...
  76. ncbi request reprint Lower limb immobilization is associated with increased corticospinal excitability
    Donna R Roberts
    Brain Stimulation Laboratory BSL, Institute of Psychiatry, Medical University of South Carolina, MUSC IOP, 502 N, 67 President Street, Charleston, SC 29425, USA
    Exp Brain Res 181:213-20. 2007
    ..A control group did not wear a cast and underwent the same TMS sessions. Significant excitability changes occurred and peaked at 24 h post cast removal in the TMS experimental group but not the non-casted group...
  77. ncbi request reprint Decision analysis of the cost-effectiveness of repetitive transcranial magnetic stimulation versus electroconvulsive therapy for treatment of nonpsychotic severe depression
    F Andrew Kozel
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, and Ralph H Johnson Veterans Affairs Medical Center, Charleston, USA
    CNS Spectr 9:476-82. 2004
    ..Repetitive transcranial magnetic stimulation (rTMS) is a new treatment with promise for resistant depression...
  78. ncbi request reprint Postoperative left prefrontal repetitive transcranial magnetic stimulation reduces patient-controlled analgesia use
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, SC, USA
    Anesthesiology 105:557-62. 2006
    ..No studies have investigated the effects of prefrontal cortex stimulation using transcranial magnetic stimulation on postoperative pain...
  79. ncbi request reprint A replication study of the neural correlates of deception
    Frank Andrew Kozel
    Center for Advanced Imaging Research and the Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Behav Neurosci 118:852-6. 2004
    ..Individual results of the lie minus true condition were variable. Results show that functional MRI is a reasonable tool with which to study deception...
  80. ncbi request reprint Vagus nerve stimulation therapy: a research update
    Mark S George
    502 North, IoP, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Neurology 59:S56-61. 2002
    ....
  81. pmc Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)
    Mark S George
    Departments of Psychiatry, Radiology and Neuroscience, Institute of Psychiatry, MUSC Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 35:301-16. 2010
    ..These techniques are transcranial magnetic stimulation, vagus nerve stimulation, and transcranial direct current stimulation. Two of these approaches have FDA approval as therapies...
  82. ncbi request reprint Transcranial magnetic stimulation: a stimulating new method for treating depression, but saddled with the same old problems
    Mark S George
    Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Neuropsychopharmacol 9:637-40. 2006
  83. ncbi request reprint Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:347-54. 2005
    ..Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy...
  84. ncbi request reprint Durability of antidepressant response to vagus nerve stimulation (VNS)
    Harold A Sackeim
    Departments of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 10:817-26. 2007
    ..Yet patients who showed substantial clinical benefit maintained the improvement at remarkably high rates. This durability of benefit was not attributable to alterations in other treatments...
  85. ncbi request reprint Managing the risks of repetitive transcranial stimulation
    Bob Belmaker
    Department of Psychiatry, Ben Gurion University, Beersheva, Israel
    CNS Spectr 8:489. 2003
  86. ncbi request reprint Modeling the effects of electrical conductivity of the head on the induced electric field in the brain during magnetic stimulation
    Kent Davey
    Pickle Research Center, Center for Electromechanics, University of Texas, J J Pickle Research Campus, 10100 Burnet Road, EME 133, Austin, TX 78758, USA
    Clin Neurophysiol 114:2204-9. 2003
    ..The objective of this document is to quantify the effect of changing conductivity within the brain in transcranial magnetic stimulation...
  87. ncbi request reprint Information for assistants of repeated transcranial magnetic stimulation
    Saxby Pridmore
    Department of Psychological Medicine, Royal Hobart Hospital, Discipline of Psychiatry, University of Tasmania, GPO Box 1061 L, Hobart 7001, Tasmania, Australia
    Int J Ment Health Nurs 12:22-9. 2003
    ..rTMS does not involve anaesthesia or seizure. Side-effects appear to be few. Much remains uncertain, however, even including the most appropriate treatment parameters...
  88. ncbi request reprint Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:355-63. 2005
    ..The need for effective, long-term treatment for recurrent or chronic, treatment-resistant depression is well established...
  89. ncbi request reprint VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 31:1345-55. 2006
    ..Mechanisms that mediate the beneficial effects of VNS therapy for treatment-resistant depression remain obscure. Suggestions for future research directions are described...
  90. ncbi request reprint Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, One Baylor Plaza, BCM 350, Houston, TX 77030, USA
    Biol Psychiatry 51:280-7. 2002
    ..This open, naturalistic follow-up study was conducted to determine whether the initial promising effects were sustained, and whether changes in function would be observed...
  91. ncbi request reprint A double blind study showing that two weeks of daily repetitive TMS over the left or right temporoparietal cortex reduces symptoms in patients with schizophrenia who are having treatment-refractory auditory hallucinations
    Seung Hwan Lee
    Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea, Koyang, South Korea
    Neurosci Lett 376:177-81. 2005
    ....
  92. ncbi request reprint Vagus nerve stimulation affects pain perception in depressed adults
    Jeffrey J Borckardt
    Medical University of South Carolina, Charleston 29425, USA
    Pain Res Manag 10:9-14. 2005
    ....
  93. ncbi request reprint Cerebral blood flow changes during vagus nerve stimulation for depression
    Charles R Conway
    Department of Psychiatry, Saint Louis University School of Medicine, 1221 South Grand Boulevard, St Louis, MO 63104, USA
    Psychiatry Res 146:179-84. 2006
    ..Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve...