Association of device surface and biomaterials with immunologic sensitization after mechanical supportIsaac George
Department of Surgery, Division of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, USA
J Thorac Cardiovasc Surg 135:1372-9. 2008
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- Stentless bioprosthesis in a valved conduit: implications for pulmonary reconstruction
Isaac George
Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Ann Thorac Surg 88:2022-4. 2009
..We report a case of pulmonary valve replacement and right ventricular outflow tract reconstruction using a stentless bioprosthetic aortic valve and polyester graft as a novel approach after radical pulmonary artery sarcoma resection...
Effect of clenbuterol on cardiac and skeletal muscle function during left ventricular assist device supportIsaac George
Department of Surgery, Division of Cardiothoracic Surgery, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
J Heart Lung Transplant 25:1084-90. 2006
..High-dose clenbuterol (a selective beta2-adrenergic agonist) has been proposed to promote myocardial recovery during left ventricular assist device (LVAD) support, but its effects on cardiac and skeletal muscle are largely unknown...
Myostatin activation in patients with advanced heart failure and after mechanical unloadingIsaac George
Division of Cardiothoracic Surgery, Department of Surgery, Columbia University College of Physicians and Surgeons, Milstein Hospital Building, 7GN 435, 177 Fort Washington Avenue, New York, NY 10032, USA
Eur J Heart Fail 12:444-53. 2010
..This study sought to characterize myostatin expression and activation in advanced HF before and after LVAD support...
- Clinical indication for use and outcomes after inhaled nitric oxide therapy
Isaac George
Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Ann Thorac Surg 82:2161-9. 2006
..Inhaled nitric oxide (iNO) use is widespread, but the long-term outcomes after therapy in adult patients remain unknown...
- The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database
Mark J Russo
Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, USA
J Thorac Cardiovasc Surg 133:554-9. 2007
..1) To examine the interaction of donor age with ischemic time and their effect on survival and (2) to define ranges of ischemic time associated with differences in survival...
- Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure
Gayathri Kamalakkannan
Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
J Heart Lung Transplant 27:457-61. 2008
..Prior data support combining exercise training with clenbuterol to maximize performance, and on-going studies will evaluate this approach...
- Long-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat model
Isaac George
Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Cardiovasc Pharmacol 55:14-20. 2010
..We tested the hypothesis that in vivo infusion of BNP would improve cardiac function and affect left ventricular (LV) remodeling in an experimental model of MI...
- Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury
Isaac George
Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York, USA
Am J Physiol Heart Circ Physiol 297:H708-17. 2009
..Treatment with continuous infusion of BNP preserved LV geometry, improved systolic function, and prevented the progression of systolic HF after persistent ischemic injury...
- Erythropoietin derivate improves left ventricular systolic performance and attenuates left ventricular remodeling in rats with myocardial infarct-induced heart failure
Kai Xu
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Cardiovasc Pharmacol 56:506-12. 2010
..It is unknown whether EPO alters the left ventricular (LV) remodeling process after ischemic insult. Accordingly, we tested the potential benefits of carbamylated EPO (CEPO) on LV remodeling in rats with myocardial infarction (MI)...
- Effect of passive cardiac containment on ventricular synchrony and cardiac function in awake dogs
Isaac George
Department of Surgery, Division of Cardiothoracic Surgery, Columbia University, College of Physicians and Surgeons, New York, NY, United States
Eur J Cardiothorac Surg 31:55-64. 2007
..The goals of this study were to test whether a left ventricular support device (LVSD) improves LV synchrony and/or affects cardiac performance...
- Matching high-risk recipients with marginal donor hearts is a clinically effective strategy
Mark J Russo
Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Ann Thorac Surg 87:1066-70; discussion 1071. 2009
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- Ventricular assist device use for the treatment of acute viral myocarditis
Veli K Topkara
Columbia University College of Physicians and Surgeons, Department of Cardiothoracic Surgery, New York, NY 10032, USA
J Thorac Cardiovasc Surg 131:1190-1. 2006
- Discharge to home rates are significantly lower for octogenarians undergoing coronary artery bypass graft surgery
Hasmet Bardakci
Division of Cardiothoracic Surgery, College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital, New York, New York 10032, USA
Ann Thorac Surg 83:483-9. 2007
..We sought to evaluate clinical outcomes of octogenarians undergoing CABG using an audited state-wide mandatory database...
- Direct left ventricle-to-coronary artery stent restores perfusion to chronic ischemic swine myocardium
Geng-Hua Yi
Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
Heart Surg Forum 9:E744-9. 2006
..Four of 5 animals had patent and functional devices at the end of the study. CONCLUSION: Chronic VSTENT placement improves RMP and may promote arterial remodeling in chronically ischemic porcine myocardium...
- Aortic root and right ventricular outflow tract reconstruction using composite biological valved conduits after failed Ross procedure
Mark J Russo
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Ann Thorac Surg 91:e87-9. 2011
..We describe a novel approach to this complication using composite biological valved conduits comprised of stentless bioprosthetic valves and polyester grafts...
- β-adrenergic receptor blockade reduces endoplasmic reticulum stress and normalizes calcium handling in a coronary embolization model of heart failure in canines
Isaac George
Division of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, USA
Cardiovasc Res 91:447-55. 2011
..However, the role of ER stress in β-blocker therapy for congestive heart failure (CHF) has not been studied. This study examined ER stress in CHF and evaluated its role in β-blocker therapy in a canine model of ischaemic CHF...
- Predictors and outcomes of continuous veno-venous hemodialysis use after implantation of a left ventricular assist device
Veli K Topkara
Department of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Heart Lung Transplant 25:404-8. 2006
..Pre-operative evaluation of patient risk factors and optimization of peri-operative hemodynamics are of utmost importance to prevent this major complication...
- Adult-age donors offer acceptable long-term survival to pediatric heart transplant recipients: an analysis of the United Network of Organ Sharing database
Mark J Russo
Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Thorac Cardiovasc Surg 132:1208-12. 2006
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- A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia
Isaac George
Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, NY, and The Jack H. Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY 10962, USA
Am J Physiol Heart Circ Physiol 291:H1126-37. 2006
..05) and 49% after Phe (P=not significant). HBOC-201 administration after induction of severe myocardial ischemia by acute coronary stenosis reduces infarct size and improves myocardial viability...
- A stepwise progression in the treatment of cardiogenic shock
Ari Pollack
Department of Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, New York, USA
Heart Lung 41:500-4. 2012
..We also review the literature with regard to the use of percutaneous left ventricular assist devices in the setting of cardiogenic shock...
- Myocardial function improved by electromagnetic field induction of stress protein hsp70
Isaac George
Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Physiol 216:816-23. 2008
..In conclusion, non-invasive EMF induction of hsp70 preserved myocardial function and has the potential to improve tolerance to ischemic injury...
- Efficacy and safety of postdilatation to reduce paravalvular regurgitation during balloon-expandable transcatheter aortic valve replacement
Benoit Daneault
Columbia University Medical Center New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY 10032, USA
Circ Cardiovasc Interv 6:85-91. 2013
..Postdilatation (PD) has been proposed to treat PVR without being formally studied. We performed a study to evaluate the safety and efficacy of PD after balloon expandable TAVR...
- Bradycardic therapy improves left ventricular function and remodeling in dogs with coronary embolization-induced chronic heart failure
Yanping Cheng
The Institute of Molecular and Experimental Therapeutics, East China Normal University, Shanghai, and Department of Cardiac Nephrology, Chinese PLA General Hospital, Beijing, People s Republic of China
J Pharmacol Exp Ther 321:469-76. 2007
..Restored protein levels of SERCA2a and improved function of RyR2 may be important mechanisms associated with cilobradine therapy...
