Isaac George

Summary

Publications

  1. pmc Myostatin activation in patients with advanced heart failure and after mechanical unloading
    Isaac George
    Division of Cardiothoracic Surgery, Department of Surgery, Columbia University College of Physicians and Surgeons, Milstein Hospital Building, 7GN 435, 177 Fort Washington Avenue, New York, NY 10032, USA
    Eur J Heart Fail 12:444-53. 2010
  2. doi request reprint Stentless bioprosthesis in a valved conduit: implications for pulmonary reconstruction
    Isaac George
    Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann Thorac Surg 88:2022-4. 2009
  3. doi request reprint Association of device surface and biomaterials with immunologic sensitization after mechanical support
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    J Thorac Cardiovasc Surg 135:1372-9. 2008
  4. ncbi request reprint Effect of clenbuterol on cardiac and skeletal muscle function during left ventricular assist device support
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
    J Heart Lung Transplant 25:1084-90. 2006
  5. ncbi request reprint Clinical indication for use and outcomes after inhaled nitric oxide therapy
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann Thorac Surg 82:2161-9. 2006
  6. ncbi request reprint The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database
    Mark J Russo
    Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, USA
    J Thorac Cardiovasc Surg 133:554-9. 2007
  7. pmc Long-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat model
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cardiovasc Pharmacol 55:14-20. 2010
  8. doi request reprint Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure
    Gayathri Kamalakkannan
    Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    J Heart Lung Transplant 27:457-61. 2008
  9. doi request reprint Predicting paravalvular regurgitation following transcatheter valve replacement: utility of a novel method for three-dimensional echocardiographic measurements of the aortic annulus
    Rebecca T Hahn
    Columbia University Medical Center New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY 10032, USA
    J Am Soc Echocardiogr 26:1043-52. 2013
  10. pmc Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury
    Isaac George
    Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Am J Physiol Heart Circ Physiol 297:H708-17. 2009

Collaborators

Detail Information

Publications28

  1. pmc Myostatin activation in patients with advanced heart failure and after mechanical unloading
    Isaac George
    Division of Cardiothoracic Surgery, Department of Surgery, Columbia University College of Physicians and Surgeons, Milstein Hospital Building, 7GN 435, 177 Fort Washington Avenue, New York, NY 10032, USA
    Eur J Heart Fail 12:444-53. 2010
    ..This study sought to characterize myostatin expression and activation in advanced HF before and after LVAD support...
  2. doi request reprint Stentless bioprosthesis in a valved conduit: implications for pulmonary reconstruction
    Isaac George
    Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann Thorac Surg 88:2022-4. 2009
    ..We report a case of pulmonary valve replacement and right ventricular outflow tract reconstruction using a stentless bioprosthetic aortic valve and polyester graft as a novel approach after radical pulmonary artery sarcoma resection...
  3. doi request reprint Association of device surface and biomaterials with immunologic sensitization after mechanical support
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    J Thorac Cardiovasc Surg 135:1372-9. 2008
    ....
  4. ncbi request reprint Effect of clenbuterol on cardiac and skeletal muscle function during left ventricular assist device support
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
    J Heart Lung Transplant 25:1084-90. 2006
    ..High-dose clenbuterol (a selective beta2-adrenergic agonist) has been proposed to promote myocardial recovery during left ventricular assist device (LVAD) support, but its effects on cardiac and skeletal muscle are largely unknown...
  5. ncbi request reprint Clinical indication for use and outcomes after inhaled nitric oxide therapy
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann Thorac Surg 82:2161-9. 2006
    ..Inhaled nitric oxide (iNO) use is widespread, but the long-term outcomes after therapy in adult patients remain unknown...
  6. ncbi request reprint The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database
    Mark J Russo
    Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, USA
    J Thorac Cardiovasc Surg 133:554-9. 2007
    ..1) To examine the interaction of donor age with ischemic time and their effect on survival and (2) to define ranges of ischemic time associated with differences in survival...
  7. pmc Long-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat model
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cardiovasc Pharmacol 55:14-20. 2010
    ..We tested the hypothesis that in vivo infusion of BNP would improve cardiac function and affect left ventricular (LV) remodeling in an experimental model of MI...
  8. doi request reprint Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure
    Gayathri Kamalakkannan
    Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    J Heart Lung Transplant 27:457-61. 2008
    ..Prior data support combining exercise training with clenbuterol to maximize performance, and on-going studies will evaluate this approach...
  9. doi request reprint Predicting paravalvular regurgitation following transcatheter valve replacement: utility of a novel method for three-dimensional echocardiographic measurements of the aortic annulus
    Rebecca T Hahn
    Columbia University Medical Center New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY 10032, USA
    J Am Soc Echocardiogr 26:1043-52. 2013
    ....
  10. pmc Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury
    Isaac George
    Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Am J Physiol Heart Circ Physiol 297:H708-17. 2009
    ..Treatment with continuous infusion of BNP preserved LV geometry, improved systolic function, and prevented the progression of systolic HF after persistent ischemic injury...
  11. ncbi request reprint Effect of passive cardiac containment on ventricular synchrony and cardiac function in awake dogs
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia University, College of Physicians and Surgeons, New York, NY, United States
    Eur J Cardiothorac Surg 31:55-64. 2007
    ..The goals of this study were to test whether a left ventricular support device (LVSD) improves LV synchrony and/or affects cardiac performance...
  12. doi request reprint Erythropoietin derivate improves left ventricular systolic performance and attenuates left ventricular remodeling in rats with myocardial infarct-induced heart failure
    Kai Xu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Cardiovasc Pharmacol 56:506-12. 2010
    ..It is unknown whether EPO alters the left ventricular (LV) remodeling process after ischemic insult. Accordingly, we tested the potential benefits of carbamylated EPO (CEPO) on LV remodeling in rats with myocardial infarction (MI)...
  13. ncbi request reprint Ventricular assist device use for the treatment of acute viral myocarditis
    Veli K Topkara
    Columbia University College of Physicians and Surgeons, Department of Cardiothoracic Surgery, New York, NY 10032, USA
    J Thorac Cardiovasc Surg 131:1190-1. 2006
  14. pmc Matching high-risk recipients with marginal donor hearts is a clinically effective strategy
    Mark J Russo
    Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Ann Thorac Surg 87:1066-70; discussion 1071. 2009
    ....
  15. ncbi request reprint Direct left ventricle-to-coronary artery stent restores perfusion to chronic ischemic swine myocardium
    Geng Hua Yi
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Heart Surg Forum 9:E744-9. 2006
    ..The goal of this study was to examine quantitative changes in myocardial perfusion and possible mechanisms of revascularization with an LV-to-coronary shunt...
  16. ncbi request reprint Discharge to home rates are significantly lower for octogenarians undergoing coronary artery bypass graft surgery
    Hasmet Bardakci
    Division of Cardiothoracic Surgery, College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital, New York, New York 10032, USA
    Ann Thorac Surg 83:483-9. 2007
    ..We sought to evaluate clinical outcomes of octogenarians undergoing CABG using an audited state-wide mandatory database...
  17. doi request reprint Aortic root and right ventricular outflow tract reconstruction using composite biological valved conduits after failed Ross procedure
    Mark J Russo
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Ann Thorac Surg 91:e87-9. 2011
    ..We describe a novel approach to this complication using composite biological valved conduits comprised of stentless bioprosthetic valves and polyester grafts...
  18. doi request reprint β-adrenergic receptor blockade reduces endoplasmic reticulum stress and normalizes calcium handling in a coronary embolization model of heart failure in canines
    Isaac George
    Division of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Cardiovasc Res 91:447-55. 2011
    ..However, the role of ER stress in β-blocker therapy for congestive heart failure (CHF) has not been studied. This study examined ER stress in CHF and evaluated its role in β-blocker therapy in a canine model of ischaemic CHF...
  19. doi request reprint Efficacy and safety of postdilatation to reduce paravalvular regurgitation during balloon-expandable transcatheter aortic valve replacement
    Benoit Daneault
    Columbia University Medical Center New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY 10032, USA
    Circ Cardiovasc Interv 6:85-91. 2013
    ..Postdilatation (PD) has been proposed to treat PVR without being formally studied. We performed a study to evaluate the safety and efficacy of PD after balloon expandable TAVR...
  20. ncbi request reprint Predictors and outcomes of continuous veno-venous hemodialysis use after implantation of a left ventricular assist device
    Veli K Topkara
    Department of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Heart Lung Transplant 25:404-8. 2006
    ..Post-operative renal failure is a common complication after left ventricular assist device (LVAD) implantation. This study was designed to evaluate predictors and outcomes of acute renal failure after LVAD insertion...
  21. ncbi request reprint Adult-age donors offer acceptable long-term survival to pediatric heart transplant recipients: an analysis of the United Network of Organ Sharing database
    Mark J Russo
    Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Thorac Cardiovasc Surg 132:1208-12. 2006
    ....
  22. ncbi request reprint A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, NY, and The Jack H Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY 10962, USA
    Am J Physiol Heart Circ Physiol 291:H1126-37. 2006
    ..05) and 49% after Phe (P=not significant). HBOC-201 administration after induction of severe myocardial ischemia by acute coronary stenosis reduces infarct size and improves myocardial viability...
  23. doi request reprint A stepwise progression in the treatment of cardiogenic shock
    Ari Pollack
    Department of Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, New York, USA
    Heart Lung 41:500-4. 2012
    ..We also review the literature with regard to the use of percutaneous left ventricular assist devices in the setting of cardiogenic shock...
  24. pmc Myocardial function improved by electromagnetic field induction of stress protein hsp70
    Isaac George
    Department of Surgery, Division of Cardiothoracic Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 216:816-23. 2008
    ..In conclusion, non-invasive EMF induction of hsp70 preserved myocardial function and has the potential to improve tolerance to ischemic injury...
  25. doi request reprint Management of significant left main coronary disease before and after trans-apical transcatheter aortic valve replacement in a patient with severe and complex arterial disease
    Jean Michel Paradis
    Columbia University Medical Center, New York, New York Cardiovascular Research Foundation, New York, New York
    Catheter Cardiovasc Interv 82:E262-5. 2013
    ..This multifaceted case clearly underlines the importance of a well functioning heart team including the interventional cardiologist, the cardiovascular surgeon, and the echocardiographer...
  26. doi request reprint Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration
    Ziad A Ali
    Center for Interventional Vascular Therapy, Division of Cardiology, New York Presbyterian Hospital and Columbia University, New York, NY Z A A, W Q, I G Cardiovascular Research Foundation, New York, NY Z A A Department of Cardiovascular Medicine, John Radcliffe Hospital and University of Oxford, Oxford, United Kingdom Z A A, R R, G D, E M, C B, K M C Cardiovascular Division, King s College Hospital, London, United Kingdom Y H, Q Xiao, Q Xu and Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom D R G
    Circulation 128:S50-8. 2013
    ..Nitric oxide (NO) is a key regulator of EC and endothelial progenitor cell function, but the pathophysiological mechanisms that regulate endothelial NO synthase in endothelial regeneration remain unclear...
  27. doi request reprint Stent exteriorization facilitates surgical repair for large-bore sheath complications
    Isaac George
    Divisions of Cardiothoracic Surgery and Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York Center for Interventional Vascular Therapeutics, College of Physicians and Surgeons of Columbia University, New York, New York
    Catheter Cardiovasc Interv 82:E257-61. 2013
    ..We describe a patient with a complex, post-dissection, descending aortic aneurysm who required TEVAR and had a vascular access complication repaired with stent exteriorization with open repair...
  28. ncbi request reprint Bradycardic therapy improves left ventricular function and remodeling in dogs with coronary embolization-induced chronic heart failure
    Yanping Cheng
    The Institute of Molecular and Experimental Therapeutics, East China Normal University, Shanghai, and Department of Cardiac Nephrology, Chinese PLA General Hospital, Beijing, People s Republic of China
    J Pharmacol Exp Ther 321:469-76. 2007
    ..Restored protein levels of SERCA2a and improved function of RyR2 may be important mechanisms associated with cilobradine therapy...