C George Priya Doss

Summary

Publications

  1. pmc Path to facilitate the prediction of functional amino acid substitutions in red blood cell disorders--a computational approach
    Rajith B
    Medical Biotechnology Division, Center for NanoBiotechnology, School of Biosciences and Technology, Vellore Institute of Technology University, Vellore, Tamil Nadu, India
    PLoS ONE 6:e24607. 2011
  2. doi In silico profiling and structural insights of missense mutations in RET protein kinase domain by molecular dynamics and docking approach
    C George Priya Doss
    Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India
    Mol Biosyst 10:421-36. 2014
  3. doi Predicting the impact of deleterious mutations in the protein kinase domain of FGFR2 in the context of function, structure, and pathogenesis--a bioinformatics approach
    George Priya Doss C
    Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Appl Biochem Biotechnol 170:1853-70. 2013
  4. doi Glutathione-responsive nano-transporter-mediated siRNA delivery: silencing the mRNA expression of Ras
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Protoplasma 250:787-92. 2013
  5. doi Predicting the impact of deleterious single point mutations in SMAD gene family using structural bioinformatics approach
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Interdiscip Sci 4:103-15. 2012
  6. pmc Computational refinement of functional single nucleotide polymorphisms associated with ATM gene
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, Vellore Institute of Technology University, Vellore, Tamil Nadu, India
    PLoS ONE 7:e34573. 2012
  7. pmc Investigating the structural impacts of I64T and P311S mutations in APE1-DNA complex: a molecular dynamics approach
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
    PLoS ONE 7:e31677. 2012
  8. doi Applications of computational algorithm tools to identify functional SNPs
    C George Priya Doss
    School of Biotechnology, Chemical and Biomedical Engineering, Bioinformatics Division, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India
    Funct Integr Genomics 8:309-16. 2008
  9. pmc Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach
    C George Priya Doss
    Medical Biotechnology Division, Centre for Nanobiotechnology, School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu 632014, India
    Hum Genomics 7:10. 2013
  10. doi Studies on flexibility and binding affinity of Asp25 of HIV-1 protease mutants
    Rituraj Purohit
    School of Biotechnology, Chemical and Biomedical Engineering, Bioinformatics Division, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India
    Int J Biol Macromol 42:386-91. 2008

Collaborators

Detail Information

Publications26

  1. pmc Path to facilitate the prediction of functional amino acid substitutions in red blood cell disorders--a computational approach
    Rajith B
    Medical Biotechnology Division, Center for NanoBiotechnology, School of Biosciences and Technology, Vellore Institute of Technology University, Vellore, Tamil Nadu, India
    PLoS ONE 6:e24607. 2011
    ..As a result, the prediction of non-synonymous SNPs (nsSNPs) that affect protein functions and relate to disease is an important task...
  2. doi In silico profiling and structural insights of missense mutations in RET protein kinase domain by molecular dynamics and docking approach
    C George Priya Doss
    Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India
    Mol Biosyst 10:421-36. 2014
    ..Overall, our findings may provide useful structural insights for in-depth understanding of the molecular mechanism underlying RET mutation and developing effective drugs. ..
  3. doi Predicting the impact of deleterious mutations in the protein kinase domain of FGFR2 in the context of function, structure, and pathogenesis--a bioinformatics approach
    George Priya Doss C
    Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Appl Biochem Biotechnol 170:1853-70. 2013
    ..Our strategy may be helpful for understanding SNP effects on proteins with function and their role in human genetic diseases and for the development of novel pharmacological strategies...
  4. doi Glutathione-responsive nano-transporter-mediated siRNA delivery: silencing the mRNA expression of Ras
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Protoplasma 250:787-92. 2013
    ..Henceforth, gene silencing technology through nano-drug delivery can be combined as a single weapon to terminate malignancy...
  5. doi Predicting the impact of deleterious single point mutations in SMAD gene family using structural bioinformatics approach
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Interdiscip Sci 4:103-15. 2012
    ..In addition, we used MAPPER to identify SNPs present in transcription factor binding sites. These findings demonstrate that the in silico approaches can be used efficiently to identify potential candidate SNPs in large scale analysis...
  6. pmc Computational refinement of functional single nucleotide polymorphisms associated with ATM gene
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, Vellore Institute of Technology University, Vellore, Tamil Nadu, India
    PLoS ONE 7:e34573. 2012
    ..However, the extent to which SNPs interferes with the gene regulation and affects cancer susceptibility remains largely unknown...
  7. pmc Investigating the structural impacts of I64T and P311S mutations in APE1-DNA complex: a molecular dynamics approach
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
    PLoS ONE 7:e31677. 2012
    ..Further, these mutations disrupt the binding sites and prohibit the protein to form complexes with its interacting DNA...
  8. doi Applications of computational algorithm tools to identify functional SNPs
    C George Priya Doss
    School of Biotechnology, Chemical and Biomedical Engineering, Bioinformatics Division, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India
    Funct Integr Genomics 8:309-16. 2008
    ..Our results endorse the study with in vivo experimental protocols...
  9. pmc Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach
    C George Priya Doss
    Medical Biotechnology Division, Centre for Nanobiotechnology, School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu 632014, India
    Hum Genomics 7:10. 2013
    ..Here, we described a theoretical assessment for the discovery of new drugs or drug targets in CDK7 protein owing to the changes caused by deleterious nsSNPs...
  10. doi Studies on flexibility and binding affinity of Asp25 of HIV-1 protease mutants
    Rituraj Purohit
    School of Biotechnology, Chemical and Biomedical Engineering, Bioinformatics Division, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India
    Int J Biol Macromol 42:386-91. 2008
    ..The overall analysis of our study brings clarity to the binding behavior with respect to the different mutants with Ritonavir on the basis RMSD and also on the flexible nature of HIV-1 protease enzyme with respect to Asp25 position...
  11. doi Computational detection of deleterious SNPs and their effect on sequence and structural level of the VHL gene
    R Rajasekaran
    School of Biotechnology, Chemical and Biomedical Engineering, Bioinformatics Division, Vellore Institute of Technology University, Vellore, 632014, Tamil Nadu, India
    Mamm Genome 19:654-61. 2008
    ..78 A. Based on this work, we propose that the nsSNP with a SNPid of rs5030812 is an important candidate for the cause of von Hippel-Lindau syndrome via the VHL gene...
  12. doi Effect of deleterious nsSNP on the HER2 receptor based on stability and binding affinity with herceptin: a computational approach
    R Rajasekaran
    School of Biotechnology, Chemical and Biomedical Engineering, Bioinformatics Division, Vellore Institute of Technology University, Vellore, Tamil Nadu, India
    C R Biol 331:409-17. 2008
    ..Based on our investigations, we propose that SNPid rs4252633 could be the most deleterious nsSNP for HER2 receptor, and that herceptin could be the best drug for mutant compared to the native HER2 target...
  13. ncbi Analysis of binding residues between scorpion neurotoxins and D2 dopamine receptor: a computational docking study
    C Sudandiradoss
    Bioinformatics Division, School of Biotechnology, Chemical and Biomedical Engineering, Vellore Institute of Technology University, Vellore 632014, Tamil Nadu, India
    Comput Biol Med 38:1056-67. 2008
    ..Overall, we emphasize that the results obtained in this work will be very helpful in further enhancement of understanding the research on modeling and drug design with respect to the D2 dopamine receptor...
  14. ncbi Computational identification and structural analysis of deleterious functional SNPs in MLL gene causing acute leukemia
    C George Priya Doss
    Bioinformatics Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Interdiscip Sci 2:247-55. 2010
    ..From the overall results obtained, nsSNP with id (rs1784246) at the amino acid position Q1198P could be considered as deleterious mutation in the acute leukemia caused by MLL gene...
  15. doi Computational and structural analysis of deleterious functional SNPs in ARNT oncogene
    C George Priya Doss
    School of Biotechnology, Chemical and Biomedical Engineering, Vellore Institute of Technology University, Vellore, 632014, Tamil Nadu, India
    Interdiscip Sci 1:220-8. 2009
    ..The models built in this work would be applicable for predicting the deleterious nsSNPs which would be helpful for further genotype-phenotype research as well as pharmacogenetics studies...
  16. doi In silico analysis of prion protein mutants: a comparative study by molecular dynamics approach
    C George Priya Doss
    Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India
    Cell Biochem Biophys 67:1307-18. 2013
    ..Our observations in this study could help to further understand the structural stability of prion proteins. ..
  17. doi Prioritization of candidate SNPs in colon cancer using bioinformatics tools: an alternative approach for a cancer biologist
    C George Priya Doss
    Bioinformatics Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
    Interdiscip Sci 2:320-46. 2010
    ..We have shown a "real world" application of interesting existing bioinformatics tools for SNP analysis in colon cancer...
  18. doi Impact of single nucleotide polymorphisms in HBB gene causing haemoglobinopathies: in silico analysis
    C George Priya Doss
    Bioinformatics Division, School of Biotechnology, Chemical and Biomedical Engineering, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India
    N Biotechnol 25:214-9. 2009
    ..The functional analysis presented here may be a good model for further research...
  19. doi A new insight into structural and functional impact of single-nucleotide polymorphisms in PTEN gene
    C George Priya Doss
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, Vellore, India
    Cell Biochem Biophys 66:249-63. 2013
    ..These in silico predictions could provide a new insight into structural and functional impact of PTEN polymorphisms...
  20. pmc A novel computational and structural analysis of nsSNPs in CFTR gene
    C George Priya Doss
    Bioinformatics Division, School of Biotechnology, Chemical and Biomedical Engineering, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India
    Genomic Med 2:23-32. 2008
    ..The SNPs were further subjected to iHAP analysis to identify htSNPs, and we report potential candidates for future studies on CFTR mutations...
  21. doi Computational approaches and resources in single amino Acid substitutions analysis toward clinical research
    C George Priya Doss
    Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India Electronic address
    Adv Protein Chem Struct Biol 94:365-423. 2014
    ....
  22. doi LSHGD: a database for human leprosy susceptible genes
    C George Priya Doss
    Medical Biotechnology Division, School of Biosciences and Technology, Center for NanoBiotechnology, VIT University, Vellore 632014, Tamil Nadu, India
    Genomics 100:162-6. 2012
    ..In conclusion, this will serve as a multifunctional valuable tool and convenient information platform which is freely available at http://www.vit.ac.in/leprosy/leprosy.htm and enables the user to retrieve information of their interest...
  23. doi Application of evolutionary based in silico methods to predict the impact of single amino Acid substitutions in vitelliform macular dystrophy
    C George Priya Doss
    Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India Electronic address
    Adv Protein Chem Struct Biol 94:177-267. 2014
    ..Furthermore, based on the prediction scores, a ranking system was developed to prioritize the functional SAPs in order to minimize the number of SAPs screened for further genotyping. ..
  24. doi Predicting the impact of single-nucleotide polymorphisms in CDK2-flavopiridol complex by molecular dynamics analysis
    N Nagasundaram
    Medical Biotechnology Division, Centre for Nanobiotechnology, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
    Cell Biochem Biophys 66:681-95. 2013
    ..Overall, this study explores the possible relationship between the CDK2 deleterious variants and the drug-binding ability with the help of molecular docking and MD approaches. ..
  25. doi Disease-causing mutation in extracellular and intracellular domain of FGFR1 protein: computational approach
    B Rajith
    Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore 632014 Tamil Nadu, India
    Appl Biochem Biotechnol 169:1659-71. 2013
    ....
  26. doi Identification and structural comparison of deleterious mutations in nsSNPs of ABL1 gene in chronic myeloid leukemia: a bio-informatics study
    C George Priya Doss
    School of Biotechnology, Chemical and Biomedical Engineering, Vellore Institute of Technology University, Vellore 632014, Tamil Nadu, India
    J Biomed Inform 41:607-12. 2008
    ..Our results on this computational study will find good application with the cancer biologist working on experimental protocols...