P Genton

Summary

Publications

  1. ncbi request reprint Is it juvenile myoclonic epilepsy?
    P Gelisse
    Centre Saint Paul, Marseille, France
    Epileptic Disord 2:27-32. 2000
  2. ncbi request reprint Progress in pharmaceutical development presentation with improved pharmacokinetics: a new formulation for valproate
    P Genton
    Centre Saint Paul, Marseille, France
    Acta Neurol Scand Suppl 182:26-32. 2005
  3. doi request reprint Clinical aspects of juvenile myoclonic epilepsy
    Pierre Genton
    Centre Saint Paul, Hôpital Henri Gastaut, Marseille, France
    Epilepsy Behav 28:S8-14. 2013
  4. doi request reprint The history of juvenile myoclonic epilepsy
    Pierre Genton
    Centre Saint Paul Hôpital Henri Gastaut, Marseille, France
    Epilepsy Behav 28:S2-7. 2013
  5. ncbi request reprint Tiagabine in clinical practice
    P Genton
    Centre Saint Paul, 13258 Marseille 09, France
    Epilepsia 42:42-5. 2001
  6. ncbi request reprint Premature death in juvenile myoclonic epilepsy
    P Genton
    Centre Saint Paul H Gastaut, 300 Bd de Sainte Marguerite, 13258 Marseille 09, France
    Acta Neurol Scand 104:125-9. 2001
  7. ncbi request reprint [The definition of drug resistance: an epileptologist's perspective]
    P Genton
    Centre Saint Paul, HGG, 300 Boulevard de Sainte Marguerite, 13009 Marseille, France
    Rev Neurol (Paris) 160:5S53-9. 2004
  8. ncbi request reprint Valproic acid in epilepsy : pregnancy-related issues
    Pierre Genton
    Centre Saint Paul, Hôpital Gastaut, Marseille, France
    Drug Saf 29:1-21. 2006
  9. ncbi request reprint Levetiracetam in a broad population of patients with refractory epilepsy: interim results of the international SKATE trial
    P Genton
    Hôpital Henri Gastaut Centre Saint Paul, Marseille, France
    Acta Neurol Scand 113:387-94. 2006
  10. ncbi request reprint [Unverricht-Lundborg disease (PME1)]
    P Genton
    Centre Saint Paul H Gastaut, Marseille
    Rev Neurol (Paris) 162:819-26. 2006

Detail Information

Publications31

  1. ncbi request reprint Is it juvenile myoclonic epilepsy?
    P Gelisse
    Centre Saint Paul, Marseille, France
    Epileptic Disord 2:27-32. 2000
    ..In our opinion, JME can be diagnosed in very uncommon settings, including patients with significant brain damage, as long as all the other criteria for the diagnosis are present...
  2. ncbi request reprint Progress in pharmaceutical development presentation with improved pharmacokinetics: a new formulation for valproate
    P Genton
    Centre Saint Paul, Marseille, France
    Acta Neurol Scand Suppl 182:26-32. 2005
    ..A stick pack presentation allows individualized dosing and greater convenience...
  3. doi request reprint Clinical aspects of juvenile myoclonic epilepsy
    Pierre Genton
    Centre Saint Paul, Hôpital Henri Gastaut, Marseille, France
    Epilepsy Behav 28:S8-14. 2013
    ..With JME being so common, we propose that a first GTCS episode in a teenager should be considered as revealing JME until proven otherwise...
  4. doi request reprint The history of juvenile myoclonic epilepsy
    Pierre Genton
    Centre Saint Paul Hôpital Henri Gastaut, Marseille, France
    Epilepsy Behav 28:S2-7. 2013
    ..Juvenile myoclonic epilepsy may not qualify as a "benign" epilepsy, but seizures in most patients can be managed adequately and patients will not suffer severe limitations in their lifetime expectations...
  5. ncbi request reprint Tiagabine in clinical practice
    P Genton
    Centre Saint Paul, 13258 Marseille 09, France
    Epilepsia 42:42-5. 2001
    ..Particularly beneficial indications for TGB and/or AED associations including TGB have not been pointed out, but there is a hint that it works best in temporal lobe epilepsies...
  6. ncbi request reprint Premature death in juvenile myoclonic epilepsy
    P Genton
    Centre Saint Paul H Gastaut, 300 Bd de Sainte Marguerite, 13258 Marseille 09, France
    Acta Neurol Scand 104:125-9. 2001
    ..To report three cases of premature death in juvenile myoclonic epilepsy (JME), a benign form of idiopathic generalized epilepsy (IGE) in which no case of epilepsy-related death has been reported...
  7. ncbi request reprint [The definition of drug resistance: an epileptologist's perspective]
    P Genton
    Centre Saint Paul, HGG, 300 Boulevard de Sainte Marguerite, 13009 Marseille, France
    Rev Neurol (Paris) 160:5S53-9. 2004
    ....
  8. ncbi request reprint Valproic acid in epilepsy : pregnancy-related issues
    Pierre Genton
    Centre Saint Paul, Hôpital Gastaut, Marseille, France
    Drug Saf 29:1-21. 2006
    ..Future research on valproic acid and pregnancy should involve risk assessment in large, population-based prospective studies...
  9. ncbi request reprint Levetiracetam in a broad population of patients with refractory epilepsy: interim results of the international SKATE trial
    P Genton
    Hôpital Henri Gastaut Centre Saint Paul, Marseille, France
    Acta Neurol Scand 113:387-94. 2006
    ..To prospectively assess the safety and efficacy of levetiracetam in patients with uncontrolled focal epilepsy, in a common practice-based setting...
  10. ncbi request reprint [Unverricht-Lundborg disease (PME1)]
    P Genton
    Centre Saint Paul H Gastaut, Marseille
    Rev Neurol (Paris) 162:819-26. 2006
    ..Clinicians and patients are still waiting for an etiologically oriented treatment, which should, ideally, be admnistered early in the course of the disease, if possible before the onset of invalidating symptoms...
  11. ncbi request reprint Epilepsy with myoclonic absences
    Pierre Genton
    Centre Saint Paul, Hôpital Henri Gastaut, Marseille, France
    CNS Drugs 20:911-6. 2006
    ..The more benign cases usually present with MA as the only seizure type, while patients who experience other seizures, especially generalised tonic-clonic seizures, in association with MA may have a less favourable outcome...
  12. ncbi request reprint [Lafora's disease (EPM2)]
    P Genton
    Centre Saint Paul H Gastaut, Marseille
    Rev Neurol (Paris) 163:47-53. 2007
    ..The treatment of LD remains purely symptomatic. Drugs that may aggravate myoclonus must be avoided. Psychological and social management is of utmost importance in LD. Death occurs 4 to 10 years after onset in typical forms...
  13. ncbi request reprint Absence status epilepsy: delineation of a distinct idiopathic generalized epilepsy syndrome
    Pierre Genton
    Centre Saint Paul, Hôpital Henri Gastaut, Marseille, France
    Epilepsia 49:642-9. 2008
    ..Absence status epilepticus (AS) is a prolonged, generalized, and nonconvulsive seizure that may occur in various circumstances. We report a series of patients in whom recurrent, unprovoked, typical AS was the main clinical feature...
  14. doi request reprint Dravet syndrome: the long-term outcome
    Pierre Genton
    Centre Saint Paul Hôpital Henri Gastaut, Marseille, France
    Epilepsia 52:44-9. 2011
    ..Dependency in adulthood is nearly constant: Only 3 of our 24 adult patients lived independently...
  15. ncbi request reprint On the association between valproate and polycystic ovary syndrome
    P Genton
    Centre Saint Paul, Marseille, France
    Epilepsia 42:295-304. 2001
    ..To date, there is no reason to contraindicate the use of VPA in women with epilepsy. However, patients should be informed about the risk of weight gain and its consequences...
  16. ncbi request reprint [Use of topiramate in clinical practice (part 2). Multicentric retrospective evaluation of its safety]
    P Genton
    Centre St Paul, 300 Bd Ste Marguerite, 13258 Marseille cedex 9
    Rev Neurol (Paris) 156:1120-5. 2000
    ..1p.100) or by a combination of these (5p.100). It is useful to use slow titration, in order to allow the greatest possible number of patients to benefit from its efficacy as an add-on drug in the treatment of resistant focal epilepsies...
  17. ncbi request reprint [Psychiatric disorders in juvenile myoclonic epilepsy]
    P Gelisse
    Centre Saint Paul, Marseille, France
    Rev Neurol (Paris) 157:297-302. 2001
    ..The presence of PD does not exclude the diagnosis of JME, and PD may represent a further challenge in the comprehensive care of these patients...
  18. ncbi request reprint [Benign epilepsy in children and adolescents]
    P Genton
    Centre Saint Paul, Marseille
    Presse Med 28:1385-91. 1999
    ..The appropriate therapeutic attitude is usually abstention from long-term antiepileptic treatment. It is importance for all clinicians to be familiar with "benign" epilepsy...
  19. ncbi request reprint When antiepileptic drugs aggravate epilepsy
    P Genton
    Centre Saint Paul, 13258, Marseille, France
    Brain Dev 22:75-80. 2000
    ..Patients are usually aware of aggravation before their doctors: we should listen carefully whenever they express a 'dislike' for an AED...
  20. ncbi request reprint Antimyoclonic effect of levetiracetam
    P Genton
    Centre Saint Paul, 300, boulevard Saint Marguerite, 13009 Marseille, France
    Epileptic Disord 2:209-12. 2000
    ..These preliminary findings suggest that LEV may have interesting antimyoclonic properties that deserve further investigation...
  21. ncbi request reprint Piracetam and levetiracetam: close structural similarities but different pharmacological and clinical profiles
    P Genton
    Centre Saint Paul, Marseille, France
    Epileptic Disord 2:99-105. 2000
    ..LEV is an antiepileptic drug. Clinical trials have confirmed its efficacy in partial seizures and preliminary findings suggest that it is also effective in generalized seizures and myoclonus...
  22. ncbi request reprint Do carbamazepine and phenytoin aggravate juvenile myoclonic epilepsy?
    P Genton
    Centre Saint Paul, Marseille, France
    Neurology 55:1106-9. 2000
    ..However, juvenile myoclonic epilepsy is often misdiagnosed, and some drugs, especially carbamazepine and phenytoin, may have an aggravating effect...
  23. ncbi request reprint Are there generalised spike waves and typical absences in benign rolandic epilepsy?
    P Gelisse
    Centre Saint Paul, Marseilles, France
    Brain Dev 21:390-6. 1999
    ..Brief bursts of bilateral abnormalities occur in about 25% of the cases, mostly with sleepiness. Such findings do not substantiate the existence of a continuum between CAE and BECTS...
  24. ncbi request reprint Incidence of drug-induced aggravation in benign epilepsy with centrotemporal spikes
    D Corda
    Centre Saint Paul, 13258 Marseille 09, France
    Epilepsia 42:754-9. 2001
    ..There is a minor risk of aggravation with CBZ and also probably with PB. Drug-induced aggravation may occur only during certain periods coinciding with spontaneous worsening of BECTS...
  25. pmc Clinical factors of drug resistance in juvenile myoclonic epilepsy
    P Gelisse
    Centre Saint Paul, 300 Bd de Sainte Marguerite, 13009 Marseille, France
    J Neurol Neurosurg Psychiatry 70:240-3. 2001
    ..There is thus a significant subgroup of patients with juvenile myoclonic epilepsy who pose difficult therapeutic problems, and the prevalence of resistant cases may be increased in the experience of a referral epilepsy centre...
  26. ncbi request reprint Startle response: epileptic or non-epileptic? The case for "flash" SMA reflex seizures
    O Cokar
    Centre Saint Paul, 13258 Marseille 09, France
    Epileptic Disord 3:7-12. 2001
    ..We concluded that the patient had an unusual form of cryptogenic focal epilepsy originating from the supplementary motor area, presenting as strictly stimulus-triggered "flash" seizures...
  27. ncbi request reprint Continuous focal spikes during REM sleep in a case of acquired aphasia (Landau-Kleffner syndrome)
    P Genton
    Centre Saint Paul, Marseille, France
    Sleep 15:454-60. 1992
    ..However, this profile was transient and all epileptiform changes disappeared during clinical recovery at 18 months of follow-up...
  28. ncbi request reprint Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A
    S Pereira
    INSERM U491, Marseille, France
    Neurology 63:191-2. 2004
  29. ncbi request reprint [GEFS + syndrome: phenotypic variations from the newborn to the adult in a large French pedigree]
    F Audic-Gerard
    INSERM U491, Faculte de Medecine, Marseille, France
    Rev Neurol (Paris) 159:189-95. 2003
    ..No patient had temporal lobe seizures; they did not have myoclonias nor typical absences. The seizure profile in this family appears to be original, and the existence of yet another type of underlying genetic defect can be suspected...
  30. ncbi request reprint The Ramsay Hunt syndrome revisited: Mediterranean myoclonus versus mitochondrial encephalomyopathy with ragged-red fibers and Baltic myoclonus
    P Genton
    Centre Saint Paul, Marseille, France
    Acta Neurol Scand 81:8-15. 1990
    ..The authors propose that this form of PME, formerly reported as RHS, be more properly described as Mediterranean myoclonus...
  31. ncbi request reprint Phenotype variability in a caucasian family with dentatorubral-pallidoluysian atrophy
    W Casseron
    Centre St Paul, Hôpital Henri Gastaut, Marseille, France
    Eur Neurol 52:175-6. 2004