Auguste Genovesio

Summary

Publications

  1. doi request reprint Automated genome-wide visual profiling of cellular proteins involved in HIV infection
    Auguste Genovesio
    Institut Pasteur Korea, Gyeonggi Do, Korea
    J Biomol Screen 16:945-58. 2011
  2. pmc Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum
    Carolina B Moraes
    Center for Neglected Diseases Drug Discovery CND3, Institut Pasteur Korea, Gyeonggi Do, South Korea
    PLoS ONE 8:e55539. 2013
  3. pmc Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection
    Auguste Genovesio
    Image Mining Group, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, South Korea
    PLoS ONE 6:e19733. 2011
  4. doi request reprint Development of a multiplex phenotypic cell-based high throughput screening assay to identify novel hepatitis C virus antivirals
    Hee Young Kim
    Applied Molecular Virology, Institut Pasteur Korea, 696 Sampyeong dong, Bundang gu, Seongnam si, Gyeonggi Do, South Korea
    Antiviral Res 99:6-11. 2013
  5. pmc An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes
    Min Je Ku
    Center for Neglected Diseases Drug Discovery CND3, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, South Korea
    PLoS ONE 7:e41765. 2012
  6. doi request reprint A novel specific edge effect correction method for RNA interference screenings
    Jean Philippe Carralot
    Biology of Intracellular Pathogens, Inserm Avenir Team, Institut Pasteur Korea, Seongnam si, Korea
    Bioinformatics 28:261-8. 2012
  7. ncbi request reprint High-content classification of nucleocytoplasmic import or export inhibitors
    Yong Jun Kwon
    Institut Pasteur Korea, Seongbuk gu, Seoul, Korea
    J Biomol Screen 12:621-7. 2007
  8. doi request reprint Quantification of protein interaction in living cells by two-photon spectral imaging with fluorescent protein fluorescence resonance energy transfer pair devoid of acceptor bleed-through
    Jiho Kim
    Neurodegeneration and Applied Microscopy, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, 463 400 South Korea
    Cytometry A 81:112-9. 2012
  9. pmc An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages
    Jair L Siqueira-Neto
    Center for Neglected Diseases Drug Discovery CND3, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, South Korea
    PLoS Negl Trop Dis 6:e1671. 2012
  10. doi request reprint A high-content subtractive screen for selecting small molecules affecting internalization of GPCRs
    Yong Jun Kwon
    Institut Pasteur Korea, Gyeonggi Do, Korea
    J Biomol Screen 17:379-85. 2012

Collaborators

Detail Information

Publications12

  1. doi request reprint Automated genome-wide visual profiling of cellular proteins involved in HIV infection
    Auguste Genovesio
    Institut Pasteur Korea, Gyeonggi Do, Korea
    J Biomol Screen 16:945-58. 2011
    ..As proof of concept, the authors confirmed that silencing of PAK1, Ku70, and RNAseH2A impaired HIV replication in Jurkat cells. In summary, multidimensional, visual profiling can identify genes required for HIV infection...
  2. pmc Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum
    Carolina B Moraes
    Center for Neglected Diseases Drug Discovery CND3, Institut Pasteur Korea, Gyeonggi Do, South Korea
    PLoS ONE 8:e55539. 2013
    ..In conclusion, these data suggest that transcription is spatially contained in discrete foci that are developmentally regulated during the asexual cycle of malaria parasites and located in areas of low chromatin density...
  3. pmc Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection
    Auguste Genovesio
    Image Mining Group, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, South Korea
    PLoS ONE 6:e19733. 2011
    ..cruzi infection. This study represents a significant step toward unveiling the key molecular requirements for host cell invasion and revealing new potential targets for antiparasitic therapy...
  4. doi request reprint Development of a multiplex phenotypic cell-based high throughput screening assay to identify novel hepatitis C virus antivirals
    Hee Young Kim
    Applied Molecular Virology, Institut Pasteur Korea, 696 Sampyeong dong, Bundang gu, Seongnam si, Gyeonggi Do, South Korea
    Antiviral Res 99:6-11. 2013
    ..Taken together, this multiplex phenotypic platform facilitates the identification of novel compounds for drug development and chemical probes for continuing efforts to understand the HCV life cycle...
  5. pmc An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes
    Min Je Ku
    Center for Neglected Diseases Drug Discovery CND3, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, South Korea
    PLoS ONE 7:e41765. 2012
    ..Taken together, our data establish that the developed assay is highly suitable for drug studies targeting placental malaria, and will facilitate the discovery and rapid development of new therapies against malaria...
  6. doi request reprint A novel specific edge effect correction method for RNA interference screenings
    Jean Philippe Carralot
    Biology of Intracellular Pathogens, Inserm Avenir Team, Institut Pasteur Korea, Seongnam si, Korea
    Bioinformatics 28:261-8. 2012
    ..The proposed algorithm was able to correct the edge effect biasing the control data and thus improve assay quality and, consequently, the hit-selection step...
  7. ncbi request reprint High-content classification of nucleocytoplasmic import or export inhibitors
    Yong Jun Kwon
    Institut Pasteur Korea, Seongbuk gu, Seoul, Korea
    J Biomol Screen 12:621-7. 2007
    ..The results establish a robust method for identifying compounds regulating nucleocytoplasmic import or export and also implicate MAP kinases in nuclear import of nuclear factor kappa B...
  8. doi request reprint Quantification of protein interaction in living cells by two-photon spectral imaging with fluorescent protein fluorescence resonance energy transfer pair devoid of acceptor bleed-through
    Jiho Kim
    Neurodegeneration and Applied Microscopy, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, 463 400 South Korea
    Cytometry A 81:112-9. 2012
    ..We believe that the FRET approach using two-photon and fluorescent YFP/mCherry pair is a promising method to monitor protein interaction in living cells...
  9. pmc An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages
    Jair L Siqueira-Neto
    Center for Neglected Diseases Drug Discovery CND3, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, South Korea
    PLoS Negl Trop Dis 6:e1671. 2012
    ..These data corroborate the idea that the intracellular amastigote form of the parasite is the most appropriate to be used in primary screening assay for Leishmania...
  10. doi request reprint A high-content subtractive screen for selecting small molecules affecting internalization of GPCRs
    Yong Jun Kwon
    Institut Pasteur Korea, Gyeonggi Do, Korea
    J Biomol Screen 17:379-85. 2012
    ..Selective analysis can therefore rapidly select compounds selectively affecting GPCR activity with specificity to one receptor class through high-content screening...
  11. doi request reprint Contextual automated 3D analysis of subcellular organelles adapted to high-content screening
    Thierry Dorval
    Cellular Differentiation, Institut Pasteur Korea, Seongnam si, Gyeonggi Do, Korea
    J Biomol Screen 15:847-57. 2010
    ..They show that their method enables the classification of various translocation levels of torsinA and opens the possibility for compound-based screening campaigns restoring the normal torsinA phenotype...
  12. ncbi request reprint A modified fluorescence in situ hybridization protocol for Plasmodium falciparum greatly improves nuclear architecture conservation
    Monica Contreras-Dominguez
    Center for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang gu, Seongnam si, Gyeonggi Do, South Korea
    Mol Biochem Parasitol 173:48-52. 2010
    ....